FI118034B - Serotoniiniantagonistien (5HT3) käyttö fibromyalgian hoitoon - Google Patents
Serotoniiniantagonistien (5HT3) käyttö fibromyalgian hoitoon Download PDFInfo
- Publication number
- FI118034B FI118034B FI964004A FI964004A FI118034B FI 118034 B FI118034 B FI 118034B FI 964004 A FI964004 A FI 964004A FI 964004 A FI964004 A FI 964004A FI 118034 B FI118034 B FI 118034B
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- FI
- Finland
- Prior art keywords
- alkyl
- methyl
- hydrogen
- formula
- pain
- Prior art date
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- 208000001640 Fibromyalgia Diseases 0.000 title claims abstract description 12
- 229940082988 antihypertensives serotonin antagonists Drugs 0.000 title description 2
- 239000003420 antiserotonin agent Substances 0.000 title description 2
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims abstract description 10
- 125000000217 alkyl group Chemical group 0.000 claims description 34
- 229910052739 hydrogen Inorganic materials 0.000 claims description 19
- 239000001257 hydrogen Substances 0.000 claims description 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
- 150000002431 hydrogen Chemical group 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 7
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 5
- 125000003884 phenylalkyl group Chemical group 0.000 claims description 5
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- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
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Classifications
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- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Cardiology (AREA)
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- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
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- Heart & Thoracic Surgery (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9406857 | 1994-04-07 | ||
| GB9406857A GB9406857D0 (en) | 1994-04-07 | 1994-04-07 | Improvements in or relating to organic compounds |
| EP9501264 | 1995-04-06 | ||
| PCT/EP1995/001264 WO1995027490A1 (en) | 1994-04-07 | 1995-04-06 | Use of serotonin antagonists (5ht3) for treating fibromyalgia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI964004A0 FI964004A0 (fi) | 1996-10-04 |
| FI964004L FI964004L (fi) | 1996-11-29 |
| FI118034B true FI118034B (fi) | 2007-06-15 |
Family
ID=10753131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI964004A FI118034B (fi) | 1994-04-07 | 1996-10-04 | Serotoniiniantagonistien (5HT3) käyttö fibromyalgian hoitoon |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US5773436A (cs) |
| EP (1) | EP0804196B1 (cs) |
| JP (1) | JP2818303B2 (cs) |
| KR (1) | KR100415181B1 (cs) |
| CN (1) | CN1084618C (cs) |
| AT (1) | ATE225176T1 (cs) |
| AU (1) | AU706279B2 (cs) |
| CA (1) | CA2186844C (cs) |
| CZ (1) | CZ290359B6 (cs) |
| DE (1) | DE69528475T2 (cs) |
| DK (1) | DK0804196T3 (cs) |
| ES (1) | ES2184797T3 (cs) |
| FI (1) | FI118034B (cs) |
| GB (1) | GB9406857D0 (cs) |
| HU (1) | HU226892B1 (cs) |
| MX (1) | MX9604589A (cs) |
| NO (1) | NO312745B1 (cs) |
| PL (1) | PL316658A1 (cs) |
| PT (1) | PT804196E (cs) |
| RU (1) | RU2165760C2 (cs) |
| SK (1) | SK281603B6 (cs) |
