FI113865B - Menetelmä 2-aryylisubstituoidut-4-hydroksi-1,2,5,10-tetrahydropyridatsino[4,5-b]-kinoliini-1,10-dionijohdannaisten valmistamiseksi, jotka ovat terapeuttisesti käyttökelpoisia aivojen iskeemisten sairauksien hoidossa - Google Patents
Menetelmä 2-aryylisubstituoidut-4-hydroksi-1,2,5,10-tetrahydropyridatsino[4,5-b]-kinoliini-1,10-dionijohdannaisten valmistamiseksi, jotka ovat terapeuttisesti käyttökelpoisia aivojen iskeemisten sairauksien hoidossaInfo
- Publication number
- FI113865B FI113865B FI961696A FI961696A FI113865B FI 113865 B FI113865 B FI 113865B FI 961696 A FI961696 A FI 961696A FI 961696 A FI961696 A FI 961696A FI 113865 B FI113865 B FI 113865B
- Authority
- FI
- Finland
- Prior art keywords
- phenyl
- quinoline
- deriv
- tetrahydropyridazino
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI970907A FI114916B (fi) | 1993-10-22 | 1997-03-03 | Menetelmä 2-aryylisubstituoidut-4-hydroksi-1,2,5,10-tetrahydropyridatsino- [4,5-b]kinoliini-1,10-dionijohdannaisten valmistamiseksi, jotka ovat terapeuttisesti käyttökelpoisia aivojen iskeemisten sairauksien hoidossa |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939321854A GB9321854D0 (en) | 1993-10-22 | 1993-10-22 | Pyridazino quinoline compounds |
| GB9417171A GB9417171D0 (en) | 1994-08-25 | 1994-08-25 | Pyridazino quinoline compounds |
| PCT/GB1994/002295 WO1995011244A1 (en) | 1993-10-22 | 1994-10-20 | Pyridazino quinoline compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI961696A FI961696A (fi) | 1996-04-18 |
| FI961696A0 FI961696A0 (fi) | 1996-04-18 |
| FI113865B true FI113865B (fi) | 2004-06-30 |
Family
ID=26303731
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI961696A FI113865B (fi) | 1993-10-22 | 1996-04-18 | Menetelmä 2-aryylisubstituoidut-4-hydroksi-1,2,5,10-tetrahydropyridatsino[4,5-b]-kinoliini-1,10-dionijohdannaisten valmistamiseksi, jotka ovat terapeuttisesti käyttökelpoisia aivojen iskeemisten sairauksien hoidossa |
| FI970907A FI114916B (fi) | 1993-10-22 | 1997-03-03 | Menetelmä 2-aryylisubstituoidut-4-hydroksi-1,2,5,10-tetrahydropyridatsino- [4,5-b]kinoliini-1,10-dionijohdannaisten valmistamiseksi, jotka ovat terapeuttisesti käyttökelpoisia aivojen iskeemisten sairauksien hoidossa |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI970907A FI114916B (fi) | 1993-10-22 | 1997-03-03 | Menetelmä 2-aryylisubstituoidut-4-hydroksi-1,2,5,10-tetrahydropyridatsino- [4,5-b]kinoliini-1,10-dionijohdannaisten valmistamiseksi, jotka ovat terapeuttisesti käyttökelpoisia aivojen iskeemisten sairauksien hoidossa |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US5744471A (fi) |
| EP (2) | EP0724583B1 (fi) |
| JP (1) | JP3583132B2 (fi) |
| KR (1) | KR100261209B1 (fi) |
| CN (1) | CN1053189C (fi) |
| AT (2) | ATE198072T1 (fi) |
| AU (2) | AU688393B2 (fi) |
| CA (1) | CA2171332A1 (fi) |
| CZ (1) | CZ292311B6 (fi) |
| DE (2) | DE69426422T2 (fi) |
| DK (2) | DK1004582T3 (fi) |
| ES (2) | ES2241513T3 (fi) |
