FI119245B - Menetelmä (4,10-diasetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi,1,7bet a-dihydroksi-9-oksotaks-11-en-13alfa-yyli)-(2R,3S)-3-bentsoyyliamino- 3-fenyyli-2-hydroksipropionaattitrihydraatinvalmistamiseksi - Google Patents

Menetelmä (4,10-diasetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi,1,7bet a-dihydroksi-9-oksotaks-11-en-13alfa-yyli)-(2R,3S)-3-bentsoyyliamino- 3-fenyyli-2-hydroksipropionaattitrihydraatinvalmistamiseksi Download PDF

Info

Publication number
FI119245B
FI119245B FI973105A FI973105A FI119245B FI 119245 B FI119245 B FI 119245B FI 973105 A FI973105 A FI 973105A FI 973105 A FI973105 A FI 973105A FI 119245 B FI119245 B FI 119245B
Authority
FI
Finland
Prior art keywords
diacetoxy
epoxy
oxotax
phenyl
dihydroxy
Prior art date
Application number
FI973105A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI973105A0 (fi
FI973105A (fi
Inventor
Eric Didier
Jean-Rene Authelin
Franck Leveiller
Isabelle Taillepied
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of FI973105A0 publication Critical patent/FI973105A0/fi
Publication of FI973105A publication Critical patent/FI973105A/fi
Application granted granted Critical
Publication of FI119245B publication Critical patent/FI119245B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI973105A 1995-01-25 1997-07-24 Menetelmä (4,10-diasetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi,1,7bet a-dihydroksi-9-oksotaks-11-en-13alfa-yyli)-(2R,3S)-3-bentsoyyliamino- 3-fenyyli-2-hydroksipropionaattitrihydraatinvalmistamiseksi FI119245B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9500816 1995-01-25
FR9500816A FR2729666A1 (fr) 1995-01-25 1995-01-25 Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle
FR9600104 1996-01-23
PCT/FR1996/000104 WO1996022984A1 (fr) 1995-01-25 1996-01-23 PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4,10-DIACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β-DIHYDROXY-9-OXO-TAX-11-EN-13α-YLE

Publications (3)

Publication Number Publication Date
FI973105A0 FI973105A0 (fi) 1997-07-24
FI973105A FI973105A (fi) 1997-07-24
FI119245B true FI119245B (fi) 2008-09-15

Family

ID=9475464

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973105A FI119245B (fi) 1995-01-25 1997-07-24 Menetelmä (4,10-diasetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi,1,7bet a-dihydroksi-9-oksotaks-11-en-13alfa-yyli)-(2R,3S)-3-bentsoyyliamino- 3-fenyyli-2-hydroksipropionaattitrihydraatinvalmistamiseksi

Country Status (43)

Country Link
US (1) US6002022A (zh)
EP (1) EP0805806B1 (zh)
JP (1) JP3782449B2 (zh)
KR (1) KR100384773B1 (zh)
CN (1) CN1067997C (zh)
AP (1) AP750A (zh)
AT (1) ATE187719T1 (zh)
AU (1) AU707603B2 (zh)
BG (1) BG62769B1 (zh)
BR (1) BR9606853A (zh)
CO (1) CO4700286A1 (zh)
CZ (1) CZ287079B6 (zh)
DE (1) DE69605651T2 (zh)
DK (1) DK0805806T3 (zh)
DZ (1) DZ1977A1 (zh)
EE (1) EE03396B1 (zh)
ES (1) ES2139332T3 (zh)
FI (1) FI119245B (zh)
FR (1) FR2729666A1 (zh)
GE (1) GEP19991833B (zh)
GR (1) GR3032110T3 (zh)
HU (1) HU223352B1 (zh)
IL (1) IL116903A (zh)
IN (1) IN184427B (zh)
IS (1) IS2033B (zh)
MA (1) MA23782A1 (zh)
MY (1) MY113230A (zh)
NO (1) NO316987B1 (zh)
NZ (1) NZ300958A (zh)
OA (1) OA10438A (zh)
PE (1) PE64896A1 (zh)
PL (1) PL183773B1 (zh)
PT (1) PT805806E (zh)
RO (1) RO115728B1 (zh)
RU (1) RU2154642C2 (zh)
SK (1) SK281958B6 (zh)
TN (1) TNSN96011A1 (zh)
TR (1) TR199700676T1 (zh)
TW (1) TW356469B (zh)
UA (1) UA47420C2 (zh)
UY (1) UY24149A1 (zh)
WO (1) WO1996022984A1 (zh)
ZA (1) ZA96523B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
WO2005061474A1 (en) * 2003-12-12 2005-07-07 Quiral Química Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
US20090292131A1 (en) * 2008-05-07 2009-11-26 Ladislav Cvak Processes for preparation of taxanes and intermediates thereof
US8633240B2 (en) * 2012-06-01 2014-01-21 The University Of Utah Research Foundation Paclitaxel trihydrates and methods of making thereof
CN103833693B (zh) * 2014-03-04 2016-02-24 悦康药业集团有限公司 一种紫杉醇化合物及含该紫杉醇化合物的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021662A1 (en) * 1993-03-15 1994-09-29 Yale University Diagnosis of human inflammatory bowel diseases and nucleic acid reagents therefor
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
CA2163837C (en) * 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates

Also Published As

Publication number Publication date
EP0805806B1 (fr) 1999-12-15
MX9705460A (es) 1997-10-31
HUP9801437A1 (hu) 1999-09-28
ZA96523B (en) 1996-10-15
AU4625596A (en) 1996-08-14
SK281958B6 (sk) 2001-09-11
NZ300958A (en) 1999-09-29
US6002022A (en) 1999-12-14
HU223352B1 (hu) 2004-06-28
IL116903A (en) 2003-01-12
IL116903A0 (en) 1996-05-14
UY24149A1 (es) 1996-05-20
IS4529A (is) 1997-07-22
SK100897A3 (en) 1998-01-14
IS2033B (is) 2005-08-15
GR3032110T3 (en) 2000-03-31
DK0805806T3 (da) 2000-05-01
ATE187719T1 (de) 2000-01-15
FI973105A0 (fi) 1997-07-24
JP3782449B2 (ja) 2006-06-07
TR199700676T1 (xx) 1998-01-21
PL321493A1 (en) 1997-12-08
KR19980701623A (ko) 1998-06-25
KR100384773B1 (ko) 2003-08-21
TNSN96011A1 (fr) 2005-03-15
BR9606853A (pt) 1997-11-25
NO316987B1 (no) 2004-07-19
UA47420C2 (uk) 2002-07-15
RU2154642C2 (ru) 2000-08-20
BG62769B1 (bg) 2000-07-31
MA23782A1 (fr) 1996-10-01
EE03396B1 (et) 2001-04-16
IN184427B (zh) 2000-08-26
CN1067997C (zh) 2001-07-04
OA10438A (fr) 2002-03-22
BG101794A (en) 1998-10-30
ES2139332T3 (es) 2000-02-01
PL183773B1 (pl) 2002-07-31
HUP9801437A3 (en) 2001-02-28
FR2729666A1 (fr) 1996-07-26
AU707603B2 (en) 1999-07-15
WO1996022984A1 (fr) 1996-08-01
GEP19991833B (en) 1999-11-05
AP750A (en) 1999-07-06
EE9700157A (et) 1997-12-15
NO973247D0 (no) 1997-07-11
DE69605651D1 (de) 2000-01-20
DE69605651T2 (de) 2000-07-06
CN1169724A (zh) 1998-01-07
CZ236297A3 (en) 1997-11-12
FI973105A (fi) 1997-07-24
MY113230A (en) 2001-12-31
JPH10512871A (ja) 1998-12-08
FR2729666B1 (zh) 1997-02-28
TW356469B (en) 1999-04-21
DZ1977A1 (fr) 2002-07-20
CZ287079B6 (en) 2000-08-16
PT805806E (pt) 2000-05-31
CO4700286A1 (es) 1998-12-29
AP9701035A0 (en) 1997-07-31
RO115728B1 (ro) 2000-05-30
PE64896A1 (es) 1997-02-23
EP0805806A1 (fr) 1997-11-12
NO973247L (no) 1997-07-11

Similar Documents

Publication Publication Date Title
FI119245B (fi) Menetelmä (4,10-diasetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi,1,7bet a-dihydroksi-9-oksotaks-11-en-13alfa-yyli)-(2R,3S)-3-bentsoyyliamino- 3-fenyyli-2-hydroksipropionaattitrihydraatinvalmistamiseksi
FI112478B (fi) Menetelmä lääkeaineena käyttökelpoisten 3'-alkoksikarbonyyliamino-substituoitujen taksaanijohdannaisten valmistamiseksi
US8002987B2 (en) Stationary phase and column using cucurbituril bonded silica gel, and separation method of taxol using the column
JPH0651689B2 (ja) タキソ−ル誘導体類、それらの製造およびそれらを含有する製薬学的組成物
KR100878455B1 (ko) 안정한 무수결정형 도세탁셀 및 이의 제조방법
GB2254612A (en) Conversion of ginkgolide c to ginkgolide b
US6281368B1 (en) Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
WO1996022984A9 (fr) PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4,10-DIACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β-DIHYDROXY-9-OXO-TAX-11-EN-13α-YLE
MXPA97005460A (en) Procedure for the preparation of trihydrate (2r, 3s) -3-benzoylamino-2-hydroxy-3-phenylpropionate de4, 10-diacetoxy-2alfa-benzoiloxi-5beta; 20-epoxy-1, 7beta-dihidroxi-9-oxo-tax -11-en-13alfa-
FI113641B (fi) Menetelmä (2R,3S)-beta-fenyyli-isoseriinin valmistamiseksi, sen käyttö ja sen suolat
CA2211808C (fr) Procede de preparation du trihydrate du (2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta.-dihydroxy-9-oxo-tax-11-en-13.alpha.-yle
RU2017724C1 (ru) Способ получения производных таксола
MXPA98004604A (en) Dihydrate (2r, 3s) -3-ter-butoxicarbonilamino-2-hidroxi-3-fenilpropionato de 4, iobeta-diacetoxi-2alfa-benzoiloxi-5beta, 20-epoxi-1-hidroxi-9-oxo-19-nor- ciclopropa [g] tax-11- en-13alfa-ilo, and its preparation procedure
CA2374639C (en) Process for the preparation of fumagillin
RU2059631C1 (ru) Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью
BG63010B1 (bg) Дихидрат на (2r,3s)-3-терц-бутоксикарбониламино-2-хидрокси- 3-фенилпропионат на 4,10 бета-диацетокси-2 алфа-бензоилокси- 5 бета, 20-епокси-1-хидрокси-9-оксо-19-нор-циклопропа/g/ такс-11-ен-13-алфа-ил, и метод за получаването му
FR2746797A1 (fr) Nouveaux derives du 10-acetyldocetaxel et leur procede de preparation

Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: AVENTIS PHARMA S.A.

FG Patent granted

Ref document number: 119245

Country of ref document: FI

MM Patent lapsed