FI120096B - Lusiferaaseja - Google Patents
Lusiferaaseja Download PDFInfo
- Publication number
- FI120096B FI120096B FI963741A FI963741A FI120096B FI 120096 B FI120096 B FI 120096B FI 963741 A FI963741 A FI 963741A FI 963741 A FI963741 A FI 963741A FI 120096 B FI120096 B FI 120096B
- Authority
- FI
- Finland
- Prior art keywords
- amino acid
- luciferase
- protein
- leu
- gly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
- C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
- C12Y113/12007—Photinus-luciferin 4-monooxygenase (ATP-hydrolysing) (1.13.12.7), i.e. firefly-luciferase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9405750A GB9405750D0 (en) | 1994-03-23 | 1994-03-23 | Luciferases |
| GB9405750 | 1994-03-23 | ||
| GBGB9501170.6A GB9501170D0 (en) | 1994-03-23 | 1995-01-20 | Luciferases |
| GB9501170 | 1995-01-20 | ||
| PCT/GB1995/000629 WO1995025798A1 (en) | 1994-03-23 | 1995-03-22 | Luciferases |
| GB9500629 | 1995-03-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI963741A0 FI963741A0 (fi) | 1996-09-20 |
| FI963741A FI963741A (fi) | 1996-11-20 |
| FI120096B true FI120096B (fi) | 2009-06-30 |
Family
ID=26304561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI963741A FI120096B (fi) | 1994-03-23 | 1996-09-20 | Lusiferaaseja |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6132983A (de) |
| EP (2) | EP0751996B1 (de) |
| JP (3) | JP4490508B2 (de) |
| KR (1) | KR100392020B1 (de) |
| CN (1) | CN100387720C (de) |
| AT (1) | ATE230800T1 (de) |
| AU (1) | AU697883B2 (de) |
| BR (1) | BR9507140A (de) |
| CA (1) | CA2186144C (de) |
| DE (1) | DE69529337T2 (de) |
| DK (1) | DK0751996T3 (de) |
| ES (1) | ES2185697T3 (de) |
| FI (1) | FI120096B (de) |
| GB (1) | GB9501170D0 (de) |
| NO (1) | NO319706B1 (de) |
| RU (1) | RU2192467C2 (de) |
| WO (1) | WO1995025798A1 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501170D0 (en) * | 1994-03-23 | 1995-03-08 | Secr Defence | Luciferases |
| EP0804587B1 (de) * | 1995-01-20 | 2004-08-18 | The Secretary of State for Defence | Mutierte luziferasen |
| GB2311525B (en) * | 1995-01-20 | 1998-11-11 | Secr Defence | Mutant Luciferases |
| GB9707486D0 (en) * | 1997-04-11 | 1997-05-28 | Secr Defence | Enzyme assays |
| EP2860252A1 (de) * | 1997-09-19 | 2015-04-15 | Promega Corporation | Thermostabile Luciferasen und Verfahren zur Herstellung |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| GB9722481D0 (en) * | 1997-10-25 | 1997-12-24 | Secr Defence | Expression system |
| US6117643A (en) * | 1997-11-25 | 2000-09-12 | Ut Battelle, Llc | Bioluminescent bioreporter integrated circuit |
| EP1925320A3 (de) | 1998-03-27 | 2008-09-03 | Prolume, Ltd. | Luciferasen, fluoreszierende Proteine, Nukleinsäuren zur Kodierung der Luciferasen und der fluoreszierenden Proteine sowie deren Verwendung zur Diagnose, zum Screening mit hohem Durchsatz und zur Behandlung neuartiger Probleme |
| AU765703B2 (en) * | 1998-03-27 | 2003-09-25 | Bruce J. Bryan | Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items |
| GB9823468D0 (en) | 1998-10-28 | 1998-12-23 | Secr Defence | Novel enzyme |
| GB9925161D0 (en) * | 1999-10-26 | 1999-12-22 | Secr Defence | Novel enzyme |
| ES2292479T3 (es) * | 1999-10-26 | 2008-03-16 | The Secretary Of State For Defence | Luciferasa mutante. |
