FI111716B - Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi Download PDF

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Publication number
FI111716B
FI111716B FI924453A FI924453A FI111716B FI 111716 B FI111716 B FI 111716B FI 924453 A FI924453 A FI 924453A FI 924453 A FI924453 A FI 924453A FI 111716 B FI111716 B FI 111716B
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FI
Finland
Prior art keywords
group
amino
dimethylamino
dioxo
tetrahydroxy
Prior art date
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FI924453A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924453A (fi
FI924453A0 (fi
Inventor
Phaik-Eng Sum
Ving J Lee
Joseph J Hlavka
Yakov Gluzman
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FI924453A0 publication Critical patent/FI924453A0/fi
Publication of FI924453A publication Critical patent/FI924453A/fi
Application granted granted Critical
Publication of FI111716B publication Critical patent/FI111716B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Tires In General (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Moulding By Coating Moulds (AREA)
  • Luminescent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI924453A 1991-10-04 1992-10-02 Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi FI111716B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77169791 1991-10-04
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Publications (3)

Publication Number Publication Date
FI924453A0 FI924453A0 (fi) 1992-10-02
FI924453A FI924453A (fi) 1993-04-05
FI111716B true FI111716B (fi) 2003-09-15

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924453A FI111716B (fi) 1991-10-04 1992-10-02 Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi

Country Status (25)

Country Link
US (3) US5281628A (sk)
EP (1) EP0535346B1 (sk)
JP (1) JP3183729B2 (sk)
KR (1) KR100261528B1 (sk)
CN (1) CN1053182C (sk)
AT (1) ATE129697T1 (sk)
AU (1) AU651734B2 (sk)
CA (1) CA2079703C (sk)
CZ (1) CZ285015B6 (sk)
DE (1) DE69205792T2 (sk)
DK (1) DK0535346T3 (sk)
ES (1) ES2081005T3 (sk)
FI (1) FI111716B (sk)
GR (1) GR3017978T3 (sk)
HK (1) HK1000319A1 (sk)
HU (2) HU211214B (sk)
IL (1) IL103319A (sk)
MX (1) MX9205573A (sk)
NO (1) NO300129B1 (sk)
NZ (1) NZ244556A (sk)
PH (1) PH30343A (sk)
PL (2) PL170933B1 (sk)
SK (1) SK281113B6 (sk)
TW (1) TW222616B (sk)
ZA (1) ZA927608B (sk)

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US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
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US5834450A (en) * 1994-02-17 1998-11-10 Pfizer Inc. 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
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US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
EP2327687A3 (en) * 1999-09-14 2012-08-15 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
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KR101014918B1 (ko) * 2002-03-08 2011-02-15 파라테크 파마슈티컬스, 인크. 아미노-메틸 치환된 테트라시클린 화합물
IL164180A0 (en) 2002-03-21 2005-12-18 Paratek Pharm Innc Substituted tetracycline compounds
KR101148415B1 (ko) 2002-07-12 2012-05-21 파라테크 파마슈티컬스, 인크. 3, 10, 및 12ａ 치환된 테트라시클린 화합물
AU2003300379A1 (en) * 2002-12-27 2004-07-29 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collagen and MMPI
EA201100956A1 (ru) 2003-07-09 2012-01-30 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
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AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
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EP2026776A2 (en) 2006-05-15 2009-02-25 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
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Also Published As

Publication number Publication date
CN1053182C (zh) 2000-06-07
KR100261528B1 (ko) 2000-07-15
NO300129B1 (no) 1997-04-14
HU9203143D0 (en) 1992-12-28
ATE129697T1 (de) 1995-11-15
DK0535346T3 (da) 1995-12-04
NO923856D0 (no) 1992-10-02
AU651734B2 (en) 1994-07-28
CA2079703A1 (en) 1993-04-05
DE69205792D1 (de) 1995-12-07
NZ244556A (en) 1994-06-27
JPH05239006A (ja) 1993-09-17
HU211214B (en) 1995-11-28
IL103319A (en) 1996-07-23
CZ297292A3 (en) 1993-04-14
TW222616B (sk) 1994-04-21
HUT64298A (en) 1993-12-28
KR930007895A (ko) 1993-05-20
FI924453A (fi) 1993-04-05
DE69205792T2 (de) 1996-06-20
ZA927608B (en) 1993-04-13
HU211922A9 (en) 1996-01-29
MX9205573A (es) 1993-05-01
PL170939B1 (pl) 1997-02-28
PH30343A (en) 1997-04-02
SK281113B6 (sk) 2000-12-11
IL103319A0 (en) 1993-03-15
US5401863A (en) 1995-03-28
US5281628A (en) 1994-01-25
CN1071415A (zh) 1993-04-28
CA2079703C (en) 2004-07-20
JP3183729B2 (ja) 2001-07-09
GR3017978T3 (en) 1996-02-29
PL296140A1 (en) 1993-11-02
US5326759A (en) 1994-07-05
CZ285015B6 (cs) 1999-05-12
EP0535346A1 (en) 1993-04-07
EP0535346B1 (en) 1995-11-02
HK1000319A1 (en) 1998-02-27
SK297292A3 (en) 1994-12-07
ES2081005T3 (es) 1996-02-16
PL170933B1 (pl) 1997-02-28
AU2618292A (en) 1993-04-08
FI924453A0 (fi) 1992-10-02
NO923856L (no) 1993-04-05

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