SI9110630B - Derivati nitratoalkankarbonskih kislin, postopek za njihovo pridobivanje, njihova uporaba in zdravila, ki jih vsebujejo - Google Patents
Derivati nitratoalkankarbonskih kislin, postopek za njihovo pridobivanje, njihova uporaba in zdravila, ki jih vsebujejo Download PDFInfo
- Publication number
- SI9110630B SI9110630B SI9110630A SI9110630A SI9110630B SI 9110630 B SI9110630 B SI 9110630B SI 9110630 A SI9110630 A SI 9110630A SI 9110630 A SI9110630 A SI 9110630A SI 9110630 B SI9110630 B SI 9110630B
- Authority
- SI
- Slovenia
- Prior art keywords
- compounds according
- carbon atoms
- nitrate
- thioesters
- amino acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims abstract 5
- 239000003814 drug Substances 0.000 title claims abstract 3
- 150000007513 acids Chemical class 0.000 title 1
- 150000002823 nitrates Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 10
- 229910002651 NO3 Inorganic materials 0.000 claims abstract 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims abstract 4
- -1 hydroxy, amino Chemical group 0.000 claims 6
- 235000001014 amino acid Nutrition 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 150000007970 thio esters Chemical class 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 2
- OKJIRPAQVSHGFK-UHFFFAOYSA-N N-acetylglycine Chemical compound CC(=O)NCC(O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 235000018417 cysteine Nutrition 0.000 claims 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229930182817 methionine Natural products 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 1
- 125000003047 N-acetyl group Chemical group 0.000 claims 1
- KTHDTJVBEPMMGL-VKHMYHEASA-N N-acetyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(C)=O KTHDTJVBEPMMGL-VKHMYHEASA-N 0.000 claims 1
- WXNXCEHXYPACJF-ZETCQYMHSA-N N-acetyl-L-leucine Chemical compound CC(C)C[C@@H](C(O)=O)NC(C)=O WXNXCEHXYPACJF-ZETCQYMHSA-N 0.000 claims 1
- 241000275031 Nica Species 0.000 claims 1
- 229960000669 acetylleucine Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000002653 sulfanylmethyl group Chemical group [H]SC([H])([H])[*] 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000000916 dilatatory effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000003313 weakening effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4011505A DE4011505C2 (de) | 1990-04-10 | 1990-04-10 | Nitratoalkancarbonsäure-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| YU63091A YU48610B (sh) | 1990-04-10 | 1991-04-08 | Derivati nitratoalkankarbonskih kiselina i postupak za njihovo dobijanje |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9110630A SI9110630A (en) | 1997-06-30 |
| SI9110630B true SI9110630B (sl) | 2000-08-31 |
Family
ID=6404098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9110630A SI9110630B (sl) | 1990-04-10 | 1991-04-08 | Derivati nitratoalkankarbonskih kislin, postopek za njihovo pridobivanje, njihova uporaba in zdravila, ki jih vsebujejo |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0451760B1 (cs) |
| JP (1) | JP2848979B2 (cs) |
| AT (1) | ATE127787T1 (cs) |
| CZ (1) | CZ279744B6 (cs) |
| DE (2) | DE4011505C2 (cs) |
| DK (1) | DK0451760T3 (cs) |
| ES (1) | ES2079506T3 (cs) |
| FI (1) | FI111074B (cs) |
| GR (1) | GR3017418T3 (cs) |
| HR (1) | HRP920948B1 (cs) |
| HU (1) | HU218202B (cs) |
| IE (1) | IE68060B1 (cs) |
| PL (1) | PL167089B1 (cs) |
| PT (1) | PT97279B (cs) |
| RU (1) | RU2017748C1 (cs) |
| SI (1) | SI9110630B (cs) |
| SK (1) | SK278385B6 (cs) |
| YU (1) | YU48610B (cs) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4321306A1 (de) * | 1993-06-26 | 1995-01-05 | Sanol Arznei Schwarz Gmbh | Disulfide |
| GB9504350D0 (en) * | 1995-03-04 | 1995-04-26 | Sod Conseils Rech Applic | Arginine derivatives |
