FI116059B - Analogiförfarande för framställning av ett rekombinantprotein kallat komponent B samt DNA-molekyl, expressionsvektor och värdcell - Google Patents
Analogiförfarande för framställning av ett rekombinantprotein kallat komponent B samt DNA-molekyl, expressionsvektor och värdcell Download PDFInfo
- Publication number
- FI116059B FI116059B FI20040608A FI20040608A FI116059B FI 116059 B FI116059 B FI 116059B FI 20040608 A FI20040608 A FI 20040608A FI 20040608 A FI20040608 A FI 20040608A FI 116059 B FI116059 B FI 116059B
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- sequence
- dna
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- dna molecule
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (9)
1. Analogiförfarande för framställning av ett som läkemedel användbart . . rekombinantprotein, dess salter, funktionella derivat, för- stadier, vilka i kroppen *. * förvandlas tili B-komponent, aktiva fraktioner eller blandningar av dessa, vilket ’ ‘; rekombinant protein är försett med B-komponentaktivitet och innehäller peptidsekvensen ;;; SEKV. ID NO:l, kännetecknat därav, att enligt förfarandet odlas en värdcell, vilken ’ * * * * transformerats med en expressionsvektor, vilken innehäller en DNA-molekyl, vilken är • · · en isolerad och renad nukleotidsekvens SEKV. ID NO:2, cDNA som innehäller '*··' nukleotidsekvensen SEKV. ID NO:3, en aktiv mutant av dessa nukleotidsekvenser eller en aktiv fraktion av dessa eller en DNA-sekvens, som kan hybridisera sig med nämnda : nukleotidsekvenser i en hybridisationslösning, vilken innehäller 5xSSC, 0,02% SDS, .* 0,1% lauroylsarkosin och 0,5% blocking-reagens i 42°C eller 50°C och i en sista : : tvättlösning, vilken innehäller 3xSSC, 0,1% SDS, 0, 9, 18, 27 tai 36% urea i 42°C, vilken : ; DNA-molekyl kodar den aminosyrasekvens, som innehäller peptiden SEKV. ID NO:l • _ eller dess aktiva mutant, vilken har samma aktivitet som komponent B. 116059
2. Förfarandet enligt patentkrav 1, kännetecknat därav att en eller flera aminosyror eliminerats eller substituerats med andra aminosyror i mutantpeptidens aminosyra-sekvens eller en eller flera aminosyror tillsatts tili densamma..
3. Förfarandet enligt patentkrav 1, kännetecknat därav att mutanten är ett fusionsproteini, vilket innehäller immunoglobulin.
4. Förfarandet enligt nägot av patentkraven 1, 2 eller 3, kännetecknat därav att rekombinantproteinet tillvaratas frän en transformerad värdcells cell eller ur odlingsmediet.
5. En DNA-molekyl, kännetecknad därav att den är en isolerad och renad nukleotidsekvens SEKV. ID NO:2 eller cDNA, vars sekvens är SEKV. ID NO:3 eller en aktiv mutant av nämnda nukleotidsekvenser eller en aktiv fraktion av dessa eller en DNA-sekvens, vilken hybridiserar sig med nämnda nukleotidsekvenser i en hybridisationslösning, vilken innehäller 5xSSC, 0,02 % SDS, 0,1 % lauroylsarkosin och 0,5% blocking-reagens i 42°C eller 50°C: och i en sista tvättlösning, vilken innehäller 3xSSC, 0,1% SDS och 0, 9, 18, 27 eller 36% urea i 42°C, vilken DNA-sekvens kodar en aminosyrasekvens, vilken innehäller en peptid SEKV. ID NO: 1 eller dess aktiva mutant, vilken har samma aktivitet som komponent B och i vilken en eller flera aminosyror har • eliminerats eller substituerats med andra aminosyror eller en eller flera aminosyror har ^tillsatts tili dennsa sekvens. I!
’ 6. DNA-molekylen enligt patentkrav 5, kännetecknad därav, att den är den isolerade och ’' I renade nukleotidsekvensen SEKV. ID NO:2.
