FI109207B - Tumör/kolhydratantigenspecifik monoklonal antikropp samt cellinje - Google Patents

Tumör/kolhydratantigenspecifik monoklonal antikropp samt cellinje Download PDF

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Publication number
FI109207B
FI109207B FI935970A FI935970A FI109207B FI 109207 B FI109207 B FI 109207B FI 935970 A FI935970 A FI 935970A FI 935970 A FI935970 A FI 935970A FI 109207 B FI109207 B FI 109207B
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FI
Finland
Prior art keywords
antibody
tyr
cell line
leu
antigen
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Application number
FI935970A
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English (en)
Finnish (fi)
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FI935970A (fi
FI935970A0 (fi
Inventor
Jan Holmgren
Peter Lind
Leif Lindholm
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Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of FI935970A publication Critical patent/FI935970A/fi
Publication of FI935970A0 publication Critical patent/FI935970A0/fi
Application granted granted Critical
Publication of FI109207B publication Critical patent/FI109207B/sv

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1063—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from stomach or intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1057—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from liver or pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3046—Stomach, Intestines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (6)

18 109207
1. Antikropp för CA-242-antigen för annan än terapeutisk användning, känne-tecknad av att den produceras av hybridomcellinje C242:II, som har ECACC-identifikationsnummer 90012601, eller av en antikropp som har väsentligen samma 5 antikroppsbindningsegenskaper (epitopspecificitet).
2. Monoklonal antikropp i enlighet med patentkrav 1, kännetecknad av att den används diagnostisia in vivo.
3. Antikropp i enlighet med patentkrav 1 eller 2, kännetecknad av att den är i fragmenterad form.
4. Antikropp i enlighet med vilket som heist av patentkraven 1-3, kännetecknad av att den binder sig specifikt vid samma epitop som antikroppen, som har i sinä CDR-omräden: κ-kedja: CDR1: Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 15 CDR2: Arg Met Ser Asn Leu Vai Ser CDR3: Leu Gin His Leu Glu Tyr Pro Phe Thr :' Tung kedja: [·' ' CDR1: Tyr Tyr Gly Met Asn • ‘ ; CDR2: Trp Ile Asp Thr Thr Thr Gly Glu Pro Thr Tyr Ala Glu Asp Phe Lys Gly • ‘ 20 CDR3: Arg Gly Pro Tyr Asn Trp Tyr Phe Asp Vai. •;" | 5. Förfarande för in vitro diagnosticering, kännetecknat av att i det bringas ett • ·. prov i kontakt med en monoklonal antikropp i enlighet med vilket som heist av pa- , tentkraven 1-4 i förhällanden, i vilka det bildas ett komplex innehällande den mo- : noklonala antikroppen bunden vid sin antigen, och därefter bestäms komplexet som 25 formats, vars mängd korrelerar med mängden antigen som firms i provet.
6. Cellinje, kännetecknad av att det är en hybridomcellinje C242:II, som har • ECACC-identifikationsnummer 90012601. 109207 I S ro ro I s Fig. 1
FI935970A 1991-07-03 1993-12-31 Tumör/kolhydratantigenspecifik monoklonal antikropp samt cellinje FI109207B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9102074A SE9102074D0 (sv) 1991-07-03 1991-07-03 Tomour antigen specific antibody
SE9102074 1991-07-03
SE9200502 1992-02-20
PCT/SE1992/000502 WO1993001303A1 (en) 1991-07-03 1992-07-03 Tumor, carbohydrate antigen specific monoclonal antibody and cell line

Publications (3)

Publication Number Publication Date
FI935970A FI935970A (fi) 1993-12-31
FI935970A0 FI935970A0 (fi) 1993-12-31
FI109207B true FI109207B (sv) 2002-06-14

Family

ID=20383243

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935970A FI109207B (sv) 1991-07-03 1993-12-31 Tumör/kolhydratantigenspecifik monoklonal antikropp samt cellinje

Country Status (19)

