FI20001593A - Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia - Google Patents
Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisiaInfo
- Publication number
- FI20001593A FI20001593A FI20001593A FI20001593A FI20001593A FI 20001593 A FI20001593 A FI 20001593A FI 20001593 A FI20001593 A FI 20001593A FI 20001593 A FI20001593 A FI 20001593A FI 20001593 A FI20001593 A FI 20001593A
- Authority
- FI
- Finland
- Prior art keywords
- sub
- inhibitory activity
- coumarin derivatives
- enzyme inhibitory
- comt enzyme
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (30)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20001593A FI20001593A (fi) | 2000-07-03 | 2000-07-03 | Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia |
PL01359068A PL359068A1 (en) | 2000-07-03 | 2001-06-28 | Coumarin derivatives with comt inhibiting activity |
HU0301706A HUP0301706A3 (en) | 2000-07-03 | 2001-06-28 | Coumarin derivatives with comt inhibiting activity |
IL15335201A IL153352A0 (en) | 2000-07-03 | 2001-06-28 | Coumarin derivatives with comt inhibiting activity |
CA2414787A CA2414787C (fr) | 2000-07-03 | 2001-06-28 | Derives de coumarine ayant une activite d'inhibition de la comt |
NZ523121A NZ523121A (en) | 2000-07-03 | 2001-06-28 | Coumarin derivatives with COMT inhibiting activity |
EEP200300008A EE200300008A (et) | 2000-07-03 | 2001-06-28 | COMT-i inhibeeriva aktiivsusega kumariini derivaadid |
DK01951741T DK1301503T3 (da) | 2000-07-03 | 2001-06-28 | Coumarinderivater med COMT-inhiberende aktivitet |
US10/312,817 US6951870B2 (en) | 2000-07-03 | 2001-06-28 | Coumarin derivatives with COMT inhibiting activity |
AU2001272597A AU2001272597B9 (en) | 2000-07-03 | 2001-06-28 | Coumarin derivatives with comt inhibiting activity |
TR2004/00802T TR200400802T4 (tr) | 2000-07-03 | 2001-06-28 | COMT inhibe edici etkiye sahip kumarin türevleri |
BR0111969-9A BR0111969A (pt) | 2000-07-03 | 2001-06-28 | Derivados da cumarina com atividade inibidora da comt |
MXPA02012657A MXPA02012657A (es) | 2000-07-03 | 2001-06-28 | Derivados de coumarina con actividad inhibidora de comt. |
SK1845-2002A SK18452002A3 (sk) | 2000-07-03 | 2001-06-28 | Deriváty kumarínu inhibujúce COMT, farmaceutická kompozícia, ktorá ich obsahuje, a ich použitie |
JP2002507800A JP4851051B2 (ja) | 2000-07-03 | 2001-06-28 | Comt阻害活性を有するクマリン誘導体 |
KR1020027017767A KR20030040225A (ko) | 2000-07-03 | 2001-06-28 | 씨오엠티 저해효과를 가지는 쿠마린 유도체 |
PT01951741T PT1301503E (pt) | 2000-07-03 | 2001-06-28 | Derivados da cumarina com actividade inibidora de comt |
EP01951741A EP1301503B1 (fr) | 2000-07-03 | 2001-06-28 | Derives de coumarine ayant une activite d'inhibition de la comt |
PCT/FI2001/000613 WO2002002548A1 (fr) | 2000-07-03 | 2001-06-28 | Derives de coumarine ayant une activite d'inhibition de la comt |
ES01951741T ES2215919T3 (es) | 2000-07-03 | 2001-06-28 | Derivados de cumarina con actividad inhibidora de comt. |
DE60102161T DE60102161T2 (de) | 2000-07-03 | 2001-06-28 | Cumarin-derivate mit comt hemmender wirkung |
RU2003102894/04A RU2282627C2 (ru) | 2000-07-03 | 2001-06-28 | Кумариновые производные с подавляющей комт активностью |
SI200130095T SI1301503T1 (en) | 2000-07-03 | 2001-06-28 | Coumarin derivatives with comt inhibiting activity |
AT01951741T ATE260268T1 (de) | 2000-07-03 | 2001-06-28 | Cumarin-derivate mit comt hemmender wirkung |
CNB018121934A CN1199963C (zh) | 2000-07-03 | 2001-06-28 | 具comt抑制活性的香豆素衍生物 |
