FI117436B - Menetelmä levobupivakaiinin ja sen analogien optisesti rikastuneen muodon rasemisoimiseksi - Google Patents
Menetelmä levobupivakaiinin ja sen analogien optisesti rikastuneen muodon rasemisoimiseksi Download PDFInfo
- Publication number
- FI117436B FI117436B FI971202A FI971202A FI117436B FI 117436 B FI117436 B FI 117436B FI 971202 A FI971202 A FI 971202A FI 971202 A FI971202 A FI 971202A FI 117436 B FI117436 B FI 117436B
- Authority
- FI
- Finland
- Prior art keywords
- acid
- compound
- racemization
- optically enriched
- pct
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measurement Of Radiation (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94306962 | 1994-09-23 | ||
| EP94306962 | 1994-09-23 | ||
| GBGB9504927.6A GB9504927D0 (en) | 1995-03-10 | 1995-03-10 | Racemisation and asymmetric transformation |
| GB9504927 | 1995-03-10 | ||
| PCT/GB1995/002247 WO1996009290A1 (fr) | 1994-09-23 | 1995-09-22 | Procedes d'obtention de racemiques et de transformation asymetrique utilises dans la preparation de levobupivacaine et de ses analogues |
| GB9502247 | 1995-09-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI971202A FI971202A (fi) | 1997-03-21 |
| FI971202A0 FI971202A0 (fi) | 1997-03-21 |
| FI117436B true FI117436B (fi) | 2006-10-13 |
Family
ID=26137306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI971202A FI117436B (fi) | 1994-09-23 | 1997-03-21 | Menetelmä levobupivakaiinin ja sen analogien optisesti rikastuneen muodon rasemisoimiseksi |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5786484A (fr) |
| EP (1) | EP0782569B1 (fr) |
| JP (1) | JP3898220B2 (fr) |
| KR (1) | KR100393133B1 (fr) |
| CN (1) | CN1104416C (fr) |
| AT (1) | ATE214695T1 (fr) |
| AU (1) | AU695479B2 (fr) |
| CA (1) | CA2200490C (fr) |
| DE (1) | DE69525950T2 (fr) |
| DK (1) | DK0782569T3 (fr) |
| ES (1) | ES2173194T3 (fr) |
| FI (1) | FI117436B (fr) |
| HU (1) | HU216291B (fr) |
| MX (1) | MX9702210A (fr) |
| NO (1) | NO308074B1 (fr) |
| PL (1) | PL183204B1 (fr) |
| PT (1) | PT782569E (fr) |
| WO (1) | WO1996009290A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6384227B2 (en) | 1995-01-18 | 2002-05-07 | Darwin Discovery Ltd. | Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents |
| JP2000256359A (ja) * | 1999-03-11 | 2000-09-19 | Japan Science & Technology Corp | 面性キラリティーを有する分子群の高選択的不斉変換法 |
| US6288280B1 (en) * | 1999-07-09 | 2001-09-11 | Hoffmann-La Roche Inc. | Racemization of atropisomeric bis(phosphine oxide) compounds |
| BR0002246A (pt) | 2000-04-06 | 2003-04-15 | Cristalia Prod Quimicos Farm | Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis |
| EP1295873A4 (fr) * | 2000-06-14 | 2004-05-19 | Procedes de production de derive de piperidine racemique et de production de derive de piperidine a activite optique | |
| DE10029851A1 (de) * | 2000-06-16 | 2001-12-20 | Boehringer Ingelheim Pharma | Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers |
| US6495694B2 (en) | 2000-06-16 | 2002-12-17 | Boehringer Ingelheim Pharma Kg | Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer |
| BRPI0104491B8 (pt) * | 2001-10-10 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica. |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| EP2959893A1 (fr) | 2002-12-13 | 2015-12-30 | DURECT Corporation | Système d'administration de médicament par voie orale comprenant des matériaux de support liquides à viscosité élevée |
