JP5233177B2 - 安中散末および四逆散エキス含有経口組成物 - Google Patents
安中散末および四逆散エキス含有経口組成物 Download PDFInfo
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Description
(製造例1) 安中散末の製造
縮砂、延胡索、良姜、茴香、桂皮および牡蛎を混合し、粗粉砕をした後に気流式滅菌した。また、甘草を粗粉砕し、蒸留滅菌した後に振動ミル粉砕した。これら滅菌済み粗粉砕品を混合し、凍結粉砕することによって安中散末を得た。
柴胡、芍薬および枳実をそれぞれ2g、甘草を1g混合し、10倍量の水を添加し沸騰後30分間抽出した。その抽出エキスを約60℃で減圧濃縮した後に、瞬間液体殺菌機を用いて殺菌した。このエキスにデキストリンを0.80g添加し、噴霧乾燥をおこなうことにより四逆散乾燥エキス末を得た。
安中散末は630mgを水15mLに懸濁させることにより調製した。四逆散エキスは乾燥エキス末390mg(乾燥エキス末重量)を水15mLに溶解させることにより調製した。安中散末と四逆散エキスの混合物は安中散末630mgと四逆散乾燥エキス末390mgを混合し、水15mLに懸濁させることにより調製した。安中散エキスは安中散乾燥エキス末原生薬末換算630mgを水15mLに溶解させることにより調製した。安中散エキスと四逆散エキスの混合物は安中散乾燥エキス末原生薬末換算630mgと四逆散乾燥エキス末390mgを混合し、水15mLに溶解させることにより調製した。
実施例2(散剤)
*デキストリン配合原料、**デキストリンなし原料
24時間絶食及び18時間絶水したラット(Crl:CD(SD)(IGS)系,雄性)に被験物質を5mL/kg経口投与し、その30分後に150mmol/L塩酸/80vol%エタノールを5mL/kg経口投与した。塩酸エタノール投与1時間後にラットを麻酔死させ、胃を摘出し、胃粘膜傷害面積を測定した。
1) 安中散末と四逆散エキスの併用での作用(図1)
ラット塩酸エタノール誘発胃粘膜傷害において、安中散末(210 mg/kg)または四逆散エキス(130 mg/kg)は単独ではコントロール群と比較して有意な胃粘膜障害抑制作用を示さなかった。一方、安中散末および四逆散エキスの混合物(340 mg/kg)はコントロール群と比較して有意な傷害発生抑制作用を示した。安中散末と四逆散エキスの混合物(340 mg/kg)群における胃粘膜傷害面積は、安中散生薬末(210 mg/kg)単独群または四逆散乾燥エキス(130 mg/kg)単独群いずれの胃粘膜傷害面積と比較しても有意に小さいものであった。
以上より、塩酸エタノール誘発胃粘膜傷害において、安中散末と四逆散エキスの併用による作用増強が確認された。
ラット塩酸エタノール誘発胃粘膜傷害に対して安中散エキスおよび四逆散エキスの混合物(340 mg/kg)は胃粘膜傷害抑制作用を示さなかった。安中散エキス単独群(原生薬量として,210 mg/kg)または四逆散エキス単独群(130 mg/kg)でのそれぞれの胃粘膜傷害抑制作用も認められなかった.
以上より、安中散エキスを用いた場合、塩酸エタノール誘発胃粘膜傷害において、安中散エキスと四逆散エキスの併用による効果は認められなかった。
Claims (2)
- 安中散末および四逆散エキスを含有することを特徴とする胃粘膜の傷害を予防または改善するための経口組成物。
- 安中散末が凍結粉砕末である請求項1に記載の経口組成物。
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JP2007156118A JP5233177B2 (ja) | 2006-06-14 | 2007-06-13 | 安中散末および四逆散エキス含有経口組成物 |
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