FI3740504T3 - CD70-yhdistelmähoito - Google Patents
CD70-yhdistelmähoito Download PDFInfo
- Publication number
- FI3740504T3 FI3740504T3 FIEP19702014.2T FI19702014T FI3740504T3 FI 3740504 T3 FI3740504 T3 FI 3740504T3 FI 19702014 T FI19702014 T FI 19702014T FI 3740504 T3 FI3740504 T3 FI 3740504T3
- Authority
- FI
- Finland
- Prior art keywords
- sequence
- sequence seq
- amino acid
- acid sequence
- seo
- Prior art date
Links
- 102100025221 CD70 antigen Human genes 0.000 title claims 13
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 title claims 13
- 238000002648 combination therapy Methods 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 65
- 230000011664 signaling Effects 0.000 claims 12
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 10
- 101710083479 Hepatitis A virus cellular receptor 2 homolog Proteins 0.000 claims 10
- 101000960952 Homo sapiens Interleukin-1 receptor accessory protein Proteins 0.000 claims 10
- 102100039880 Interleukin-1 receptor accessory protein Human genes 0.000 claims 10
- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 10
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 10
- 210000000130 stem cell Anatomy 0.000 claims 8
- 230000027455 binding Effects 0.000 claims 7
- 230000001771 impaired effect Effects 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 5
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000003211 malignant effect Effects 0.000 claims 4
- 102000003945 NF-kappa B Human genes 0.000 claims 3
- 108010057466 NF-kappa B Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 102000016362 Catenins Human genes 0.000 claims 2
- 108010067316 Catenins Proteins 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 230000005888 antibody-dependent cellular phagocytosis Effects 0.000 claims 1
- 230000009149 molecular binding Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1800649.4A GB201800649D0 (en) | 2018-01-16 | 2018-01-16 | CD70 Combination Therapy |
| PCT/EP2019/051058 WO2019141732A1 (en) | 2018-01-16 | 2019-01-16 | Cd70 combination therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3740504T3 true FI3740504T3 (fi) | 2023-10-11 |
Family
ID=61256176
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP19702014.2T FI3740504T3 (fi) | 2018-01-16 | 2019-01-16 | CD70-yhdistelmähoito |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11530271B2 (enExample) |
| EP (2) | EP3740504B9 (enExample) |
| JP (2) | JP7511479B2 (enExample) |
| KR (1) | KR102790232B1 (enExample) |
| CN (1) | CN111836830B (enExample) |
| AU (1) | AU2019209503B2 (enExample) |
| BR (1) | BR112020014321A2 (enExample) |
| CA (1) | CA3086448A1 (enExample) |
| DK (1) | DK3740504T5 (enExample) |
| EA (1) | EA202091714A1 (enExample) |
| ES (1) | ES2956258T3 (enExample) |
| FI (1) | FI3740504T3 (enExample) |
| GB (1) | GB201800649D0 (enExample) |
| HU (1) | HUE063783T2 (enExample) |
| IL (1) | IL276103A (enExample) |
| LT (1) | LT3740504T (enExample) |
| MX (1) | MX2020007606A (enExample) |
| PL (1) | PL3740504T3 (enExample) |
| PT (1) | PT3740504T (enExample) |
| SG (1) | SG11202006007YA (enExample) |
| WO (1) | WO2019141732A1 (enExample) |
| ZA (1) | ZA202003986B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103596979B (zh) | 2011-03-16 | 2018-01-26 | 阿尔金-X有限公司 | 针对cd70的抗体 |
| US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
| CN118994394A (zh) | 2017-06-12 | 2024-11-22 | 蓝鳍生物医药公司 | 抗-il1rap抗体和抗体药物缀合物 |
