FI111943B - Analogiamenetelmä terapeuttisesti käyttökelpoisen enantiomeerisen yhdisteen valmistamiseksi, joka on (S)- tai (R)-2-[3-[4-(3-kloorifenyyli)-1-(2-alkyyli)-piperatsinyyli]propyyli]-1,2,4-triatsolo[4,3-a]pyridin-3-(2H)-oni, ja välituotteet - Google Patents

Analogiamenetelmä terapeuttisesti käyttökelpoisen enantiomeerisen yhdisteen valmistamiseksi, joka on (S)- tai (R)-2-[3-[4-(3-kloorifenyyli)-1-(2-alkyyli)-piperatsinyyli]propyyli]-1,2,4-triatsolo[4,3-a]pyridin-3-(2H)-oni, ja välituotteet Download PDF

Info

Publication number
FI111943B
FI111943B FI956334A FI956334A FI111943B FI 111943 B FI111943 B FI 111943B FI 956334 A FI956334 A FI 956334A FI 956334 A FI956334 A FI 956334A FI 111943 B FI111943 B FI 111943B
Authority
FI
Finland
Prior art keywords
chlorophenyl
triazolo
propyl
pyridin
piperazinyl
Prior art date
Application number
FI956334A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI956334A0 (fi
FI956334L (fi
Inventor
Leandro Baiocchi
Valerio Cioli
Original Assignee
Angelini Ricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angelini Ricerche Spa filed Critical Angelini Ricerche Spa
Publication of FI956334A0 publication Critical patent/FI956334A0/fi
Publication of FI956334L publication Critical patent/FI956334L/fi
Application granted granted Critical
Publication of FI111943B publication Critical patent/FI111943B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
FI956334A 1993-07-01 1995-12-29 Analogiamenetelmä terapeuttisesti käyttökelpoisen enantiomeerisen yhdisteen valmistamiseksi, joka on (S)- tai (R)-2-[3-[4-(3-kloorifenyyli)-1-(2-alkyyli)-piperatsinyyli]propyyli]-1,2,4-triatsolo[4,3-a]pyridin-3-(2H)-oni, ja välituotteet FI111943B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT93MI001418A IT1268414B1 (it) 1993-07-01 1993-07-01 Enantiomeri farmacologicamente attivi
ITMI931418 1993-07-01
PCT/EP1994/002061 WO1995001354A1 (en) 1993-07-01 1994-06-21 Pharmacologically active enantiomers
EP9402061 1994-06-21

Publications (3)

Publication Number Publication Date
FI956334A0 FI956334A0 (fi) 1995-12-29
FI956334L FI956334L (fi) 1996-02-19
FI111943B true FI111943B (fi) 2003-10-15

Family

ID=11366510

Family Applications (1)

Application Number Title Priority Date Filing Date
FI956334A FI111943B (fi) 1993-07-01 1995-12-29 Analogiamenetelmä terapeuttisesti käyttökelpoisen enantiomeerisen yhdisteen valmistamiseksi, joka on (S)- tai (R)-2-[3-[4-(3-kloorifenyyli)-1-(2-alkyyli)-piperatsinyyli]propyyli]-1,2,4-triatsolo[4,3-a]pyridin-3-(2H)-oni, ja välituotteet

Country Status (29)

Country Link
US (3) US5741907A (cs)
EP (1) EP0707587B1 (cs)
JP (1) JP3096065B2 (cs)
KR (1) KR100306018B1 (cs)
CN (3) CN1046281C (cs)
AT (1) ATE158796T1 (cs)
AU (1) AU689478B2 (cs)
BG (1) BG61815B1 (cs)
BR (1) BR9406996A (cs)
CA (1) CA2166470C (cs)
CZ (1) CZ289526B6 (cs)
DE (1) DE69405999T2 (cs)
DK (1) DK0707587T3 (cs)
ES (1) ES2111309T3 (cs)
FI (1) FI111943B (cs)
GE (1) GEP19991791B (cs)
GR (1) GR3025806T3 (cs)
HU (1) HU221631B1 (cs)
IT (1) IT1268414B1 (cs)
LV (1) LV11546B (cs)
NO (1) NO305957B1 (cs)
NZ (1) NZ268014A (cs)
PL (1) PL181831B1 (cs)
RO (2) RO116899B1 (cs)
RU (1) RU2128180C1 (cs)
SK (1) SK281060B6 (cs)
UA (1) UA53607C2 (cs)
WO (1) WO1995001354A1 (cs)
ZA (1) ZA944570B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1268414B1 (it) * 1993-07-01 1997-02-27 Angelini Francesco Ist Ricerca Enantiomeri farmacologicamente attivi
JP2009018992A (ja) * 2007-07-10 2009-01-29 Sumitomo Chemical Co Ltd 光学活性ミルタザピンの製造方法
RU2706700C1 (ru) 2019-09-24 2019-11-20 Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях
KR20230083318A (ko) * 2020-10-07 2023-06-09 암젠 인크 7-클로로-6-플루오로-1-(2-이소프로필-4-메틸피리딘-3-일)피리도[2,3-d]피리미딘-2,4(1H,3H)-디온의 회전장애이성질체의 라세미화 및 단리 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365453A (en) * 1963-10-28 1968-01-23 Sterling Drug Inc 1-phenyl-4-lower-alkyl-2-piperazinones
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
SU368258A1 (ru) * 1970-01-27 1973-01-26 Днепчопетровский химико технологический институт Ф. Э. Дзержинского Способ получения 1,4-диарил-2-карбоксиметил- 3-оксопиперазинов
US5303837A (en) * 1991-03-05 1994-04-19 Portola Packaging, Inc. One-piece fitment and plug with tamper-evident band
US5543563A (en) * 1992-01-17 1996-08-06 Istituto Ricerca Francesco Angelini S.P.A. Alkyl derivatives of trazodone with CNS activity
GEP20001939B (en) * 1992-01-17 2000-02-05 Angelini Ricerca S P A Soc Consortile Alkyl Derivatives of Trazodone with CNS Activity
IT1268414B1 (it) * 1993-07-01 1997-02-27 Angelini Francesco Ist Ricerca Enantiomeri farmacologicamente attivi
US5399765A (en) * 1994-05-23 1995-03-21 Sepracor, Inc. Enantioselective preparation of optically pure albuterol