| WO (1) | WO1995027490A1 (cs) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000511173A (ja) * | 1996-05-27 | 2000-08-29 | 藤沢薬品工業株式会社 | 一酸化窒素産生阻害剤としての新規なインドリルおよびベンゾフラニルカルボキサミド |
| US6323242B1 (en) | 1998-12-02 | 2001-11-27 | Peter Sterling Mueller | Treatment of disorders secondary to organic impairments |
| US6696495B2 (en) * | 1998-12-02 | 2004-02-24 | Snowden Pharmaceuticals, Llc | Treatment of disorders secondary to organic impairments |
| WO2000048597A1 (en) | 1999-02-18 | 2000-08-24 | Novartis Ag | Systemic use of 5-ht3 receptor antagonists against rheumatic inflammatory processes |
| JP2002537245A (ja) * | 1999-02-18 | 2002-11-05 | ノバルティス アクチエンゲゼルシャフト | ５−ｈｔ３レセプターアンタゴニストの使用 |
| TW518218B (en) * | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
| GB9918425D0 (en) * | 1999-08-04 | 1999-10-06 | Novartis Ag | Organic compounds |
| GB0216027D0 (en) * | 2002-07-10 | 2002-08-21 | Arachnova Therapeutics Ltd | New therapeutic use |
| US20040048874A1 (en) * | 2001-05-22 | 2004-03-11 | Bardsley Hazel Judith | New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine |
| AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
| AR036041A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
| ES2383001T3 (es) | 2001-10-02 | 2012-06-15 | Pharmacia & Upjohn Company Llc | Compuestos de heteroarilo condensado sustituidos con azabicíclico para el tratamiento de enfermedades |
| AU2002339810A1 (en) * | 2001-10-16 | 2003-04-28 | Astrazeneca Ab | Azabicyclic compounds for the treatment of fibromyalgia syndrome |
| US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
| WO2003070731A2 (en) | 2002-02-19 | 2003-08-28 | Pharmacia & Upjohn Company | Azabicyclic compounds for the treatment of disease |
| CA2476681A1 (en) | 2002-02-19 | 2003-08-28 | Bruce N. Rogers | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
| WO2003100091A1 (en) * | 2002-05-24 | 2003-12-04 | Epidauros Biotechnologie Ag | Means and methods for improved treatment using 'setrones' |
| NZ539049A (en) * | 2002-09-25 | 2007-02-23 | Memory Pharm Corp | Indazoles, benzothiazoles, and benzoisothiazoles and preparation and uses thereof |
| KR20050094843A (ko) * | 2003-01-13 | 2005-09-28 | 다이노젠 파마세우티컬스, 인코포레이티드 | 욕지기, 구토, 구역질 또는 이들의 조합을 치료하는 방법 |
| US20040147509A1 (en) * | 2003-01-13 | 2004-07-29 | Dynogen Pharmaceuticals, Inc. | Method of treating functional bowel disorders |
| CA2550689A1 (en) | 2003-12-22 | 2005-07-14 | Memory Pharmaceuticals Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| BRPI0508771A (pt) | 2004-03-25 | 2007-08-14 | Memory Pharm Corp | indazóis, benzotiazóis, benzoisotiazóis, benzisoxazóis, e a preparação e usos dos mesmos |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| CA2567977A1 (en) * | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| DE602005027452D1 (de) * | 2004-05-07 | 2011-05-26 | Memory Pharm Corp | 1h-indazole, benzothiazole, 1,2-benzisoxazole, 1,2-benzisothiazole und chromone und deren herstellung und verwendungen |
| US7399862B2 (en) * | 2004-11-05 | 2008-07-15 | Theravance, Inc. | 5-HT4 receptor agonist compounds |
| WO2006052889A2 (en) * | 2004-11-05 | 2006-05-18 | Theravance, Inc. | Quinolinone-carboxamide compounds |
| ES2347265T3 (es) * | 2004-12-22 | 2010-10-27 | Theravance, Inc. | Compuestos de indazol-carboxamida. |
| KR20070087674A (ko) * | 2004-12-22 | 2007-08-28 | 메모리 파마슈티칼스 코포레이션 | 니코틴 α-７ 수용체 리간드 및 이의 제조 및 용도 |
