CO4700286A1 - PROCEDIMIENTO DE PREPARACION DEL TRIHIDRATO DEL (2R,3S)-3- BENZOILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4,10-DIACETOXI- 2(alfa)-BENZOILOXI-5(beta),20-EPOXI-1,7(beta)-DIHIDROXI-9- OXO-TAX-11-EN 13(beta)-ILO - Google Patents

PROCEDIMIENTO DE PREPARACION DEL TRIHIDRATO DEL (2R,3S)-3- BENZOILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4,10-DIACETOXI- 2(alfa)-BENZOILOXI-5(beta),20-EPOXI-1,7(beta)-DIHIDROXI-9- OXO-TAX-11-EN 13(beta)-ILO

Info

Publication number
CO4700286A1
CO4700286A1 CO96002860A CO96002860A CO4700286A1 CO 4700286 A1 CO4700286 A1 CO 4700286A1 CO 96002860 A CO96002860 A CO 96002860A CO 96002860 A CO96002860 A CO 96002860A CO 4700286 A1 CO4700286 A1 CO 4700286A1
Authority
CO
Colombia
Prior art keywords
beta
alpha
benzoiloxi
epoxi
ilo
Prior art date
Application number
CO96002860A
Other languages
English (en)
Inventor
Jean Rene Authelin
Eric Didier
Frank Leveiller
Isabelle Taillepied
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of CO4700286A1 publication Critical patent/CO4700286A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. PROCEDIMIENTO DE PREPARACION DEL TRIHIDRATO DE (2R,3S)-3-BENZOILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4,10-DIACETOXI-2[ALFA]-BENZOILOXI-5[BETA],20- EPOXI-1,7[BETA]DIHIDROXI-9-OXO-TAX-11-EN-13[ALFA]- ILO CARACTERIZADO PORQUE SE CRISTALIZA EL (2R, 3S) -3-BENZOILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4, 10-DIACETOXI-2[ALFA]-BENZOILOXI-5[BETA],20-EPOXI- 1, 7[BETA]-DIHIDROXI-9-OXO-TAX-11-EN-13[ALFA]-ILO EN UNA MEZCLA DE AGUA Y DE UN ALCOHOL ALIFATICO QUE TIENE DE 1 A 3 ATOMOS DE CARBONO, SEGUIDO DEL SECADO DEL PRODUCTO OBTENIDO BAJO PRESION REDUCI- DA DESPUES MANTENIENDOLO EVENTUALMENTE EN CONDI- CIONES DE HUMEDAD RELATIVA SUPERIORES A 20% .
CO96002860A 1995-01-25 1996-01-24 PROCEDIMIENTO DE PREPARACION DEL TRIHIDRATO DEL (2R,3S)-3- BENZOILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4,10-DIACETOXI- 2(alfa)-BENZOILOXI-5(beta),20-EPOXI-1,7(beta)-DIHIDROXI-9- OXO-TAX-11-EN 13(beta)-ILO CO4700286A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9500816A FR2729666A1 (fr) 1995-01-25 1995-01-25 Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle

Publications (1)

Publication Number Publication Date
CO4700286A1 true CO4700286A1 (es) 1998-12-29

Family

ID=9475464

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96002860A CO4700286A1 (es) 1995-01-25 1996-01-24 PROCEDIMIENTO DE PREPARACION DEL TRIHIDRATO DEL (2R,3S)-3- BENZOILAMINO-2-HIDROXI-3-FENILPROPIONATO DE 4,10-DIACETOXI- 2(alfa)-BENZOILOXI-5(beta),20-EPOXI-1,7(beta)-DIHIDROXI-9- OXO-TAX-11-EN 13(beta)-ILO

Country Status (43)

