FI120093B - Metod att framställa aminoalkylguanidiner - Google Patents
Metod att framställa aminoalkylguanidiner Download PDFInfo
- Publication number
- FI120093B FI120093B FI955800A FI955800A FI120093B FI 120093 B FI120093 B FI 120093B FI 955800 A FI955800 A FI 955800A FI 955800 A FI955800 A FI 955800A FI 120093 B FI120093 B FI 120093B
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- FI
- Finland
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
Claims (10)
1. Förfarande för framställning av skyddade ω-aminoalkylguanidiner med den all-30 männa formeln III, dess tautomerer eller salter • · · · · • · *:2 H2N-CnH2n-NH-C-(=NH)-NH-C(0)-0-R (III) • · · • · · · 2 • · · k ä n n e t e c k n a t av att en diamin med den allmänna formeln I 35 NH2-CnH2n - NH2 (I) • · · • · omsättes med ett guanyleringsreagens med den allmänna formeln II, dess tautomer eller salter R0C(0)-N=C(L)-NH2 (II) 5 i vilka formler -C„H2n- är en linjär eller grenad alkylgrupp, n är ett heltal 2-18; R är vald frän gruppen som bestär av en linjär eller grenad CM2-alkylgrupp, säsom en lägre alkylgrupp och en aralkylgrupp, säsom en bensyl- eller substituerad bensyl-10 grupp; och L är en avgängsgrupp vald frän gruppen som bestär av föreningar med den allmänna formeln R~0, R S, pyrazolyl- och substituerad pyrazolylgrupp, väri R är en lägre alkylgrupp. 15
2. Förfarande enligt patentkrav l,kännetecknat avatt -CnH2n- är en linjär alkylgrupp, väri n är 2 - 12.
3. Förfarande enligt patentkrav 1, kännetecknat avatt -CnH2n- är en linjär 20 alkylgrupp, väri n är 2 - 5, 8 eller 12 och R är en t-butyl- eller hensylgrupp. ... 4. Förfarande enligt patentkrav 3, k ä n n e t e c k n a t av att n är 3 och R är en • · bensylgrupp • · • · ··· • · ·.·.· '* '25 5. Förfarande enligt patentkrav 1, kännetecknat av att nämnda reaktion • · :.· · utfors i fränvaro av eller i närvaro av ett lösningsmedel, företrädesvis i fränvaro eller : om ett lösningsmedel används, utgörs detsamma företrädesvis av ett aromatiskt kol- väte, säsom alkylbensen, och mera specifikt toluen eller xylen; ett kolväte som är lin- järt eller grenat, cykliskt eller acykliskt, säsom hexan, heptan eller cyklohexan; alkyl- .·;·. 30 nitril, säsom acetonitril; en alkohol, säsom isopropanol; eller vatten. • * • · · ♦ · • ·
6. Förfarande enligt patentkrav 1, kännetecknat av att nämnda reaktion utfores med användning av ungefär minst en stökiometrisk mängd av diaminreagen- • · · set, företrädesvis 1-10 molekvivalenter av diaminreagenset i förhällande tili :v. 35 guanyleringsreagenset. • · • · • » • · · • ·· 1 Förfarande enligt patentkrav 6, k ä n n e t e c k n a t av att diaminreagenset används i en mängd av 1,5 - 6 molekvivalenter, företrädesvis 2 - 4 molekvivalenter i förhällande tili guanyleringsreagenset.
8. Förfarande enligt patentkrav 1, kännetecknat avatt nämnda reaktion 5 utförs vid en reaktionstemperatur av cirka 20 - 80 °C, företrädesvis cirka 40 - 60 °C.
9. Förfarande enligt patentkrav 1,kännetecknat avatt föreningen III isole-ras genom utfällning ur reaktionsblandningen i form av en kristallin produkt. 10 10. Förfarande enligt patentkrav 9, k ä n n e t e c k n a t av att föreningen III utfälls med en syra, företrädesvis klorvätesyra. • M • · • · ··· • · · • · • · ··· • · • · · • « · • · • · • · · • · · ··# · • · • 1 · • · · ··· · ··· • · · • · · »·· • · · • · · ··♦ • · • · ··· ··· ···· ··· • · • · ··· t ·1 · • · · • · • · · * I · • · · • ·
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9301912 | 1993-06-03 | ||
| SE19939301912A SE9301912D0 (sv) | 1993-06-03 | 1993-06-03 | Process for the production of aminoalkylguandines |
| SE9400517 | 1994-06-01 | ||
| PCT/SE1994/000517 WO1994029269A1 (en) | 1993-06-03 | 1994-06-01 | Process for the production of aminoalkylguanidines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI955800A FI955800A (sv) | 1995-12-01 |
| FI955800A0 FI955800A0 (sv) | 1995-12-01 |
| FI120093B true FI120093B (sv) | 2009-06-30 |
Family
ID=20390162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI955800A FI120093B (sv) | 1993-06-03 | 1995-12-01 | Metod att framställa aminoalkylguanidiner |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5659071A (sv) |
| EP (1) | EP0701550B1 (sv) |
| JP (1) | JP3662925B2 (sv) |
| CN (1) | CN1124956A (sv) |
| AT (1) | ATE178316T1 (sv) |
| AU (1) | AU674970B2 (sv) |
| BR (1) | BR9406713A (sv) |
| CA (1) | CA2162920C (sv) |
| CZ (1) | CZ320095A3 (sv) |
| DE (1) | DE69417554T2 (sv) |
| DK (1) | DK0701550T3 (sv) |
| EE (1) | EE9400348A (sv) |
| ES (1) | ES2131688T3 (sv) |
| FI (1) | FI120093B (sv) |
| GR (1) | GR3030501T3 (sv) |
| HR (1) | HRP940317A2 (sv) |
| HU (1) | HUT74293A (sv) |
| IL (1) | IL109683A0 (sv) |
| IS (1) | IS4165A (sv) |
| LT (1) | LT3309B (sv) |
| NO (1) | NO305514B1 (sv) |
| NZ (1) | NZ267192A (sv) |
| PL (1) | PL311760A1 (sv) |
| SE (1) | SE9301912D0 (sv) |
| SK (1) | SK151895A3 (sv) |
| WO (1) | WO1994029269A1 (sv) |
| YU (1) | YU33594A (sv) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610308A (en) * | 1995-05-18 | 1997-03-11 | Bristol-Myers Squibb Company | Process for preparing intermediates for thrombin inhibitors |
| TW455580B (en) * | 1995-12-09 | 2001-09-21 | Roche Diagnostics Gmbh | 3-aminoethyl-N-amidino-2,5-dihyropyrrole-derivatives having arginine mimentic properties and pharmaceutical compositions containing these compounds |
| AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| US7129233B2 (en) * | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| FR2822463B1 (fr) | 2001-03-21 | 2004-07-30 | Lipha | Derives bicycliques de guanidines et leurs applications en therapeutique |
| AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
| US9375499B2 (en) * | 2006-07-14 | 2016-06-28 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
| TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
| JP6006634B2 (ja) * | 2011-12-28 | 2016-10-12 | 東和薬品株式会社 | イソウレア化合物を用いるエピナスチンの製造方法 |
| US10202337B2 (en) * | 2014-03-28 | 2019-02-12 | Kaneka Corporation | Method for producing tri-carbobenzoxy-arginine |
| EP3877439A4 (en) | 2018-11-07 | 2022-08-10 | Regents of the University of Minnesota | ANALGESIC AND ANTI-ADDICTION COMPOSITIONS FOR THE TREATMENT OF CHRONIC PAIN AND OPIOID DEPENDENCE |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE463576C (de) * | 1924-08-06 | 1928-07-31 | Schering Kahlbaum Akt Ges | Verfahren zur Darstellung von Aminoguanidinen oder deren Salzen |
| FR2294699A1 (fr) * | 1974-12-19 | 1976-07-16 | Bottu | Nouveaux derives du pyrazole et compositions pharmaceutiques les renfermant |
| HU178398B (en) * | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| US4387049A (en) | 1982-02-22 | 1983-06-07 | Smithkline Beckman Corporation | Adamantyl containing peptides |
| DE3222342A1 (de) * | 1982-06-14 | 1983-12-15 | Hoechst Ag, 6230 Frankfurt | 6-aryl-1,2,4-triazolo (4,3-b) pyridazin-3-carbaminate, ihre herstellung und sie enthaltende arzneimittel |
| US4914189A (en) * | 1987-02-05 | 1990-04-03 | The Adminstrators Of The Tulane Educational Fund | Synthetic GHRH analogs |
| JPH06509101A (ja) * | 1991-07-03 | 1994-10-13 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | ペンタフルオロエタンおよびプロパンまたはイソブタンの共沸または共沸混合物様組成物 |
| US5498724A (en) * | 1994-06-28 | 1996-03-12 | Aktiebolaget Astra | Pyrazoleamidine compounds |
-
1993
- 1993-06-03 SE SE19939301912A patent/SE9301912D0/sv unknown
-
1994
- 1994-05-11 IS IS4165A patent/IS4165A/is unknown
- 1994-05-18 LT LTIP1940A patent/LT3309B/lt not_active IP Right Cessation
- 1994-05-19 IL IL10968394A patent/IL109683A0/xx unknown
- 1994-05-23 HR HR9301912-3A patent/HRP940317A2/xx not_active Application Discontinuation
- 1994-06-01 CA CA002162920A patent/CA2162920C/en not_active Expired - Fee Related
- 1994-06-01 ES ES94917867T patent/ES2131688T3/es not_active Expired - Lifetime
- 1994-06-01 JP JP50165295A patent/JP3662925B2/ja not_active Expired - Fee Related
- 1994-06-01 WO PCT/SE1994/000517 patent/WO1994029269A1/en active IP Right Grant
- 1994-06-01 SK SK1518-95A patent/SK151895A3/sk unknown
- 1994-06-01 AU AU69404/94A patent/AU674970B2/en not_active Ceased
- 1994-06-01 HU HU9503444A patent/HUT74293A/hu unknown
- 1994-06-01 AT AT94917867T patent/ATE178316T1/de active
- 1994-06-01 EP EP94917867A patent/EP0701550B1/en not_active Expired - Lifetime
- 1994-06-01 NZ NZ267192A patent/NZ267192A/en not_active IP Right Cessation
- 1994-06-01 PL PL94311760A patent/PL311760A1/xx unknown
- 1994-06-01 DK DK94917867T patent/DK0701550T3/da active
- 1994-06-01 US US08/244,924 patent/US5659071A/en not_active Expired - Lifetime
- 1994-06-01 CN CN94192325A patent/CN1124956A/zh active Pending
- 1994-06-01 DE DE69417554T patent/DE69417554T2/de not_active Expired - Lifetime
- 1994-06-01 BR BR9406713A patent/BR9406713A/pt not_active Application Discontinuation
- 1994-06-01 CZ CZ953200A patent/CZ320095A3/cs unknown
- 1994-06-03 YU YU33594A patent/YU33594A/sh unknown
- 1994-11-17 EE EE9400348A patent/EE9400348A/xx unknown
-
1995
- 1995-11-28 NO NO954835A patent/NO305514B1/no not_active IP Right Cessation
- 1995-12-01 FI FI955800A patent/FI120093B/sv not_active IP Right Cessation
-
1999
- 1999-06-10 GR GR990401576T patent/GR3030501T3/el unknown
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