| MX2007010769A (es) * | 2005-03-02 | 2008-03-07 | Theravance Inc | Compuestos de quinolina como agonistas de receptor 5-ht4. |
| US20060293309A1 (en) * | 2005-03-28 | 2006-12-28 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
| US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| RU2557533C2 (ru) | 2009-11-06 | 2015-07-20 | Ск Биофармасъютиклс Ко., Лтд. | Способы лечения синдрома фибромиалгии |
| JOP20130213B1 (ar) | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
| JP7055017B2 (ja) | 2014-09-29 | 2022-04-15 | 武田薬品工業株式会社 | 結晶形の１－（１－メチル－１ｈ－ピラゾール－４－イル）－ｎ－（（１ｒ，５ｓ，７ｓ）－９－メチル－３－オキサ－９－アザビシクロ［３．３．１］ノナン－７－イル）－１ｈ－インドール－３－カルボキサミド |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE86110T1 (de) * | 1984-12-20 | 1993-03-15 | Sandoz Ag | Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten. |
| GB8623142D0 (en) * | 1986-09-26 | 1986-10-29 | Beecham Group Plc | Compounds |
| DE3650772T2 (de) * | 1985-04-27 | 2003-04-03 | F. Hoffmann-La Roche Ag, Basel | Derivate von Indazole-3-carboxamide und -3-carboxylsäure |
| US5246942A (en) * | 1988-04-27 | 1993-09-21 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Pharmaceutically useful dibenzofurancarboxamides of specific stereo-configuration |
| US4963689A (en) * | 1989-05-19 | 1990-10-16 | Pfizer Inc. | Heterocyclicguanidines as 5HT3 antagonists |
| GB8928208D0 (en) * | 1989-12-13 | 1990-02-14 | Glaxo Group Ltd | Medicaments |
| EP0517984A1 (en) * | 1991-06-11 | 1992-12-16 | Merrell Dow Pharmaceuticals Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
-
1994
- 1994-04-07 GB GB9406857A patent/GB9406857D0/en active Pending
-
1995
- 1995-04-06 DE DE69528475T patent/DE69528475T2/de not_active Expired - Lifetime
- 1995-04-06 ES ES95916611T patent/ES2184797T3/es not_active Expired - Lifetime
- 1995-04-06 AU AU23052/95A patent/AU706279B2/en not_active Ceased
- 1995-04-06 EP EP95916611A patent/EP0804196B1/en not_active Expired - Lifetime
- 1995-04-06 DK DK95916611T patent/DK0804196T3/da active
- 1995-04-06 WO PCT/EP1995/001264 patent/WO1995027490A1/en active IP Right Grant
- 1995-04-06 AT AT95916611T patent/ATE225176T1/de not_active IP Right Cessation
- 1995-04-06 CZ CZ19962915A patent/CZ290359B6/cs not_active IP Right Cessation
- 1995-04-06 RU RU96121561/14A patent/RU2165760C2/ru not_active IP Right Cessation
- 1995-04-06 JP JP7526064A patent/JP2818303B2/ja not_active Expired - Fee Related
- 1995-04-06 HU HU9602721A patent/HU226892B1/hu not_active IP Right Cessation
- 1995-04-06 CN CN95192946A patent/CN1084618C/zh not_active Expired - Fee Related
- 1995-04-06 PL PL95316658A patent/PL316658A1/xx unknown
- 1995-04-06 SK SK1278-96A patent/SK281603B6/sk not_active IP Right Cessation
- 1995-04-06 MX MX9604589A patent/MX9604589A/es not_active IP Right Cessation
- 1995-04-06 KR KR1019960705579A patent/KR100415181B1/ko not_active Expired - Fee Related
- 1995-04-06 CA CA002186844A patent/CA2186844C/en not_active Expired - Fee Related
- 1995-04-06 PT PT95916611T patent/PT804196E/pt unknown
- 1995-04-06 US US08/721,988 patent/US5773436A/en not_active Expired - Lifetime
-
1996
- 1996-10-04 NO NO19964236A patent/NO312745B1/no not_active IP Right Cessation
- 1996-10-04 FI FI964004A patent/FI118034B/fi not_active IP Right Cessation
-
1998
- 1998-05-18 US US09/080,605 patent/US5985866A/en not_active Expired - Fee Related
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