| PL1809329T3 (pl) | 2004-09-17 | 2012-08-31 | Durect Corp | Kompozycja znieczulająca zawierająca saib o przedłużonym uwalnianiu do stosowania miejscowego |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| US8337883B2 (en) | 2006-11-03 | 2012-12-25 | Durect Corporation | Transdermal delivery systems |
| WO2009088414A2 (fr) | 2007-12-06 | 2009-07-16 | Durect Corporation | Formes posologiques pharmaceutiques orales |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| CN102093284B (zh) * | 2010-12-29 | 2013-05-08 | 宜昌人福药业有限责任公司 | 富集哌啶-2-甲酰苯胺类旋光化合物的方法 |
| CA2905131A1 (fr) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions ayant un agent de modification rheologique pour reduire une variabilite de dissolution |
| CN103664744B (zh) * | 2013-11-30 | 2015-07-15 | 山东永泰化工有限公司 | 一种左布比卡因的制备方法 |
| AU2019270163A1 (en) * | 2018-05-18 | 2020-12-03 | Kura Oncology, Inc. | Synthesis of tipifarnib |
| KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE451840B (sv) * | 1986-01-03 | 1987-11-02 | Astra Laekemedel Ab | Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning |
-
1995
- 1995-09-22 US US08/809,941 patent/US5786484A/en not_active Expired - Lifetime
- 1995-09-22 AT AT95932092T patent/ATE214695T1/de active
- 1995-09-22 AU AU35279/95A patent/AU695479B2/en not_active Expired
- 1995-09-22 CN CN95195252A patent/CN1104416C/zh not_active Expired - Lifetime
- 1995-09-22 HU HU9702212A patent/HU216291B/hu unknown
- 1995-09-22 MX MX9702210A patent/MX9702210A/es unknown
- 1995-09-22 ES ES95932092T patent/ES2173194T3/es not_active Expired - Lifetime
- 1995-09-22 PL PL95319368A patent/PL183204B1/pl unknown
- 1995-09-22 KR KR1019970701774A patent/KR100393133B1/ko not_active IP Right Cessation
- 1995-09-22 DK DK95932092T patent/DK0782569T3/da active
- 1995-09-22 PT PT95932092T patent/PT782569E/pt unknown
- 1995-09-22 DE DE69525950T patent/DE69525950T2/de not_active Expired - Lifetime
- 1995-09-22 CA CA002200490A patent/CA2200490C/fr not_active Expired - Lifetime
- 1995-09-22 WO PCT/GB1995/002247 patent/WO1996009290A1/fr active IP Right Grant
- 1995-09-22 EP EP95932092A patent/EP0782569B1/fr not_active Expired - Lifetime
- 1995-09-22 JP JP51069496A patent/JP3898220B2/ja not_active Expired - Lifetime
-
1997
- 1997-03-21 FI FI971202A patent/FI117436B/fi not_active IP Right Cessation
- 1997-03-21 NO NO971358A patent/NO308074B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69525950T2 (de) | 2002-09-19 |
| HUT77055A (hu) | 1998-03-02 |
| DK0782569T3 (da) | 2002-07-22 |
| AU3527995A (en) | 1996-04-09 |
| FI971202A (fi) | 1997-03-21 |
| ATE214695T1 (de) | 2002-04-15 |
| US5786484A (en) | 1998-07-28 |
| CN1159184A (zh) | 1997-09-10 |
| CN1104416C (zh) | 2003-04-02 |
| NO971358L (no) | 1997-03-21 |
| HU216291B (hu) | 1999-06-28 |
| DE69525950D1 (de) | 2002-04-25 |
| ES2173194T3 (es) | 2002-10-16 |
| PL319368A1 (en) | 1997-08-04 |
| KR100393133B1 (ko) | 2003-11-17 |
| NO308074B1 (no) | 2000-07-17 |
| EP0782569B1 (fr) | 2002-03-20 |
| MX9702210A (es) | 1998-05-31 |
| CA2200490A1 (fr) | 1996-03-28 |
| FI971202A0 (fi) | 1997-03-21 |
| PT782569E (pt) | 2002-09-30 |
| PL183204B1 (pl) | 2002-06-28 |
| EP0782569A1 (fr) | 1997-07-09 |
| NO971358D0 (no) | 1997-03-21 |
| WO1996009290A1 (fr) | 1996-03-28 |
| JPH10505855A (ja) | 1998-06-09 |
| AU695479B2 (en) | 1998-08-13 |
| JP3898220B2 (ja) | 2007-03-28 |
| CA2200490C (fr) | 2007-01-09 |
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| FG | Patent granted |
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| MA | Patent expired |