7. DNA-molekylen enligt patentkrav 5, kännetecknad därav, att den bestär av cDNA, som har sekvensen SEKV. ID NO:3. 1 2 En expressionsvektor, kännetecknad därav, att den innehäller en DNA-molekyl enligt ; nägot av patentkraven 5, 6 eller 7. > 2 En värdcell, kännetecknad därav, att den är transformerad med en expressionsvektor , .; enligt patentkrav 8, vilken innehäller en DNA-molekyl enligt patentkrav 5.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM920919A IT1257184B (it) | 1992-12-22 | 1992-12-22 | Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale |
| ITRM920919 | 1992-12-22 | ||
| EP9303645 | 1993-12-21 | ||
| PCT/EP1993/003645 WO1994014959A1 (en) | 1992-12-22 | 1993-12-21 | New protein from urine named component b |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI20040608A FI20040608A (sv) | 2004-04-29 |
| FI116059B true FI116059B (sv) | 2005-09-15 |
Family
ID=11401349
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI953091A FI114478B (sv) | 1992-12-22 | 1995-06-21 | Förfarande för framställning av protein kallat komponent B ur urin |
| FI20040608A FI116059B (sv) | 1992-12-22 | 2004-04-29 | Analogiförfarande för framställning av ett rekombinantprotein kallat komponent B samt DNA-molekyl, expressionsvektor och värdcell |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI953091A FI114478B (sv) | 1992-12-22 | 1995-06-21 | Förfarande för framställning av protein kallat komponent B ur urin |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5908827A (sv) |
| EP (1) | EP0675956B1 (sv) |
| JP (1) | JP3025014B2 (sv) |
| KR (1) | KR100193107B1 (sv) |
| AT (1) | ATE236976T1 (sv) |
| AU (1) | AU690093B2 (sv) |
| CA (1) | CA2151156A1 (sv) |
| DE (1) | DE69332861T2 (sv) |
| DK (1) | DK0675956T3 (sv) |
| ES (1) | ES2193152T3 (sv) |
| FI (2) | FI114478B (sv) |
| IL (1) | IL108149A (sv) |
| IT (1) | IT1257184B (sv) |
| NO (1) | NO315800B1 (sv) |
| PT (1) | PT675956E (sv) |
| RU (1) | RU2177480C2 (sv) |
| UA (1) | UA46702C2 (sv) |
| WO (1) | WO1994014959A1 (sv) |
| ZA (1) | ZA939621B (sv) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA001077B1 (ru) * | 1996-04-24 | 2000-10-30 | Апплайд Резеч Системз Арс Холдинг Н.В. | Компонент в, используемый в качестве рубцующего агента, содержащая его фармацевтическая композиция и способ лечения |
| WO1998056810A2 (de) * | 1997-06-09 | 1998-12-17 | Forssmann Wolf Georg | Humanes protein lus-i, seine herstellung und verwendung |
| AU765600B2 (en) | 1998-07-09 | 2003-09-25 | Merck Serono Sa | Compound B as angiogenic agent in combination with human growth factors |
| US6962700B1 (en) | 2000-09-13 | 2005-11-08 | Atopix Pharmaceuticals Corporation | Method of manufacturing immune globulin |
| AU2004229237B2 (en) * | 2003-04-16 | 2009-06-04 | Merck Serono Sa | Use of SLURP-1 for treating diseases related to acetylcholine receptors dysfunction |
| US7343581B2 (en) * | 2005-06-27 | 2008-03-11 | Tela Innovations, Inc. | Methods for creating primitive constructed standard cells |
| US7590968B1 (en) | 2006-03-01 | 2009-09-15 | Tela Innovations, Inc. | Methods for risk-informed chip layout generation |
| US8245180B2 (en) | 2006-03-09 | 2012-08-14 | Tela Innovations, Inc. | Methods for defining and using co-optimized nanopatterns for integrated circuit design and apparatus implementing same |
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| US7908578B2 (en) | 2007-08-02 | 2011-03-15 | Tela Innovations, Inc. | Methods for designing semiconductor device with dynamic array section |
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| US9563733B2 (en) | 2009-05-06 | 2017-02-07 | Tela Innovations, Inc. | Cell circuit and layout with linear finfet structures |
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| US7763534B2 (en) | 2007-10-26 | 2010-07-27 | Tela Innovations, Inc. | Methods, structures and designs for self-aligning local interconnects used in integrated circuits |
| US8658542B2 (en) | 2006-03-09 | 2014-02-25 | Tela Innovations, Inc. | Coarse grid design methods and structures |
| US8225239B2 (en) | 2006-03-09 | 2012-07-17 | Tela Innovations, Inc. | Methods for defining and utilizing sub-resolution features in linear topology |
