FI120260B - Förfarande för framställning av farmakologiskt aktiva aminobensoesyraderivat - Google Patents
Förfarande för framställning av farmakologiskt aktiva aminobensoesyraderivat Download PDFInfo
- Publication number
- FI120260B FI120260B FI930462A FI930462A FI120260B FI 120260 B FI120260 B FI 120260B FI 930462 A FI930462 A FI 930462A FI 930462 A FI930462 A FI 930462A FI 120260 B FI120260 B FI 120260B
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- FI
- Finland
- Prior art keywords
- compound
- formula
- amino
- group
- chloro
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
Claims (5)
1. Förfarande för framställning av ett farmakologiskt aktivt aminobensoesyraderivat med följande allmänna formel (I), (1-2) eller (1-3) eller ett farmakologiskt acceptabelt sait därav: j~7\ COX-( I N-CH, 1 v_V (I) /y L-/7Y i vv nch3 ^Ss^a-r1 Af « rKDv : : : ..a-r1 * · · i • · · 9 /Sf : · : r2 • · »·· • · · • · · * väri R1 är en alkenylgrupp eller en alkynylgrupp: * · · • ♦ • · 2 *1* R är en amino-, karboxiammo-, alkylamino- eller acylammo- ,.*·* grupp väri acylgruppen är formyl, acetyl, propionyl, butyryl, valeryl, isovaleryl, pivaloyl, bensoyl, toluoyl, naftoyl, furo-yl, nikotinoyl eller isonikotinoyl; • · · R är en halogenatom; R4 är en Ci-8-alkylgrupp eller aralkylgrupp; 81 X är -O- eller -NH-; och A är -0- eller -S-, kännetecknat av att a) för framställning av en förening med formeln (I), kondense-ras en förening med formeln C02H ^\.ä-r1 Λτ R (a) väri R1, R2, R3 och A har ovan angiven betydelse, eller ett re-aktivt derivat därav, med en förening med formeln . . CH3 ch I I 3 :i |Q 01 f* T Y :.T: nh2 tai oh b) för framställning av en förening med formeln (1-2), omsättes ... en förening med formeln (I), van R , R , R , X och A har ovan • · • · *** angiven betydelse, med en förening med formeln • ♦ · ···· Λ ··. R-Hal • · • · «·· :*·*; väri R4 har ovan angiven betydelse och Hai är halogen, eller ·»· • · • · • · · 82 c) för framställning av en förening med formeln (1-3), oxideras en förening med formeln (I), väri R1, R2, R3, X och A har ovan angiven betydelse, och om sei önskas 1. separeras en förening med formeln (I), (1-2) eller (1-3) som är i form av ett racemat i en optiskt aktiv isomer och/eller ii) överförs en förening med formeln (I), (1-2) eller (1-3) tili ett farmakologiskt acceptabelt sait.
2. Förfarande enligt patentkrav 1, kännetecknat av att man framställer ett aminobensoesyraderivat med formeln (I), (1-2) eller (1-3), väri R1 är en alkynylgrupp, eller ett farmakologiskt acceptabelt sait därav.
3. Förfarande enligt patentkrav 1 eller 2, kännetecknat av att man framställer ett aminobensoesyraderivat med formeln (I), (I- 2. eller (1-3), väri R2 är en aminogrupp, eller ett farmakologiskt acceptabelt sait därav.
4. Förfarande enligt patentkrav 1, kännetecknat av att man framställer ett aminobensoesyraderivat med följande formel (I- • · . 1-1) , (1-2-1) eller (1-3-1) eller ett farmakologiskt accepta- • · · .:. belt salt av ett aminobensoesyraderivat med formeln (1-1-1) el-ler (1-3-1) • · • · · • · · • · · • · • · • · · • · · • · · • · · • · · • ♦ · • · · • · • · • · · • · · « • · « · • · * • · • · ·«» ··· • ♦ · • · ♦ ·»· • ♦ • · • · · 83 ci/IOJ nh2 Me V P JOf°i c^J II-2-1) nh2 =.=.= °γ- l> ···· S [of t =:== C1A^ nh2 • 1
· ^ • · · • · · :...: 5. Förfarande enligt patentkrav 1, kännetecknat av att man .:. framställer (- )-endo-4-amino-5-klor-N-( 8-metyl-8- .···. azabicyklo [3.2.1] okt-3-yl )-2-( (3-pentyn-2- • · T yl)oxijbensamidhydroklorid. • · · • · · • · · 1 1 • · • · • · ·
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1895992 | 1992-02-04 | ||
| JP1895992 | 1992-02-04 | ||
| JP23553392 | 1992-09-03 | ||
| JP23553392 | 1992-09-03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI930462A0 FI930462A0 (fi) | 1993-02-02 |
| FI930462A FI930462A (fi) | 1993-08-05 |
| FI120260B true FI120260B (sv) | 2009-08-31 |
Family
ID=26355729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI930462A FI120260B (sv) | 1992-02-04 | 1993-02-02 | Förfarande för framställning av farmakologiskt aktiva aminobensoesyraderivat |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US5389643A (sv) |
| EP (1) | EP0554794B1 (sv) |
| JP (2) | JP2721631B2 (sv) |
| KR (3) | KR970005192B1 (sv) |
| CN (1) | CN1039909C (sv) |
| AT (1) | ATE169015T1 (sv) |
| AU (2) | AU653094B2 (sv) |
| CA (1) | CA2088702C (sv) |
| DE (1) | DE69319939T2 (sv) |
