ES2118842T3 - Derivados del acido aminobenzoico. - Google Patents

Derivados del acido aminobenzoico.

Info

Publication number
ES2118842T3
ES2118842T3 ES93101312T ES93101312T ES2118842T3 ES 2118842 T3 ES2118842 T3 ES 2118842T3 ES 93101312 T ES93101312 T ES 93101312T ES 93101312 T ES93101312 T ES 93101312T ES 2118842 T3 ES2118842 T3 ES 2118842T3
Authority
ES
Spain
Prior art keywords
group
aminobenzoic acid
derivatives
activity
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93101312T
Other languages
English (en)
Inventor
Shuhei Miyazawa
Shigeki Hibi
Hiroyuki Yoshimura
Takashi Mori
Yorihisa Hoshino
Mitsuo Nagai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ES2118842T3 publication Critical patent/ES2118842T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

UN DERIVADO DEL ACIDO AMINOBENZOICO REPRESENTADO POR LAS SIGUIENTES FORMULAS GENERALES (I), (I-2) O (I-3), O UNA SAL DE EL ACEPTABLE FARMACOLOGICAMENTE, EL CUAL PRESENTA UN ANTAGONISMO SEROTONINO Y UNA ACTIVIDAD QUE ACELERA LA LIBERACION DE ACETILCOLINA CON UNA RELACION DE ACTIVIDAD BIEN EQUILIBRADA Y QUE ES EFICAZ COMO MEDICAMENTO PARA PACIENTES CON ENFERMEDADES GASTROINTESTINALES NO IDENTIFICADAS: EN LAS QUE R1 REPRESENTA UN GRUPO TAL COMO UN GRUPO ALQUINILO O CIANOALQUILO; R2 REPRESENTA UN GRUPO TAL COMO UN GRUPO AMINO O ACILAMINO; R3 REPRESENTA UN ATOMO DE HALOGENO; X REPRESENTA -OO -NH-; Y A REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE.
ES93101312T 1992-02-04 1993-01-28 Derivados del acido aminobenzoico. Expired - Lifetime ES2118842T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1895992 1992-02-04
JP23553392 1992-09-03

Publications (1)

Publication Number Publication Date
ES2118842T3 true ES2118842T3 (es) 1998-10-01

Family

ID=26355729

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93101312T Expired - Lifetime ES2118842T3 (es) 1992-02-04 1993-01-28 Derivados del acido aminobenzoico.

Country Status (18)

Country Link
US (4) US5389643A (es)
EP (1) EP0554794B1 (es)
JP (2) JP2721631B2 (es)
KR (3) KR970005192B1 (es)
CN (1) CN1039909C (es)
AT (1) ATE169015T1 (es)
AU (2) AU653094B2 (es)
CA (1) CA2088702C (es)
DE (1) DE69319939T2 (es)
DK (1) DK0554794T3 (es)
ES (1) ES2118842T3 (es)
FI (1) FI120260B (es)
HU (1) HU221301B1 (es)
MX (1) MX9300638A (es)
NO (1) NO302821B1 (es)
NZ (2) NZ264220A (es)
PH (1) PH31171A (es)
TW (1) TW309521B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30413A (en) * 1992-03-26 1997-05-09 Boehringer Ingelheim Italia Crystalline forms of endo-2,3-dihydro-n-(8-methyl)-8-azabicyclo-(3,2,1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamides
GB9214184D0 (en) * 1992-07-03 1992-08-12 Smithkline Beecham Plc Pharmaceuticals
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
FR2762316B1 (fr) * 1997-04-18 1999-12-17 Sanofi Synthelabo Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
TWI331920B (en) 2001-11-14 2010-10-21 Sucampo Ag Unit dosage form for relieving or treating constipation in human patients
WO2005007600A2 (en) * 2003-07-11 2005-01-27 Eisai Co., Ltd. Novel methods using aminobenzoic acid compounds
JPWO2005099698A1 (ja) * 2004-04-15 2008-03-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定化された４−アミノ−５−クロロ−Ｎ−［（１Ｒ，３ｒ，５Ｓ）−８−メチル−８−アザビシクロ［３．２．１］オクタ−３−イル］−２−［１−メチルブタ−２−インイルオキシ］ベンズアミド含有組成物
CN114315585B (zh) * 2022-03-04 2022-05-13 中国医学科学院药用植物研究所 一种羟戊苯甲酸双酯化合物及其制备方法和制药应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59004A0 (en) * 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
EP0220011A3 (en) * 1985-10-12 1990-01-03 Beecham Group Plc Use of azabicloalkylbenzamides in the treatment of gastrointestinal motility disorders, migraine, emesis, cluster headaches, trigeminal neuralgia and arrhythmia
GB8718345D0 (en) * 1987-08-03 1987-09-09 Fordonal Sa N-substituted benzamides
PT100990A (pt) * 1991-10-24 1994-01-31 Smithkline Beecham Plc Derivados de piridina e sua utilizacao como substancia terapeutica