| FI (2) | FI113865B (fi) |
| GB (1) | GB9420590D0 (fi) |
| GR (1) | GR3035080T3 (fi) |
| HK (1) | HK1013997A1 (fi) |
| HU (1) | HUT74161A (fi) |
| IL (1) | IL111266A (fi) |
| MY (2) | MY132875A (fi) |
| NO (1) | NO306995B1 (fi) |
| NZ (2) | NZ329303A (fi) |
| PL (1) | PL180679B1 (fi) |
| PT (2) | PT724583E (fi) |
| RU (1) | RU2168511C2 (fi) |
| SG (2) | SG59971A1 (fi) |
| SI (2) | SI0724583T1 (fi) |
| SK (1) | SK282491B6 (fi) |
| TW (1) | TW406082B (fi) |
| UA (1) | UA60291C2 (fi) |
| WO (1) | WO1995011244A1 (fi) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9420590D0 (en) * | 1993-10-22 | 1994-11-30 | Zeneca Ltd | Pyridazino quinoline compounds |
| US6214826B1 (en) | 1994-11-12 | 2001-04-10 | Zeneca Limited | Pyridazino quinoline compounds |
| GB9422894D0 (en) * | 1994-11-12 | 1995-01-04 | Zeneca Ltd | Pyridazino quinoline compounds |
| GB9507318D0 (en) * | 1995-04-07 | 1995-05-31 | Zeneca Ltd | Alpha substituted pyridazino quinoline compounds |
| JP2003519146A (ja) * | 1999-12-23 | 2003-06-17 | アストラゼネカ・アクチエボラーグ | 痛みの処置のための方法および組成物 |
| AU2566201A (en) * | 1999-12-23 | 2001-07-09 | Astrazeneca Ab | Compounds and methods for the treatment of pain |
| US20050124622A1 (en) * | 1999-12-23 | 2005-06-09 | Brown Dean G. | Compounds and methods for the treatment of pain |
| EP1244453A1 (en) * | 1999-12-23 | 2002-10-02 | AstraZeneca AB | Method and composition for the treatment of pain |
| US6943165B2 (en) * | 1999-12-23 | 2005-09-13 | Astrazeneca Ab | Compound and method for the treatment of pain |
| US20030176435A1 (en) * | 2002-12-17 | 2003-09-18 | Brown Dean Gordon | Compounds and methods for the treatment of pain |
| US6787547B2 (en) | 1999-12-23 | 2004-09-07 | Astrazeneca Ab | Compound and method for the treatment of pain |
| US6730675B2 (en) | 1999-12-23 | 2004-05-04 | Astrazeneca Ab | Compounds and methods for the treatment of pain |
| EP1248621A1 (en) * | 1999-12-23 | 2002-10-16 | AstraZeneca AB | Method and composition for the treatment of pain |
| SI1244662T1 (fi) * | 1999-12-23 | 2005-08-31 | Astrazeneca Ab | |
| DE60013326T2 (de) * | 1999-12-23 | 2005-09-08 | Astrazeneca Ab | Verbindungen und verfahren zur behandlung von schmerz |
| BR0016654A (pt) * | 1999-12-23 | 2002-09-03 | Astrazeneca Ab | Composto, método para o tratamento da dor, e, composição farmacêutica |
| US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
| WO2002026739A1 (en) * | 2000-09-29 | 2002-04-04 | Astrazeneca Ab | 1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain |
| WO2002026741A1 (en) * | 2000-09-29 | 2002-04-04 | Astrazeneca Ab | 1,2,5,10-TETRAHYDROPYRIDAZINO[4,5-b]QUINOLINE-1,10-DIONES AND THEIR USE FOR THE TREATMENT OF PAIN |
| EP1325002B1 (en) | 2000-09-29 | 2006-05-24 | AstraZeneca AB | 1,2,5,10-tetrahydropyridazino¬4,5-b|quinoline-1,10-diones and their use for the treatment of pain |
