FI108943B - Menetelmiä seriiniproteaasi-inhibiittorien valmistamiseksi ja menetelmässä käytettävä synteettinen tai eristetty DNA-sekvenssi, yhdistelmävektori sekä bakteeri- tai hiivaisäntäsolu - Google Patents

Menetelmiä seriiniproteaasi-inhibiittorien valmistamiseksi ja menetelmässä käytettävä synteettinen tai eristetty DNA-sekvenssi, yhdistelmävektori sekä bakteeri- tai hiivaisäntäsolu Download PDF

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Publication number
FI108943B
FI108943B FI863188A FI863188A FI108943B FI 108943 B FI108943 B FI 108943B FI 863188 A FI863188 A FI 863188A FI 863188 A FI863188 A FI 863188A FI 108943 B FI108943 B FI 108943B
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pro
gly
asp
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FI863188A
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English (en)
Finnish (fi)
Swedish (sv)
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FI863188A0 (fi
FI863188A (fi
Inventor
Robert C Thompson
Pradip K Bandyopadhyay
Stephen P Eisenberg
Gary L Stetler
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Amgen Inc
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Application filed by Amgen Inc filed Critical Amgen Inc
Publication of FI863188A0 publication Critical patent/FI863188A0/fi
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
FI863188A 1984-12-06 1986-08-05 Menetelmiä seriiniproteaasi-inhibiittorien valmistamiseksi ja menetelmässä käytettävä synteettinen tai eristetty DNA-sekvenssi, yhdistelmävektori sekä bakteeri- tai hiivaisäntäsolu FI108943B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US67882284A 1984-12-06 1984-12-06
US67882284 1984-12-06
US80347185A 1985-12-02 1985-12-02
US80347185 1985-12-02
US8502385 1985-12-04
PCT/US1985/002385 WO1986003519A1 (en) 1984-12-06 1985-12-04 Recombinant methods for production of serine protease inhibitors and dna sequences useful for same

Publications (3)

Publication Number Publication Date
FI863188A0 FI863188A0 (fi) 1986-08-05
FI863188A FI863188A (fi) 1986-08-05
FI108943B true FI108943B (fi) 2002-04-30

Family

ID=27102096

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863188A FI108943B (fi) 1984-12-06 1986-08-05 Menetelmiä seriiniproteaasi-inhibiittorien valmistamiseksi ja menetelmässä käytettävä synteettinen tai eristetty DNA-sekvenssi, yhdistelmävektori sekä bakteeri- tai hiivaisäntäsolu

Country Status (18)

Country Link
EP (1) EP0205475B2 (de)
JP (1) JP2683500B2 (de)
AT (1) ATE108205T1 (de)
AU (1) AU590238B2 (de)
CA (1) CA1296273C (de)
DD (1) DD253642A5 (de)
DE (1) DE3587875T3 (de)
DK (1) DK372086D0 (de)
FI (1) FI108943B (de)
GR (1) GR852940B (de)
HU (1) HU204563B (de)
IE (1) IE64175B1 (de)
IL (3) IL95223A (de)
MX (1) MX9203519A (de)
NO (1) NO301122B1 (de)
NZ (1) NZ214456A (de)
PT (1) PT81624B (de)
WO (1) WO1986003519A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
US5871956A (en) * 1984-12-06 1999-02-16 Amgen Inc. Recombinant methods for production of serine inhibitors and DNA sequences useful for same
WO1986003497A1 (en) * 1984-12-06 1986-06-19 Synergen Biologicals, Inc. Serine protease inhibitors and methods for isolation of same
US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
US5900400A (en) * 1984-12-06 1999-05-04 Amgen Inc. Serine protease inhibitor analogs
DK4286A (da) * 1985-01-07 1986-07-08 Celltech Ltd Fremgangsmaade til fremstilling af en metalloproteinaseinhibitor
DE3600571A1 (de) * 1986-01-10 1987-08-06 Gruenenthal Gmbh Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel
US5278049A (en) * 1986-06-03 1994-01-11 Incyte Pharmaceuticals, Inc. Recombinant molecule encoding human protease nexin
JPH0616716B2 (ja) * 1986-10-14 1994-03-09 塩野義製薬株式会社 酵母におけるヒトｐｓｔｉの製造法
AU8172787A (en) * 1986-10-30 1988-05-25 Synergen Biologicals, Inc. Human pancreatic secretory trypsin inhibitors produced by recombinant dna methods and processes for the production of same
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
US5851983A (en) * 1987-12-28 1998-12-22 Teijin Limited Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
ATE103930T1 (de) * 1988-03-07 1994-04-15 Ciba Geigy Ag Modifizierte proteine.
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
US5223407A (en) * 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
US5646015A (en) * 1988-08-31 1997-07-08 Astra Ab Excretion of heterologous proteins from E. coli
US6869925B1 (en) * 1992-09-09 2005-03-22 Amgen Inc. Inhibition of retrovirus infection
US6017880A (en) * 1994-03-09 2000-01-25 Amgen Inc. Inhibition of retrovirus infection
BR9507165A (pt) * 1994-03-23 1997-09-09 Tokyo Tanase Company Limited Inibidor da triptase clara agente terapêutico ou profilático para doenças virais processo terapêutico para doenças virais e uso da antileucoprotease
US5633227A (en) * 1994-09-12 1997-05-27 Miles, Inc. Secretory leukocyte protease inhibitor as an inhibitor of tryptase
SE9702401D0 (sv) 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
DE3247922A1 (de) * 1982-12-24 1984-06-28 Boehringer Ingelheim International GmbH, 6507 Ingelheim Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten
WO1984003711A1 (en) * 1983-03-25 1984-09-27 Celltech Ltd A process for the production of a protein
JPS60186290A (ja) * 1983-08-10 1985-09-21 チモ−ジエネテイツクス　インコ−ポレ−テツド アルフア−１−アンチトリプシンを細菌に表現させる方法
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin

Also Published As

Publication number Publication date
DE3587875D1 (de) 1994-08-11
ATE108205T1 (de) 1994-07-15
PT81624B (pt) 1987-10-20
DE3587875T3 (de) 2003-01-02
IL95223A (en) 1992-08-18
AU5202986A (en) 1986-07-01
HU204563B (en) 1992-01-28
AU590238B2 (en) 1989-11-02
EP0205475B1 (de) 1994-07-06
CA1296273C (en) 1992-02-25
MX9203519A (es) 1992-08-01
DK372086A (da) 1986-08-05
IL95223A0 (en) 1991-06-10
NO863182L (no) 1986-08-06
GR852940B (de) 1986-04-07
DD253642A5 (de) 1988-01-27
IL77227A (en) 1992-08-18
EP0205475A4 (de) 1990-06-27
NZ214456A (en) 1988-02-12
JPH06315384A (ja) 1994-11-15
HUT41442A (en) 1987-04-28
FI863188A0 (fi) 1986-08-05
NO863182D0 (no) 1986-08-06
DE3587875T2 (de) 1994-10-13
PT81624A (en) 1986-01-01
NO301122B1 (no) 1997-09-15
EP0205475A1 (de) 1986-12-30
EP0205475B2 (de) 2002-09-04
FI863188A (fi) 1986-08-05
JP2683500B2 (ja) 1997-11-26
WO1986003519A1 (en) 1986-06-19
DK372086D0 (da) 1986-08-05
IE64175B1 (en) 1995-07-12
IE853083L (en) 1986-06-06

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