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| NZ583783A (en) * | 2007-09-20 | 2012-10-26 | Commw Scient Ind Res Org | Avian interferon-lambda polypeptide and genetic sequences encoding the same |
| RU2486245C2 (ru) * | 2007-10-15 | 2013-06-27 | Чугаи Сейяку Кабусики Кайся | Способ получения клетки, способной продуцировать гетеропротеины с высоким выходом |
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| GB0820631D0 (en) * | 2008-11-11 | 2008-12-17 | London School Hygiene & Tropical Medicine | Vectors |
| EP2239322A1 (en) * | 2009-04-07 | 2010-10-13 | Basf Se | Use of enzymes to reduce formaldehyde from formaldehyde-containing products |
| US8661392B2 (en) | 2009-10-13 | 2014-02-25 | Tela Innovations, Inc. | Methods for cell boundary encroachment and layouts implementing the Same |
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| EP2740485B1 (en) * | 2012-12-07 | 2018-10-31 | Brightpulse Holding LTD. | Protein slurp-1 for use in the treatment of ocular diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4359415A (en) * | 1981-06-03 | 1982-11-16 | University Of Tennessee Research Corporation | Isolation of an antineoplastic protein fraction and an antineoplastic peptide fraction from human urine |
| US4470970A (en) * | 1981-07-02 | 1984-09-11 | Burzynski Stanislaw R | Purified antineoplaston fractions and methods of treating neoplastic disease |
| US5298604A (en) * | 1992-07-27 | 1994-03-29 | Sloane Nathan H | Parital primary amino acid sequence of the antineoplastic protein (ANUP); a cytokine present in granulocytes |
-
1992
- 1992-12-22 IT ITRM920919A patent/IT1257184B/it active IP Right Grant
-
1993
- 1993-12-21 KR KR1019950702407A patent/KR100193107B1/ko not_active IP Right Cessation
- 1993-12-21 WO PCT/EP1993/003645 patent/WO1994014959A1/en active IP Right Grant
- 1993-12-21 DE DE69332861T patent/DE69332861T2/de not_active Expired - Fee Related
- 1993-12-21 UA UA95062918A patent/UA46702C2/uk unknown
- 1993-12-21 CA CA002151156A patent/CA2151156A1/en not_active Abandoned
- 1993-12-21 PT PT94904167T patent/PT675956E/pt unknown
- 1993-12-21 US US08/448,561 patent/US5908827A/en not_active Expired - Fee Related
- 1993-12-21 AT AT94904167T patent/ATE236976T1/de not_active IP Right Cessation
- 1993-12-21 EP EP94904167A patent/EP0675956B1/en not_active Expired - Lifetime
- 1993-12-21 DK DK94904167T patent/DK0675956T3/da active
- 1993-12-21 AU AU58335/94A patent/AU690093B2/en not_active Ceased
- 1993-12-21 JP JP6514813A patent/JP3025014B2/ja not_active Expired - Fee Related
- 1993-12-21 ES ES94904167T patent/ES2193152T3/es not_active Expired - Lifetime
- 1993-12-22 ZA ZA939621A patent/ZA939621B/xx unknown
- 1993-12-22 RU RU95113418/13A patent/RU2177480C2/ru not_active IP Right Cessation
- 1993-12-22 IL IL10814993A patent/IL108149A/xx not_active IP Right Cessation
-
1995
- 1995-06-21 FI FI953091A patent/FI114478B/sv active IP Right Grant
- 1995-06-21 NO NO19952494A patent/NO315800B1/no not_active IP Right Cessation
-
2004
- 2004-04-29 FI FI20040608A patent/FI116059B/sv active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08509359A (ja) | 1996-10-08 |
| ATE236976T1 (de) | 2003-04-15 |
| UA46702C2 (uk) | 2002-06-17 |
| IL108149A0 (en) | 1994-04-12 |
| JP3025014B2 (ja) | 2000-03-27 |
| US5908827A (en) | 1999-06-01 |
| DE69332861D1 (de) | 2003-05-15 |
| ZA939621B (en) | 1995-06-22 |
| FI20040608A (sv) | 2004-04-29 |
| FI114478B (sv) | 2004-10-29 |
| IL108149A (en) | 2005-05-17 |
| KR100193107B1 (ko) | 1999-06-15 |
| ITRM920919A0 (it) | 1992-12-22 |
| EP0675956A1 (en) | 1995-10-11 |
| DE69332861T2 (de) | 2004-01-29 |
| FI953091A0 (sv) | 1995-06-21 |
| EP0675956B1 (en) | 2003-04-09 |
| WO1994014959A1 (en) | 1994-07-07 |
| ITRM920919A1 (it) | 1994-06-22 |
| FI953091A (sv) | 1995-06-21 |
| CA2151156A1 (en) | 1994-07-07 |
| AU5833594A (en) | 1994-07-19 |
| NO952494L (no) | 1995-08-21 |
| ES2193152T3 (es) | 2003-11-01 |
| KR950704486A (ko) | 1995-11-20 |
| AU690093B2 (en) | 1998-04-23 |
| PT675956E (pt) | 2003-07-31 |
| DK0675956T3 (da) | 2003-07-07 |
| NO315800B1 (no) | 2003-10-27 |
| IT1257184B (it) | 1996-01-10 |
| NO952494D0 (no) | 1995-06-21 |
| RU2177480C2 (ru) | 2001-12-27 |
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