FI109764B - Kudostekijään perustuva protrombiiniaikareagenssi - Google Patents

Kudostekijään perustuva protrombiiniaikareagenssi Download PDF

Info

Publication number
FI109764B
FI109764B FI932148A FI932148A FI109764B FI 109764 B FI109764 B FI 109764B FI 932148 A FI932148 A FI 932148A FI 932148 A FI932148 A FI 932148A FI 109764 B FI109764 B FI 109764B
Authority
FI
Finland
Prior art keywords
mol
tissue factor
reagent
mmol
prothrombin time
Prior art date
Application number
FI932148A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI932148A0 (fi
FI932148A (fi
Inventor
Scott Martin Brown
Original Assignee
Corvas Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27086686&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI109764(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Corvas Int Inc filed Critical Corvas Int Inc
Publication of FI932148A0 publication Critical patent/FI932148A0/fi
Publication of FI932148A publication Critical patent/FI932148A/fi
Application granted granted Critical
Publication of FI109764B publication Critical patent/FI109764B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
FI932148A 1990-11-13 1993-05-12 Kudostekijään perustuva protrombiiniaikareagenssi FI109764B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US61211890A 1990-11-13 1990-11-13
US61211890 1990-11-13
US07/784,326 US5314695A (en) 1990-11-13 1991-10-29 Tissue factor based prothrombin time reagent
US78432691 1991-10-29
US9108174 1991-11-04
PCT/US1991/008174 WO1992008479A1 (en) 1990-11-13 1991-11-04 Tissue factor based prothrombin time reagent

Publications (3)

Publication Number Publication Date
FI932148A0 FI932148A0 (fi) 1993-05-12
FI932148A FI932148A (fi) 1993-06-03
FI109764B true FI109764B (fi) 2002-10-15

Family

ID=27086686

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932148A FI109764B (fi) 1990-11-13 1993-05-12 Kudostekijään perustuva protrombiiniaikareagenssi

Country Status (18)