AU7259701A AU7259701A (en) | 2000-07-03 | 2001-06-28 | Coumarin derivatives with comt inhibiting activity |
IL153352A IL153352A (en) | 2000-07-03 | 2002-12-10 | History of coumarin with inhibitory COMT action |
ZA200210161A ZA200210161B (en) | 2000-07-03 | 2002-12-13 | Coumarin derivatives with COMT inhibiting activity. |
NO20026095A NO328699B1 (no) | 2000-07-03 | 2002-12-18 | Nye forbindelser, sammensetninger inneholdende nevnte forbindelser, samt anvendelse derav som inhibitorer av katekol-O-metyltransferase (COMT) enzymet |
BG107513A BG107513A (bg) | 2000-07-03 | 2003-01-31 | Кумаринови производни със сомт инхибираща активност |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20001593A FI20001593A (fi) | 2000-07-03 | 2000-07-03 | Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia |
Publications (2)
Publication Number | Publication Date |
---|---|
FI20001593A0 FI20001593A0 (fi) | 2000-07-03 |
FI20001593A true FI20001593A (fi) | 2002-01-04 |
Family
ID=8558717
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI20001593A FI20001593A (fi) | 2000-07-03 | 2000-07-03 | Comt-entsyymiõ inhiboivaa aktiivisuutta omaavia kumariinijohdannaisia |
Country Status (27)
Country | Link |
---|---|
US (1) | US6951870B2 (fr) |
EP (1) | EP1301503B1 (fr) |
JP (1) | JP4851051B2 (fr) |
KR (1) | KR20030040225A (fr) |
CN (1) | CN1199963C (fr) |
AT (1) | ATE260268T1 (fr) |
AU (2) | AU7259701A (fr) |
BG (1) | BG107513A (fr) |
BR (1) | BR0111969A (fr) |
CA (1) | CA2414787C (fr) |
DE (1) | DE60102161T2 (fr) |
DK (1) | DK1301503T3 (fr) |
EE (1) | EE200300008A (fr) |
ES (1) | ES2215919T3 (fr) |
FI (1) | FI20001593A (fr) |
HU (1) | HUP0301706A3 (fr) |
IL (2) | IL153352A0 (fr) |
MX (1) | MXPA02012657A (fr) |
NO (1) | NO328699B1 (fr) |
NZ (1) | NZ523121A (fr) |
PL (1) | PL359068A1 (fr) |
PT (1) | PT1301503E (fr) |
RU (1) | RU2282627C2 (fr) |
SK (1) | SK18452002A3 (fr) |
TR (1) | TR200400802T4 (fr) |
WO (1) | WO2002002548A1 (fr) |
ZA (1) | ZA200210161B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPR846401A0 (en) * | 2001-10-25 | 2001-11-15 | Novogen Research Pty Ltd | 6-Hydroxy isoflavones, derivatives and medicaments involving same |
AU2002951833A0 (en) | 2002-10-02 | 2002-10-24 | Novogen Research Pty Ltd | Compositions and therapeutic methods invloving platinum complexes |
AU2003265737B2 (en) * | 2002-10-02 | 2008-10-16 | Novogen Research Pty Ltd | Combination chemotherapy compositions and methods |
CN1506359A (zh) * | 2002-12-05 | 2004-06-23 | �й�ҽѧ��ѧԺҩ���о��� | 新的香豆素酰胺衍生物及其制法和其药物组合物与用途 |
CN101056868B (zh) | 2004-09-21 | 2012-05-02 | 马休爱德华兹股份有限公司 | 取代的苯并二氢吡喃衍生物、药物及其在治疗中的应用 |
US8080675B2 (en) | 2004-09-21 | 2011-12-20 | Marshall Edwards, Inc. | Chroman derivatives, medicaments and use in therapy |
MY148644A (en) * | 2005-07-18 | 2013-05-15 | Orion Corp | New pharmaceutical compounds |
US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
WO2007124617A1 (fr) * | 2006-04-28 | 2007-11-08 | Institute Of Mataria Medica, Chinese Academy Of Medical Sciences | Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations |
ES2343347B2 (es) * | 2009-01-27 | 2011-12-07 | Universidade De Santiago De Compostela | Uso de derivados de 3-fenilcumarinas 6-sustituidas y preparacion de nuevos derivados. |
CA2816319C (fr) | 2010-11-01 | 2020-06-30 | Marshall Edwards, Inc. | Composes d'isoflavonoides et procedes pour le traitement du cancer |
TWI638802B (zh) | 2012-05-24 | 2018-10-21 | 芬蘭商奧利安公司 | 兒茶酚o-甲基轉移酶活性抑制化合物 |