| US7879540B1 (en) | 2000-08-24 | 2011-02-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| US20020073441A1 (en) | 2000-12-13 | 2002-06-13 | Ross Brian D. | Compositions and methods for detecting proteolytic activity |
| GB0111275D0 (en) | 2001-05-09 | 2001-06-27 | Secr Defence | Analytical method and kit |
| CA2477235A1 (en) | 2002-02-21 | 2003-09-04 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| WO2004042010A2 (en) * | 2002-10-30 | 2004-05-21 | University Of Tennessee Research Foundation | Modified luciferase nucleic acids and methods of use |
| US7413874B2 (en) | 2002-12-09 | 2008-08-19 | University Of Miami | Nucleic acid encoding fluorescent proteins from aquatic species |
| JP2006521116A (ja) | 2003-03-27 | 2006-09-21 | ピーティーシー セラピューティクス，インコーポレーテッド | 抗真菌性および／または抗増殖性分子を同定するためのｔＲＮＡスプライシング経路の酵素の標的化 |
| EP1613158A4 (de) | 2003-03-27 | 2007-08-22 | Ptc Therapeutics Inc | Verfahren zur identifikation von verbindungen mit einer trna-splicenden endonuklease als angriffsort, sowie verwendungen für diese verbindungen als proliferationshemmende mittel |
| AU2004236536A1 (en) * | 2003-05-06 | 2004-11-18 | National Institute Of Advanced Industrial Science And Technology | Multiple gene transcription activity determining sysyem |
| US7728118B2 (en) | 2004-09-17 | 2010-06-01 | Promega Corporation | Synthetic nucleic acid molecule compositions and methods of preparation |
| GB0517005D0 (en) | 2005-08-19 | 2005-09-28 | Enigma Diagnostics Ltd | Analytical method and kit |
| US7807429B2 (en) * | 2006-02-13 | 2010-10-05 | Connecticut College | Isolated luciferase gene of L. italica |
| JP5188771B2 (ja) | 2007-09-26 | 2013-04-24 | 株式会社日立製作所 | 変異型ホタルルシフェラーゼ |
| CN103983634A (zh) * | 2008-07-22 | 2014-08-13 | 普罗美加公司 | 基于adp检测的发光磷酸转移酶或atp水解酶测定 |
| JP2010081908A (ja) * | 2008-10-02 | 2010-04-15 | Hitachi Ltd | 変異型のホタルルシフェラーゼ |
| JP2011120559A (ja) * | 2008-12-26 | 2011-06-23 | Kikkoman Corp | ホタルルシフェラーゼ、その遺伝子、およびホタルルシフェラーゼの製造法 |
| US20110076706A1 (en) * | 2009-06-26 | 2011-03-31 | Genprime, Inc. | Methods and kits for the rapid detection of microorganisms |
| PL2635583T3 (pl) | 2010-11-02 | 2015-11-30 | Promega Corp | Pochodne koelenterazyny i metody ich wykorzystania |
| JP5889910B2 (ja) | 2010-11-02 | 2016-03-22 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 新規セレンテラジン基質及び使用法 |
| US9487814B2 (en) | 2013-02-22 | 2016-11-08 | Promega Corporation | Stabilized formulation for luminescent detection of luciferase and nucleoside phosphates |
| WO2015116806A1 (en) | 2014-01-29 | 2015-08-06 | Promega Corporation | Pro-substrates for live cell applications |
| EP3099683B1 (de) | 2014-01-29 | 2020-08-05 | Promega Corporation | Chinonmaskierte sonden als markierungsreagenzien für zellaufnahmemessungen |
| JP6811173B2 (ja) | 2014-09-11 | 2021-01-13 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 増強された発光を産生するために赤外発光基質を活用するルシフェラーゼ配列 |
| EP3204509B1 (de) | 2014-10-08 | 2019-07-10 | Promega Corporation | Biolumineszierender test zum nachweis von succinat |
| CN105200022B (zh) * | 2015-11-03 | 2018-11-16 | 南京工业大学 | 萤火虫荧光素酶热稳定性改造的方法 |
| JP6349003B1 (ja) * | 2017-03-17 | 2018-06-27 | 東洋ビーネット株式会社 | 耐熱性ルシフェラーゼ |
| CN115087743A (zh) | 2020-02-14 | 2022-09-20 | 龟甲万株式会社 | 用于测定样本中的atp、以及amp和/或adp的液体组合物 |
| CN114015664B (zh) * | 2021-12-06 | 2023-07-21 | 郑州伊美诺生物技术有限公司 | 荧光素酶突变体及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229285A (en) * | 1991-06-27 | 1993-07-20 | Kikkoman Corporation | Thermostable luciferase of firefly, thermostable luciferase gene of firefly, novel recombinant dna, and process for the preparation of thermostable luciferase of firefly |