| US5929063A (en) * | 1995-03-24 | 1999-07-27 | Children's Hospital Medical Center | Mercapto and seleno derivatives as inhibitors of nitric oxide synthase |
| US5807847A (en) * | 1996-06-04 | 1998-09-15 | Queen's University At Kingston | Nitrate esters |
| DE19634793A1 (de) * | 1996-08-29 | 1998-03-05 | Sanol Arznei Schwarz Gmbh | S- und O-Nitratoacylverbindungen |
| WO2003013432A2 (en) * | 2001-08-10 | 2003-02-20 | Nitromed, Inc. | Methods of use for novel sulfur containing organic nitrate compounds |
| ES2542702T3 (es) | 2011-10-24 | 2015-08-10 | Nicox Science Ireland | Compuestos donantes de óxido nítrico a base de quinona |
| CA2876021C (en) * | 2012-07-10 | 2020-09-22 | Xpd Holdings, Llc | Stabilized multi-functional antioxidant compounds and methods of use |
| WO2014169976A1 (en) | 2013-04-18 | 2014-10-23 | Nicox Science Ireland | Quinone based nitric oxide donating compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3443998A1 (de) * | 1984-12-01 | 1986-06-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
| DE3512627A1 (de) * | 1985-04-06 | 1986-10-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel |
| JP2628756B2 (ja) * | 1988-09-15 | 1997-07-09 | シュバルツファルマ アクチェンゲゼルシャフト | 新規有機ニトレート及びそれらの製造方法 |
-
1990
- 1990-04-10 DE DE4011505A patent/DE4011505C2/de not_active Expired - Fee Related
-
1991
- 1991-03-27 IE IE102391A patent/IE68060B1/en not_active IP Right Cessation
- 1991-04-08 YU YU63091A patent/YU48610B/sh unknown
- 1991-04-08 PT PT97279A patent/PT97279B/pt not_active IP Right Cessation
- 1991-04-08 AT AT91105540T patent/ATE127787T1/de not_active IP Right Cessation
- 1991-04-08 ES ES91105540T patent/ES2079506T3/es not_active Expired - Lifetime
- 1991-04-08 EP EP91105540A patent/EP0451760B1/de not_active Expired - Lifetime
- 1991-04-08 SI SI9110630A patent/SI9110630B/sl not_active IP Right Cessation
- 1991-04-08 DK DK91105540.8T patent/DK0451760T3/da active
- 1991-04-08 DE DE59106452T patent/DE59106452D1/de not_active Expired - Fee Related
- 1991-04-08 PL PL91289788A patent/PL167089B1/pl not_active IP Right Cessation
- 1991-04-09 JP JP3076186A patent/JP2848979B2/ja not_active Expired - Fee Related
- 1991-04-09 RU SU914895074A patent/RU2017748C1/ru not_active IP Right Cessation
- 1991-04-09 SK SK984-91A patent/SK278385B6/sk unknown
- 1991-04-09 CZ CS91984A patent/CZ279744B6/cs not_active IP Right Cessation
- 1991-04-09 HU HU143/91A patent/HU218202B/hu not_active IP Right Cessation
- 1991-04-09 FI FI911703A patent/FI111074B/fi not_active IP Right Cessation
-
1992
- 1992-10-02 HR HRP-630/91A patent/HRP920948B1/xx not_active IP Right Cessation
-
1995
- 1995-09-14 GR GR950402480T patent/GR3017418T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2079506T3 (es) | 1996-01-16 |
| HU218202B (hu) | 2000-06-28 |
| HU911143D0 (en) | 1991-10-28 |
| SK278385B6 (en) | 1997-02-05 |
| DK0451760T3 (da) | 1996-01-02 |
| PT97279B (pt) | 1998-08-31 |
| HRP920948A2 (en) | 1997-10-31 |
| DE4011505A1 (de) | 1991-10-24 |
| FI911703A0 (fi) | 1991-04-09 |
| RU2017748C1 (ru) | 1994-08-15 |
| HRP920948B1 (en) | 2000-04-30 |
| ATE127787T1 (de) | 1995-09-15 |
| PL167089B1 (pl) | 1995-07-31 |
| GR3017418T3 (en) | 1995-12-31 |
| IE911023A1 (en) | 1991-10-23 |
| HUT57707A (en) | 1991-12-30 |
| CS9100984A2 (en) | 1991-11-12 |
| FI911703A7 (fi) | 1991-10-11 |
| SK98491A3 (en) | 1995-07-11 |
| SI9110630A (en) | 1997-06-30 |
| EP0451760A1 (de) | 1991-10-16 |
| DE59106452D1 (de) | 1995-10-19 |
| JP2848979B2 (ja) | 1999-01-20 |
| FI111074B (fi) | 2003-05-30 |
| YU63091A (sh) | 1994-01-20 |
| JPH05178804A (ja) | 1993-07-20 |
| CZ279744B6 (cs) | 1995-06-14 |
| DE4011505C2 (de) | 1995-01-12 |
| EP0451760B1 (de) | 1995-09-13 |
| PT97279A (pt) | 1991-12-31 |
| IE68060B1 (en) | 1996-05-15 |
| YU48610B (sh) | 1999-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KO00 | Lapse of patent |
Effective date: 20050103 |