Country Link
US (1) US5552293A (sv)
EP (1) EP0521842B1 (sv)
JP (1) JP3194020B2 (sv)
KR (1) KR100246681B1 (sv)
AT (1) ATE171193T1 (sv)
AU (2) AU2292092A (sv)
CA (1) CA2073124C (sv)
DE (1) DE69226990T2 (sv)
DK (1) DK0521842T3 (sv)
EE (1) EE03031B1 (sv)
ES (1) ES2124250T3 (sv)
FI (1) FI109207B (sv)
HU (2) HU218084B (sv)
IE (1) IE80841B1 (sv)
IL (1) IL102390A (sv)
NO (1) NO315472B1 (sv)
NZ (1) NZ243435A (sv)
SE (1) SE9102074D0 (sv)
WO (2) WO1993001302A1 (sv)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402430L (sv) 1994-07-11 1996-01-12 Pharmacia Ab Konjugat mellan modifierat superantigen och en målsökande förening samt användning av konjugaten
SE9601245D0 (sv) 1996-03-29 1996-03-29 Pharmacia Ab Chimeric superantigens and their use
TW517061B (en) 1996-03-29 2003-01-11 Pharmacia & Amp Upjohn Ab Modified/chimeric superantigens and their use
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
EP1411962B1 (en) * 2001-03-15 2011-01-19 Neogenix Oncology, Inc. Monoclonal antibody therapy for pancreas cancer
DE10116552A1 (de) * 2001-04-03 2002-10-10 Abc Armbruster Biochemicals Verfahren zur Bestimmung der wirksamen Parathormon-Aktivität in einer Probe
NZ537610A (en) * 2002-07-02 2006-07-28 Smithkline Beecham Corp Stable formulations of the C242 antibody
US7390898B2 (en) 2002-08-02 2008-06-24 Immunogen Inc. Cytotoxic agents containing novel potent taxanes and their therapeutic use
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
SI1651162T1 (sl) 2003-05-20 2016-02-29 Immunogen, Inc. Izboljšani citotoksični agenti, ki vsebujejo nove majtanzinoide
US20060182750A1 (en) * 2005-02-11 2006-08-17 Immunogen, Inc. Process for preparing stable drug conjugates
US20110166319A1 (en) * 2005-02-11 2011-07-07 Immunogen, Inc. Process for preparing purified drug conjugates
CA2618796C (en) * 2005-08-11 2018-01-02 Arpi Matossian-Rogers Peptides for treatment and diagnosis of autoimmune disease
AU2012244244B2 (en) * 2005-08-11 2015-08-27 Arpi Matossian-Rogers TCR-V-beta related peptides for treatment and diagnosis of autoimmune disease
CA2620343C (en) 2005-08-24 2013-01-08 Immunogen, Inc. Process for preparing antibody maytansinoid conjugates
DK2733492T3 (en) 2008-08-05 2016-04-25 Toray Industries Method for detection of cancer
TR201907573T4 (tr) 2009-06-03 2019-06-21 Immunogen Inc Konjugasyon yöntemleri̇
RS58367B1 (sr) 2011-03-29 2019-03-29 Immunogen Inc Priprema konjugata antitela i majtanzinoida jednostepenim postupkom
SG193997A1 (en) 2011-03-29 2013-11-29 Immunogen Inc Process for manufacturing conjugates of improved homogeneity
RU2018122734A (ru) 2012-10-04 2018-07-24 Иммуноджен, Инк. Использование пвдф-мембраны для очистки конъюгатов клеточно-связывающий агент-цитотоксический агент
WO2015076425A1 (ja) * 2013-11-25 2015-05-28 リンク・ジェノミクス株式会社 新規モノクローナル抗体
KR20170088905A (ko) 2014-11-19 2017-08-02 이뮤노젠 아이엔씨 세포 결합 작용제-세포독성 작용제 접합체를 제조하기 위한 공정
CN109195988B (zh) 2016-01-10 2023-12-01 尼奥克斯医疗有限公司 用于增强超抗原介导的癌症免疫疗法效力的方法和组合物
RU2018130108A (ru) 2016-02-05 2020-03-06 Иммуноджен, Инк. Эффективный способ получения конъюгатов связывающийся с клеткой агент цитотоксический агент
CN107167590B (zh) * 2017-04-14 2019-03-08 江苏福隆生物技术有限公司 糖类抗原242的板式化学发光法检测试剂盒及制备方法
WO2019035034A1 (en) * 2017-08-16 2019-02-21 The Broad Institute, Inc. NEURONAL DOSAGE METHOD INVOLVING CALCINEURIN
KR20220009428A (ko) 2019-05-15 2022-01-24 네오티엑스 테라퓨틱스 엘티디. 암 치료
EP4114449A2 (en) 2020-03-05 2023-01-11 Neotx Therapeutics Ltd. Methods and compositions for treating cancer with immune cells

Family Cites Families (5)

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US4752569A (en) * 1984-06-21 1988-06-21 The Regents Of The University Of California Sialylated Lewisx epitope, antibodies and diagnosis
US4904596A (en) * 1985-08-07 1990-02-27 Fred Hutchinson Cancer Research Center Hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside
SE8902043L (sv) * 1988-11-10 1990-05-11 Pharmacia Ab Foerfarande foer karakterisering av makromolekyler
EP0540612A1 (en) * 1990-07-20 1993-05-12 Pharmacia AB Heterobifunctional reagents and conjugates with oxaalkylene units for amphiphilic bridge structures
DK0610179T3 (da) * 1990-07-20 1997-03-24 Pharmacia & Upjohn Ab Målspecifikke antistof-superantigenkonjugater og fremstilling deraf

Also Published As

Publication number Publication date
AU658198B2 (en) 1995-04-06
CA2073124A1 (en) 1993-01-04
IE922188A1 (en) 1993-01-13
SE9102074D0 (sv) 1991-07-03
EP0521842A3 (sv) 1994-01-26
HU211512A9 (en) 1995-11-28
NZ243435A (en) 1994-10-26
FI935970A (fi) 1993-12-31
HU218084B (hu) 2000-05-28
DE69226990T2 (de) 1999-03-25
AU2292092A (en) 1993-02-11
HUT71193A (en) 1995-11-28
AU1942592A (en) 1993-01-07
DE69226990D1 (de) 1998-10-22
NO315472B1 (no) 2003-09-08
JP3194020B2 (ja) 2001-07-30
JPH05276987A (ja) 1993-10-26
FI935970A0 (fi) 1993-12-31
DK0521842T3 (da) 1999-06-14
EP0521842A2 (en) 1993-01-07
NO934777D0 (no) 1993-12-22
ATE171193T1 (de) 1998-10-15
IE80841B1 (en) 1999-03-24
EE03031B1 (et) 1997-08-15
NO934777L (no) 1994-02-11
IL102390A (en) 1996-01-19
US5552293A (en) 1996-09-03
EP0521842B1 (en) 1998-09-16
HU9400011D0 (en) 1994-05-30
ES2124250T3 (es) 1999-02-01
KR100246681B1 (ko) 2000-04-01
IL102390A0 (en) 1993-01-14
WO1993001303A1 (en) 1993-01-21
CA2073124C (en) 2007-06-19
WO1993001302A1 (en) 1993-01-21

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Owner name: PHARMACIA AB

MA Patent expired