| DE60121978D1 (de) * | 2000-09-29 | 2006-09-14 | Astrazeneca Ab | 7-CHLOR-4-HYDROXY-2-(2-PYRIDYLETHYL)-1,2,5,10-TETRAHYDROPYRIDAZINOi4,5-BöCHINOLIN-1,10-DIONE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON SCHMERZEN |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| WO2002096879A1 (en) | 2001-05-31 | 2002-12-05 | Sanofi-Synthelabo | Aminoquinoline and aminopyridine derivatives and their use as adenosine a3 ligands |
| US8592421B2 (en) | 2003-08-04 | 2013-11-26 | Valery Khazhmuratovich Zhilov | Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon |
| HUE032540T2 (en) | 2004-06-24 | 2017-09-28 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| CA2634113A1 (en) * | 2005-12-24 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Quinolin- 4 - one derivatives as modulators of abc transporters |
| PL1993360T3 (pl) * | 2005-12-28 | 2017-08-31 | Vertex Pharmaceuticals Incorporated | Stałe postacie n-[2,4-bis(1,1-dimetyloetylo)-5-hydroksyfenylo]-1,4- dihydro-4-oksochinolino-3-karboksyamidu |
| WO2010108162A1 (en) | 2009-03-20 | 2010-09-23 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| US20130224293A1 (en) | 2012-02-27 | 2013-08-29 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| JP6746569B2 (ja) | 2014-10-07 | 2020-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9109972D0 (en) * | 1991-05-09 | 1991-07-03 | Ici Plc | Therapeutic compounds |
| GB9208511D0 (en) * | 1991-05-09 | 1992-06-03 | Ici Plc | Compounds |
| GB9420590D0 (en) * | 1993-10-22 | 1994-11-30 | Zeneca Ltd | Pyridazino quinoline compounds |
| GB9422894D0 (en) * | 1994-11-12 | 1995-01-04 | Zeneca Ltd | Pyridazino quinoline compounds |
| GB9507318D0 (en) * | 1995-04-07 | 1995-05-31 | Zeneca Ltd | Alpha substituted pyridazino quinoline compounds |
-
1994
- 1994-10-12 GB GB9420590A patent/GB9420590D0/en active Pending
- 1994-10-12 IL IL11126694A patent/IL111266A/xx not_active IP Right Cessation
- 1994-10-20 PL PL94314041A patent/PL180679B1/pl not_active IP Right Cessation
- 1994-10-20 DE DE69426422T patent/DE69426422T2/de not_active Expired - Fee Related
- 1994-10-20 PT PT94930275T patent/PT724583E/pt unknown
- 1994-10-20 MY MYPI98002508A patent/MY132875A/en unknown
- 1994-10-20 RU RU96109470/04A patent/RU2168511C2/ru not_active IP Right Cessation
- 1994-10-20 SG SG1996007261A patent/SG59971A1/en unknown
- 1994-10-20 CA CA002171332A patent/CA2171332A1/en not_active Abandoned
- 1994-10-20 WO PCT/GB1994/002295 patent/WO1995011244A1/en active IP Right Grant
- 1994-10-20 KR KR1019960702011A patent/KR100261209B1/ko not_active IP Right Cessation
- 1994-10-20 MY MYPI94002796A patent/MY124316A/en unknown
- 1994-10-20 CZ CZ19961138A patent/CZ292311B6/cs not_active IP Right Cessation
- 1994-10-20 AT AT94930275T patent/ATE198072T1/de not_active IP Right Cessation
- 1994-10-20 ES ES00101917T patent/ES2241513T3/es not_active Expired - Lifetime
- 1994-10-20 DE DE69434380T patent/DE69434380T2/de not_active Expired - Fee Related
- 1994-10-20 NZ NZ329303A patent/NZ329303A/xx not_active IP Right Cessation
- 1994-10-20 ES ES94930275T patent/ES2154686T3/es not_active Expired - Lifetime
