FI117137B - Salmonellan tunnistus polymeraasiketjureaktorilla - Google Patents
Salmonellan tunnistus polymeraasiketjureaktorilla Download PDFInfo
- Publication number
- FI117137B FI117137B FI956052A FI956052A FI117137B FI 117137 B FI117137 B FI 117137B FI 956052 A FI956052 A FI 956052A FI 956052 A FI956052 A FI 956052A FI 117137 B FI117137 B FI 117137B
- Authority
- FI
- Finland
- Prior art keywords
- dna
- nucleic acid
- salmonella
- acid molecule
- pcr
- Prior art date
Links
- 241000607142 Salmonella Species 0.000 title claims abstract description 55
- 238000003752 polymerase chain reaction Methods 0.000 title claims description 42
- 239000000523 sample Substances 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 23
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 17
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 16
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 16
- 238000001514 detection method Methods 0.000 claims abstract description 13
- 108091034117 Oligonucleotide Proteins 0.000 claims description 45
- 108020004414 DNA Proteins 0.000 claims description 41
- 239000013615 primer Substances 0.000 claims description 37
- 239000012634 fragment Substances 0.000 claims description 23
- 238000009396 hybridization Methods 0.000 claims description 23
- 101000710013 Homo sapiens Reversion-inducing cysteine-rich protein with Kazal motifs Proteins 0.000 claims description 18
- 101000661807 Homo sapiens Suppressor of tumorigenicity 14 protein Proteins 0.000 claims description 15
- 238000012360 testing method Methods 0.000 claims description 13
- 230000003321 amplification Effects 0.000 claims description 9
- 230000000295 complement effect Effects 0.000 claims description 9
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 9
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- 239000003155 DNA primer Substances 0.000 claims description 6
- 102000053602 DNA Human genes 0.000 claims description 4
- 102000003960 Ligases Human genes 0.000 claims description 4
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- 108020004682 Single-Stranded DNA Proteins 0.000 claims description 4
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- VHTUHGNVVZPWGO-UHFFFAOYSA-N 7-(2-hydroxyethyl)-1,3-dimethyl-8-(pyridin-3-ylmethyl)purine-2,6-dione Chemical group OCCN1C=2C(=O)N(C)C(=O)N(C)C=2N=C1CC1=CC=CN=C1 VHTUHGNVVZPWGO-UHFFFAOYSA-N 0.000 claims description 3
- 108020004635 Complementary DNA Proteins 0.000 claims description 3
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims description 3
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims description 3
- 108020004518 RNA Probes Proteins 0.000 claims description 3
- 239000003391 RNA probe Substances 0.000 claims description 3
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- 239000002299 complementary DNA Substances 0.000 claims description 3
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- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 18
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- 238000012163 sequencing technique Methods 0.000 description 4
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- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 3
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 3
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 3
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- HPQYKCJIWQFJMS-UHFFFAOYSA-L tetrathionate(2-) Chemical compound [O-]S(=O)(=O)SSS([O-])(=O)=O HPQYKCJIWQFJMS-UHFFFAOYSA-L 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- 239000013598 vector Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- YTPMCWYIRHLEGM-BQYQJAHWSA-N 1-[(e)-2-propylsulfonylethenyl]sulfonylpropane Chemical compound CCCS(=O)(=O)\C=C\S(=O)(=O)CCC YTPMCWYIRHLEGM-BQYQJAHWSA-N 0.000 description 1
- LLBZPESJRQGYMB-UHFFFAOYSA-N 4-one Natural products O1C(C(=O)CC)CC(C)C11C2(C)CCC(C3(C)C(C(C)(CO)C(OC4C(C(O)C(O)C(COC5C(C(O)C(O)CO5)OC5C(C(OC6C(C(O)C(O)C(CO)O6)O)C(O)C(CO)O5)OC5C(C(O)C(O)C(C)O5)O)O4)O)CC3)CC3)=C3C2(C)CC1 LLBZPESJRQGYMB-UHFFFAOYSA-N 0.000 description 1
- 241000046143 Cedecea davisae Species 0.000 description 1
- 241000043249 Cedecea lapagei Species 0.000 description 1
- 241000043250 Cedecea neteri Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000588923 Citrobacter Species 0.000 description 1
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- 241000305071 Enterobacterales Species 0.000 description 1