| GB201800649D0 (en) | 2018-01-16 | 2018-02-28 | Argenx Bvba | CD70 Combination Therapy |
| MY205933A (en) | 2018-09-27 | 2024-11-21 | Celgene Corp | Sirp-alpha binding proteins and methods of use thereof |
| US11591390B2 (en) | 2018-09-27 | 2023-02-28 | Celgene Corporation | SIRP-α binding proteins and methods of use thereof |
| TWI848030B (zh) * | 2018-12-18 | 2024-07-11 | 比利時商阿根思公司 | Ｃｄ７０組合治療 |
| EP4041394A1 (en) * | 2019-09-16 | 2022-08-17 | Novartis AG | Use of high-affinity, ligand-blocking, humanized anti-t-cell immunoglobulin domain and mucin domain-3 (tim-3) igg4 antibody for the treatment of myelofibrosis |
| TW202140037A (zh) * | 2020-01-17 | 2021-11-01 | 瑞士商諾華公司 | 組合療法 |
| WO2021226289A2 (en) * | 2020-05-05 | 2021-11-11 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using cd70 specific fusion proteins |
| JP2023546679A (ja) * | 2020-10-22 | 2023-11-07 | アクティニウム ファーマシューティカルズ インコーポレイテッド | がん治療における放射免疫療法とｃｄ４７遮断の併用 |
| CN114765061B (zh) * | 2021-01-15 | 2024-12-27 | 深圳哲源生物科技有限责任公司 | Pd-1/pd-l1抑制剂的不良预后的数据处理系统及方法 |
| CN113150140B (zh) * | 2021-01-25 | 2022-11-04 | 山西农业大学 | 一种sox6二价纳米抗体及其应用 |
| US20240165229A1 (en) * | 2021-06-29 | 2024-05-23 | Seagen Inc. | Methods of treating cancer with a combination of a nonfucosylated anti-cd70 antibody and a cd47 antagonist |
| WO2024126833A1 (en) * | 2022-12-16 | 2024-06-20 | Ichnos Sciences SA | Cd47-il1rap bispecific antibodies |
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| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5573924A (en) | 1992-09-08 | 1996-11-12 | Immunex Corporation | CD27 ligand |
| DE19747418C1 (de) | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
| US6500633B1 (en) | 2000-04-26 | 2002-12-31 | Atairgin Technologies, Inc. | Method of detecting carcinomas |
| US20030148321A1 (en) | 2001-08-24 | 2003-08-07 | Iris Pecker | Methods and kits for diagnosing and monitoring hematopoietic cancers |
| EP1470247A2 (en) | 2001-11-05 | 2004-10-27 | Deutsches Krebsforschungszentrum | Novel genetic markers for leukemias |
| US20050118656A1 (en) | 2001-11-27 | 2005-06-02 | Terrett Jonathan A. | Methods for diagnosis and treatment of epithelial-derived cancers |
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| US20220136068A1 (en) | 2019-03-06 | 2022-05-05 | The Regents Of The University Of Colorado, A Body Corporate | Methods of detecting and treating venetoclax-resistant acute myeloid leukemia |
| IL300996A (en) | 2020-08-29 | 2023-04-01 | argenx BV | Treatment method for patients with reduced sensitivity to BCL-2 inhibitor |
| AU2021358768A1 (en) | 2020-10-06 | 2023-05-18 | The Regents Of The University Of Colorado, A Body Corporate | Subject-specific treatments for venetoclax-resistant acute myeloid leukemia |
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2018
- 2018-01-16 GB GBGB1800649.4A patent/GB201800649D0/en not_active Ceased
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2019
- 2019-01-16 HU HUE19702014A patent/HUE063783T2/hu unknown
- 2019-01-16 EA EA202091714A patent/EA202091714A1/ru unknown
- 2019-01-16 EP EP19702014.2A patent/EP3740504B9/en active Active
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- 2019-01-16 EP EP23177089.2A patent/EP4275702A3/en not_active Withdrawn
- 2019-01-16 US US16/249,480 patent/US11530271B2/en active Active
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2020
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