YU48610B - Derivati nitratoalkankarbonskih kiselina i postupak za njihovo dobijanje - Google Patents

Derivati nitratoalkankarbonskih kiselina i postupak za njihovo dobijanje

Info

Publication number
YU48610B
YU48610B YU63091A YU63091A YU48610B YU 48610 B YU48610 B YU 48610B YU 63091 A YU63091 A YU 63091A YU 63091 A YU63091 A YU 63091A YU 48610 B YU48610 B YU 48610B
Authority
YU
Yugoslavia
Prior art keywords
general formula
acids
derivatives
nitratoalkanocarbonic
obtaining
Prior art date
Application number
YU63091A
Other languages
English (en)
Other versions
YU63091A (sh
Inventor
Sandrock Dr. Klaus
Noack Prof. Dr. Eike
Fritschi Dr. Edgar
Kanzler Ralf
Feelisch Martin
Original Assignee
Schwarz Pharma Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schwarz Pharma Ag. filed Critical Schwarz Pharma Ag.
Priority to SI9110630A priority Critical patent/SI9110630B/sl
Priority to HRP-630/91A priority patent/HRP920948B1/xx
Publication of YU63091A publication Critical patent/YU63091A/sh
Publication of YU48610B publication Critical patent/YU48610B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Lubricants (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivati nitratoalkankarbonskih kiselina opšte formule (1): gde R predstavlja hidroksi, amino ili etoksi, R1 predstavlja vodonik ili alkil sa 1 do 6 ugljenikovih atoma, R2 predstavlja vodonik ili alkil sa 1 do 6 ugljenikovih atoma, R3 predstavlja vodonik, R4 predstavlja vodonik, fenil ili metoksifenil, R5 predstavlja S-acilderivate merkaptometila, birane od tio estara amino kiseline, tio estara N-acil-amino kiseline, peptid-tio estara i N-acilpeptid tio estara sa 2-5 peptidno vezanih grupa amino kiselina, R i R4 mogu biti međusobno spojeni u obliku estra ili amida, R3 i R4 mogu biti međusobno spojeni u vidu alkilenskog mosta sa 2 do 4 ugljenikova atoma, alkilenskog mosta sa 2 do 3 ugljenikova atoma i jednim atomom sumpora, alkilenskog mosta sa 3 do 4 ugljenikova atoma koji sadrži jednu dvostruku vezu, ili alkilenskog mosta kako je napred pomenuto supstituisanog sa hidroksi, m, n i o su celi brojevi od 0 do 10. - Prijava sadrži još 1 nezavisan i 6 zavisnih zahteva.
YU63091A 1990-04-10 1991-04-08 Derivati nitratoalkankarbonskih kiselina i postupak za njihovo dobijanje YU48610B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9110630A SI9110630B (sl) 1990-04-10 1991-04-08 Derivati nitratoalkankarbonskih kislin, postopek za njihovo pridobivanje, njihova uporaba in zdravila, ki jih vsebujejo
HRP-630/91A HRP920948B1 (en) 1990-04-10 1992-10-02 Nitratoalkanecarbone acid derivatives, process for the preparation thereof, the use of the same and drugs containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4011505A DE4011505C2 (de) 1990-04-10 1990-04-10 Nitratoalkancarbonsäure-Derivate, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
YU63091A YU63091A (sh) 1994-01-20
YU48610B true YU48610B (sh) 1999-03-04

Family

ID=6404098

Family Applications (1)

Application Number Title Priority Date Filing Date
YU63091A YU48610B (sh) 1990-04-10 1991-04-08 Derivati nitratoalkankarbonskih kiselina i postupak za njihovo dobijanje

Country Status (18)

Country Link
EP (1) EP0451760B1 (sh)
JP (1) JP2848979B2 (sh)
AT (1) ATE127787T1 (sh)
CZ (1) CZ279744B6 (sh)
DE (2) DE4011505C2 (sh)
DK (1) DK0451760T3 (sh)
ES (1) ES2079506T3 (sh)
FI (1) FI111074B (sh)
GR (1) GR3017418T3 (sh)
HR (1) HRP920948B1 (sh)
HU (1) HU218202B (sh)
IE (1) IE68060B1 (sh)
PL (1) PL167089B1 (sh)
PT (1) PT97279B (sh)
RU (1) RU2017748C1 (sh)
SI (1) SI9110630B (sh)
SK (1) SK278385B6 (sh)
YU (1) YU48610B (sh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4321306A1 (de) * 1993-06-26 1995-01-05 Sanol Arznei Schwarz Gmbh Disulfide
US5807847A (en) * 1996-06-04 1998-09-15 Queen's University At Kingston Nitrate esters
DE19634793A1 (de) * 1996-08-29 1998-03-05 Sanol Arznei Schwarz Gmbh S- und O-Nitratoacylverbindungen
CA2453433A1 (en) * 2001-08-10 2003-02-20 Nitromed, Inc. Methods of use for novel sulfur containing organic nitrate compounds
WO2013060673A1 (en) 2011-10-24 2013-05-02 Nicox S.A. Quinone based nitric oxide donating compounds
CA3078006C (en) * 2012-07-10 2022-04-26 Xpd Holdings, Llc Stabilized multi-functional antioxidant compounds and methods of use
WO2014169976A1 (en) 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3512627A1 (de) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel
JP2628756B2 (ja) * 1988-09-15 1997-07-09 シュバルツファルマ アクチェンゲゼルシャフト 新規有機ニトレート及びそれらの製造方法

Also Published As

Publication number Publication date
DK0451760T3 (da) 1996-01-02
GR3017418T3 (en) 1995-12-31
HRP920948A2 (en) 1997-10-31
SI9110630A (en) 1997-06-30
ES2079506T3 (es) 1996-01-16
JP2848979B2 (ja) 1999-01-20
PL167089B1 (pl) 1995-07-31
CZ279744B6 (cs) 1995-06-14
EP0451760A1 (de) 1991-10-16
FI911703A0 (fi) 1991-04-09
HU911143D0 (en) 1991-10-28
YU63091A (sh) 1994-01-20
PT97279B (pt) 1998-08-31
JPH05178804A (ja) 1993-07-20
SI9110630B (sl) 2000-08-31
SK98491A3 (en) 1995-07-11
FI911703A (fi) 1991-10-11
DE4011505C2 (de) 1995-01-12
IE911023A1 (en) 1991-10-23
HUT57707A (en) 1991-12-30
CS9100984A2 (en) 1991-11-12
IE68060B1 (en) 1996-05-15
ATE127787T1 (de) 1995-09-15
DE59106452D1 (de) 1995-10-19
FI111074B (fi) 2003-05-30
HRP920948B1 (en) 2000-04-30
DE4011505A1 (de) 1991-10-24
RU2017748C1 (ru) 1994-08-15
HU218202B (hu) 2000-06-28
PT97279A (pt) 1991-12-31
EP0451760B1 (de) 1995-09-13
SK278385B6 (en) 1997-02-05

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