FI121468B - Betuliiniperäiset yhdisteet antimikrobisina aineina - Google Patents

Betuliiniperäiset yhdisteet antimikrobisina aineina Download PDF

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Publication number
FI121468B
FI121468B FI20065388A FI20065388A FI121468B FI 121468 B FI121468 B FI 121468B FI 20065388 A FI20065388 A FI 20065388A FI 20065388 A FI20065388 A FI 20065388A FI 121468 B FI121468 B FI 121468B
Authority
FI
Finland
Prior art keywords
group
linear
branched alkyl
betulin
alkenyl
Prior art date
Application number
FI20065388A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI20065388A0 (fi
FI20065388A (fi
Inventor
Salme Koskimies
Jari Yli-Kauhaluoma
Sami Alakurtti
Pia Bergstroem
Taru Maekelae
Jaana Minkkinen
Leena Pohjala
Paeivi Tammela
Pia Vuorela
Original Assignee
Valtion Teknillinen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Valtion Teknillinen filed Critical Valtion Teknillinen
Publication of FI20065388A0 publication Critical patent/FI20065388A0/fi
Priority to FI20065388A priority Critical patent/FI121468B/fi
Priority to CNA2007800291147A priority patent/CN101500534A/zh
Priority to EP07730817A priority patent/EP2024384A1/en
Priority to EP07730819A priority patent/EP2037872A4/en
Priority to PCT/FI2007/050329 priority patent/WO2007141390A1/en
Priority to CA002654352A priority patent/CA2654352A1/en
Priority to US12/303,664 priority patent/US20100273801A1/en
Priority to US12/303,665 priority patent/US20100196290A1/en
Priority to EP07765903A priority patent/EP2024385A1/en
Priority to PCT/FI2007/050331 priority patent/WO2007141391A1/en
Priority to PCT/FI2007/050328 priority patent/WO2007141389A1/en
Priority to JP2009513721A priority patent/JP2009539812A/ja
Priority to US12/303,707 priority patent/US20100190795A1/en
Priority to PCT/FI2007/050333 priority patent/WO2007141392A2/en
Publication of FI20065388A publication Critical patent/FI20065388A/fi
Application granted granted Critical
Publication of FI121468B publication Critical patent/FI121468B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
FI20065388A 2006-06-07 2006-06-07 Betuliiniperäiset yhdisteet antimikrobisina aineina FI121468B (fi)

Priority Applications (14)

Application Number Priority Date Filing Date Title
FI20065388A FI121468B (fi) 2006-06-07 2006-06-07 Betuliiniperäiset yhdisteet antimikrobisina aineina
US12/303,664 US20100273801A1 (en) 2006-06-07 2007-06-06 Betulin derived compounds useful as antibacterial agents
EP07765903A EP2024385A1 (en) 2006-06-07 2007-06-06 Betulin derived compounds useful as antibacterial agents
EP07730819A EP2037872A4 (en) 2006-06-07 2007-06-06 COMPOSITIONS COMPRISING BITULONIC ACID
PCT/FI2007/050329 WO2007141390A1 (en) 2006-06-07 2007-06-06 Betulin derived compounds useful as antiviral agents
CA002654352A CA2654352A1 (en) 2006-06-07 2007-06-06 Compositions comprising betulonic acid
CNA2007800291147A CN101500534A (zh) 2006-06-07 2007-06-06 包含桦木酮酸的组合物
US12/303,665 US20100196290A1 (en) 2006-06-07 2007-06-06 Compositions comprising betulonic acid
EP07730817A EP2024384A1 (en) 2006-06-07 2007-06-06 Betulin derived compounds useful as antiprotozoal agents
PCT/FI2007/050331 WO2007141391A1 (en) 2006-06-07 2007-06-06 Betulin derived compounds useful as antiprotozoal agents
PCT/FI2007/050328 WO2007141389A1 (en) 2006-06-07 2007-06-06 Betulin derived compounds useful as antibacterial agents
JP2009513721A JP2009539812A (ja) 2006-06-07 2007-06-06 ベツリン酸を含む組成物
US12/303,707 US20100190795A1 (en) 2006-06-07 2007-06-06 Betulin derived compounds useful as antiprotozoal agents
PCT/FI2007/050333 WO2007141392A2 (en) 2006-06-07 2007-06-06 Compositions comprising betulonic acid

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20065388 2006-06-07
FI20065388A FI121468B (fi) 2006-06-07 2006-06-07 Betuliiniperäiset yhdisteet antimikrobisina aineina

Publications (3)

Publication Number Publication Date
FI20065388A0 FI20065388A0 (fi) 2006-06-07
FI20065388A FI20065388A (fi) 2007-12-08
FI121468B true FI121468B (fi) 2010-11-30