Country Link
US (1) US5314695A (es)
EP (1) EP0564495B2 (es)
JP (1) JP3441456B2 (es)
KR (1) KR100196107B1 (es)
AT (1) ATE179608T1 (es)
AU (2) AU9090791A (es)
CA (1) CA2096109C (es)
DE (1) DE69131204T3 (es)
DK (1) DK0564495T4 (es)
ES (1) ES2133310T5 (es)
FI (1) FI109764B (es)
GR (1) GR3030906T3 (es)
IE (1) IE913955A1 (es)
MX (1) MX9102042A (es)
NO (1) NO314617B1 (es)
NZ (2) NZ264556A (es)
PT (1) PT99499B (es)
WO (1) WO1992008479A1 (es)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3416778B2 (ja) * 1991-10-04 2003-06-16 デイド、ベーリング、インコーポレイテッド 組換えヒト組織因子及び精製された天然及び合成のリン脂質からのプロトロンビン時間試薬の製造
US6093399A (en) * 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US6749853B1 (en) 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US6036955A (en) * 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
AU674139B2 (en) * 1992-04-13 1996-12-12 Ortho Diagnostic Systems Inc. Synthetic phospholipid reagent
DE59309374D1 (de) * 1992-05-15 1999-03-25 Immuno Ag Reagens zur Bestimmung der aktivierten partiellen Thromboplastinzeit (aPTT)
DE4243729A1 (de) * 1992-12-23 1994-06-30 Behringwerke Ag Verfahren zur Reaktivierung von gereinigten Membranproteinen
NZ261190A (en) * 1993-01-29 1997-12-19 Bjorn Dahlback Assaying for functional activity of a blood coagulation component involved in the protein c anticoagulant system (protein c, activated protein c, protein s or anticoagulant factor v)
US7393682B1 (en) 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
US5780248A (en) 1993-07-15 1998-07-14 Ortho Diagnostic Systems, Inc. Foil sealed cassette for agglutination reactions and liner therefor
IL115849A0 (en) * 1994-11-03 1996-01-31 Merz & Co Gmbh & Co Tangential filtration preparation of liposomal drugs and liposome product thereof
AT403437B (de) * 1995-02-15 1998-02-25 Immuno Ag Physiologisch aktive gewebefaktor-präparation
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
BR9806793A (pt) * 1997-01-22 2000-05-16 Univ Texas Processos e composições de fator tissular para coagulação e tratamento de tumores.
WO1998048283A1 (en) * 1997-04-23 1998-10-29 Instrumentation Laboratory S.P.A. Recombinant rabbit tissue factor based prothrombin time reagent
DE19720853A1 (de) * 1997-05-17 1998-11-19 Dade Behring Marburg Gmbh Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes
US6656475B1 (en) 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6245573B1 (en) 1998-02-12 2001-06-12 University Of Medicine And Dentistry Of New Jersey Rapid assessment of the coagulant activity of blood
DE19811016A1 (de) * 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor
US6733985B1 (en) * 1999-05-19 2004-05-11 International Technidyne Corporation Preparation of stable liquid and dried synthetic prothrombin time reagents
ATE268477T1 (de) * 1999-09-03 2004-06-15 Roche Diagnostics Corp Verfahren, reagenz und messkartusche zur bestimmung der gerinnungszeit
US6576610B1 (en) 1999-10-04 2003-06-10 Nuvas, Llc Use of a context-dependent functional entity to enhance the efficacy of an agent
CA2393595A1 (en) * 1999-12-10 2001-06-14 Gigi Chiu Lipid carrier compositions with protected surface reactive functions
US6248353B1 (en) 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
US6855509B2 (en) 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US6596543B2 (en) 2001-03-22 2003-07-22 Dade Behring Inc. Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
EP2390308A1 (en) 2002-02-25 2011-11-30 Vaxiion Therapeutics Inc Minicell compositions and methods
AU2003220277A1 (en) * 2002-03-12 2003-09-29 The Johns Hopkins University School Of Medicine Manganese ion regulation of reverse transcriptase activity and methods of modulating same
US20030232075A1 (en) * 2002-05-06 2003-12-18 University Of Minnesota, A Minnesota Corporation Compositions for producing factor Xa
US20040091952A1 (en) * 2002-07-25 2004-05-13 Sysmex Corporation Reagent kit for detecting lupus anticoagulant
US7358337B2 (en) * 2002-08-16 2008-04-15 International Technidyne Corporation Assay for low molecular weight heparin
US7049087B2 (en) * 2002-11-05 2006-05-23 Lifescan, Inc. Method for manufacturing a tissue factor-based prothrombin time reagent
AU2004263538B2 (en) * 2003-08-08 2009-09-17 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
EP1562047B1 (en) * 2004-02-06 2008-05-14 Sysmex Corporation Reagent kit for detecting lupus anticoagulant
