FI115630B - Förfarande för framställning av 4-(3-cyanfenyl)-2-trifluormetyl-5-oxo-1,4,5,6,7,8-hexahydrokinolin-3-karboxylsyra - Google Patents

Förfarande för framställning av 4-(3-cyanfenyl)-2-trifluormetyl-5-oxo-1,4,5,6,7,8-hexahydrokinolin-3-karboxylsyra Download PDF

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Publication number
FI115630B
FI115630B FI20040352A FI20040352A FI115630B FI 115630 B FI115630 B FI 115630B FI 20040352 A FI20040352 A FI 20040352A FI 20040352 A FI20040352 A FI 20040352A FI 115630 B FI115630 B FI 115630B
Authority
FI
Finland
Prior art keywords
cyanophenyl
trifluoromethyl
compound
oxo
carboxylic acid
Prior art date
Application number
FI20040352A
Other languages
English (en)
Finnish (fi)
Other versions
FI20040352A (sv
Inventor
Diane Amy Trainor
James Michael Hulsizer
Jr Cyrus John Ohnmacht
John Edward Warawa
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of FI20040352A publication Critical patent/FI20040352A/sv
Application granted granted Critical
Publication of FI115630B publication Critical patent/FI115630B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Claims (4)

1. Förfarande för framställning av 4-(3-cyanfenyl)-2-trifluormetyl-5-oxo-1,4,5,6,7,8-hexahydrokinolin-3-karboxylsyra, kännetecknat därav, 5 att (+)-isobornyl-4-(3-cyanfenyl)-2-trifluormetyl-2-hydroxi-5-oxo-1,2,3,4,5,6,7,8-oktahydrokinolin-3-karboxylat omsätts med p-toluensulfonsyra och i närvaro av ett väsentligen vattenfritt lösningsmedel.
2. Förfarande enligt patentkrav 1, kännetecknat därav, att lösningsmedlet är isättiksyra. 10
3. Förfarande enligt patentkrav 1 eller 2, kännetecknat där av, att reaktionen utfors vid en temperatur av 100 - 104 °C.
4. Förfarande enligt patentkrav 3, kännetecknat därav, att reaktionen utförs vid en temperatur av 102 - 104 °C. f * f · * * · » · * ♦ · > v * *
FI20040352A 1994-04-14 2004-03-04 Förfarande för framställning av 4-(3-cyanfenyl)-2-trifluormetyl-5-oxo-1,4,5,6,7,8-hexahydrokinolin-3-karboxylsyra FI115630B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9407432 1994-04-14
GB9407432A GB9407432D0 (en) 1994-04-14 1994-04-14 Heterocyclic derivative
PCT/GB1995/000845 WO1995028388A1 (en) 1994-04-14 1995-04-13 Quinolone derivative for treatment of urinary incontinence
GB9500845 1995-04-13

Publications (2)

Publication Number Publication Date
FI20040352A FI20040352A (sv) 2004-03-04
FI115630B true FI115630B (sv) 2005-06-15

Family

ID=10753541

Family Applications (2)

Application Number Title Priority Date Filing Date
FI964019A FI114705B (sv) 1994-04-14 1996-10-07 Kinolonderivat för behandling av urininkontinens
FI20040352A FI115630B (sv) 1994-04-14 2004-03-04 Förfarande för framställning av 4-(3-cyanfenyl)-2-trifluormetyl-5-oxo-1,4,5,6,7,8-hexahydrokinolin-3-karboxylsyra

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI964019A FI114705B (sv) 1994-04-14 1996-10-07 Kinolonderivat för behandling av urininkontinens

Country Status (25)

Country Link
EP (1) EP0755382B1 (sv)
JP (1) JP3782445B2 (sv)
KR (1) KR100344885B1 (sv)
CN (1) CN1058708C (sv)
AT (1) ATE202089T1 (sv)
AU (1) AU700773B2 (sv)
BR (1) BR9507366A (sv)
CA (1) CA2187525C (sv)
CZ (1) CZ284652B6 (sv)
DE (1) DE69521310T2 (sv)
DK (1) DK0755382T3 (sv)
ES (1) ES2159633T3 (sv)
FI (2) FI114705B (sv)
GB (1) GB9407432D0 (sv)
GR (1) GR3036482T3 (sv)
HK (1) HK1013999A1 (sv)
HU (1) HU215387B (sv)
MX (1) MX9603920A (sv)
NO (1) NO307177B1 (sv)
NZ (1) NZ283779A (sv)
PL (2) PL183095B1 (sv)
PT (1) PT755382E (sv)
RU (1) RU2149870C1 (sv)
SK (1) SK281124B6 (sv)
WO (1) WO1995028388A1 (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2292462T3 (es) * 1999-08-03 2008-03-16 Abbott Laboratories Agentes abridores de los canales del potasio.
US7074931B2 (en) 2000-08-02 2006-07-11 Astrazeneca Ab Process for asymmetric synthesis of substituted 1,4 -dihydropyridines
SE0200205D0 (sv) * 2002-01-24 2002-01-24 Astrazeneca Ab Method
CN102532015B (zh) * 2012-01-18 2013-10-23 云南大学 香豆素及其类似物的固相合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2003148A1 (de) * 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
GB9220570D0 (en) * 1991-10-21 1992-11-11 Ici Plc Therapeutic agent
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives

Also Published As

Publication number Publication date
AU700773B2 (en) 1999-01-14
NO307177B1 (no) 2000-02-21
FI20040352A (sv) 2004-03-04
DK0755382T3 (da) 2001-09-10
FI964019A0 (sv) 1996-10-07
SK131796A3 (en) 1997-05-07
CN1058708C (zh) 2000-11-22
JPH09512254A (ja) 1997-12-09
ATE202089T1 (de) 2001-06-15
PL183095B1 (pl) 2002-05-31
PL316790A1 (en) 1997-02-17
FI114705B (sv) 2004-12-15
RU2149870C1 (ru) 2000-05-27
EP0755382A1 (en) 1997-01-29
AU2219995A (en) 1995-11-10
PL182031B1 (pl) 2001-10-31
GR3036482T3 (en) 2001-11-30
HU9602747D0 (en) 1996-11-28
JP3782445B2 (ja) 2006-06-07
WO1995028388A1 (en) 1995-10-26
DE69521310T2 (de) 2002-04-18
KR100344885B1 (ko) 2002-11-30
NZ283779A (en) 1998-02-26
GB9407432D0 (en) 1994-06-08
HUT76132A (en) 1997-06-30
PT755382E (pt) 2001-11-30
MX9603920A (es) 1997-04-30
EP0755382B1 (en) 2001-06-13
ES2159633T3 (es) 2001-10-16
DE69521310D1 (de) 2001-07-19
NO964345D0 (no) 1996-10-11
CA2187525C (en) 2006-01-24
FI964019A (sv) 1996-10-07
SK281124B6 (sk) 2000-12-11
CZ298196A3 (en) 1997-02-12
HK1013999A1 (en) 1999-09-17
HU215387B (hu) 1998-12-28
BR9507366A (pt) 1997-09-23
NO964345L (no) 1996-12-11
CZ284652B6 (cs) 1999-01-13
CA2187525A1 (en) 1995-10-26
CN1146202A (zh) 1997-03-26

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