- 241000588921 Enterobacteriaceae Species 0.000 description 1
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- 241000131486 Ewingella Species 0.000 description 1
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- 241000341859 Providencia heimbachae Species 0.000 description 1
- 241000773293 Rappaport Species 0.000 description 1
- 206010039438 Salmonella Infections Diseases 0.000 description 1
- 241001138501 Salmonella enterica Species 0.000 description 1
- 241000607356 Salmonella enterica subsp. arizonae Species 0.000 description 1
- 241000607351 Salmonella enterica subsp. houtenae Species 0.000 description 1
- 241000607358 Salmonella enterica subsp. salamae Species 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- 244000297179 Syringa vulgaris Species 0.000 description 1
- 235000004338 Syringa vulgaris Nutrition 0.000 description 1
- 241000607757 Xenorhabdus Species 0.000 description 1
- 241000607447 Yersinia enterocolitica Species 0.000 description 1
- 241000043486 Yokenella Species 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
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- 210000000349 chromosome Anatomy 0.000 description 1
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- 229940104302 cytosine Drugs 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
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- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- MKHLSGKJYGBQLI-UHFFFAOYSA-N ethoxy-(2-ethylsulfanylethylsulfanyl)-methoxy-sulfanylidene-$l^{5}-phosphane Chemical compound CCOP(=S)(OC)SCCSCC MKHLSGKJYGBQLI-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
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- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- CJNBYAVZURUTKZ-UHFFFAOYSA-N hafnium(IV) oxide Inorganic materials O=[Hf]=O CJNBYAVZURUTKZ-UHFFFAOYSA-N 0.000 description 1
- 238000012744 immunostaining Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
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- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 206010039447 salmonellosis Diseases 0.000 description 1
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- 229940115939 shigella sonnei Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
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- 235000018553 tannin Nutrition 0.000 description 1
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- 238000006177 thiolation reaction Methods 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 229940098232 yersinia enterocolitica Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9312508 | 1993-06-17 | ||
GB939312508A GB9312508D0 (en) | 1993-06-17 | 1993-06-17 | Compounds |
GB9401316 | 1994-01-25 | ||
PCT/GB1994/001316 WO1995000664A1 (fr) | 1993-06-17 | 1994-06-17 | Identification de salmonella par amplification enzymatique |
Publications (3)
Publication Number | Publication Date |
---|---|
FI956052A FI956052A (fi) | 1995-12-15 |
FI956052A0 FI956052A0 (fi) | 1995-12-15 |
FI117137B true FI117137B (fi) | 2006-06-30 |
Family
ID=10737324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI956052A FI117137B (fi) | 1993-06-17 | 1995-12-15 | Salmonellan tunnistus polymeraasiketjureaktorilla |
Country Status (12)
Country | Link |
---|---|
US (1) | US6004747A (fr) |
EP (1) | EP0707659B1 (fr) |
JP (1) | JP3016399B2 (fr) |
AT (1) | ATE160822T1 (fr) |
AU (1) | AU6975694A (fr) |
CA (1) | CA2164941C (fr) |
DE (1) | DE69407187T2 (fr) |
DK (1) | DK0707659T3 (fr) |
FI (1) | FI117137B (fr) |
GB (1) | GB9312508D0 (fr) |
NO (1) | NO317797B1 (fr) |
WO (1) | WO1995000664A1 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2729392B1 (fr) * | 1995-01-16 | 1997-03-28 | Pasteur Institut | Oligonucleotides pour la detection de salmonella |
JP2792462B2 (ja) * | 1995-04-28 | 1998-09-03 | 株式会社島津製作所 | サルモネラ属菌検出のためのオリゴヌクレオチドおよびそれを用いた検出法 |
EP2264045B1 (fr) * | 1996-08-14 | 2015-10-21 | Life Technologies Corporation | Composition pour l'amplification et pour la séquenciation de l'ADN |
US6312930B1 (en) | 1996-09-16 | 2001-11-06 | E. I. Du Pont De Nemours And Company | Method for detecting bacteria using PCR |
GB9624165D0 (en) * | 1996-11-19 | 1997-01-08 | Amdex A S | Use of nucleic acids bound to carrier macromolecules |
FR2760749B1 (fr) * | 1997-03-14 | 1999-04-30 | Veterinaires Et Alimentaires C | Oligonucleotides derives des genes vts de bacteries e. coli productrices de verotoxines, et leurs utilisations |
