FI56771C - Foerfarande foer rening av ett vaextextrakt av loev fraon zoapatle-vaexten saosom montanoa tomentosa eller montanoa floribunda-vaexten innehaollande livmodertoemmande foereningar - Google Patents
Foerfarande foer rening av ett vaextextrakt av loev fraon zoapatle-vaexten saosom montanoa tomentosa eller montanoa floribunda-vaexten innehaollande livmodertoemmande foereningar Download PDFInfo
- Publication number
- FI56771C FI56771C FI751085A FI751085A FI56771C FI 56771 C FI56771 C FI 56771C FI 751085 A FI751085 A FI 751085A FI 751085 A FI751085 A FI 751085A FI 56771 C FI56771 C FI 56771C
- Authority
- FI
- Finland
- Prior art keywords
- organic
- montanoa
- water
- room temperature
- vaexten
- Prior art date
Links
- 241000396685 Montanoa Species 0.000 title claims description 7
- 241000401894 Montanoa tomentosa Species 0.000 title claims description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 30
- 150000001875 compounds Chemical class 0.000 claims description 27
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 230000000779 depleting effect Effects 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 13
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 12
- 241000196324 Embryophyta Species 0.000 claims description 11
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- 239000000284 extract Substances 0.000 claims description 9
- XRDHAXIOHKTIGF-UKHUEATNSA-N 9-[(2r,3s,6e)-3-hydroxy-6-(2-hydroxyethylidene)-2-methyloxepan-2-yl]-2,6-dimethylnon-2-en-5-one Chemical compound CC(C)=CCC(=O)C(C)CCC[C@@]1(C)OC\C(=C\CO)CC[C@@H]1O XRDHAXIOHKTIGF-UKHUEATNSA-N 0.000 claims description 8
- 239000000419 plant extract Substances 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 239000012074 organic phase Substances 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 4
- 239000003463 adsorbent Substances 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 239000000499 gel Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000012454 non-polar solvent Substances 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 230000008020 evaporation Effects 0.000 claims description 2
- 229920000620 organic polymer Polymers 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000005416 organic matter Substances 0.000 claims 1
- 239000012071 phase Substances 0.000 claims 1
- 239000000287 crude extract Substances 0.000 description 7
- 230000035935 pregnancy Effects 0.000 description 7
- 210000004291 uterus Anatomy 0.000 description 7
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 6
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 6
- 238000004817 gas chromatography Methods 0.000 description 6
- 210000003101 oviduct Anatomy 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 244000269722 Thea sinensis Species 0.000 description 4
- 238000004809 thin layer chromatography Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- WGXZDYPGLJYBJW-UHFFFAOYSA-N chloroform;propan-2-ol Chemical compound CC(C)O.ClC(Cl)Cl WGXZDYPGLJYBJW-UHFFFAOYSA-N 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229960003387 progesterone Drugs 0.000 description 3
- 239000000186 progesterone Substances 0.000 description 3
- 206010000234 Abortion spontaneous Diseases 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000700198 Cavia Species 0.000 description 2
- 206010000210 abortion Diseases 0.000 description 2
- 231100000176 abortion Toxicity 0.000 description 2
- 238000000451 chemical ionisation Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000001819 mass spectrum Methods 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 208000015994 miscarriage Diseases 0.000 description 2
- 239000003791 organic solvent mixture Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 208000000995 spontaneous abortion Diseases 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010012186 Delayed delivery Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 1
