YU40717B - Process for obtaininga 5-suvstituted (1,2-dihydro-3h-pyrrolo-(1,2-a)pyrrol-lcarboxylic acids - Google Patents

Process for obtaininga 5-suvstituted (1,2-dihydro-3h-pyrrolo-(1,2-a)pyrrol-lcarboxylic acids

Info

Publication number
YU40717B
YU40717B YU1741/78A YU174178A YU40717B YU 40717 B YU40717 B YU 40717B YU 1741/78 A YU1741/78 A YU 1741/78A YU 174178 A YU174178 A YU 174178A YU 40717 B YU40717 B YU 40717B
Authority
YU
Yugoslavia
Prior art keywords
suvstituted
obtaininga
lcarboxylic
pyrrol
pyrrolo
Prior art date
Application number
YU1741/78A
Other languages
English (en)
Other versions
YU174178A (en
Inventor
A Vanhorn
P Gallegra
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25225403&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU40717(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of YU174178A publication Critical patent/YU174178A/xx
Publication of YU40717B publication Critical patent/YU40717B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
YU1741/78A 1977-07-25 1978-07-20 Process for obtaininga 5-suvstituted (1,2-dihydro-3h-pyrrolo-(1,2-a)pyrrol-lcarboxylic acids YU40717B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81837777A 1977-07-25 1977-07-25

Publications (2)

Publication Number Publication Date
YU174178A YU174178A (en) 1983-01-21
YU40717B true YU40717B (en) 1986-04-30

Family

ID=25225403

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1741/78A YU40717B (en) 1977-07-25 1978-07-20 Process for obtaininga 5-suvstituted (1,2-dihydro-3h-pyrrolo-(1,2-a)pyrrol-lcarboxylic acids

Country Status (27)

Country Link
US (1) US4140698A (el)
EP (1) EP0000649B1 (el)
JP (1) JPS5424889A (el)
AT (1) AT364843B (el)
AU (1) AU515352B2 (el)
CA (1) CA1111431A (el)
CS (1) CS201015B2 (el)
DD (1) DD137229A5 (el)
DE (1) DE2860560D1 (el)
DK (1) DK146720C (el)
ES (1) ES472002A1 (el)
FI (1) FI64597C (el)
GR (1) GR63733B (el)
HK (1) HK17186A (el)
HU (1) HU178354B (el)
IE (1) IE47138B1 (el)
IL (1) IL55181A (el)
IT (1) IT1160443B (el)
MY (1) MY8800142A (el)
NO (2) NO166863C (el)
NZ (1) NZ187924A (el)
PL (1) PL111419B1 (el)
PT (1) PT68328A (el)
SG (1) SG31884G (el)
SU (1) SU1138029A3 (el)
YU (1) YU40717B (el)
ZA (1) ZA784216B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232038A (en) * 1979-08-31 1980-11-04 Syntex (U.S.A.) Inc. 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids
EP0034481B1 (en) * 1980-02-14 1984-05-30 Grigg, Ronald Ernest 2-methyl-5-thiazole-methylamine and carboxamide derivatives
US4344943A (en) * 1980-06-09 1982-08-17 Syntex (U.S.A.) Inc. 6-Chloro- or 6-bromo-1,2-dihydro-3H-pyrrolo[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof
US4353829A (en) * 1980-11-21 1982-10-12 Syntex (U.S.A.) Inc. Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
WO1983001382A1 (en) * 1981-10-13 1983-04-28 Mroszczak, Edward Gastrointestinal sparing thioester pro-drugs
US4397862A (en) * 1981-10-13 1983-08-09 Syntex (U.S.A.) Inc. Gastrointestinal sparing thioester drugs
US4454151A (en) * 1982-03-22 1984-06-12 Syntex (U.S.A.) Inc. Use of pyrrolo pyrroles in treatment of ophthalmic diseases
US4457941A (en) * 1982-03-22 1984-07-03 Syntex (U.S.A.) Inc. Use of pyrrolo-pyrrole in treating microvascular diseases associated with diabetes
EP0117675B1 (en) * 1983-02-19 1986-07-23 Beecham Group Plc Benzofuran and benzothiophene-carboxylic-acid derivatives
US4874871A (en) * 1987-03-25 1989-10-17 Syntex (U.S.A.) Inc. Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
JP2649168B2 (ja) * 1988-02-25 1997-09-03 久光製薬株式会社 新規な５，６−ジフェニル−１，２−ジヒドロ−３Ｈ−ピロロ［１，２−ａ］ピロール−１−カルボン酸誘導体
WO1995001767A1 (en) * 1993-07-08 1995-01-19 Cygnus Therapeutic Systems Monolithic matrix transdermal delivery system
US5621115A (en) * 1996-02-21 1997-04-15 Ohmeda Pharmaceutical Products Division Inc. Methods for preparing 5-aroyl-1,2-dihydro-3H-pyrrolo-[1,2-A]pyrrole-1-carboxylic acids
US6191285B1 (en) 1997-07-03 2001-02-20 Abbott Laboratories Process for the preparation of ketorolac tromethamine
EP1097152B1 (en) * 1998-07-10 2006-04-19 Mallinckrodt Inc. Synthesis of compounds useful in the manufacture of ketorolac

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS539789A (en) * 1976-07-14 1978-01-28 Syntex Inc Production of 55*22floyl** * 55*22thenoyl** * 55*33 floyl** and 55*33thenoyl** 1*22dihydroo3hhpyroro * 1*22a*pyrolee11carboxylic acid derivative
JPS539788A (en) * 1976-07-14 1978-01-28 Syntex Inc 55aloyll1*22dihydroo3hh pyroro *1*22a* pyroll11 carboxylic acid derivative
US4087539A (en) * 1976-07-14 1978-05-02 Syntex (U.S.A.) Inc. 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4089969A (en) * 1976-07-14 1978-05-16 Syntex (U.S.A.) Inc. 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4097579A (en) * 1977-03-31 1978-06-27 Syntex (U.S.A.) Inc. 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof

Also Published As

Publication number Publication date
IE47138B1 (en) 1983-12-28
YU174178A (en) 1983-01-21
IL55181A0 (en) 1978-09-29
US4140698A (en) 1979-02-20
FI64597C (fi) 1983-12-12
IE781473L (en) 1979-01-25
ES472002A1 (es) 1984-07-16
EP0000649A1 (en) 1979-02-07
DK146720C (da) 1984-08-20
NO155244C (no) 1987-03-04
AU515352B2 (en) 1981-04-02
NO155244B (no) 1986-11-24
HU178354B (en) 1982-04-28
CS201015B2 (en) 1980-10-31
IT7868765A0 (it) 1978-07-24
ATA528978A (de) 1981-04-15
JPS5424889A (en) 1979-02-24
FI64597B (fi) 1983-08-31
GR63733B (en) 1979-12-04
NO851935L (no) 1979-01-26
PL208576A1 (pl) 1979-05-07
EP0000649B1 (en) 1981-03-25
SG31884G (en) 1985-09-13
CA1111431A (en) 1981-10-27
MY8800142A (en) 1988-12-31
SU1138029A3 (ru) 1985-01-30
IT1160443B (it) 1987-03-11
PL111419B1 (en) 1980-08-30
HK17186A (en) 1986-03-21
NO166863B (no) 1991-06-03
NO782545L (no) 1979-01-26
DK325078A (da) 1979-01-26
NZ187924A (en) 1980-03-05
JPS6337793B2 (el) 1988-07-27
NO166863C (no) 1991-09-11
AT364843B (de) 1981-11-25
DD137229A5 (de) 1979-08-22
AU3826978A (en) 1980-01-31
DE2860560D1 (en) 1981-04-16
FI782307A (fi) 1979-01-26
ZA784216B (en) 1980-02-27
DK146720B (da) 1983-12-12
PT68328A (en) 1978-08-01
IL55181A (en) 1981-12-31

Similar Documents

Publication Publication Date Title
YU201180A (en) Process for preparingnew 2,4,6-triiodo-isophalic acid derivatives
HU177900B (en) Process for preparing 7alpha-methoxy-7beta-malonamido-3-/1,3,4-thiadiazoly-5-yl/-thiomethy/-1-dethia-1-oxa-3-cefem-4-carboxylic acid derivatives
AU512051B2 (en) Process for preparing 1, 4: , 6-dianhydro-d-glucitol-2-nitrate
HU178910B (en) Process for preparing 2,3-disubstituted-4-oxo-4h-pyrido/1,2-a/-pyrimidines
YU40717B (en) Process for obtaininga 5-suvstituted (1,2-dihydro-3h-pyrrolo-(1,2-a)pyrrol-lcarboxylic acids
YU287779A (en) Process for obtaining 7-oxo-4-thia-1-aca-bicyclo(3.2.0)heptane derivatives
AU520715B2 (en) PROCESS FOR PRODUCING (d. 1)-5-METHYL-TETRAHYDROFOLIC ACID
YU40704B (en) Process for obtaininga 5(6)-thiobenzamidazole derivatives
YU40816B (en) Process for obtaining 5-aroyl-1,2 dihydro-3h-pyrrolo (1,2-a)pyrrol-1-carboxylic derivatives
GB2000137B (en) Process for the preparation of 7,8-dihydro-14-hydroxynormorphine
YU44663B (en) Process for obtaining 4-substituted imidazo /1,2a/ hynoxaline
YU78679A (en) Process for obtaining 1,3-dibenzoyloxy-17 alpha-ethinyl-7 alpha-methyl-1,3,5(10)-estratriene-17 beta-ol
DE2860031D1 (en) Process for the preparation of 3,4-methylendioxymandelic acid
SU913942A3 (en) Process for producing 2,4-diamino-6-pyperidinopyrimidine-3-oxy (its modifications)
HU174059B (hu) Sposob poluchenija 2,3-dimetil-pentanala
GR65275B (en) Method for the preparation of 2,3-polymethyleno-4-oxo-4h-pyrido(1,2-a)pyrimidins
YU296479A (en) Process for obtaining 1,3,4-thiadiazole-2-carboxylic acid derivatives
PH17661A (en) Process for preparation of 9(2,6-dihalobenzyl)adedines
YU220082A (en) Process for producing 2,3-dicyanopyrazine
PH15677A (en) Process for the production of 2,9-dioxatricyclo(4,3,1,0 3)decanes
YU55679A (en) Process for obtaining 1,2-dioximes
GB2008116B (en) Process for preparing 2,5-diketogluconic acid
PT67605A (en) Process for the preparation of 2,9-dioxatricyclo(4,3,1,o,3,7)decanes
PT68626A (en) Process for the preparation of 2-furyl-(3,4-dimethyl-2-pyridyl)-carbinol
YU40759B (en) Process for obtaining 1,2,3-thiadiazole-5-yl-carbamide