DE19734940A1 (de) * | 1997-08-12 | 1999-02-18 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Nucleinsäuremolekül-Satz für Salmonella-Nachweis, Nucleinsäuren, Kit und Verwendung |
US6225058B1 (en) * | 1998-01-13 | 2001-05-01 | Invitro Diagnostics, Inc. | Compositions, methods, kits and apparatus for determining the presence or absence of target molecules |
WO2003000935A1 (fr) * | 2001-06-22 | 2003-01-03 | Marshfield Clinic | Procedes et oligonucleotides pour la detection de salmonella sp., e. coli o157:h7, et de listeria monocytogenes |
US20060177824A1 (en) * | 2003-04-29 | 2006-08-10 | Procop Gary W | Salmonella detection identification |
WO2005059182A2 (fr) * | 2003-12-19 | 2005-06-30 | Roche Diagnostics Gmbh | Reactifs et procedes de detection de neisseria gonorrhoeae |
US7393903B2 (en) * | 2004-08-04 | 2008-07-01 | Guerry Grune | Devices and methods for the rapid, reliable detection and determination of acrylamide concentration in food substances and prevention of acrylamide formation in the same |
US20060240442A1 (en) * | 2005-04-20 | 2006-10-26 | Vevea Dirk N | Methods and oligonucleotides for the detection of Salmonella SP., E coli 0157:H7, and Listeria monocytogenes |
US20060246463A1 (en) * | 2005-04-20 | 2006-11-02 | Vevea Dirk N | Methods and oligonucleotides for the detection of Salmonella SP., E coli 0157:H7, and Listeria monocytogenes |
ES2300174B1 (es) * | 2006-01-27 | 2009-05-01 | Universidad Del Pais Vasco-Euskal-Herrico Unibertsitatea | Deteccion y tipificacion de salmonella en muestras alimentarias mediante pcr multiple. |
EP2019687B1 (fr) | 2006-03-29 | 2014-03-19 | Merial Limited | Vaccin anti-streptocoques |
JP5224539B2 (ja) * | 2008-07-08 | 2013-07-03 | 独立行政法人農業・食品産業技術総合研究機構 | 特異的遺伝子の多重検出によるSalmonellaTyphimuriumの迅速同定法 |
US9115408B2 (en) | 2010-10-26 | 2015-08-25 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention | Rapid Salmonella serotyping assay |
CA2816060C (fr) | 2010-10-26 | 2021-04-13 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Dosage de serotypage rapide de salmonella |
WO2014175892A1 (fr) * | 2013-04-26 | 2014-10-30 | Centers For Disease Control And Prevention | Dosage de sérotypage rapide de salmonella |
WO2017216635A1 (fr) * | 2016-06-16 | 2017-12-21 | Bio-Rad Laboratories, Inc. | Procédé de détection de salmonella typhimurium |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2664614B1 (fr) * | 1990-07-11 | 1992-10-16 | Pasteur Institut | Sequences nucleiques issues du genome de salmonella typhi, et leurs utilisations notamment pour le diagnostic in vitro de la presence de bacteries du genre salmonella dans les produits alimentaires. |
NL9002696A (nl) * | 1990-11-15 | 1992-06-01 | U Gene Research Bv | Werkwijze en kit voor het aantonen van microoerganismen. |
GB9107124D0 (en) * | 1991-04-05 | 1991-05-22 | Dynal As | Chemical process |
-
1993
- 1993-06-17 GB GB939312508A patent/GB9312508D0/en active Pending
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1994
- 1994-06-17 JP JP7502557A patent/JP3016399B2/ja not_active Expired - Lifetime
- 1994-06-17 WO PCT/GB1994/001316 patent/WO1995000664A1/fr active IP Right Grant
- 1994-06-17 AT AT94918438T patent/ATE160822T1/de active
- 1994-06-17 CA CA002164941A patent/CA2164941C/fr not_active Expired - Lifetime
- 1994-06-17 DK DK94918438.6T patent/DK0707659T3/da active
- 1994-06-17 DE DE69407187T patent/DE69407187T2/de not_active Expired - Lifetime
- 1994-06-17 EP EP94918438A patent/EP0707659B1/fr not_active Expired - Lifetime
- 1994-06-17 US US08/564,110 patent/US6004747A/en not_active Expired - Lifetime
- 1994-06-17 AU AU69756/94A patent/AU6975694A/en not_active Abandoned
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DE69407187D1 (de) | 1998-01-15 |
US6004747A (en) | 1999-12-21 |
WO1995000664A1 (fr) | 1995-01-05 |
DE69407187T2 (de) | 1998-05-07 |
FI956052A (fi) | 1995-12-15 |
EP0707659A1 (fr) | 1996-04-24 |
NO955119D0 (no) | 1995-12-15 |
FI956052A0 (fi) | 1995-12-15 |
GB9312508D0 (en) | 1993-08-04 |
AU6975694A (en) | 1995-01-17 |
NO317797B1 (no) | 2004-12-13 |
ATE160822T1 (de) | 1997-12-15 |
JP3016399B2 (ja) | 2000-03-06 |
EP0707659B1 (fr) | 1997-12-03 |
NO955119L (no) | 1995-12-15 |
JPH08510386A (ja) | 1996-11-05 |
CA2164941C (fr) | 2001-04-17 |
DK0707659T3 (da) | 1998-01-12 |
CA2164941A1 (fr) | 1995-01-05 |
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