EE03396B1 - Meetod 4,10-diatsetoksü-2a-bensoüüloksü-5ß,20 -epoksü-1,7ß-dihüdroksü-9-okso-taks-11-een-13a-üüli (2R,3S)-3-bensoüülamino-2-hüdroksü-3-fenüülpropionaadi trihüdraadi valmistamiseks - Google Patents

Meetod 4,10-diatsetoksü-2a-bensoüüloksü-5ß,20 -epoksü-1,7ß-dihüdroksü-9-okso-taks-11-een-13a-üüli (2R,3S)-3-bensoüülamino-2-hüdroksü-3-fenüülpropionaadi trihüdraadi valmistamiseks

Info

Publication number
EE03396B1
EE03396B1 EE9700157A EE9700157A EE03396B1 EE 03396 B1 EE03396 B1 EE 03396B1 EE 9700157 A EE9700157 A EE 9700157A EE 9700157 A EE9700157 A EE 9700157A EE 03396 B1 EE03396 B1 EE 03396B1
Authority
EE
Estonia
Prior art keywords
taxa
diacetoxy
benzoylamino
benzoyloxy
ene
Prior art date
Application number
EE9700157A
Other languages
English (en)
Estonian (et)
Other versions
EE9700157A (et
Inventor
Authelin Jean-Ren�
Didier Eric
Leveiller Franck
Taillepied Isabelle
Original Assignee
Rh�Ne-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rh�Ne-Poulenc Rorer S.A. filed Critical Rh�Ne-Poulenc Rorer S.A.
Publication of EE9700157A publication Critical patent/EE9700157A/xx
Publication of EE03396B1 publication Critical patent/EE03396B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EE9700157A 1995-01-25 1996-01-23 Meetod 4,10-diatsetoksü-2a-bensoüüloksü-5ß,20 -epoksü-1,7ß-dihüdroksü-9-okso-taks-11-een-13a-üüli (2R,3S)-3-bensoüülamino-2-hüdroksü-3-fenüülpropionaadi trihüdraadi valmistamiseks EE03396B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9500816A FR2729666A1 (fr) 1995-01-25 1995-01-25 Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle
PCT/FR1996/000104 WO1996022984A1 (fr) 1995-01-25 1996-01-23 PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4,10-DIACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β-DIHYDROXY-9-OXO-TAX-11-EN-13α-YLE

Publications (2)

Publication Number Publication Date
EE9700157A EE9700157A (et) 1997-12-15
EE03396B1 true EE03396B1 (et) 2001-04-16

Family

ID=9475464

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9700157A EE03396B1 (et) 1995-01-25 1996-01-23 Meetod 4,10-diatsetoksü-2a-bensoüüloksü-5ß,20 -epoksü-1,7ß-dihüdroksü-9-okso-taks-11-een-13a-üüli (2R,3S)-3-bensoüülamino-2-hüdroksü-3-fenüülpropionaadi trihüdraadi valmistamiseks

Country Status (43)

Country Link
US (1) US6002022A (es)
EP (1) EP0805806B1 (es)
JP (1) JP3782449B2 (es)
KR (1) KR100384773B1 (es)
CN (1) CN1067997C (es)
AP (1) AP750A (es)
AT (1) ATE187719T1 (es)
AU (1) AU707603B2 (es)
BG (1) BG62769B1 (es)
BR (1) BR9606853A (es)
CO (1) CO4700286A1 (es)
CZ (1) CZ287079B6 (es)
DE (1) DE69605651T2 (es)
DK (1) DK0805806T3 (es)
DZ (1) DZ1977A1 (es)
EE (1) EE03396B1 (es)
ES (1) ES2139332T3 (es)
FI (1) FI119245B (es)
FR (1) FR2729666A1 (es)
GE (1) GEP19991833B (es)
GR (1) GR3032110T3 (es)
HU (1) HU223352B1 (es)
IL (1) IL116903A (es)
IN (1) IN184427B (es)
IS (1) IS2033B (es)
MA (1) MA23782A1 (es)
MY (1) MY113230A (es)
NO (1) NO316987B1 (es)
NZ (1) NZ300958A (es)
OA (1) OA10438A (es)
PE (1) PE64896A1 (es)
PL (1) PL183773B1 (es)
PT (1) PT805806E (es)
RO (1) RO115728B1 (es)
RU (1) RU2154642C2 (es)
SK (1) SK281958B6 (es)
TN (1) TNSN96011A1 (es)
TR (1) TR199700676T1 (es)
TW (1) TW356469B (es)
UA (1) UA47420C2 (es)
UY (1) UY24149A1 (es)
WO (1) WO1996022984A1 (es)
ZA (1) ZA96523B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
ES2325506T3 (es) 2003-12-12 2009-09-07 Quiral Quimica Do Brasil Procedimiento para la preparacion de principios activos farmaceuticos (api) anhidros e hidratados; composiciones farmaceuticas estables preparadas a partir de los mismos y usos de dichas composiciones.
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
US20090292131A1 (en) * 2008-05-07 2009-11-26 Ladislav Cvak Processes for preparation of taxanes and intermediates thereof
US8633240B2 (en) * 2012-06-01 2014-01-21 The University Of Utah Research Foundation Paclitaxel trihydrates and methods of making thereof
CN103833693B (zh) * 2014-03-04 2016-02-24 悦康药业集团有限公司 一种紫杉醇化合物及含该紫杉醇化合物的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021662A1 (en) * 1993-03-15 1994-09-29 Yale University Diagnosis of human inflammatory bowel diseases and nucleic acid reagents therefor
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
CA2163837C (en) * 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates

Also Published As

Publication number Publication date
OA10438A (fr) 2002-03-22
UY24149A1 (es) 1996-05-20
ZA96523B (en) 1996-10-15
NO973247L (no) 1997-07-11
SK100897A3 (en) 1998-01-14
FI119245B (fi) 2008-09-15
TW356469B (en) 1999-04-21
NO973247D0 (no) 1997-07-11
IS4529A (is) 1997-07-22
BR9606853A (pt) 1997-11-25
JP3782449B2 (ja) 2006-06-07
WO1996022984A1 (fr) 1996-08-01
NO316987B1 (no) 2004-07-19
AP750A (en) 1999-07-06
IL116903A0 (en) 1996-05-14
FI973105A0 (fi) 1997-07-24
AP9701035A0 (en) 1997-07-31
PE64896A1 (es) 1997-02-23
IN184427B (es) 2000-08-26
NZ300958A (en) 1999-09-29
MX9705460A (es) 1997-10-31
FR2729666B1 (es) 1997-02-28
HU223352B1 (hu) 2004-06-28
KR19980701623A (ko) 1998-06-25
CZ236297A3 (en) 1997-11-12
ES2139332T3 (es) 2000-02-01
ATE187719T1 (de) 2000-01-15
HUP9801437A1 (hu) 1999-09-28
HUP9801437A3 (en) 2001-02-28
IL116903A (en) 2003-01-12
KR100384773B1 (ko) 2003-08-21
SK281958B6 (sk) 2001-09-11
US6002022A (en) 1999-12-14
MA23782A1 (fr) 1996-10-01
PT805806E (pt) 2000-05-31
UA47420C2 (uk) 2002-07-15
GEP19991833B (en) 1999-11-05
AU707603B2 (en) 1999-07-15
CO4700286A1 (es) 1998-12-29
EE9700157A (et) 1997-12-15
RU2154642C2 (ru) 2000-08-20
BG62769B1 (bg) 2000-07-31
TNSN96011A1 (fr) 2005-03-15
PL183773B1 (pl) 2002-07-31
TR199700676T1 (xx) 1998-01-21
DZ1977A1 (fr) 2002-07-20
DE69605651T2 (de) 2000-07-06
MY113230A (en) 2001-12-31
JPH10512871A (ja) 1998-12-08
AU4625596A (en) 1996-08-14
IS2033B (is) 2005-08-15
GR3032110T3 (en) 2000-03-31
PL321493A1 (en) 1997-12-08
EP0805806A1 (fr) 1997-11-12
FR2729666A1 (fr) 1996-07-26
RO115728B1 (ro) 2000-05-30
DK0805806T3 (da) 2000-05-01
CZ287079B6 (en) 2000-08-16
BG101794A (en) 1998-10-30
CN1169724A (zh) 1998-01-07
CN1067997C (zh) 2001-07-04
EP0805806B1 (fr) 1999-12-15
FI973105A (fi) 1997-07-24
DE69605651D1 (de) 2000-01-20

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