FI111074B - Menetelmä nitraattoalkaanikarboksyylihappojohdannaisten valmistamiseksi - Google Patents

Menetelmä nitraattoalkaanikarboksyylihappojohdannaisten valmistamiseksi Download PDF

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Publication number
FI111074B
FI111074B FI911703A FI911703A FI111074B FI 111074 B FI111074 B FI 111074B FI 911703 A FI911703 A FI 911703A FI 911703 A FI911703 A FI 911703A FI 111074 B FI111074 B FI 111074B
Authority
FI
Finland
Prior art keywords
acid
nitrate
ethyl ester
general formula
preparation
Prior art date
Application number
FI911703A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI911703A7 (fi
FI911703A0 (fi
Inventor
Edgar Fritschi
Martin Feelisch
Eike Noack
Klaus Sandrock
Ralf Kanzler
Original Assignee
Sanol Arznei Schwarz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of FI911703A0 publication Critical patent/FI911703A0/fi
Publication of FI911703A7 publication Critical patent/FI911703A7/fi
Application granted granted Critical
Publication of FI111074B publication Critical patent/FI111074B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI911703A 1990-04-10 1991-04-09 Menetelmä nitraattoalkaanikarboksyylihappojohdannaisten valmistamiseksi FI111074B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4011505A DE4011505C2 (de) 1990-04-10 1990-04-10 Nitratoalkancarbonsäure-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE4011505 1990-04-10

Publications (3)

Publication Number Publication Date
FI911703A0 FI911703A0 (fi) 1991-04-09
FI911703A7 FI911703A7 (fi) 1991-10-11
FI111074B true FI111074B (fi) 2003-05-30

Family

ID=6404098

Family Applications (1)

Application Number Title Priority Date Filing Date
FI911703A FI111074B (fi) 1990-04-10 1991-04-09 Menetelmä nitraattoalkaanikarboksyylihappojohdannaisten valmistamiseksi

Country Status (18)

Country Link
EP (1) EP0451760B1 (cs)
JP (1) JP2848979B2 (cs)
AT (1) ATE127787T1 (cs)
CZ (1) CZ279744B6 (cs)
DE (2) DE4011505C2 (cs)
DK (1) DK0451760T3 (cs)
ES (1) ES2079506T3 (cs)
FI (1) FI111074B (cs)
GR (1) GR3017418T3 (cs)
HR (1) HRP920948B1 (cs)
HU (1) HU218202B (cs)
IE (1) IE68060B1 (cs)
PL (1) PL167089B1 (cs)
PT (1) PT97279B (cs)
RU (1) RU2017748C1 (cs)
SI (1) SI9110630B (cs)
SK (1) SK278385B6 (cs)
YU (1) YU48610B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4321306A1 (de) * 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh Disulfide
GB9504350D0 (en) * 1995-03-04 1995-04-26 Sod Conseils Rech Applic Arginine derivatives
US5929063A (en) * 1995-03-24 1999-07-27 Children's Hospital Medical Center Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
DE19634793A1 (de) * 1996-08-29 1998-03-05 Sanol Arznei Schwarz Gmbh S- und O-Nitratoacylverbindungen
JP2005501060A (ja) * 2001-08-10 2005-01-13 ニトロメッド，インク． 硫黄含有有機硝酸化合物の使用法
EP2707354B1 (en) 2011-10-24 2015-04-29 Nicox Science Ireland Quinone based nitric oxide donating compounds
US9382211B2 (en) * 2012-07-10 2016-07-05 Xpd Holdings, Llc Stabilized multi-functional antioxidant compounds and methods of use
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3512627A1 (de) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel
JP2628756B2 (ja) * 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法

Also Published As

Publication number Publication date
PT97279A (pt) 1991-12-31
HUT57707A (en) 1991-12-30
ATE127787T1 (de) 1995-09-15
SI9110630B (sl) 2000-08-31
GR3017418T3 (en) 1995-12-31
DE4011505A1 (de) 1991-10-24
IE911023A1 (en) 1991-10-23
IE68060B1 (en) 1996-05-15
FI911703A7 (fi) 1991-10-11
EP0451760A1 (de) 1991-10-16
HRP920948A2 (en) 1997-10-31
EP0451760B1 (de) 1995-09-13
DE4011505C2 (de) 1995-01-12
JPH05178804A (ja) 1993-07-20
FI911703A0 (fi) 1991-04-09
CS9100984A2 (en) 1991-11-12
SI9110630A (en) 1997-06-30
PL167089B1 (pl) 1995-07-31
HU911143D0 (en) 1991-10-28
HU218202B (hu) 2000-06-28
YU63091A (sh) 1994-01-20
YU48610B (sh) 1999-03-04
DK0451760T3 (da) 1996-01-02
HRP920948B1 (en) 2000-04-30
JP2848979B2 (ja) 1999-01-20
RU2017748C1 (ru) 1994-08-15
ES2079506T3 (es) 1996-01-16
DE59106452D1 (de) 1995-10-19
CZ279744B6 (cs) 1995-06-14
PT97279B (pt) 1998-08-31
SK98491A3 (en) 1995-07-11
SK278385B6 (en) 1997-02-05

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MA Patent expired