FI62309C - Analogifoerfarande foer framstaellning av farmakologiskt aktiva alkyl-5-(3,6-dihydro-1(2h)-pyridyl)-2-oxo-2h-(1,2,4)oxadiatzolo(2,3-a)-pyrimidin-7-karbamat - Google Patents
Analogifoerfarande foer framstaellning av farmakologiskt aktiva alkyl-5-(3,6-dihydro-1(2h)-pyridyl)-2-oxo-2h-(1,2,4)oxadiatzolo(2,3-a)-pyrimidin-7-karbamat Download PDFInfo
- Publication number
- FI62309C FI62309C FI780343A FI780343A FI62309C FI 62309 C FI62309 C FI 62309C FI 780343 A FI780343 A FI 780343A FI 780343 A FI780343 A FI 780343A FI 62309 C FI62309 C FI 62309C
- Authority
- FI
- Finland
- Prior art keywords
- dihydro
- pyridyl
- pyrimidine
- oxo
- formula
- Prior art date
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- -1 3,6-DIHYDRO-1 (2H) -PYRIDYL Chemical class 0.000 title claims description 21
- 230000000144 pharmacologic effect Effects 0.000 title 1
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- 150000001875 compounds Chemical class 0.000 claims description 38
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- 238000000034 method Methods 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- 238000005809 transesterification reaction Methods 0.000 claims description 7
- 239000007858 starting material Substances 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 4
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- QJIUMVUZDYPQRT-UHFFFAOYSA-N 6-chloro-2,4-pyrimidinediamine Chemical compound NC1=CC(Cl)=NC(N)=N1 QJIUMVUZDYPQRT-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
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- 229910002027 silica gel Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000012982 x-ray structure analysis Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI813544A FI813544L (fi) | 1977-02-04 | 1978-02-02 | Pyrimidinderivat |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT73877 | 1977-02-04 | ||
| AT73877A AT351036B (de) | 1977-02-04 | 1977-02-04 | Verfahren zur herstellung von neuen oxadiazolopyrimidinderivaten und von deren salzen |
| LU78639 | 1977-12-05 | ||
| LU7778639A LU78639A1 (de) | 1977-02-04 | 1977-12-05 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI780343A7 FI780343A7 (fi) | 1978-08-05 |
| FI62309B FI62309B (fi) | 1982-08-31 |
| FI62309C true FI62309C (fi) | 1982-12-10 |
Family
ID=25593772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI780343A FI62309C (fi) | 1977-02-04 | 1978-02-02 | Analogifoerfarande foer framstaellning av farmakologiskt aktiva alkyl-5-(3,6-dihydro-1(2h)-pyridyl)-2-oxo-2h-(1,2,4)oxadiatzolo(2,3-a)-pyrimidin-7-karbamat |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4150132A (de) |
| JP (1) | JPS6024794B2 (de) |
| AR (1) | AR223642A1 (de) |
| CA (1) | CA1092108A (de) |
| CH (1) | CH638215A5 (de) |
| DE (1) | DE2804518C2 (de) |
| DK (1) | DK50878A (de) |
| ES (2) | ES466589A1 (de) |
| FI (1) | FI62309C (de) |
| FR (2) | FR2379538A1 (de) |
| GB (2) | GB1563888A (de) |
| GR (1) | GR72280B (de) |
| IE (1) | IE46318B1 (de) |
| IL (2) | IL53925A (de) |
| IT (1) | IT1092334B (de) |
| MC (1) | MC1183A1 (de) |
| NL (1) | NL179585C (de) |
| NO (2) | NO780396L (de) |
| NZ (1) | NZ186334A (de) |
| PH (3) | PH13962A (de) |
| PT (1) | PT67614B (de) |
| SE (1) | SE7801311L (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1103245A (en) * | 1978-07-21 | 1981-06-16 | Jean-Claude Muller | Process for the manufacture of novel oxadiazolopyrimidine derivatives |
| NZ190915A (en) * | 1978-07-31 | 1984-07-31 | Hoffmann La Roche | Oxadiazolotriazine derivatives and pharmaceutical compositions |
| US4307093A (en) * | 1980-06-23 | 1981-12-22 | The Upjohn Company | Animal feed and process |
