IL111266A - 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
IL111266A
IL111266A IL11126694A IL11126694A IL111266A IL 111266 A IL111266 A IL 111266A IL 11126694 A IL11126694 A IL 11126694A IL 11126694 A IL11126694 A IL 11126694A IL 111266 A IL111266 A IL 111266A
Authority
IL
Israel
Prior art keywords
phenyl
deriv
quinoline
heteroaryl
arylpyridazino
Prior art date
Application number
IL11126694A
Other languages
English (en)
Other versions
IL111266A0 (en
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939321854A external-priority patent/GB9321854D0/en
Priority claimed from GB9417171A external-priority patent/GB9417171D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of IL111266A0 publication Critical patent/IL111266A0/xx
Publication of IL111266A publication Critical patent/IL111266A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
IL11126694A 1993-10-22 1994-10-12 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM IL111266A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939321854A GB9321854D0 (en) 1993-10-22 1993-10-22 Pyridazino quinoline compounds
GB9417171A GB9417171D0 (en) 1994-08-25 1994-08-25 Pyridazino quinoline compounds

Publications (2)

Publication Number Publication Date
IL111266A0 IL111266A0 (en) 1994-12-29
IL111266A true IL111266A (en) 2002-03-10

Family

ID=26303731

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11126694A IL111266A (en) 1993-10-22 1994-10-12 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (30)

Country Link
US (3) US5744471A (xx)
EP (2) EP0724583B1 (xx)
JP (1) JP3583132B2 (xx)
KR (1) KR100261209B1 (xx)
CN (1) CN1053189C (xx)
AT (2) ATE198072T1 (xx)
AU (2) AU688393B2 (xx)
CA (1) CA2171332A1 (xx)
CZ (1) CZ292311B6 (xx)
DE (2) DE69426422T2 (xx)
DK (2) DK1004582T3 (xx)
ES (2) ES2241513T3 (xx)
FI (2) FI113865B (xx)
GB (1) GB9420590D0 (xx)
GR (1) GR3035080T3 (xx)
HK (1) HK1013997A1 (xx)
HU (1) HUT74161A (xx)
IL (1) IL111266A (xx)
MY (2) MY124316A (xx)
NO (1) NO306995B1 (xx)
NZ (2) NZ329303A (xx)
PL (1) PL180679B1 (xx)
PT (2) PT1004582E (xx)
RU (1) RU2168511C2 (xx)
SG (2) SG59971A1 (xx)
SI (2) SI0724583T1 (xx)
SK (1) SK282491B6 (xx)
TW (1) TW406082B (xx)
UA (1) UA60291C2 (xx)
WO (1) WO1995011244A1 (xx)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111266A (en) * 1993-10-22 2002-03-10 Zeneca Ltd 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9422894D0 (en) * 1994-11-12 1995-01-04 Zeneca Ltd Pyridazino quinoline compounds
US6214826B1 (en) 1994-11-12 2001-04-10 Zeneca Limited Pyridazino quinoline compounds
GB9507318D0 (en) 1995-04-07 1995-05-31 Zeneca Ltd Alpha substituted pyridazino quinoline compounds
US6787547B2 (en) 1999-12-23 2004-09-07 Astrazeneca Ab Compound and method for the treatment of pain
US6943165B2 (en) * 1999-12-23 2005-09-13 Astrazeneca Ab Compound and method for the treatment of pain
US20030181449A1 (en) * 1999-12-23 2003-09-25 Urbanek Rebecca Ann Methods and compositions for the treatment of pain
AU2420201A (en) * 1999-12-23 2001-07-09 Astrazeneca Ab Compounds and methods for the treatment of pain
WO2001047925A1 (en) * 1999-12-23 2001-07-05 Astrazeneca Ab Compounds and methods for the treatment of pain
SI1244662T1 (xx) * 1999-12-23 2005-08-31 Astrazeneca Ab
NZ519389A (en) * 1999-12-23 2004-05-28 Astrazeneca Ab Method and composition for the treatment of pain
JP2003519145A (ja) * 1999-12-23 2003-06-17 アストラゼネカ・アクチエボラーグ 痛みの処置のための化合物および方法
WO2001047524A1 (en) * 1999-12-23 2001-07-05 Astrazeneca Ab Method and composition for the treatment of pain
US6730675B2 (en) 1999-12-23 2004-05-04 Astrazeneca Ab Compounds and methods for the treatment of pain
EE200200350A (et) * 1999-12-23 2003-10-15 Astrazeneca Ab Ühend ja meetod valu raviks
US20030176435A1 (en) * 2002-12-17 2003-09-18 Brown Dean Gordon Compounds and methods for the treatment of pain
US6403818B1 (en) 2000-02-28 2002-06-11 Eisai Co., Ltd. Process for producing α-hydroxy-carbonyl compound
AU2001292500A1 (en) 2000-09-29 2002-04-08 Astrazeneca Ab 1,2,5,10-tetrahydropyridazino(4,5-b)quinoline-1,10-diones and their use for the treatment of pain
AU2001292499A1 (en) * 2000-09-29 2002-04-08 Astrazeneca Ab 7-chloro-4-hydroxy-2-(2-pyridylethyl)-1,2,5,10- tetrahydropyridazino(4,5-b)quinoline-1,10-dione and the use thereof for the treatment of pain
US20050070544A1 (en) * 2000-09-29 2005-03-31 Astrazeneca Ab 1,2,5,10-tetrahydropyridazino{4,5-b}quinoline-1,10-diones and their use for the treatment of pain
ATE327235T1 (de) * 2000-09-29 2006-06-15 Astrazeneca Ab 1,2,5,10-tetrahydropyridazino 4,5-böchinolin-1, 0-dione und ihre anwendung in der behandlung von schmerzen
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
RS95003A (xx) * 2001-05-31 2007-02-05 Sanofi-Aventis, Derivati aminohinolina i aminopiridina i njihova upotreba kao liganada adenozinskih a3 receptora
WO2005012309A1 (en) * 2003-08-04 2005-02-10 Valery Khazhmuratovich Zhilov Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
BR122018075478B8 (pt) * 2004-06-24 2023-10-31 Vertex Pharma moduladores de transportadores de cassete de ligação de atp
US20090105272A1 (en) * 2005-12-24 2009-04-23 Grootenhuis Peter D J Prodrugs of modulators of ABC transporters
HUE049976T2 (hu) 2005-12-28 2020-11-30 Vertex Pharma N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói
SG10201504084QA (en) 2009-03-20 2015-06-29 Vertex Pharma Process for making modulators of cystic fibrosis transmembrane conductance regulator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
CN109966264A (zh) 2012-02-27 2019-07-05 沃泰克斯药物股份有限公司 药物组合物及其施用
CN107250113B (zh) 2014-10-07 2019-03-29 弗特克斯药品有限公司 囊性纤维化跨膜传导调节蛋白的调节剂的共晶