HUE054998T2 (hu) | 2015-02-02 | 2021-10-28 | Mei Pharma Inc | Kombinációs terápiák emlõrák kezelésében való alkalmazásra |
EP3390351A1 (fr) * | 2015-12-18 | 2018-10-24 | Koester, Hubert | Nouveaux composés bicycliques destinés à être utilisés comme médicament, en particulier pour le traitement de la maladie de parkinson |
CN107868069A (zh) * | 2017-10-31 | 2018-04-03 | 山东新华制药股份有限公司 | 7‑羟基‑8‑甲基‑6‑硝基‑2‑氧‑2h‑苯并吡喃‑3‑羧酸的制备工艺 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3973608A (en) | 1973-08-01 | 1976-08-10 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Microbial production of certain isoflavones |
JPS5035393A (fr) * | 1973-08-01 | 1975-04-04 | ||
US5236952A (en) * | 1986-03-11 | 1993-08-17 | Hoffmann-La Roche Inc. | Catechol derivatives |
US5283352A (en) * | 1986-11-28 | 1994-02-01 | Orion-Yhtyma Oy | Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same |
GB8816519D0 (en) | 1987-07-23 | 1988-08-17 | Ici Plc | Antibiotic compounds |
HUT63843A (en) | 1992-02-13 | 1993-10-28 | Biosignal Kutato Fejlesztoe Kf | Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds |
JP3166094B2 (ja) * | 1993-09-08 | 2001-05-14 | 森永乳業株式会社 | クマリン誘導体及びそれらの用途 |
JPH0892157A (ja) | 1994-05-02 | 1996-04-09 | F Hoffmann La Roche Ag | プルプロガリン誘導体 |
GB9626472D0 (en) | 1996-12-20 | 1997-02-05 | Aperia Anita C | New use of comt inhibitors |
-
2000
- 2000-07-03 FI FI20001593A patent/FI20001593A/fi unknown
-
2001
- 2001-06-28 CA CA2414787A patent/CA2414787C/fr not_active Expired - Fee Related
- 2001-06-28 EP EP01951741A patent/EP1301503B1/fr not_active Expired - Lifetime
- 2001-06-28 AU AU7259701A patent/AU7259701A/xx active Pending
- 2001-06-28 SK SK1845-2002A patent/SK18452002A3/sk unknown
- 2001-06-28 BR BR0111969-9A patent/BR0111969A/pt not_active IP Right Cessation
- 2001-06-28 EE EEP200300008A patent/EE200300008A/xx unknown
- 2001-06-28 ES ES01951741T patent/ES2215919T3/es not_active Expired - Lifetime
- 2001-06-28 RU RU2003102894/04A patent/RU2282627C2/ru not_active IP Right Cessation
- 2001-06-28 KR KR1020027017767A patent/KR20030040225A/ko not_active Application Discontinuation
- 2001-06-28 HU HU0301706A patent/HUP0301706A3/hu unknown
- 2001-06-28 IL IL15335201A patent/IL153352A0/xx unknown
- 2001-06-28 CN CNB018121934A patent/CN1199963C/zh not_active Expired - Fee Related
- 2001-06-28 AU AU2001272597A patent/AU2001272597B9/en not_active Ceased
- 2001-06-28 TR TR2004/00802T patent/TR200400802T4/xx unknown
- 2001-06-28 JP JP2002507800A patent/JP4851051B2/ja not_active Expired - Fee Related
- 2001-06-28 PL PL01359068A patent/PL359068A1/xx not_active Application Discontinuation
- 2001-06-28 DE DE60102161T patent/DE60102161T2/de not_active Expired - Lifetime
- 2001-06-28 US US10/312,817 patent/US6951870B2/en not_active Expired - Fee Related
- 2001-06-28 AT AT01951741T patent/ATE260268T1/de active
- 2001-06-28 PT PT01951741T patent/PT1301503E/pt unknown
- 2001-06-28 WO PCT/FI2001/000613 patent/WO2002002548A1/fr active IP Right Grant
- 2001-06-28 NZ NZ523121A patent/NZ523121A/en not_active IP Right Cessation
- 2001-06-28 MX MXPA02012657A patent/MXPA02012657A/es active IP Right Grant
- 2001-06-28 DK DK01951741T patent/DK1301503T3/da active
-
2002
- 2002-12-10 IL IL153352A patent/IL153352A/en not_active IP Right Cessation
- 2002-12-13 ZA ZA200210161A patent/ZA200210161B/en unknown
- 2002-12-18 NO NO20026095A patent/NO328699B1/no not_active IP Right Cessation
-
2003
- 2003-01-31 BG BG107513A patent/BG107513A/bg unknown
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