FI113865B - Förfarande för framställning av 2-arylsubstituerade-4-hydroxi-1,2,5,10-tetrahydropyridazino[4,5-b]-kinolin-1,10-dionderivat, som är terapeutiskt användbara vid vård av iskemiska sjukdomar i hjärnan - Google Patents

Förfarande för framställning av 2-arylsubstituerade-4-hydroxi-1,2,5,10-tetrahydropyridazino[4,5-b]-kinolin-1,10-dionderivat, som är terapeutiskt användbara vid vård av iskemiska sjukdomar i hjärnan

Info

Publication number
FI113865B
FI113865B FI961696A FI961696A FI113865B FI 113865 B FI113865 B FI 113865B FI 961696 A FI961696 A FI 961696A FI 961696 A FI961696 A FI 961696A FI 113865 B FI113865 B FI 113865B
Authority
FI
Finland
Prior art keywords
phenyl
quinoline
deriv
tetrahydropyridazino
aryl
Prior art date
Application number
FI961696A
Other languages
English (en)
Finnish (fi)
Other versions
FI961696A0 (sv
FI961696A (sv
Inventor
Thomas Michael Bare
Richard Bruce Sparks
James Roy Empfield
Timothy Wayne Davenport
Jeffrey Alan Mckinney
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939321854A external-priority patent/GB9321854D0/en
Priority claimed from GB9417171A external-priority patent/GB9417171D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of FI961696A0 publication Critical patent/FI961696A0/sv
Publication of FI961696A publication Critical patent/FI961696A/sv
Priority to FI970907A priority Critical patent/FI114916B/sv
Application granted granted Critical
Publication of FI113865B publication Critical patent/FI113865B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI961696A 1993-10-22 1996-04-18 Förfarande för framställning av 2-arylsubstituerade-4-hydroxi-1,2,5,10-tetrahydropyridazino[4,5-b]-kinolin-1,10-dionderivat, som är terapeutiskt användbara vid vård av iskemiska sjukdomar i hjärnan FI113865B (sv)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI970907A FI114916B (sv) 1993-10-22 1997-03-03 Förfarande för framställning av 2-aryl-substituerade-4-hydroxi-1,2,5,10-tetrahydropyridazino [4,5-b] kinolin-1,10-dionderivat, som är terapeutiskt användbara vid vård av iskemiska sjukdomar i hjärnan

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939321854A GB9321854D0 (en) 1993-10-22 1993-10-22 Pyridazino quinoline compounds
GB9417171A GB9417171D0 (en) 1994-08-25 1994-08-25 Pyridazino quinoline compounds
PCT/GB1994/002295 WO1995011244A1 (en) 1993-10-22 1994-10-20 Pyridazino quinoline compounds

Publications (3)

Publication Number Publication Date
FI961696A0 FI961696A0 (sv) 1996-04-18
FI961696A FI961696A (sv) 1996-04-18
FI113865B true FI113865B (sv) 2004-06-30

Family

ID=26303731

Family Applications (2)

Application Number Title Priority Date Filing Date
FI961696A FI113865B (sv) 1993-10-22 1996-04-18 Förfarande för framställning av 2-arylsubstituerade-4-hydroxi-1,2,5,10-tetrahydropyridazino[4,5-b]-kinolin-1,10-dionderivat, som är terapeutiskt användbara vid vård av iskemiska sjukdomar i hjärnan
FI970907A FI114916B (sv) 1993-10-22 1997-03-03 Förfarande för framställning av 2-aryl-substituerade-4-hydroxi-1,2,5,10-tetrahydropyridazino [4,5-b] kinolin-1,10-dionderivat, som är terapeutiskt användbara vid vård av iskemiska sjukdomar i hjärnan

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI970907A FI114916B (sv) 1993-10-22 1997-03-03 Förfarande för framställning av 2-aryl-substituerade-4-hydroxi-1,2,5,10-tetrahydropyridazino [4,5-b] kinolin-1,10-dionderivat, som är terapeutiskt användbara vid vård av iskemiska sjukdomar i hjärnan

Country Status (30)