JP4617458B2 (ja) * 2004-02-10 2011-01-26 財団法人ヒューマンサイエンス振興財団 中空糸透析カラムを利用したリポソームの製造方法
US20050221414A1 (en) * 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
US7635754B2 (en) * 2004-09-22 2009-12-22 Aerovance, Inc. Interleukin-9 and interleukin-4 chimeric antagonist muteins and methods of using same
CN101151533A (zh) * 2005-02-16 2008-03-26 伊利诺斯大学理事会 基于金属螯合脂质的促凝血剂
AT501650A1 (de) * 2005-02-22 2006-10-15 Technoclone Ges M B H Verfahren zur bestimmung der gerinnungsaktivierung sowie gerät zur durchführung des verfahrens
JP5214252B2 (ja) 2005-03-03 2013-06-19 イミューノメディクス、インコーポレイテッド ヒト化ｌ２４３抗体
JP2008531692A (ja) * 2005-03-04 2008-08-14 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 凝固及び線維素溶解カスケードのモジュレーター
JP2007091625A (ja) * 2005-09-28 2007-04-12 Shino Test Corp 血液凝固反応促進剤
JP5017622B2 (ja) * 2005-11-30 2012-09-05 株式会社シノテスト 血液凝固反応抑制剤
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
CA2654266A1 (en) 2006-06-12 2007-12-27 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers
JP5073270B2 (ja) * 2006-11-14 2012-11-14 シスメックス株式会社 凝固検査用試薬及びその製造方法
US8821861B2 (en) * 2007-10-05 2014-09-02 The Board Of Trustees Of The University Of Illinois Fibrin sealant
US20100297257A1 (en) * 2007-11-09 2010-11-25 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) Anticoagulant antagonist and hemophillia procoagulant
US20100112670A1 (en) 2008-06-25 2010-05-06 Vaxiion Therapeutics, Inc. Regulated genetic suicide mechanism compositions and methods
WO2011148207A1 (en) 2010-05-28 2011-12-01 Diagon Kft. Procedure for biphasic preparation of liposomes and application thereof in manufacturing diagnostic reagents
WO2012057765A1 (en) 2010-10-28 2012-05-03 The Board Of Regents Of The University Of Texas System Recombinant anti-cd19 monoclonal antibodies
DK2675474T3 (en) 2011-02-15 2019-04-23 Vaxiion Therapeutics Llc THERAPEUTIC COMPOSITIONS AND PROCEDURES FOR TARGETED ADMINISTRATION OF BIOACTIVE MOLECULES BY BACK-TERIAL MINICLES BASED ON ANTIBODY AND FC-CONTAINING TAR-GETING MOLECULES
ES2806605T3 (es) 2011-09-23 2021-02-18 Univ Loma Linda Cepas bacterianas que expresan genes de metilasa y sus usos
CN102565427A (zh) * 2011-12-28 2012-07-11 苏州良辰生物医药科技有限公司 一种凝血酶原时间测定试剂的制备方法
JP2015527083A (ja) 2012-09-07 2015-09-17 チルドレンズ メディカル センター コーポレーション 造血幹細胞特異的レポーターマウスおよびその使用
CN104837506A (zh) 2012-10-02 2015-08-12 瓦克星治疗有限责任公司 免疫调节性小细胞及使用方法
JP6250306B2 (ja) * 2013-05-28 2017-12-20 株式会社Ｌｓｉメディエンス リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法
CN108348624B (zh) * 2015-08-04 2021-07-27 瓦克星治疗有限责任公司 基于细菌小细胞的生物药物的电离辐射灭菌以及使用方法
US10877052B2 (en) 2016-02-12 2020-12-29 Instrumentation Laboratory Company Two component “mix and use” liquid thromboplastin reagent, methods of making, and methods of use thereof
JP6652873B2 (ja) * 2016-03-30 2020-02-26 シスメックス株式会社 プロトロンビン時間測定用試薬、その製造方法およびプロトロンビン時間の測定方法
JP6626761B2 (ja) * 2016-03-30 2019-12-25 シスメックス株式会社 プロトロンビン時間測定用試薬およびその製造方法
US11167008B2 (en) 2016-11-23 2021-11-09 Vaxiion Therapeutics, Llc Immunomodulatory and oncolytic minicells and methods of use
CN106680339A (zh) * 2016-12-28 2017-05-17 北京乐普医疗科技有限责任公司 一种基于电化学方法的凝血酶原时间测试卡及其制备方法
CN109239373A (zh) * 2018-08-15 2019-01-18 迪瑞医疗科技股份有限公司 一种组织因子酯化物试剂及其制备方法与应用
CN109613279A (zh) * 2018-12-06 2019-04-12 太原博奥特生物技术有限公司 一种新型鞣花酸化合物及利用鞣花酸化合物制备活化部分凝血活酶时间测定试剂
CN110244066A (zh) * 2019-07-01 2019-09-17 北京乐普医疗科技有限责任公司 一种干式电化学法凝血酶原时间检测卡及制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL238873A (es) * 1958-05-16
DE2916711A1 (de) † 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
IT1212900B (it) * 1983-11-17 1989-11-30 Valle Francesco Della Uso terapeutico della fosfatidilserina in malattie del sistema nervoso centrale senza effetti sulla coagulazione sanguigna
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US5017556A (en) * 1986-11-04 1991-05-21 Genentech, Inc. Treatment of bleeding disorders using lipid-free tissue factor protein
IE81149B1 (en) † 1987-02-12 2000-05-03 Genentech Inc Methods and deoxyribonucleic acid for the preparation of tissue factor protein
US5223427A (en) † 1987-03-31 1993-06-29 The Scripps Research Institute Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
US4865984A (en) † 1988-02-08 1989-09-12 Mount Sinai School Of Medicine Of The City University Of New York Dynamic continuous flow enzyme reactor

Also Published As

Publication number Publication date
PT99499A (pt) 1992-11-30
AU4448996A (en) 1996-05-09
DK0564495T3 (da) 1999-11-15
GR3030906T3 (en) 1999-11-30
FI932148A0 (fi) 1993-05-12
DE69131204T2 (de) 1999-12-23
CA2096109A1 (en) 1992-05-14
EP0564495A1 (en) 1993-10-13
NZ264556A (en) 1996-07-26
AU9090791A (en) 1992-06-11
WO1992008479A1 (en) 1992-05-29
ES2133310T5 (es) 2007-08-16
ATE179608T1 (de) 1999-05-15
DK0564495T4 (da) 2007-04-30
DE69131204T3 (de) 2007-05-24
DE69131204D1 (de) 1999-06-10
ES2133310T3 (es) 1999-09-16
KR100196107B1 (ko) 1999-06-15
FI932148A (fi) 1993-06-03
EP0564495B2 (en) 2006-12-27
JP3441456B2 (ja) 2003-09-02
CA2096109C (en) 2004-01-06
JPH06502649A (ja) 1994-03-24
NO931708L (no) 1993-07-08
NO314617B1 (no) 2003-04-22
MX9102042A (es) 1994-01-31
PT99499B (pt) 1999-04-30
IE913955A1 (en) 1992-05-20
NZ240577A (en) 1996-07-26
EP0564495B1 (en) 1999-05-06
EP0564495A4 (es) 1994-12-21
NO931708D0 (no) 1993-05-11
US5314695A (en) 1994-05-24

Similar Documents

Publication Publication Date Title
FI109764B (fi) Kudostekijään perustuva protrombiiniaikareagenssi
IE83895B1 (en) Tissue factor based prothrombin time reagent
EP1239833B1 (en) Reconstitution of purified membrane proteins into preformed liposomes
RU2567746C2 (ru) Способ двухфазного получения липосом и способы их применения при изготовлении диагностических реагентов
CA2097199C (en) Preparation of prothrombin time reagents from recombinant human tissue factor and purified natural and synthetic phospholipids
US5698677A (en) Stable preparation for the treatment of blood coagulation disorders
MX2012012135A (es) Vesiculas enriquecidas con fosfolipidos que albergan factor tisular que tienen actividades hemostaticas y usos de las mismas.
US6733985B1 (en) Preparation of stable liquid and dried synthetic prothrombin time reagents
WO2006031387A1 (en) Thromboplastin reagents
US6203816B1 (en) Tissue factor based prothrombin time reagent
WO1989001512A1 (en) A sponge enzyme having transglutaminase-like activity
US6183979B1 (en) Preparation of dried synthetic prothrombin time reagents
AU744287B2 (en) Tissue factor based prothrombin time reagent
Van Zutphen et al. Contribution of the platelet factor V content to platelet factor 3 activity
Stevenson Studies on the development of standardised thromboplastin reagents.
Baron et al. Binding of influenza virus to a reconstituted receptor complex containing glycophorin

Legal Events

Date Code Title Description
MA Patent expired