IT1257184B - Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale - Google Patents

Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale

Info

Publication number
IT1257184B
IT1257184B ITRM920919A ITRM920919A IT1257184B IT 1257184 B IT1257184 B IT 1257184B IT RM920919 A ITRM920919 A IT RM920919A IT RM920919 A ITRM920919 A IT RM920919A IT 1257184 B IT1257184 B IT 1257184B
Authority
IT
Italy
Prior art keywords
inflammatory
agulant
prepared
tumoral activity
activity
Prior art date
Application number
ITRM920919A
Other languages
English (en)
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of ITRM920919A0 publication Critical patent/ITRM920919A0/it
Priority to ITRM920919A priority Critical patent/IT1257184B/it
Priority to DK94904167T priority patent/DK0675956T3/da
Priority to PCT/EP1993/003645 priority patent/WO1994014959A1/en
Priority to KR1019950702407A priority patent/KR100193107B1/ko
Priority to CA002151156A priority patent/CA2151156A1/en
Priority to JP6514813A priority patent/JP3025014B2/ja
Priority to AU58335/94A priority patent/AU690093B2/en
Priority to DE69332861T priority patent/DE69332861T2/de
Priority to EP94904167A priority patent/EP0675956B1/en
Priority to AT94904167T priority patent/ATE236976T1/de
Priority to UA95062918A priority patent/UA46702C2/uk
Priority to PT94904167T priority patent/PT675956E/pt
Priority to ES94904167T priority patent/ES2193152T3/es
Priority to US08/448,561 priority patent/US5908827A/en
Priority to IL10814993A priority patent/IL108149A/xx
Priority to RU95113418/13A priority patent/RU2177480C2/ru
Priority to ZA939621A priority patent/ZA939621B/xx
Publication of ITRM920919A1 publication Critical patent/ITRM920919A1/it
Priority to NO19952494A priority patent/NO315800B1/no
Priority to FI953091A priority patent/FI114478B/fi
Application granted granted Critical
Publication of IT1257184B publication Critical patent/IT1257184B/it
Priority to FI20040608A priority patent/FI116059B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Viene descritto un nuovo preparato di natura essenzialmente polipeptidica, ottenibile da urina tramite un processo di estrazione e purificazione attraverso cromatografia a scambio ionico e cromatografia ad alta risoluzione, e che risulta dotato di attività antinfiammatoria, anticoagulante e antitumorale.
ITRM920919A 1992-12-22 1992-12-22 Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale IT1257184B (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
ITRM920919A IT1257184B (it) 1992-12-22 1992-12-22 Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale
UA95062918A UA46702C2 (uk) 1992-12-22 1993-12-21 Поліпептид, спосіб одержання поліпептиду (варіанти),фрагмент днк (варіанти), експресуючий вектор (варіанти), штам e.coli, лінія клітин (варіанти), білок, фармацевтична композиція (варіанти)
ES94904167T ES2193152T3 (es) 1992-12-22 1993-12-21 Nueva proteina de la orina denominada componente b.
KR1019950702407A KR100193107B1 (ko) 1992-12-22 1993-12-21 성분b로 명명된 신규 단백질
CA002151156A CA2151156A1 (en) 1992-12-22 1993-12-21 New protein from urine named component b
JP6514813A JP3025014B2 (ja) 1992-12-22 1993-12-21 成分ｂと命名された新規な蛋白質
AU58335/94A AU690093B2 (en) 1992-12-22 1993-12-21 New protein from urine named component B
DE69332861T DE69332861T2 (de) 1992-12-22 1993-12-21 Neues protein aus urin, komponent b genannt
EP94904167A EP0675956B1 (en) 1992-12-22 1993-12-21 New protein from urine named component b
AT94904167T ATE236976T1 (de) 1992-12-22 1993-12-21 Neues protein aus urin, komponent b genannt
DK94904167T DK0675956T3 (da) 1992-12-22 1993-12-21 Nyt protein fra urin betegnet komponent B
PT94904167T PT675956E (pt) 1992-12-22 1993-12-21 Proteina nova da urina denominada componente b
PCT/EP1993/003645 WO1994014959A1 (en) 1992-12-22 1993-12-21 New protein from urine named component b
US08/448,561 US5908827A (en) 1992-12-22 1993-12-21 Protein from urine named component B
IL10814993A IL108149A (en) 1992-12-22 1993-12-22 Component b protein, its preparation and pharmaceutical compositions containing it
RU95113418/13A RU2177480C2 (ru) 1992-12-22 1993-12-22 Полипептид, способ получения (варианты), днк (варианты), вектор (варианты), клетка, применение полипептида, фармацевтическая композиция (варианты)
ZA939621A ZA939621B (en) 1992-12-22 1993-12-22 Protein named component B
NO19952494A NO315800B1 (no) 1992-12-22 1995-06-21 Polypeptid fra urin med betegnelse komponent B, fremgangsmate for fremstilling av dette, DNA-molekyl, ekspresjonsvektor, vertscelle, pattedyrscelle, anvendelse av polypeptidet for fremstilling av et medikament samt farmasoytisk preparat
FI953091A FI114478B (fi) 1992-12-22 1995-06-21 Menetelmä virtsasta peräisin olevan komponentti B: ksi kutsutun proteiinin valmistamiseksi
FI20040608A FI116059B (fi) 1992-12-22 2004-04-29 Analogiamenetelmä komponentti B:ksi kutsutun rekombinanttiproteiinin valmistamiseksi sekä DNA-molekyyli, ilmentämisvektori ja isäntäsolu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM920919A IT1257184B (it) 1992-12-22 1992-12-22 Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale

Publications (3)

Publication Number Publication Date
ITRM920919A0 ITRM920919A0 (it) 1992-12-22
ITRM920919A1 ITRM920919A1 (it) 1994-06-22
IT1257184B true IT1257184B (it) 1996-01-10

Family

ID=11401349

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM920919A IT1257184B (it) 1992-12-22 1992-12-22 Preparato ad attivita' antinfiammatoria, anticoagulante e antitumorale

Country Status (19)

Country Link
US (1) US5908827A (it)
EP (1) EP0675956B1 (it)
JP (1) JP3025014B2 (it)
KR (1) KR100193107B1 (it)
AT (1) ATE236976T1 (it)
AU (1) AU690093B2 (it)
CA (1) CA2151156A1 (it)
DE (1) DE69332861T2 (it)
DK (1) DK0675956T3 (it)
ES (1) ES2193152T3 (it)
FI (2) FI114478B (it)
IL (1) IL108149A (it)
IT (1) IT1257184B (it)
NO (1) NO315800B1 (it)
PT (1) PT675956E (it)
RU (1) RU2177480C2 (it)
UA (1) UA46702C2 (it)
WO (1) WO1994014959A1 (it)
ZA (1) ZA939621B (it)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997039765A1 (en) * 1996-04-24 1997-10-30 Applied Research Systems Ars Holding N.V. Component b as cicatrizant
AU8536698A (en) * 1997-06-09 1998-12-30 Wolf-Georg Forssmann Lus-1 human protein, its production and use
JP2002520292A (ja) 1998-07-09 2002-07-09 アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ ヒト成長因子と組み合わせた血管形成剤としてのコンパウンドｂの使用
US6962700B1 (en) 2000-09-13 2005-11-08 Atopix Pharmaceuticals Corporation Method of manufacturing immune globulin
ES2359408T3 (es) * 2003-04-16 2011-05-23 Merck Serono Sa Uso de slurp-1 para tratar enfermedades relacionadas con la disfunción de receptores de acetilcolina.
US7343581B2 (en) * 2005-06-27 2008-03-11 Tela Innovations, Inc. Methods for creating primitive constructed standard cells
US7590968B1 (en) 2006-03-01 2009-09-15 Tela Innovations, Inc. Methods for risk-informed chip layout generation
US7943967B2 (en) 2006-03-09 2011-05-17 Tela Innovations, Inc. Semiconductor device and associated layouts including diffusion contact placement restriction based on relation to linear conductive segments
US8245180B2 (en) 2006-03-09 2012-08-14 Tela Innovations, Inc. Methods for defining and using co-optimized nanopatterns for integrated circuit design and apparatus implementing same
US8653857B2 (en) 2006-03-09 2014-02-18 Tela Innovations, Inc. Circuitry and layouts for XOR and XNOR logic
US9009641B2 (en) 2006-03-09 2015-04-14 Tela Innovations, Inc. Circuits with linear finfet structures
US7446352B2 (en) 2006-03-09 2008-11-04 Tela Innovations, Inc. Dynamic array architecture
US8448102B2 (en) 2006-03-09 2013-05-21 Tela Innovations, Inc. Optimizing layout of irregular structures in regular layout context
US8658542B2 (en) 2006-03-09 2014-02-25 Tela Innovations, Inc. Coarse grid design methods and structures
US7956421B2 (en) 2008-03-13 2011-06-07 Tela Innovations, Inc. Cross-coupled transistor layouts in restricted gate level layout architecture
US7932545B2 (en) 2006-03-09 2011-04-26 Tela Innovations, Inc. Semiconductor device and associated layouts including gate electrode level region having arrangement of six linear conductive segments with side-to-side spacing less than 360 nanometers
US7763534B2 (en) 2007-10-26 2010-07-27 Tela Innovations, Inc. Methods, structures and designs for self-aligning local interconnects used in integrated circuits
US9035359B2 (en) 2006-03-09 2015-05-19 Tela Innovations, Inc. Semiconductor chip including region including linear-shaped conductive structures forming gate electrodes and having electrical connection areas arranged relative to inner region between transistors of different types and associated methods
US8839175B2 (en) 2006-03-09 2014-09-16 Tela Innovations, Inc. Scalable meta-data objects
US9563733B2 (en) 2009-05-06 2017-02-07 Tela Innovations, Inc. Cell circuit and layout with linear finfet structures
US8225261B2 (en) 2006-03-09 2012-07-17 Tela Innovations, Inc. Methods for defining contact grid in dynamic array architecture
US8541879B2 (en) 2007-12-13 2013-09-24 Tela Innovations, Inc. Super-self-aligned contacts and method for making the same
US8225239B2 (en) 2006-03-09 2012-07-17 Tela Innovations, Inc. Methods for defining and utilizing sub-resolution features in linear topology
US8247846B2 (en) 2006-03-09 2012-08-21 Tela Innovations, Inc. Oversized contacts and vias in semiconductor chip defined by linearly constrained topology
US9230910B2 (en) 2006-03-09 2016-01-05 Tela Innovations, Inc. Oversized contacts and vias in layout defined by linearly constrained topology
US7586800B1 (en) 2006-08-08 2009-09-08 Tela Innovations, Inc. Memory timing apparatus and associated methods
US8286107B2 (en) 2007-02-20 2012-10-09 Tela Innovations, Inc. Methods and systems for process compensation technique acceleration
US7979829B2 (en) * 2007-02-20 2011-07-12 Tela Innovations, Inc. Integrated circuit cell library with cell-level process compensation technique (PCT) application and associated methods
US7888705B2 (en) 2007-08-02 2011-02-15 Tela Innovations, Inc. Methods for defining dynamic array section with manufacturing assurance halo and apparatus implementing the same
US8667443B2 (en) 2007-03-05 2014-03-04 Tela Innovations, Inc. Integrated circuit cell library for multiple patterning
US9051369B2 (en) * 2007-09-20 2015-06-09 Commonwealth Scientific And Industrial Research Organisation Avian cytokines and genetic sequences encoding same
EP2194126B1 (en) * 2007-10-15 2014-01-15 Chugai Seiyaku Kabushiki Kaisha Method of constructing cells with high productivity of foreign protein
US8453094B2 (en) 2008-01-31 2013-05-28 Tela Innovations, Inc. Enforcement of semiconductor structure regularity for localized transistors and interconnect
US7939443B2 (en) 2008-03-27 2011-05-10 Tela Innovations, Inc. Methods for multi-wire routing and apparatus implementing same
SG10201608214SA (en) 2008-07-16 2016-11-29 Tela Innovations Inc Methods for cell phasing and placement in dynamic array architecture and implementation of the same
US9122832B2 (en) 2008-08-01 2015-09-01 Tela Innovations, Inc. Methods for controlling microloading variation in semiconductor wafer layout and fabrication
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US4359415A (en) * 1981-06-03 1982-11-16 University Of Tennessee Research Corporation Isolation of an antineoplastic protein fraction and an antineoplastic peptide fraction from human urine
US4470970A (en) * 1981-07-02 1984-09-11 Burzynski Stanislaw R Purified antineoplaston fractions and methods of treating neoplastic disease
US5298604A (en) * 1992-07-27 1994-03-29 Sloane Nathan H Parital primary amino acid sequence of the antineoplastic protein (ANUP); a cytokine present in granulocytes