Country Link
US (3) US5744471A (sv)
EP (2) EP1004582B1 (sv)
JP (1) JP3583132B2 (sv)
KR (1) KR100261209B1 (sv)
CN (1) CN1053189C (sv)
AT (2) ATE295846T1 (sv)
AU (2) AU688393B2 (sv)
CA (1) CA2171332A1 (sv)
CZ (1) CZ292311B6 (sv)
DE (2) DE69426422T2 (sv)
DK (2) DK0724583T3 (sv)
ES (2) ES2154686T3 (sv)
FI (2) FI113865B (sv)
GB (1) GB9420590D0 (sv)
GR (1) GR3035080T3 (sv)
HK (1) HK1013997A1 (sv)
HU (1) HUT74161A (sv)
IL (1) IL111266A (sv)
MY (2) MY132875A (sv)
NO (1) NO306995B1 (sv)
NZ (2) NZ329303A (sv)
PL (1) PL180679B1 (sv)
PT (2) PT724583E (sv)
RU (1) RU2168511C2 (sv)
SG (2) SG92630A1 (sv)
SI (2) SI0724583T1 (sv)
SK (1) SK282491B6 (sv)
TW (1) TW406082B (sv)
UA (1) UA60291C2 (sv)
WO (1) WO1995011244A1 (sv)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111266A (en) * 1993-10-22 2002-03-10 Zeneca Ltd 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US6214826B1 (en) 1994-11-12 2001-04-10 Zeneca Limited Pyridazino quinoline compounds
GB9422894D0 (en) * 1994-11-12 1995-01-04 Zeneca Ltd Pyridazino quinoline compounds
GB9507318D0 (en) * 1995-04-07 1995-05-31 Zeneca Ltd Alpha substituted pyridazino quinoline compounds
AU2420101A (en) * 1999-12-23 2001-07-09 Astrazeneca Ab Method and composition for the treatment of pain
US6943165B2 (en) * 1999-12-23 2005-09-13 Astrazeneca Ab Compound and method for the treatment of pain
US6787547B2 (en) 1999-12-23 2004-09-07 Astrazeneca Ab Compound and method for the treatment of pain
IL150208A0 (en) * 1999-12-23 2002-12-01 Astrazeneca Ab Compound and method for the treatment of pain
US20030176435A1 (en) * 2002-12-17 2003-09-18 Brown Dean Gordon Compounds and methods for the treatment of pain
US20050124622A1 (en) * 1999-12-23 2005-06-09 Brown Dean G. Compounds and methods for the treatment of pain
US6730675B2 (en) 1999-12-23 2004-05-04 Astrazeneca Ab Compounds and methods for the treatment of pain
WO2001047925A1 (en) * 1999-12-23 2001-07-05 Astrazeneca Ab Compounds and methods for the treatment of pain
EP1577311A1 (en) * 1999-12-23 2005-09-21 AstraZeneca AB Salts of a pyridazino aquinoline derivative and use for the treatment of pain
AU2420001A (en) * 1999-12-23 2001-07-09 Astrazeneca Ab Methods and compositions for the treatment of pain
JP2003519145A (ja) * 1999-12-23 2003-06-17 アストラゼネカ・アクチエボラーグ 痛みの処置のための化合物および方法
BR0016646A (pt) * 1999-12-23 2002-10-08 Astrazeneca Ab Método para tratar um paciente que sofre de dor, e, composição farmacêutica
US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
US6833368B2 (en) 2000-09-29 2004-12-21 Astrazeneca Ab 1, 2, 5, 10-tetrahydropyridazino[4, 5-b]quinoline-1,10-diones and their use for the treatment of pain
EP1325005A1 (en) * 2000-09-29 2003-07-09 AstraZeneca AB 1,2,5,10-tetrahydropyridazino 4,5-b]quinoline-1,10-diones and their use for the treatment of pain
US6933297B2 (en) 2000-09-29 2005-08-23 Astrazeneca Ab 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione and the use thereof for the treatment of pain
AU2001292500A1 (en) * 2000-09-29 2002-04-08 Astrazeneca Ab 1,2,5,10-tetrahydropyridazino(4,5-b)quinoline-1,10-diones and their use for the treatment of pain
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
AU2002304358B2 (en) * 2001-05-31 2007-08-23 Sanofi-Aventis Aminoquinoline and aminopyridine derivatives and their use as adenosine A3 ligands
WO2005012309A1 (en) * 2003-08-04 2005-02-10 Valery Khazhmuratovich Zhilov Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon
US8354427B2 (en) * 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
ES2656017T3 (es) 2004-06-24 2018-02-22 Vertex Pharmaceuticals Incorporated Moduladores de transportadores del casete de unión a ATP
JP2009521468A (ja) * 2005-12-24 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｂｃ輸送体の調節因子としてのキノリン−４−オン誘導体
PL1993360T3 (pl) 2005-12-28 2017-08-31 Vertex Pharmaceuticals Incorporated Stałe postacie n-[2,4-bis(1,1-dimetyloetylo)-5-hydroksyfenylo]-1,4- dihydro-4-oksochinolino-3-karboksyamidu
PL2408750T3 (pl) 2009-03-20 2016-02-29 Vertex Pharma Sposób otrzymywania modulatorów błonowego regulatora przewodnictwa swoistego dla mukowiscydozy
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CA2865519C (en) 2012-02-27 2018-01-02 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl0-5-hydroxyphenyl-1]-1,4-dihydro-4-oxoquinolone-3-carboxamide for treating cystic fibrosis
EP3204358B1 (en) 2014-10-07 2018-09-19 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9109972D0 (en) * 1991-05-09 1991-07-03 Ici Plc Therapeutic compounds
GB9208511D0 (en) * 1991-05-09 1992-06-03 Ici Plc Compounds
IL111266A (en) * 1993-10-22 2002-03-10 Zeneca Ltd 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9422894D0 (en) * 1994-11-12 1995-01-04 Zeneca Ltd Pyridazino quinoline compounds
GB9507318D0 (en) * 1995-04-07 1995-05-31 Zeneca Ltd Alpha substituted pyridazino quinoline compounds