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9109972D0 (en) * 1991-05-09 1991-07-03 Ici Plc Therapeutic compounds
GB9208511D0 (en) * 1991-05-09 1992-06-03 Ici Plc Compounds
IL111266A (en) * 1993-10-22 2002-03-10 Zeneca Ltd 2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9422894D0 (en) * 1994-11-12 1995-01-04 Zeneca Ltd Pyridazino quinoline compounds
GB9507318D0 (en) * 1995-04-07 1995-05-31 Zeneca Ltd Alpha substituted pyridazino quinoline compounds

Also Published As

Publication number Publication date
SG59971A1 (en) 1999-02-22
FI961696A0 (fi) 1996-04-18
CZ113896A3 (en) 1996-09-11
US6232313B1 (en) 2001-05-15
EP0724583A1 (en) 1996-08-07
US5744471A (en) 1998-04-28
ES2154686T3 (es) 2001-04-16
CN1138332A (zh) 1996-12-18
DE69426422T2 (de) 2001-05-10
US6103721A (en) 2000-08-15
SK282491B6 (sk) 2002-02-05
NO961584D0 (no) 1996-04-19
FI114916B (fi) 2005-01-31
DE69434380T2 (de) 2006-05-04
JP3583132B2 (ja) 2004-10-27
UA60291C2 (uk) 2003-10-15
PL314041A1 (en) 1996-08-05
DE69426422D1 (de) 2001-01-18
NO306995B1 (no) 2000-01-24
PT724583E (pt) 2001-03-30
FI113865B (fi) 2004-06-30
EP1004582A2 (en) 2000-05-31
NO961584L (no) 1996-04-19
SI0724583T1 (en) 2001-04-30
SK50496A3 (en) 1997-03-05
PL180679B1 (en) 2001-03-30
AU6899998A (en) 1998-07-30
EP0724583B1 (en) 2000-12-13
EP1004582B1 (en) 2005-05-18
JPH09504519A (ja) 1997-05-06
PT1004582E (pt) 2005-09-30
TW406082B (en) 2000-09-21
CA2171332A1 (en) 1995-04-27
SG92630A1 (en) 2002-11-19
AU688393B2 (en) 1998-03-12
FI961696A (fi) 1996-04-18
AU7944094A (en) 1995-05-08
DE69434380D1 (de) 2005-06-23
IL111266A0 (en) 1994-12-29
SI1004582T1 (xx) 2005-08-31
NZ275472A (en) 1998-03-25
GR3035080T3 (en) 2001-03-30
CZ292311B6 (cs) 2003-09-17
EP1004582A3 (en) 2000-08-30
ES2241513T3 (es) 2005-11-01
AU721139B2 (en) 2000-06-22
MY132875A (en) 2007-10-31
GB9420590D0 (en) 1994-11-30
FI970907A0 (fi) 1997-03-03
KR100261209B1 (ko) 2000-09-01
DK0724583T3 (da) 2001-03-05
FI970907A (fi) 1997-03-03
MY124316A (en) 2006-06-30
NZ329303A (en) 2000-01-28
HUT74161A (en) 1996-11-28
WO1995011244A1 (en) 1995-04-27
DK1004582T3 (da) 2005-08-15
RU2168511C2 (ru) 2001-06-10
HU9600889D0 (en) 1996-06-28
HK1013997A1 (en) 1999-09-17
ATE198072T1 (de) 2000-12-15
CN1053189C (zh) 2000-06-07
ATE295846T1 (de) 2005-06-15

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees