JPS6127919A - 利胆剤 - Google Patents
利胆剤Info
- Publication number
- JPS6127919A JPS6127919A JP59150088A JP15008884A JPS6127919A JP S6127919 A JPS6127919 A JP S6127919A JP 59150088 A JP59150088 A JP 59150088A JP 15008884 A JP15008884 A JP 15008884A JP S6127919 A JPS6127919 A JP S6127919A
- Authority
- JP
- Japan
- Prior art keywords
- costunolide
- cholagogue
- effect
- fraction
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008845 cholagoga Substances 0.000 title abstract 5
- 229940124571 cholagogue Drugs 0.000 title abstract 5
- HRYLQFBHBWLLLL-UHFFFAOYSA-N (+)-costunolide Natural products C1CC(C)=CCCC(C)=CC2OC(=O)C(=C)C21 HRYLQFBHBWLLLL-UHFFFAOYSA-N 0.000 claims abstract description 18
- CUGKULNFZMNVQI-UHFFFAOYSA-N Costunolid I Natural products CC1=CCC=C(/C)CCC2C(C1)OC(=O)C2=C CUGKULNFZMNVQI-UHFFFAOYSA-N 0.000 claims abstract description 18
- MMTZAJNKISZWFG-UHFFFAOYSA-N costunolide Natural products CC1CCC2C(CC(=C/C=C1)C)OC(=O)C2=C MMTZAJNKISZWFG-UHFFFAOYSA-N 0.000 claims abstract description 18
- HRYLQFBHBWLLLL-AHNJNIBGSA-N costunolide Chemical compound C1CC(/C)=C/CC\C(C)=C\[C@H]2OC(=O)C(=C)[C@@H]21 HRYLQFBHBWLLLL-AHNJNIBGSA-N 0.000 claims abstract description 17
- 239000004480 active ingredient Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract description 22
- 230000000694 effects Effects 0.000 abstract description 12
- 239000000284 extract Substances 0.000 abstract description 12
- 208000025865 Ulcer Diseases 0.000 abstract description 4
- 231100000397 ulcer Toxicity 0.000 abstract description 4
- 241000208838 Asteraceae Species 0.000 abstract description 3
- 238000010898 silica gel chromatography Methods 0.000 abstract description 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 241001664510 Saussurea costus Species 0.000 abstract 1
- 235000006784 Saussurea lappa Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002279 cholagogic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 14
- 229940079593 drug Drugs 0.000 description 12
- 239000000731 choleretic agent Substances 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 230000001989 choleretic effect Effects 0.000 description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 230000000767 anti-ulcer Effects 0.000 description 6
- 210000000941 bile Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 5
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 206010042220 Stress ulcer Diseases 0.000 description 3
- 230000037005 anaesthesia Effects 0.000 description 3
- 208000000718 duodenal ulcer Diseases 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 244000215068 Acacia senegal Species 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- FKJIJBSJQSMPTI-CAOXKPNISA-M sodium;(4r)-4-[(5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-3,7,12-trioxo-1,2,4,5,6,8,9,11,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pentanoate Chemical compound [Na+].C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C FKJIJBSJQSMPTI-CAOXKPNISA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 230000001587 cholestatic effect Effects 0.000 description 1
- 210000001953 common bile duct Anatomy 0.000 description 1
- OJPDLGRQQOMYQL-JSGCOSHPSA-N costunolide group Chemical group CC1=C2[C@H]3OC(=O)C(=C)[C@@H]3CCC(C)=C2CC1 OJPDLGRQQOMYQL-JSGCOSHPSA-N 0.000 description 1
- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59150088A JPS6127919A (ja) | 1984-07-18 | 1984-07-18 | 利胆剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59150088A JPS6127919A (ja) | 1984-07-18 | 1984-07-18 | 利胆剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6127919A true JPS6127919A (ja) | 1986-02-07 |
| JPH0378845B2 JPH0378845B2 (enExample) | 1991-12-17 |
Family
ID=15489249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59150088A Granted JPS6127919A (ja) | 1984-07-18 | 1984-07-18 | 利胆剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6127919A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100321312B1 (ko) * | 1999-04-22 | 2002-03-18 | 박호군 | 세스퀴테르펜 락톤 화합물 코스투놀라이드의 염증질환 치료제로서의 용도 |
-
1984
- 1984-07-18 JP JP59150088A patent/JPS6127919A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100321312B1 (ko) * | 1999-04-22 | 2002-03-18 | 박호군 | 세스퀴테르펜 락톤 화합물 코스투놀라이드의 염증질환 치료제로서의 용도 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0378845B2 (enExample) | 1991-12-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69007960T2 (de) | Mischungen von aus Curcuma SPP isolierten Verbindungen als entzündungshemmende Mittel. | |
| Gürbüz et al. | Anti-ulcerogenic effect of Momordica charantia L. fruits on various ulcer models in rats | |
| JP2006510592A (ja) | スイカズラ（ＬｏｎｉｃｅｒａｊａｐｏｎｉｃａＴｈｕｎｂ．）茎の活性成分の抽出および精製方法、その消炎鎮痛剤への用途 | |
| AU2008256536B2 (en) | Plant extract and its therapeutic use | |
| KR101346066B1 (ko) | 백합나무 수피 추출물을 유효 성분으로 함유하는 약학적 조성물 | |
| KR101327282B1 (ko) | 백합나무 수피 추출물을 유효 성분으로 함유하는 개선된 의약 제형 | |
| CN101588810B (zh) | 用于治疗和预防炎性疾病的包括络石藤和日本鹿蹄草提取物的组合物 | |
| JPWO2016075960A1 (ja) | 排尿障害を予防又は改善させる医薬組成物、排尿障害関連受容体に関する拮抗剤又はその医薬組成物又は拮抗剤を用いた排尿障害を予防又は改善させる方法 | |
| JPS6127919A (ja) | 利胆剤 | |
| JP2001122777A (ja) | 抗潰瘍剤 | |
| JPS58172320A (ja) | 抗高脂血症剤及びその製造方法 | |
| EP2956151B1 (de) | Verwendung von extrakten aus calendula zur behandlung und vorbeugung von störungen und beeinträchtigungen kognitiver und mentaler funktionen | |
| CN104703617A (zh) | 新的香料提取物级分及其用途 | |
| WO2023285999A1 (en) | A polyherbal formulation for weight management and a process for its preparation | |
| JP2002510640A (ja) | エイズの予防及び治療用薬草組成物 | |
| JP2729340B2 (ja) | 痴呆症治療剤 | |
| KR20150105154A (ko) | 백년초 추출물을 포함하는 위장질환 치료용 약제학적 조성물 | |
| CN107334778A (zh) | 黑果枸杞多糖在制备治疗痛风产品中的用途 | |
| JP3512118B2 (ja) | 血中脂質改善剤 | |
| JPH0363229A (ja) | 抗潰瘍作用を有する医薬組成物 | |
| JP2006028144A (ja) | 末梢血行障害による不定愁訴の治療剤 | |
| JP5233177B2 (ja) | 安中散末および四逆散エキス含有経口組成物 | |
| Anunya et al. | ANTIULCEROGENIC ACTIVITY OF ETHANOLIC EXTRACT OF MORINGA OLEIFERA BARK IN WISTAR ALBINO RATS | |
| JP2007284453A (ja) | 抗消化性潰瘍剤 | |
| JPS59106421A (ja) | 利胆剤 |