Also Published As

Publication number Publication date
NZ329303A (en) 2000-01-28
MY124316A (en) 2006-06-30
US6103721A (en) 2000-08-15
US6232313B1 (en) 2001-05-15
CZ292311B6 (cs) 2003-09-17
FI970907A (sv) 1997-03-03
CA2171332A1 (en) 1995-04-27
HUT74161A (en) 1996-11-28
SK282491B6 (sk) 2002-02-05
FI961696A0 (sv) 1996-04-18
NO961584D0 (no) 1996-04-19
UA60291C2 (uk) 2003-10-15
PL180679B1 (en) 2001-03-30
EP1004582A3 (en) 2000-08-30
FI114916B (sv) 2005-01-31
JP3583132B2 (ja) 2004-10-27
IL111266A (en) 2002-03-10
GB9420590D0 (en) 1994-11-30
US5744471A (en) 1998-04-28
PL314041A1 (en) 1996-08-05
CN1138332A (zh) 1996-12-18
DE69426422T2 (de) 2001-05-10
ATE198072T1 (de) 2000-12-15
SG92630A1 (en) 2002-11-19
EP1004582B1 (en) 2005-05-18
MY132875A (en) 2007-10-31
EP0724583A1 (en) 1996-08-07
ATE295846T1 (de) 2005-06-15
RU2168511C2 (ru) 2001-06-10
FI961696A (sv) 1996-04-18
WO1995011244A1 (en) 1995-04-27
FI970907A0 (sv) 1997-03-03
EP1004582A2 (en) 2000-05-31
NZ275472A (en) 1998-03-25
PT724583E (pt) 2001-03-30
SG59971A1 (en) 1999-02-22
KR100261209B1 (ko) 2000-09-01
PT1004582E (pt) 2005-09-30
TW406082B (en) 2000-09-21
DE69434380D1 (de) 2005-06-23
AU721139B2 (en) 2000-06-22
EP0724583B1 (en) 2000-12-13
NO306995B1 (no) 2000-01-24
NO961584L (no) 1996-04-19
SI0724583T1 (en) 2001-04-30
ES2241513T3 (es) 2005-11-01
CN1053189C (zh) 2000-06-07
JPH09504519A (ja) 1997-05-06
HU9600889D0 (en) 1996-06-28
ES2154686T3 (es) 2001-04-16
DE69426422D1 (de) 2001-01-18
AU7944094A (en) 1995-05-08
DK0724583T3 (da) 2001-03-05
GR3035080T3 (en) 2001-03-30
DK1004582T3 (da) 2005-08-15
DE69434380T2 (de) 2006-05-04
SK50496A3 (en) 1997-03-05
IL111266A0 (en) 1994-12-29
HK1013997A1 (en) 1999-09-17
AU688393B2 (en) 1998-03-12
CZ113896A3 (en) 1996-09-11
SI1004582T1 (sv) 2005-08-31
AU6899998A (en) 1998-07-30

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