| DK148826C (da) * | 1980-12-19 | 1986-03-24 | Hoffmann La Roche | Analogifremgangsmaade til fremstilling af oxadiazolopyrimidinderivater eller salte deraf med baser og pyrimidinderivat til anvendelse som mellemprodukt ved denne fremgangsmaade |
| CA1179344A (en) * | 1981-07-15 | 1984-12-11 | Jean-Claude Muller | Process for the preparation of 6-¬3,6-dihydro-1(2h)- pyridyl| pyrimidine-3-oxides |
| CH649291A5 (de) * | 1982-03-16 | 1985-05-15 | Hoffmann La Roche | Dicarbamate. |
| WO1986000616A1 (en) * | 1984-07-13 | 1986-01-30 | Gail Sansone Bazzano | Substituted pyrimidine oxides useful for hair growth promotion |
| JPH04249875A (ja) * | 1991-01-08 | 1992-09-04 | Yazaki Corp | 電線を端子化するための成形用電極及び端子化電線 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3382247A (en) * | 1965-11-01 | 1968-05-07 | Upjohn Co | 6-amino-1, 2-dihydro-1-hydroxy-2-imino-4-phenoxypyrimidines |
| CA1020558A (en) * | 1971-04-07 | 1977-11-08 | Richard C. Thomas (Jr.) | 6-amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidines |
| DE2118261A1 (de) * | 1971-04-15 | 1972-11-02 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue N-haltige Bicyclen, deren Säureadditionssalze sowie Verfahren zu deren Herstellung |
| BE786028A (fr) * | 1971-07-08 | 1973-01-08 | Boehringer Sohn Ingelheim | 2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer |
| BE790008A (fr) * | 1971-10-15 | 1973-04-12 | Fmc Corp | Nouveaux composes herbicides |
| DE2210633C2 (de) * | 1972-03-06 | 1983-09-22 | Bayer Ag, 5090 Leverkusen | Kondensierte Pyridinderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE2252122A1 (de) * | 1972-10-24 | 1974-04-25 | Hoechst Ag | Oxazolo-chinazoline und verfahren zu ihrer herstellung |
| DE2253555A1 (de) * | 1972-11-02 | 1974-05-09 | Hoechst Ag | Oxazolo-pyrimidine und verfahren zu ihrer herstellung |
| US3901928A (en) * | 1973-01-10 | 1975-08-26 | Robert Henry Hesse | 1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds |
-
1978
- 1978-01-10 CH CH22778A patent/CH638215A5/de not_active IP Right Cessation
- 1978-01-23 CA CA295,438A patent/CA1092108A/en not_active Expired
- 1978-01-27 NZ NZ186334A patent/NZ186334A/xx unknown
- 1978-01-27 US US05/873,182 patent/US4150132A/en not_active Expired - Lifetime
- 1978-01-30 IT IT19786/78A patent/IT1092334B/it active
- 1978-01-30 IE IE197/78A patent/IE46318B1/en unknown
- 1978-01-30 IL IL53925A patent/IL53925A/xx unknown
- 1978-02-02 GR GR55335A patent/GR72280B/el unknown
- 1978-02-02 MC MC781280A patent/MC1183A1/fr unknown
- 1978-02-02 FR FR7802908A patent/FR2379538A1/fr active Granted
- 1978-02-02 DE DE2804518A patent/DE2804518C2/de not_active Expired
- 1978-02-02 JP JP53009964A patent/JPS6024794B2/ja not_active Expired
- 1978-02-02 FI FI780343A patent/FI62309C/fi not_active IP Right Cessation
- 1978-02-03 GB GB2536/79A patent/GB1563888A/en not_active Expired
- 1978-02-03 NL NLAANVRAGE7801288,A patent/NL179585C/xx not_active IP Right Cessation
- 1978-02-03 PT PT67614A patent/PT67614B/pt unknown
- 1978-02-03 DK DK50878A patent/DK50878A/da not_active Application Discontinuation
- 1978-02-03 AR AR270966A patent/AR223642A1/es active
- 1978-02-03 SE SE7801311A patent/SE7801311L/xx unknown
- 1978-02-03 ES ES466589A patent/ES466589A1/es not_active Expired
- 1978-02-03 GB GB4450/78A patent/GB1563887A/en not_active Expired
- 1978-02-03 NO NO780396A patent/NO780396L/no unknown
- 1978-02-06 PH PH20750A patent/PH13962A/en unknown
- 1978-02-06 PH PH20749A patent/PH14637A/en unknown
- 1978-07-11 FR FR7820654A patent/FR2383941A1/fr active Granted
- 1978-08-28 ES ES472875A patent/ES472875A1/es not_active Expired
- 1978-11-19 PH PH21786A patent/PH15009A/en unknown
-
1980
- 1980-03-14 IL IL59627A patent/IL59627A0/xx unknown
- 1980-10-23 NO NO803160A patent/NO803160L/no unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: F. HOFFMANN-LA ROCHE & CO. |