Also Published As

Publication number Publication date
FI953091A (fi) 1995-06-21
AU690093B2 (en) 1998-04-23
ITRM920919A0 (it) 1992-12-22
FI114478B (fi) 2004-10-29
NO952494D0 (no) 1995-06-21
FI20040608A (fi) 2004-04-29
JPH08509359A (ja) 1996-10-08
ES2193152T3 (es) 2003-11-01
NO315800B1 (no) 2003-10-27
RU2177480C2 (ru) 2001-12-27
IL108149A0 (en) 1994-04-12
EP0675956B1 (en) 2003-04-09
EP0675956A1 (en) 1995-10-11
KR950704486A (ko) 1995-11-20
NO952494L (no) 1995-08-21
DE69332861T2 (de) 2004-01-29
FI953091A0 (fi) 1995-06-21
FI116059B (fi) 2005-09-15
US5908827A (en) 1999-06-01
KR100193107B1 (ko) 1999-06-15
JP3025014B2 (ja) 2000-03-27
UA46702C2 (uk) 2002-06-17
DK0675956T3 (da) 2003-07-07
ATE236976T1 (de) 2003-04-15
PT675956E (pt) 2003-07-31
IL108149A (en) 2005-05-17
CA2151156A1 (en) 1994-07-07
DE69332861D1 (de) 2003-05-15
ITRM920919A1 (it) 1994-06-22
WO1994014959A1 (en) 1994-07-07
AU5833594A (en) 1994-07-19
ZA939621B (en) 1995-06-22

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Legal Events

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Effective date: 19961217