JPH0378845B2 - - Google Patents
Info
- Publication number
- JPH0378845B2 JPH0378845B2 JP59150088A JP15008884A JPH0378845B2 JP H0378845 B2 JPH0378845 B2 JP H0378845B2 JP 59150088 A JP59150088 A JP 59150088A JP 15008884 A JP15008884 A JP 15008884A JP H0378845 B2 JPH0378845 B2 JP H0378845B2
- Authority
- JP
- Japan
- Prior art keywords
- fraction
- effect
- ulcer
- choleretic
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HRYLQFBHBWLLLL-UHFFFAOYSA-N (+)-costunolide Natural products C1CC(C)=CCCC(C)=CC2OC(=O)C(=C)C21 HRYLQFBHBWLLLL-UHFFFAOYSA-N 0.000 claims description 9
- CUGKULNFZMNVQI-UHFFFAOYSA-N Costunolid I Natural products CC1=CCC=C(/C)CCC2C(C1)OC(=O)C2=C CUGKULNFZMNVQI-UHFFFAOYSA-N 0.000 claims description 9
- MMTZAJNKISZWFG-UHFFFAOYSA-N costunolide Natural products CC1CCC2C(CC(=C/C=C1)C)OC(=O)C2=C MMTZAJNKISZWFG-UHFFFAOYSA-N 0.000 claims description 9
- HRYLQFBHBWLLLL-AHNJNIBGSA-N costunolide Chemical compound C1CC(/C)=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]21 HRYLQFBHBWLLLL-AHNJNIBGSA-N 0.000 claims description 8
- 239000000731 choleretic agent Substances 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 14
- 229940079593 drug Drugs 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 210000000941 bile Anatomy 0.000 description 7
- 230000001989 choleretic effect Effects 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 230000000767 anti-ulcer Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 206010042220 Stress ulcer Diseases 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 208000000718 duodenal ulcer Diseases 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- FKJIJBSJQSMPTI-CAOXKPNISA-M sodium;(4r)-4-[(5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-3,7,12-trioxo-1,2,4,5,6,8,9,11,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pentanoate Chemical compound [Na+].C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C FKJIJBSJQSMPTI-CAOXKPNISA-M 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 244000215068 Acacia senegal Species 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000700157 Rattus norvegicus Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- LMNJALUUIMXUQQ-UHFFFAOYSA-N saussurea lactone Chemical compound C1CC(C)(C=C)C(C(C)=C)C2OC(=O)C(C)C21 LMNJALUUIMXUQQ-UHFFFAOYSA-N 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 240000005528 Arctium lappa Species 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 101001053875 Phyllomedusa distincta Dermaseptin-DI1 Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- LMNJALUUIMXUQQ-RLPMIEJPSA-N Saussurea lactone Natural products O=C1[C@@H](C)[C@H]2[C@H]([C@@H](C(=C)C)[C@@](C=C)(C)CC2)O1 LMNJALUUIMXUQQ-RLPMIEJPSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002180 anti-stress Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 210000001953 common bile duct Anatomy 0.000 description 1
- OJPDLGRQQOMYQL-JSGCOSHPSA-N costunolide group Chemical group CC1=C2[C@H]3OC(=O)C(=C)[C@@H]3CCC(C)=C2CC1 OJPDLGRQQOMYQL-JSGCOSHPSA-N 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 239000012156 elution solvent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59150088A JPS6127919A (ja) | 1984-07-18 | 1984-07-18 | 利胆剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59150088A JPS6127919A (ja) | 1984-07-18 | 1984-07-18 | 利胆剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6127919A JPS6127919A (ja) | 1986-02-07 |
| JPH0378845B2 true JPH0378845B2 (enExample) | 1991-12-17 |
Family
ID=15489249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59150088A Granted JPS6127919A (ja) | 1984-07-18 | 1984-07-18 | 利胆剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6127919A (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100321312B1 (ko) * | 1999-04-22 | 2002-03-18 | 박호군 | 세스퀴테르펜 락톤 화합물 코스투놀라이드의 염증질환 치료제로서의 용도 |
-
1984
- 1984-07-18 JP JP59150088A patent/JPS6127919A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6127919A (ja) | 1986-02-07 |
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