Also Published As

Publication number Publication date
CA2166470C (en) 2001-12-18
EP0707587B1 (en) 1997-10-01
AU689478B2 (en) 1998-04-02
CN1129939A (zh) 1996-08-28
NO955345D0 (no) 1995-12-29
ZA944570B (en) 1995-04-11
WO1995001354A1 (en) 1995-01-12
ATE158796T1 (de) 1997-10-15
HK1018777A1 (en) 2000-01-07
HK1018781A1 (en) 2000-01-07
US5973150A (en) 1999-10-26
BR9406996A (pt) 1996-09-10
HUT73230A (en) 1996-07-29
RO121031B1 (ro) 2006-11-30
SK281060B6 (sk) 2000-11-07
AU7072994A (en) 1995-01-24
RU2128180C1 (ru) 1999-03-27
GR3025806T3 (en) 1998-03-31
KR100306018B1 (ko) 2001-11-30
CN1215053A (zh) 1999-04-28
DE69405999D1 (de) 1997-11-06
BG100331A (bg) 1996-09-30
PL181831B1 (pl) 2001-09-28
NO955345L (no) 1996-02-29
UA53607C2 (uk) 2003-02-17
CN1215052A (zh) 1999-04-28
NZ268014A (en) 1997-08-22
DE69405999T2 (de) 1998-04-16
ES2111309T3 (es) 1998-03-01
FI956334A0 (fi) 1995-12-29
BG61815B1 (bg) 1998-06-30
HU9503876D0 (en) 1996-02-28
CN1136201C (zh) 2004-01-28
NO305957B1 (no) 1999-08-23
CZ348595A3 (en) 1996-04-17
ITMI931418A0 (it) 1993-07-01
HU221631B1 (hu) 2002-12-28
JP3096065B2 (ja) 2000-10-10
CA2166470A1 (en) 1995-01-12
PL312419A1 (en) 1996-04-15
SK166495A3 (en) 1996-09-04
FI956334L (fi) 1996-02-19
EP0707587A1 (en) 1996-04-24
LV11546B (en) 1997-02-20
GEP19991791B (en) 1999-10-05
CN1046281C (zh) 1999-11-10
US5817815A (en) 1998-10-06
LV11546A (lv) 1996-10-20
IT1268414B1 (it) 1997-02-27
US5741907A (en) 1998-04-21
JPH08512036A (ja) 1996-12-17
CZ289526B6 (cs) 2002-02-13
ITMI931418A1 (it) 1995-01-01
CN1136200C (zh) 2004-01-28
DK0707587T3 (da) 1998-05-11
RO116899B1 (ro) 2001-07-30

Similar Documents

Publication Publication Date Title
AU768780B2 (en) Piperazine compounds
ES2328671T3 (es) Compuestos de piperazilpirazinas como antagonistas del receptor de serotonina 5-ht2.
EP0389352B1 (fr) Dérivés fluoro-4 benzoiques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
Bonnaud et al. 1-Aryl-2-(aminomethyl) cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants
EP0833818A1 (fr) Composes agonistes du recepteur cb 2?
FI111943B (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisen enantiomeerisen yhdisteen valmistamiseksi, joka on (S)- tai (R)-2-[3-[4-(3-kloorifenyyli)-1-(2-alkyyli)-piperatsinyyli]propyyli]-1,2,4-triatsolo[4,3-a]pyridin-3-(2H)-oni, ja välituotteet
WO1998031669A1 (fr) Nouvelles arylpiperazines derivees de piperidine comme medicaments antidepresseurs
KR100254690B1 (ko) 트라조돈의 알킬 유도체
AU2019296173B2 (en) Benzimidazole derivatives and use thereof as IDH1 inhibitors
IE52345B1 (en) Alkanolamine derivatives
CA2007401A1 (fr) Derives des bisarylalcenes, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
AU718075B2 (en) Intermediates for the preparation of pharmacologically active enantiomers of triazolone compounds
FR2761069A1 (fr) Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments
US3867372A (en) Benzodiazepine process
IE61133B1 (en) New compounds
EA040879B1 (ru) Производные бензимидазола и их применение в качестве ингибиторов idh1
CZ292867B6 (cs) Způsob cyklizace anilinových derivátů
HK1018781B (en) Pharmacologically active enantiomers
HK1018777B (en) Pharmacologically active enantiomers