IL116903A - PROCESS FOR THE PREPARATION OF 4,10-DIACETOXY-2α-BENZOYLOXY-5β, 20-EPOXY-1,7β-DIHYDROXY-9-OXO- TAX-11-EN-13α-YL(2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE TRIHYDRATE - Google Patents

PROCESS FOR THE PREPARATION OF 4,10-DIACETOXY-2α-BENZOYLOXY-5β, 20-EPOXY-1,7β-DIHYDROXY-9-OXO- TAX-11-EN-13α-YL(2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE TRIHYDRATE

Info

Publication number
IL116903A
IL116903A IL11690396A IL11690396A IL116903A IL 116903 A IL116903 A IL 116903A IL 11690396 A IL11690396 A IL 11690396A IL 11690396 A IL11690396 A IL 11690396A IL 116903 A IL116903 A IL 116903A
Authority
IL
Israel
Prior art keywords
diacetoxy
benzoylamino
benzoyloxy
tax
dihydroxy
Prior art date
Application number
IL11690396A
Other languages
English (en)
Other versions
IL116903A0 (en
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of IL116903A0 publication Critical patent/IL116903A0/xx
Publication of IL116903A publication Critical patent/IL116903A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11690396A 1995-01-25 1996-01-25 PROCESS FOR THE PREPARATION OF 4,10-DIACETOXY-2α-BENZOYLOXY-5β, 20-EPOXY-1,7β-DIHYDROXY-9-OXO- TAX-11-EN-13α-YL(2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE TRIHYDRATE IL116903A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9500816A FR2729666A1 (fr) 1995-01-25 1995-01-25 Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle

Publications (2)

Publication Number Publication Date
IL116903A0 IL116903A0 (en) 1996-05-14
IL116903A true IL116903A (en) 2003-01-12

Family

ID=9475464

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11690396A IL116903A (en) 1995-01-25 1996-01-25 PROCESS FOR THE PREPARATION OF 4,10-DIACETOXY-2α-BENZOYLOXY-5β, 20-EPOXY-1,7β-DIHYDROXY-9-OXO- TAX-11-EN-13α-YL(2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE TRIHYDRATE

Country Status (43)

Country Link
US (1) US6002022A (xx)
EP (1) EP0805806B1 (xx)
JP (1) JP3782449B2 (xx)
KR (1) KR100384773B1 (xx)
CN (1) CN1067997C (xx)
AP (1) AP750A (xx)
AT (1) ATE187719T1 (xx)
AU (1) AU707603B2 (xx)
BG (1) BG62769B1 (xx)
BR (1) BR9606853A (xx)
CO (1) CO4700286A1 (xx)
CZ (1) CZ287079B6 (xx)
DE (1) DE69605651T2 (xx)
DK (1) DK0805806T3 (xx)
DZ (1) DZ1977A1 (xx)
EE (1) EE03396B1 (xx)
ES (1) ES2139332T3 (xx)
FI (1) FI119245B (xx)
FR (1) FR2729666A1 (xx)
GE (1) GEP19991833B (xx)
GR (1) GR3032110T3 (xx)
HU (1) HU223352B1 (xx)
IL (1) IL116903A (xx)
IN (1) IN184427B (xx)
IS (1) IS2033B (xx)
MA (1) MA23782A1 (xx)
MY (1) MY113230A (xx)
NO (1) NO316987B1 (xx)
NZ (1) NZ300958A (xx)
OA (1) OA10438A (xx)
PE (1) PE64896A1 (xx)
PL (1) PL183773B1 (xx)
PT (1) PT805806E (xx)
RO (1) RO115728B1 (xx)
RU (1) RU2154642C2 (xx)
SK (1) SK281958B6 (xx)
TN (1) TNSN96011A1 (xx)
TR (1) TR199700676T1 (xx)
TW (1) TW356469B (xx)
UA (1) UA47420C2 (xx)
UY (1) UY24149A1 (xx)
WO (1) WO1996022984A1 (xx)
ZA (1) ZA96523B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
ATE427943T1 (de) 2003-12-12 2009-04-15 Quiral Quimica Do Brasil Verfahren zur herstellung von wasserfreien und hydratisierten pharmazeutischen wirkstoffen (apis); aus diesen hergestellte stabile pharmazeutische zusammensetzungen und anwendungen fur diese zusammensetzungen
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
US20090292131A1 (en) * 2008-05-07 2009-11-26 Ladislav Cvak Processes for preparation of taxanes and intermediates thereof
US8633240B2 (en) * 2012-06-01 2014-01-21 The University Of Utah Research Foundation Paclitaxel trihydrates and methods of making thereof
CN103833693B (zh) * 2014-03-04 2016-02-24 悦康药业集团有限公司 一种紫杉醇化合物及含该紫杉醇化合物的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6409094A (en) * 1993-03-15 1994-10-11 Yale University Diagnosis of human inflammatory bowel diseases and nucleic acid reagents therefor
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.
CA2163837C (en) * 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates

Also Published As

Publication number Publication date
RO115728B1 (ro) 2000-05-30
EE03396B1 (et) 2001-04-16
RU2154642C2 (ru) 2000-08-20
PE64896A1 (es) 1997-02-23
NZ300958A (en) 1999-09-29
NO973247L (no) 1997-07-11
AP750A (en) 1999-07-06
ZA96523B (en) 1996-10-15
FI973105A0 (fi) 1997-07-24
MA23782A1 (fr) 1996-10-01
DK0805806T3 (da) 2000-05-01
CZ287079B6 (en) 2000-08-16
KR100384773B1 (ko) 2003-08-21
EE9700157A (et) 1997-12-15
FI119245B (fi) 2008-09-15
WO1996022984A1 (fr) 1996-08-01
BR9606853A (pt) 1997-11-25
AU4625596A (en) 1996-08-14
US6002022A (en) 1999-12-14
GR3032110T3 (en) 2000-03-31
FR2729666B1 (xx) 1997-02-28
OA10438A (fr) 2002-03-22
AU707603B2 (en) 1999-07-15
JP3782449B2 (ja) 2006-06-07
SK281958B6 (sk) 2001-09-11
BG62769B1 (bg) 2000-07-31
TNSN96011A1 (fr) 2005-03-15
DZ1977A1 (fr) 2002-07-20
HUP9801437A1 (hu) 1999-09-28
NO316987B1 (no) 2004-07-19
BG101794A (en) 1998-10-30
JPH10512871A (ja) 1998-12-08
TW356469B (en) 1999-04-21
IS2033B (is) 2005-08-15
FI973105A (fi) 1997-07-24
NO973247D0 (no) 1997-07-11
PL183773B1 (pl) 2002-07-31
UY24149A1 (es) 1996-05-20
PL321493A1 (en) 1997-12-08
DE69605651T2 (de) 2000-07-06
UA47420C2 (uk) 2002-07-15
DE69605651D1 (de) 2000-01-20
MY113230A (en) 2001-12-31
HU223352B1 (hu) 2004-06-28
IL116903A0 (en) 1996-05-14
FR2729666A1 (fr) 1996-07-26
GEP19991833B (en) 1999-11-05
PT805806E (pt) 2000-05-31
ES2139332T3 (es) 2000-02-01
AP9701035A0 (en) 1997-07-31
EP0805806B1 (fr) 1999-12-15
MX9705460A (es) 1997-10-31
SK100897A3 (en) 1998-01-14
CO4700286A1 (es) 1998-12-29
TR199700676T1 (xx) 1998-01-21
IN184427B (xx) 2000-08-26
KR19980701623A (ko) 1998-06-25
HUP9801437A3 (en) 2001-02-28
CN1067997C (zh) 2001-07-04
EP0805806A1 (fr) 1997-11-12
CZ236297A3 (en) 1997-11-12
IS4529A (is) 1997-07-22
ATE187719T1 (de) 2000-01-15
CN1169724A (zh) 1998-01-07

Similar Documents

Publication Publication Date Title
ZA968957B (en) Process for the preparation of dihaloazolopyrimidines.
HUP9600549A3 (en) N-(3-benzofuranyl)urea-derivatives, medicaments containing the same and process for producing them
HUP9601034A2 (en) Aryl-alkyl-pyridazinone compounds, process for producing them, and pharmaceutical compositions containing them
ZA96523B (en) Process for the preparation of 4,10-diacetoxy-2aspire-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo-tax-11-en-13aspire-yl (2r,3s)-3-benzoylamino-2-hydroxy-3-phenyl-propionate trihydrate
EP0581429A3 (en) Process for the preparation of cyclic depsipeptides.
HU9602763D0 (en) Novel isoxazole derivatives, process for producing them and pharmaceutical compositions containing the same
AU4729396A (en) Process for the preparation of 1,2-benzisothiazolin-3-ones
HRP960357B1 (en) Process for the preparation of lovastatin
ZA966452B (en) Process for the preparation of substituted aminocarbonyltriazolinones.
EP0690053A3 (de) Verfahren zur Herstellung von 2,5-Dihydrofuran
EP0549872A3 (en) Process for the preparation of (2r,e3)-4-halo-3-buten-2-ols
SI0805806T1 (en) Method for preparing 4,10-diacetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo-tax-11-en-13alfa-yl (2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate
IL118731A0 (en) Process for the preparation of 2,2-dialkyl-arylidene-cycloalkanones
SG47790A1 (en) Process for the preparation of 3,4-dihalo-1,2-epoxybutanes from 3,4-epoxy-1-butene
ZA966542B (en) Process for the preparation of 3,3,5-trichloroglutarimide.
HRP960329B1 (en) Process for the preparation of alpha, omega-bromochloroalcanes
EP0747364A3 (de) Verfahren zur Herstellung von 2,4,6-Trichlorpyrimidin
AU713086C (en) 4,10beta-diacetoxy-2alpha-benzoyloxy-5beta, 20-epoxy-1- hydroxy-9-oxo-19-norcyclopropa(g)tax-11-en-13alpha-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3- phenylpropionate dihydrate and its process of preparation
IL102748A0 (en) Process for the preparation of 3a,6,6,9a-tetramethyl perhydronaphtho(2,1-b)furan
IL133533A0 (en) Non-immunosuppressive compounds, process for their preparation and different uses thereof
ZA965896B (en) Process for the preparation of alpha, omega-bromochloroalkanes.
ZA966583B (en) A pharmaceutical composition for inhibiting the growth of cancers.
GB9521168D0 (en) Taxane derivatives
GB9511475D0 (en) Taxane derivatives
GB9505805D0 (en) Taxane derivatives

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees