FI63410C - Foerfarande foer framstaellning av antibakterial 7beta-haloarylmalonamido-7alfa-metoxi-3-heterocyklisk tiometyl-1-detia-1-oxa-3-cefem-4-karboxylsyra eller derivat daerav - Google Patents
Foerfarande foer framstaellning av antibakterial 7beta-haloarylmalonamido-7alfa-metoxi-3-heterocyklisk tiometyl-1-detia-1-oxa-3-cefem-4-karboxylsyra eller derivat daerav Download PDFInfo
- Publication number
- FI63410C FI63410C FI781313A FI781313A FI63410C FI 63410 C FI63410 C FI 63410C FI 781313 A FI781313 A FI 781313A FI 781313 A FI781313 A FI 781313A FI 63410 C FI63410 C FI 63410C
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- Finland
- Prior art keywords
- acid
- oxa
- detia
- methoxy
- thiomethyl
- Prior art date
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- 125000003118 aryl group Chemical group 0.000 description 1
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- MDHYEMXUFSJLGV-UHFFFAOYSA-N beta-phenethyl acetate Natural products CC(=O)OCCC1=CC=CC=C1 MDHYEMXUFSJLGV-UHFFFAOYSA-N 0.000 description 1
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- 125000002091 cationic group Chemical group 0.000 description 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 1
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- GPLDMUXVGHQFCF-UHFFFAOYSA-N ethyl 2-(5-chloro-2-fluoro-4-methylphenyl)-2-oxoacetate Chemical compound CCOC(=O)C(=O)C1=CC(Cl)=C(C)C=C1F GPLDMUXVGHQFCF-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 description 1
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- HHLFWLYXYJOTON-UHFFFAOYSA-N glyoxylic acid Chemical compound OC(=O)C=O HHLFWLYXYJOTON-UHFFFAOYSA-N 0.000 description 1
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- 125000001072 heteroaryl group Chemical group 0.000 description 1
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- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
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- 239000011261 inert gas Substances 0.000 description 1
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- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
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- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
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- 229910052751 metal Inorganic materials 0.000 description 1
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
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- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
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- 239000000546 pharmaceutical excipient Substances 0.000 description 1
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- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 description 1
- 238000001226 reprecipitation Methods 0.000 description 1
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- 206010039083 rhinitis Diseases 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- VYPDUQYOLCLEGS-UHFFFAOYSA-M sodium;2-ethylhexanoate Chemical compound [Na+].CCCCC(CC)C([O-])=O VYPDUQYOLCLEGS-UHFFFAOYSA-M 0.000 description 1
- 125000003638 stannyl group Chemical group [H][Sn]([H])([H])* 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 125000004299 tetrazol-5-yl group Chemical class [H]N1N=NC(*)=N1 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP52049630A JPS609717B2 (ja) | 1977-04-28 | 1977-04-28 | ハロアリ―ルマロンアミドオキサセフアロスポリン |
| JP4963077 | 1977-04-28 | ||
| JP10226077 | 1977-08-25 | ||
| JP52102260A JPS6031835B2 (ja) | 1977-08-25 | 1977-08-25 | チアジアゾリルチオオキサセフアロスポリン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI781313A7 FI781313A7 (fi) | 1978-10-29 |
| FI63410B FI63410B (fi) | 1983-02-28 |
| FI63410C true FI63410C (fi) | 1983-06-10 |
Family
ID=26390044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI781313A FI63410C (fi) | 1977-04-28 | 1978-04-27 | Foerfarande foer framstaellning av antibakterial 7beta-haloarylmalonamido-7alfa-metoxi-3-heterocyklisk tiometyl-1-detia-1-oxa-3-cefem-4-karboxylsyra eller derivat daerav |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4183928A (cs) |
| AR (1) | AR227614A1 (cs) |
| AT (1) | AT357674B (cs) |
| AU (1) | AU522851B2 (cs) |
| BG (1) | BG34337A3 (cs) |
| CA (1) | CA1100962A (cs) |
| CH (1) | CH640535A5 (cs) |
| CS (1) | CS199726B2 (cs) |
| DD (1) | DD135908A5 (cs) |
| DE (1) | DE2818985C2 (cs) |
| DK (1) | DK182878A (cs) |
| ES (1) | ES469206A1 (cs) |
| FI (1) | FI63410C (cs) |
| FR (1) | FR2388815A1 (cs) |
| GB (1) | GB1574273A (cs) |
| GR (1) | GR69966B (cs) |
| HU (1) | HU178105B (cs) |
| IE (1) | IE46627B1 (cs) |
| IL (1) | IL54596A0 (cs) |
| IT (1) | IT1111469B (cs) |
| MX (1) | MX5952E (cs) |
| NL (1) | NL189669C (cs) |
| NO (1) | NO158506C (cs) |
| NZ (1) | NZ187086A (cs) |
| PH (1) | PH16851A (cs) |
| PL (1) | PL110680B1 (cs) |
| PT (1) | PT67957B (cs) |
| SU (1) | SU784779A3 (cs) |
| YU (1) | YU42477B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4259485A (en) * | 1979-04-24 | 1981-03-31 | Eli Lilly And Company | Crystallization process |
| JPS60123490A (ja) * | 1983-12-07 | 1985-07-02 | Shionogi & Co Ltd | マロニルオキサセフェムカルボン酸誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL178005C (nl) * | 1972-11-06 | 1986-01-02 | Merck & Co Inc | Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum. |
| GB1510794A (en) * | 1974-08-06 | 1978-05-17 | Univ Kingston | 1-oxacephems and intermediates therefor |
| US4045438A (en) * | 1975-10-24 | 1977-08-30 | Yeda Research And Development Co. Ltd. | Cephalosporin antibiotics |
| US4048311A (en) * | 1976-01-08 | 1977-09-13 | Smithkline Corporation | 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins |
| CA1085392A (en) * | 1976-03-25 | 1980-09-09 | Masayuki Narisada | Arylmalonamido-1-oxadethiacephalosporins |
-
1978
- 1978-04-10 CA CA300,788A patent/CA1100962A/en not_active Expired
- 1978-04-17 PH PH21016A patent/PH16851A/en unknown
- 1978-04-24 GB GB16128/78A patent/GB1574273A/en not_active Expired
- 1978-04-26 US US05/900,235 patent/US4183928A/en not_active Expired - Lifetime
- 1978-04-26 GR GR56114A patent/GR69966B/el unknown
- 1978-04-26 NZ NZ187086A patent/NZ187086A/xx unknown
- 1978-04-26 DK DK182878A patent/DK182878A/da not_active Application Discontinuation
- 1978-04-26 SU SU782608717A patent/SU784779A3/ru active
- 1978-04-27 FI FI781313A patent/FI63410C/fi not_active IP Right Cessation
- 1978-04-27 AR AR271935A patent/AR227614A1/es active
- 1978-04-27 MX MX787044U patent/MX5952E/es unknown
- 1978-04-27 PT PT67957A patent/PT67957B/pt unknown
- 1978-04-27 HU HU78SI1625A patent/HU178105B/hu not_active IP Right Cessation
- 1978-04-27 NO NO781502A patent/NO158506C/no unknown
- 1978-04-27 ES ES469206A patent/ES469206A1/es not_active Expired
- 1978-04-27 FR FR7812532A patent/FR2388815A1/fr active Granted
- 1978-04-27 IL IL54596A patent/IL54596A0/xx not_active IP Right Cessation
- 1978-04-27 AU AU35527/78A patent/AU522851B2/en not_active Expired
- 1978-04-28 IE IE844/78A patent/IE46627B1/en not_active IP Right Cessation
- 1978-04-28 BG BG039585A patent/BG34337A3/xx unknown
- 1978-04-28 IT IT67986/78A patent/IT1111469B/it active
- 1978-04-28 CS CS782774A patent/CS199726B2/cs unknown
- 1978-04-28 CH CH470478A patent/CH640535A5/de not_active IP Right Cessation
- 1978-04-28 YU YU1035/78A patent/YU42477B/xx unknown
- 1978-04-28 PL PL1978206451A patent/PL110680B1/pl unknown
- 1978-04-28 DD DD78205105A patent/DD135908A5/xx not_active IP Right Cessation
- 1978-04-28 DE DE2818985A patent/DE2818985C2/de not_active Expired - Fee Related
- 1978-04-28 NL NLAANVRAGE7804628,A patent/NL189669C/xx not_active IP Right Cessation
- 1978-04-28 AT AT311378A patent/AT357674B/de not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: SHINOGI & CO., LTD. |