Family

ID=36651482

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20065388A FI121468B (fi) 2006-06-07 2006-06-07 Betuliiniperäiset yhdisteet antimikrobisina aineina

Country Status (7)

Country Link
US (3) US20100273801A1 (zh)
EP (3) EP2024384A1 (zh)
JP (1) JP2009539812A (zh)
CN (1) CN101500534A (zh)
CA (1) CA2654352A1 (zh)
FI (1) FI121468B (zh)
WO (4) WO2007141391A1 (zh)

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WO2009090063A1 (en) * 2008-01-16 2009-07-23 Jado Technologies Gmbh Steroid sapogenin, androstane and triterpenoid sapogenin derivatives for the treatment and prevention of infectious diseases
EP2247277A2 (en) * 2008-01-25 2010-11-10 B & T S.r.l. Use of transesterified olive oil in the cosmetic field
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
US8765920B2 (en) 2009-12-23 2014-07-01 The Scripps Research Institute Tyrosine bioconjugation through aqueous Ene-like reactions
CN101759759B (zh) * 2010-01-26 2012-07-04 浙江仙居君业药业有限公司 一种桦木酮酸的制备方法
KR101119625B1 (ko) 2011-06-30 2012-03-07 한국에너지기술연구원 베툴론산의 고순도 정제방법, 고순도 베툴론산을 이용한 피페라진 베툴론산 아마이드 유도체의 제조방법과 그 유도체, 고순도 베툴론산을 이용한 고순도 비오씨-라이시네이티드 베툴론산 정제방법
SE1150819A1 (sv) 2011-09-12 2013-03-13 Stora Enso Oyj Förfarande för derivatisering av en kemisk komponent i trä
SE536995C2 (sv) 2011-09-12 2014-11-25 Stora Enso Oyj Förfarande för derivatisering av en kemisk komponent i trä
JP5978544B2 (ja) * 2011-09-29 2016-08-24 日清オイリオグループ株式会社 化粧料用組成物及び化粧料
JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
JP2016503030A (ja) 2012-12-14 2016-02-01 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ 医薬組成物
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
CA2961528A1 (en) 2014-09-26 2016-03-31 Glaxosmithkline Intellectual Property (No.2) Limited Long acting pharmaceutical compositions
CN104387440A (zh) * 2014-11-07 2015-03-04 上海应用技术学院 一种白桦脂醇氨基酸酯化合物及其制备方法和用途
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
PL227790B1 (pl) 2015-08-13 2018-01-31 Slaski Univ Medyczny W Katowicach Fosfoniany acetylenowych pochodnych betuliny o działaniu przeciwnowotworowym, sposób ich wytwarzania i zastosowanie.
JP6306634B2 (ja) * 2016-04-21 2018-04-04 公立大学法人福井県立大学 食品用組成物
CN108640964B (zh) * 2018-06-21 2020-11-17 昆明理工大学 一种三萜-氨基酸衍生物、其制备方法和应用
CN112294659B (zh) * 2020-11-06 2021-10-22 东华大学 桦木醇基抗菌型牙科复合树脂的制备方法

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US5869535A (en) * 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
JPH08301954A (ja) * 1995-04-28 1996-11-19 Toray Dow Corning Silicone Co Ltd 硬化性剥離剤組成物
DE19532006A1 (de) * 1995-08-31 1997-03-06 Thomas Samland Medizinisches bzw. kosmetisches Präparat zur Vermeidung bzw. Abbau von Hautkrebs
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US20030114526A1 (en) * 1998-07-17 2003-06-19 Procter & Gamble To The University Of Texas Southwestern Medical Center Method for regulating hair growth
US6124362A (en) * 1998-07-17 2000-09-26 The Procter & Gamble Company Method for regulating hair growth
CA2250481A1 (fr) * 1998-11-02 2000-05-02 Andre Pichette Procede de preparation de derives du betulinol directement a partir de l'ecorce du bouleau blanc
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Also Published As

Publication number Publication date
FI20065388A0 (fi) 2006-06-07
EP2037872A4 (en) 2012-10-10
WO2007141389A1 (en) 2007-12-13
US20100273801A1 (en) 2010-10-28
WO2007141392A3 (en) 2008-03-06
EP2024384A1 (en) 2009-02-18
WO2007141390A1 (en) 2007-12-13
CN101500534A (zh) 2009-08-05
CA2654352A1 (en) 2007-12-13
WO2007141391A1 (en) 2007-12-13
FI20065388A (fi) 2007-12-08
US20100196290A1 (en) 2010-08-05
JP2009539812A (ja) 2009-11-19
EP2037872A2 (en) 2009-03-25
US20100190795A1 (en) 2010-07-29
WO2007141392A2 (en) 2007-12-13
EP2024385A1 (en) 2009-02-18

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