| JP3048466B2 (ja) * | 1991-06-27 | 2000-06-05 | キッコーマン株式会社 | 耐熱性ホタルルシフェラーゼ、耐熱性ホタルルシフェラーゼ遺伝子、新規な組み換え体ｄｎａ、及び耐熱性ホタルルシフェラーゼの製造法 |
| DE4124495A1 (de) * | 1991-07-24 | 1993-01-28 | Happich Gmbh Gebr | Fenstereinfassrahmen, insbesondere fuer fahrzeuge |
| GB9501170D0 (en) * | 1994-03-23 | 1995-03-08 | Secr Defence | Luciferases |
-
1995
- 1995-01-20 GB GBGB9501170.6A patent/GB9501170D0/en active Pending
- 1995-03-22 EP EP95912320A patent/EP0751996B1/de not_active Expired - Lifetime
- 1995-03-22 BR BR9507140A patent/BR9507140A/pt not_active IP Right Cessation
- 1995-03-22 CN CNB951932594A patent/CN100387720C/zh not_active Expired - Fee Related
- 1995-03-22 EP EP02010994.8A patent/EP1281762B1/de not_active Expired - Lifetime
- 1995-03-22 KR KR1019960705464A patent/KR100392020B1/ko not_active IP Right Cessation
- 1995-03-22 CA CA002186144A patent/CA2186144C/en not_active Expired - Fee Related
- 1995-03-22 AT AT95912320T patent/ATE230800T1/de not_active IP Right Cessation
- 1995-03-22 DK DK95912320T patent/DK0751996T3/da active
- 1995-03-22 RU RU96119246/13A patent/RU2192467C2/ru active
- 1995-03-22 ES ES95912320T patent/ES2185697T3/es not_active Expired - Lifetime
- 1995-03-22 AU AU19545/95A patent/AU697883B2/en not_active Ceased
- 1995-03-22 US US08/718,425 patent/US6132983A/en not_active Expired - Lifetime
- 1995-03-22 JP JP52448695A patent/JP4490508B2/ja not_active Expired - Lifetime
- 1995-03-22 DE DE69529337T patent/DE69529337T2/de not_active Expired - Lifetime
- 1995-03-22 WO PCT/GB1995/000629 patent/WO1995025798A1/en active IP Right Grant
-
1996
- 1996-09-20 FI FI963741A patent/FI120096B/fi active IP Right Grant
- 1996-09-23 NO NO19963983A patent/NO319706B1/no not_active IP Right Cessation
-
2006
- 2006-06-13 JP JP2006163388A patent/JP2006271393A/ja active Pending
-
2009
- 2009-12-03 JP JP2009275807A patent/JP2010088440A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995025798A1 (en) | 1995-09-28 |
| JPH09510610A (ja) | 1997-10-28 |
| NO963983D0 (no) | 1996-09-23 |
| EP0751996A1 (de) | 1997-01-08 |
| DE69529337D1 (de) | 2003-02-13 |
| FI963741A0 (fi) | 1996-09-20 |
| KR970702369A (ko) | 1997-05-13 |
| CA2186144A1 (en) | 1995-09-28 |
| RU2192467C2 (ru) | 2002-11-10 |
| DK0751996T3 (da) | 2003-02-24 |
| CN1149318A (zh) | 1997-05-07 |
| CN100387720C (zh) | 2008-05-14 |
| NO963983L (no) | 1996-09-23 |
| GB9501170D0 (en) | 1995-03-08 |
| EP0751996B1 (de) | 2003-01-08 |
| EP1281762A3 (de) | 2003-11-05 |
| AU697883B2 (en) | 1998-10-22 |
| JP4490508B2 (ja) | 2010-06-30 |
| JP2006271393A (ja) | 2006-10-12 |
| ATE230800T1 (de) | 2003-01-15 |
| EP1281762B1 (de) | 2014-12-31 |
| BR9507140A (pt) | 1997-09-30 |
| US6132983A (en) | 2000-10-17 |
| DE69529337T2 (de) | 2003-10-16 |
| CA2186144C (en) | 2009-12-22 |
| EP1281762A2 (de) | 2003-02-05 |
| KR100392020B1 (ko) | 2003-10-22 |
| AU1954595A (en) | 1995-10-09 |
| FI963741A (fi) | 1996-11-20 |
| ES2185697T3 (es) | 2003-05-01 |
| NO319706B1 (no) | 2005-09-05 |
| JP2010088440A (ja) | 2010-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer of assignment of patent |
Owner name: 3M INNOVATIVE PROPERTIES COMPANY Free format text: 3M INNOVATIVE PROPERTIES COMPANY |
|
| FG | Patent granted |
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