- 208000031271 Unwanted pregnancy Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000011210 chromatographic step Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 239000002024 ethyl acetate extract Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 235000012171 hot beverage Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229940113115 polyethylene glycol 200 Drugs 0.000 description 1
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Water Treatment By Sorption (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54741575A | 1975-02-06 | 1975-02-06 | |
| US54741575 | 1975-02-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI751085A7 FI751085A7 (enExample) | 1976-08-07 |
| FI56771B FI56771B (fi) | 1979-12-31 |
| FI56771C true FI56771C (fi) | 1980-04-10 |
Family
ID=24184569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI751085A FI56771C (fi) | 1975-02-06 | 1975-04-10 | Foerfarande foer rening av ett vaextextrakt av loev fraon zoapatle-vaexten saosom montanoa tomentosa eller montanoa floribunda-vaexten innehaollande livmodertoemmande foereningar |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4086358A (enExample) |
| CA (1) | CA1048040A (enExample) |
| CS (1) | CS194222B2 (enExample) |
| DK (1) | DK142603B (enExample) |
| ES (1) | ES436513A1 (enExample) |
| FI (1) | FI56771C (enExample) |
| FR (1) | FR2316967A1 (enExample) |
| IE (1) | IE40975B1 (enExample) |
| NO (2) | NO143905C (enExample) |
| PL (1) | PL100003B1 (enExample) |
| SE (1) | SE435570B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4176188A (en) * | 1976-11-18 | 1979-11-27 | Ortho Pharmaceutical Corp. | Utero-evacuants |
| US4127651A (en) * | 1977-06-29 | 1978-11-28 | Ortho Pharmaceutical Corporation | Isolation of uteroevacuant substances from plant extracts |
| US4177194A (en) * | 1978-06-29 | 1979-12-04 | Ortho Pharmaceutical Corporation | Total synthesis of the utero-evacuant substance D,L-zoapatanol |
| US4182717A (en) * | 1978-06-29 | 1980-01-08 | Ortho Pharmaceutical Corp. | Total synthesis of the utero-evacuant substance d,l-zoapatanol |
| US4239689A (en) * | 1978-12-18 | 1980-12-16 | Ortho Pharmaceutical Corporation | Total synthesis of the utero-evacuant substance d,l-zoapatanol |
| US4296035A (en) * | 1978-12-20 | 1981-10-20 | Ortho Pharmaceutical Corporation | Total synthesis of the utero-evacuant substance d,l-zoapatanol |
| US4491593A (en) * | 1983-01-27 | 1985-01-01 | Gallegos Alfredo J | Compositions and methods for fertility control |
-
1975
- 1975-03-25 NO NO751040A patent/NO143905C/no unknown
- 1975-03-26 DK DK135475AA patent/DK142603B/da not_active IP Right Cessation
- 1975-04-09 SE SE7504061A patent/SE435570B/xx not_active IP Right Cessation
- 1975-04-09 FR FR7511100A patent/FR2316967A1/fr active Granted
- 1975-04-10 ES ES436513A patent/ES436513A1/es not_active Expired
- 1975-04-10 CS CS752492A patent/CS194222B2/cs unknown
- 1975-04-10 FI FI751085A patent/FI56771C/fi not_active IP Right Cessation
- 1975-04-10 IE IE812/75A patent/IE40975B1/xx unknown
- 1975-04-11 PL PL1975179523A patent/PL100003B1/pl unknown
- 1975-04-18 CA CA225,006A patent/CA1048040A/en not_active Expired
- 1975-12-29 NO NO754394A patent/NO143906C/no unknown
-
1976
- 1976-04-02 US US05/672,918 patent/US4086358A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FI751085A7 (enExample) | 1976-08-07 |
| ES436513A1 (es) | 1977-05-01 |
| FI56771B (fi) | 1979-12-31 |
| NO751040L (enExample) | 1976-08-09 |
| NO143906B (no) | 1981-01-26 |
| IE40975L (en) | 1976-08-06 |
| CA1048040A (en) | 1979-02-06 |
| PL100003B1 (pl) | 1978-08-31 |
| FR2316967A1 (fr) | 1977-02-04 |
| NO143905C (no) | 1981-05-06 |
| SE435570B (sv) | 1984-10-08 |
| DK142603B (da) | 1980-12-01 |
| NO143905B (no) | 1981-01-26 |
| DK135475A (enExample) | 1976-08-07 |
| US4086358A (en) | 1978-04-25 |
| DK142603C (enExample) | 1981-08-03 |
| FR2316967B1 (enExample) | 1978-10-06 |
| IE40975B1 (en) | 1979-09-26 |
| CS194222B2 (en) | 1979-11-30 |
| NO754394L (enExample) | 1976-08-09 |
| NO143906C (no) | 1981-05-06 |
| SE7504061L (sv) | 1976-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: ORTHO PHARMACEUTICAL CORPORATION |