Country Link
US (1) US6002022A (es)
EP (1) EP0805806B1 (es)
JP (1) JP3782449B2 (es)
KR (1) KR100384773B1 (es)
CN (1) CN1067997C (es)
AP (1) AP750A (es)
AT (1) ATE187719T1 (es)
AU (1) AU707603B2 (es)
BG (1) BG62769B1 (es)
BR (1) BR9606853A (es)
CO (1) CO4700286A1 (es)
CZ (1) CZ287079B6 (es)
DE (1) DE69605651T2 (es)
DK (1) DK0805806T3 (es)
DZ (1) DZ1977A1 (es)
EE (1) EE03396B1 (es)
ES (1) ES2139332T3 (es)
FI (1) FI119245B (es)
FR (1) FR2729666A1 (es)
GE (1) GEP19991833B (es)
GR (1) GR3032110T3 (es)
HU (1) HU223352B1 (es)
IL (1) IL116903A (es)
IN (1) IN184427B (es)
IS (1) IS2033B (es)
MA (1) MA23782A1 (es)
MY (1) MY113230A (es)
NO (1) NO316987B1 (es)
NZ (1) NZ300958A (es)
OA (1) OA10438A (es)
PE (1) PE64896A1 (es)
PL (1) PL183773B1 (es)
PT (1) PT805806E (es)
RO (1) RO115728B1 (es)
RU (1) RU2154642C2 (es)
SK (1) SK281958B6 (es)
TN (1) TNSN96011A1 (es)
TR (1) TR199700676T1 (es)
TW (1) TW356469B (es)
UA (1) UA47420C2 (es)
UY (1) UY24149A1 (es)
WO (1) WO1996022984A1 (es)
ZA (1) ZA96523B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
EP1947094A3 (en) 2003-12-12 2009-02-18 Quiral Quimica Do Brasil Process for the preparation of taxane derivatives
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
WO2009137084A2 (en) * 2008-05-07 2009-11-12 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof
US8633240B2 (en) * 2012-06-01 2014-01-21 The University Of Utah Research Foundation Paclitaxel trihydrates and methods of making thereof
CN103833693B (zh) * 2014-03-04 2016-02-24 悦康药业集团有限公司 一种紫杉醇化合物及含该紫杉醇化合物的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6409094A (en) * 1993-03-15 1994-10-11 Yale University Diagnosis of human inflammatory bowel diseases and nucleic acid reagents therefor
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
CA2163837C (en) * 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates

Also Published As

Publication number Publication date
MY113230A (en) 2001-12-31
IN184427B (es) 2000-08-26
FR2729666A1 (fr) 1996-07-26
EE9700157A (et) 1997-12-15
UY24149A1 (es) 1996-05-20
SK100897A3 (en) 1998-01-14
CN1169724A (zh) 1998-01-07
PE64896A1 (es) 1997-02-23
HUP9801437A1 (hu) 1999-09-28
RO115728B1 (ro) 2000-05-30
AU707603B2 (en) 1999-07-15
UA47420C2 (uk) 2002-07-15
AU4625596A (en) 1996-08-14
EP0805806B1 (fr) 1999-12-15
ES2139332T3 (es) 2000-02-01
NO973247L (no) 1997-07-11
GEP19991833B (en) 1999-11-05
KR19980701623A (ko) 1998-06-25
SK281958B6 (sk) 2001-09-11
BR9606853A (pt) 1997-11-25
ZA96523B (en) 1996-10-15
FI119245B (fi) 2008-09-15
BG101794A (en) 1998-10-30
EP0805806A1 (fr) 1997-11-12
TNSN96011A1 (fr) 2005-03-15
IS2033B (is) 2005-08-15
DK0805806T3 (da) 2000-05-01
WO1996022984A1 (fr) 1996-08-01
JPH10512871A (ja) 1998-12-08
CZ236297A3 (en) 1997-11-12
DE69605651T2 (de) 2000-07-06
NO316987B1 (no) 2004-07-19
DZ1977A1 (fr) 2002-07-20
IS4529A (is) 1997-07-22
NO973247D0 (no) 1997-07-11
HUP9801437A3 (en) 2001-02-28
IL116903A (en) 2003-01-12
MX9705460A (es) 1997-10-31
NZ300958A (en) 1999-09-29
AP750A (en) 1999-07-06
BG62769B1 (bg) 2000-07-31
CZ287079B6 (en) 2000-08-16
OA10438A (fr) 2002-03-22
FI973105A0 (fi) 1997-07-24
AP9701035A0 (en) 1997-07-31
GR3032110T3 (en) 2000-03-31
PL321493A1 (en) 1997-12-08
ATE187719T1 (de) 2000-01-15
EE03396B1 (et) 2001-04-16
FI973105A (fi) 1997-07-24
FR2729666B1 (es) 1997-02-28
RU2154642C2 (ru) 2000-08-20
CN1067997C (zh) 2001-07-04
DE69605651D1 (de) 2000-01-20
MA23782A1 (fr) 1996-10-01
JP3782449B2 (ja) 2006-06-07
IL116903A0 (en) 1996-05-14
TR199700676T1 (xx) 1998-01-21
US6002022A (en) 1999-12-14
PL183773B1 (pl) 2002-07-31
KR100384773B1 (ko) 2003-08-21
TW356469B (en) 1999-04-21
HU223352B1 (hu) 2004-06-28
PT805806E (pt) 2000-05-31

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