Also Published As

Publication number Publication date
DK0554794T3 (da) 1999-04-26
CN1075145A (zh) 1993-08-11
AU668827B2 (en) 1996-05-16
KR970005192B1 (ko) 1997-04-14
NZ245800A (en) 1995-03-28
CA2088702A1 (en) 1993-08-05
PH31171A (en) 1998-03-20
AU3217693A (en) 1993-08-05
EP0554794B1 (en) 1998-07-29
US5631402A (en) 1997-05-20
JP2721631B2 (ja) 1998-03-04
KR970002634B1 (en) 1997-03-07
DE69319939D1 (de) 1998-09-03
US5389643A (en) 1995-02-14
US5599972A (en) 1997-02-04
FI120260B (fi) 2009-08-31
US5578603A (en) 1996-11-26
NO930353L (no) 1993-08-05
ATE169015T1 (de) 1998-08-15
KR930017882A (ko) 1993-09-20
HU9300283D0 (en) 1993-04-28
NZ264220A (en) 1995-03-28
CA2088702C (en) 2003-08-12
NO302821B1 (no) 1998-04-27
HUT69691A (en) 1995-09-28
AU6890894A (en) 1994-09-29
AU653094B2 (en) 1994-09-15
FI930462A (fi) 1993-08-05
MX9300638A (es) 1993-08-01
NO930353D0 (no) 1993-02-02
EP0554794A1 (en) 1993-08-11
TW309521B (es) 1997-07-01
JPH06128254A (ja) 1994-05-10
KR970009570B1 (en) 1997-06-14
DE69319939T2 (de) 1999-02-18
FI930462A0 (fi) 1993-02-02
HU221301B1 (en) 2002-09-28
JPH107674A (ja) 1998-01-13
CN1039909C (zh) 1998-09-23

Similar Documents

Publication Publication Date Title
EA199800943A1 (ru) Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы
UY28132A1 (es) Derivados de pirrolopirimidina
NL970006I2 (nl) Gebruik van indolon-derivaten voor het bereiden van geneesmiddelen ter behandeling van de ziekte vanParkinson.
DK46789A (da) 3-indolpyrodruesyrederivater og farmaceutisk anvendelse deraf
DE69920757D1 (de) Immunsuppressive wirkungen von pteridinderivaten
SE8102193L (sv) Terapeutiskt aktiv organisk forening och dess anvendning
BR0009044A (pt) Composto, composição farmacêutica, método para tratar uma doença em um animal, uso de um composto, e, processo para fabricar um composto
ES2164889T3 (es) Semicarbazonas con actividad sobre el snc y preparados farmaceuticos a base de las mismas.
MX9303441A (es) Procedimiento para la preparacion de acido clavulanico.
AR044650A1 (es) Derivados de tiofeno - pirimidinona y su uso en la terapia de enfermedades que requieren la inhibicion de la enzima 17b-hidroxiesteroide-dehidrogenasa.
BR0309185A (pt) Medicamento contendo beta-miméticos e um novo anticolinérgico
PA8446301A1 (es) 2-amino-6-(4-fenoxi-2-sustituido)-piridinas sustituidas
UY27658A1 (es) Derivados de nicotinamida y una sal de tiotropio en combinación para el tratamiento de enfermedades
ES2118842T3 (es) Derivados del acido aminobenzoico.
KR940005274A (ko) 쇼그렌(Sjoegren)증후군 치료제
ATE325610T1 (de) Xanthinderivative zur behandlung von hirnischämie
DK166323C (da) Griseolsyrederivater og farmaceutiske midler indeholdende disse
ES2053668T3 (es) Derivados de poliamina como agentes antineoplasicos.
ES2124861T3 (es) Derivados de aminoacidos y su utilizacion como inhibidores de la encefalinasa.
CO4970779A1 (es) Derivados del acido aminoetilfenoxiacetico y agentes para reducir el dolor y promover la eliminacion de calculos en urolitiasis
AR033685A1 (es) Derivados del acido tetramico, coniosetina y derivados de la misma, procedimiento para su preparacion, medicamentos, procedimiento para la preparacion de medicamentos, empleo de dichos derivados para la preparacion de medicamentos
ATE398134T1 (de) Neue analoga von nitrobenzylthioinosin
FR2430230A1 (fr) Medicaments a base de derives de l&#39;acide anthranilique
DE3884508T2 (de) Cystein-Derivate mit Expectorans-Wirkung.
ES2160093B1 (es) Derivados del acido p-hidroxifenil propionico como agentes antiproliferativos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 554794

Country of ref document: ES