- 1994-10-20 HU HU9600889A patent/HUT74161A/hu unknown
- 1994-10-20 PT PT00101917T patent/PT1004582E/pt unknown
- 1994-10-20 JP JP51152195A patent/JP3583132B2/ja not_active Expired - Fee Related
- 1994-10-20 EP EP94930275A patent/EP0724583B1/en not_active Expired - Lifetime
- 1994-10-20 SI SI9430314T patent/SI0724583T1/xx unknown
- 1994-10-20 DK DK00101917T patent/DK1004582T3/da active
- 1994-10-20 SK SK504-96A patent/SK282491B6/sk not_active IP Right Cessation
- 1994-10-20 SG SG9900943A patent/SG92630A1/en unknown
- 1994-10-20 AT AT00101917T patent/ATE295846T1/de not_active IP Right Cessation
- 1994-10-20 EP EP00101917A patent/EP1004582B1/en not_active Expired - Lifetime
- 1994-10-20 UA UA96041567A patent/UA60291C2/uk unknown
- 1994-10-20 DK DK94930275T patent/DK0724583T3/da active
- 1994-10-20 CN CN94194578A patent/CN1053189C/zh not_active Expired - Fee Related
- 1994-10-20 US US08/637,641 patent/US5744471A/en not_active Expired - Fee Related
- 1994-10-20 SI SI9430476T patent/SI1004582T1/xx unknown
- 1994-10-20 NZ NZ275472A patent/NZ275472A/en not_active IP Right Cessation
- 1994-10-20 AU AU79440/94A patent/AU688393B2/en not_active Ceased
- 1994-11-18 TW TW083110721A patent/TW406082B/zh not_active IP Right Cessation
-
1996
- 1996-04-18 FI FI961696A patent/FI113865B/fi active
- 1996-04-19 NO NO961584A patent/NO306995B1/no not_active IP Right Cessation
-
1997
- 1997-03-03 FI FI970907A patent/FI114916B/fi active IP Right Grant
-
1998
- 1998-03-19 US US09/044,109 patent/US6232313B1/en not_active Expired - Fee Related
- 1998-05-27 AU AU68999/98A patent/AU721139B2/en not_active Ceased
- 1998-12-24 HK HK98115415A patent/HK1013997A1/xx not_active IP Right Cessation
-
1999
- 1999-12-06 US US09/455,096 patent/US6103721A/en not_active Expired - Fee Related
-
2000
- 2000-12-14 GR GR20000402690T patent/GR3035080T3/el not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI113865B (fi) | Menetelmä 2-aryylisubstituoidut-4-hydroksi-1,2,5,10-tetrahydropyridatsino[4,5-b]-kinoliini-1,10-dionijohdannaisten valmistamiseksi, jotka ovat terapeuttisesti käyttökelpoisia aivojen iskeemisten sairauksien hoidossa | |
| BR9707495A (pt) | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente | |
| EA199901014A1 (ru) | C-4"-замещенные макролидные производные | |
| TNSN87015A1 (fr) | Nouvelles n-heterocyclyl-4-piperidinamines, compositions contenant des n-heterocyclyl-4-piperidinamines, procede de traitement les utilisant et procede pour preparer des n-heterocyclyl-4- piperidinamines | |
| KR920701165A (ko) | 골수세포형성 촉진에 유용한 헤테로아릴-3-옥소-프로판니트릴 유도체 | |
| DE60216610D1 (de) | Verwendung von kondensierten Pyrazolverbindungen für die Herstellung eines Arzneimittels zur Behandlung von Bluthochdruck | |
| SE9904177D0 (sv) | Novel compounds | |
| ATE404558T1 (de) | Antimikrobielle 4-oxochinolizinverbindungen, die als teilstruktur ein 2-pyridonskelett aufweisen | |
| ZA928684B (en) | Benzimidazole anthelmintic agents |