| DK (1) | DK0554794T3 (sv) |
| ES (1) | ES2118842T3 (sv) |
| FI (1) | FI120260B (sv) |
| HU (1) | HU221301B1 (sv) |
| MX (1) | MX9300638A (sv) |
| NO (1) | NO302821B1 (sv) |
| NZ (2) | NZ245800A (sv) |
| PH (1) | PH31171A (sv) |
| TW (1) | TW309521B (sv) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH30413A (en) * | 1992-03-26 | 1997-05-09 | Boehringer Ingelheim Italia | Crystalline forms of endo-2,3-dihydro-n-(8-methyl)-8-azabicyclo-(3,2,1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamides |
| GB9214184D0 (en) * | 1992-07-03 | 1992-08-12 | Smithkline Beecham Plc | Pharmaceuticals |
| JP3235913B2 (ja) * | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | アミノ安息香酸誘導体 |
| FR2762316B1 (fr) * | 1997-04-18 | 1999-12-17 | Sanofi Synthelabo | Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique |
| AR037524A1 (es) * | 2001-11-14 | 2004-11-17 | Sucampo Ag | Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion |
| WO2005007600A2 (en) * | 2003-07-11 | 2005-01-27 | Eisai Co., Ltd. | Novel methods using aminobenzoic acid compounds |
| EP1736156A4 (en) * | 2004-04-15 | 2010-06-16 | Eisai R&D Man Co Ltd | COMPOSITION CONTAINING 4-AMINO-5-CHLORO-N-¬ (1R, 3R, 5S) -8-METHYL-8-AZABICYCLO-3.2.1 OCT-3-YL-2-β-methyl-2-ynyloxy BENZAMIDE STABILIZED |
| CN114315585B (zh) * | 2022-03-04 | 2022-05-13 | 中国医学科学院药用植物研究所 | 一种羟戊苯甲酸双酯化合物及其制备方法和制药应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL59004A0 (en) * | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
| FR2493848B2 (fr) * | 1980-11-07 | 1986-05-16 | Delalande Sa | Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique |
| EP0220011A3 (en) * | 1985-10-12 | 1990-01-03 | Beecham Group Plc | Use of azabicloalkylbenzamides in the treatment of gastrointestinal motility disorders, migraine, emesis, cluster headaches, trigeminal neuralgia and arrhythmia |
| GB8718345D0 (en) * | 1987-08-03 | 1987-09-09 | Fordonal Sa | N-substituted benzamides |
| PT100990A (pt) * | 1991-10-24 | 1994-01-31 | Smithkline Beecham Plc | Derivados de piridina e sua utilizacao como substancia terapeutica |
-
1993
- 1993-01-28 EP EP93101312A patent/EP0554794B1/en not_active Expired - Lifetime
- 1993-01-28 DK DK93101312T patent/DK0554794T3/da active
- 1993-01-28 ES ES93101312T patent/ES2118842T3/es not_active Expired - Lifetime
- 1993-01-28 AT AT93101312T patent/ATE169015T1/de active
- 1993-01-28 DE DE69319939T patent/DE69319939T2/de not_active Expired - Lifetime
- 1993-01-28 PH PH45633A patent/PH31171A/en unknown
- 1993-01-29 JP JP5013129A patent/JP2721631B2/ja not_active Expired - Fee Related
- 1993-01-29 NZ NZ245800A patent/NZ245800A/en not_active IP Right Cessation
- 1993-01-29 NZ NZ264220A patent/NZ264220A/en not_active IP Right Cessation
- 1993-02-02 NO NO19930353A patent/NO302821B1/no not_active IP Right Cessation
- 1993-02-02 TW TW082100672A patent/TW309521B/zh active
- 1993-02-02 FI FI930462A patent/FI120260B/sv not_active IP Right Cessation
- 1993-02-03 US US08/013,080 patent/US5389643A/en not_active Expired - Lifetime
- 1993-02-03 CA CA002088702A patent/CA2088702C/en not_active Expired - Fee Related
- 1993-02-03 AU AU32176/93A patent/AU653094B2/en not_active Ceased
- 1993-02-03 HU HU9300283A patent/HU221301B1/hu not_active IP Right Cessation
- 1993-02-04 KR KR1019930001489A patent/KR970005192B1/ko not_active IP Right Cessation
- 1993-02-04 CN CN93100965A patent/CN1039909C/zh not_active Expired - Fee Related
- 1993-02-04 MX MX9300638A patent/MX9300638A/es unknown
-
1994
- 1994-08-05 AU AU68908/94A patent/AU668827B2/en not_active Ceased
- 1994-11-08 US US08/337,480 patent/US5578603A/en not_active Expired - Lifetime
-
1995
- 1995-06-07 US US08/488,430 patent/US5631402A/en not_active Expired - Lifetime
- 1995-06-07 US US08/475,602 patent/US5599972A/en not_active Expired - Lifetime
-
1996
- 1996-07-06 KR KR96027317A patent/KR970002634B1/ko not_active IP Right Cessation
- 1996-07-26 KR KR96027318A patent/KR970009570B1/ko not_active IP Right Cessation
-
1997
- 1997-04-01 JP JP9082609A patent/JPH107674A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer of assignment of patent |
Owner name: EISAI R&D MANAGEMENT CO., LTD. Free format text: EISAI R&D MANAGEMENT CO., LTD. |
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| FG | Patent granted |
Ref document number: 120260 Country of ref document: FI |
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| MM | Patent lapsed |