DK372086A - Fremgangsmaade til rekombinant-dna-syntese af en serinproteaseinhibitor og dna-sekvenser, som er nyttige derved - Google Patents

Fremgangsmaade til rekombinant-dna-syntese af en serinproteaseinhibitor og dna-sekvenser, som er nyttige derved Download PDF

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Publication number
DK372086A
DK372086A DK372086A DK372086A DK372086A DK 372086 A DK372086 A DK 372086A DK 372086 A DK372086 A DK 372086A DK 372086 A DK372086 A DK 372086A DK 372086 A DK372086 A DK 372086A
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Denmark
Prior art keywords
protease inhibitor
recombinant dna
procedure
sequences used
dna sequences
Prior art date
Application number
DK372086A
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Danish (da)
English (en)
Other versions
DK372086D0 (da
Inventor
Pradip K Bandyopadhyay
Stephen P Eisenberg
Gary L Stetler
Robert C Thompson
Original Assignee
Synergen Biolog Inc
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Publication date
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Application filed by Synergen Biolog Inc filed Critical Synergen Biolog Inc
Publication of DK372086D0 publication Critical patent/DK372086D0/da
Publication of DK372086A publication Critical patent/DK372086A/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DK372086A 1984-12-06 1986-08-05 Fremgangsmaade til rekombinant-dna-syntese af en serinproteaseinhibitor og dna-sekvenser, som er nyttige derved DK372086A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67882284A 1984-12-06 1984-12-06
US80347185A 1985-12-02 1985-12-02
PCT/US1985/002385 WO1986003519A1 (en) 1984-12-06 1985-12-04 Recombinant methods for production of serine protease inhibitors and dna sequences useful for same

Publications (2)

Publication Number Publication Date
DK372086D0 DK372086D0 (da) 1986-08-05
DK372086A true DK372086A (da) 1986-08-05

Family

ID=27102096

Family Applications (1)

Application Number Title Priority Date Filing Date
DK372086A DK372086A (da) 1984-12-06 1986-08-05 Fremgangsmaade til rekombinant-dna-syntese af en serinproteaseinhibitor og dna-sekvenser, som er nyttige derved

Country Status (18)

Country Link
EP (1) EP0205475B2 (de)
JP (1) JP2683500B2 (de)
AT (1) ATE108205T1 (de)
AU (1) AU590238B2 (de)
CA (1) CA1296273C (de)
DD (1) DD253642A5 (de)
DE (1) DE3587875T3 (de)
DK (1) DK372086A (de)
FI (1) FI108943B (de)
GR (1) GR852940B (de)
HU (1) HU204563B (de)
IE (1) IE64175B1 (de)
IL (3) IL95223A (de)
MX (1) MX9203519A (de)
NO (1) NO301122B1 (de)
NZ (1) NZ214456A (de)
PT (1) PT81624B (de)
WO (1) WO1986003519A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871956A (en) * 1984-12-06 1999-02-16 Amgen Inc. Recombinant methods for production of serine inhibitors and DNA sequences useful for same
US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
EP0205555B2 (de) * 1984-12-06 2002-04-10 Amgen Inc. Serinproteaseinhibitoren und isolierungsverfahren dazu
US5900400A (en) * 1984-12-06 1999-05-04 Amgen Inc. Serine protease inhibitor analogs
EP0188312A3 (de) * 1985-01-07 1988-01-13 Celltech Limited Verfahren zur Herstellung eines Proteins
DE3600571A1 (de) * 1986-01-10 1987-08-06 Gruenenthal Gmbh Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel
US5278049A (en) * 1986-06-03 1994-01-11 Incyte Pharmaceuticals, Inc. Recombinant molecule encoding human protease nexin
JPH0616716B2 (ja) * 1986-10-14 1994-03-09 塩野義製薬株式会社 酵母におけるヒトpstiの製造法
AU8172787A (en) * 1986-10-30 1988-05-25 Synergen Biologicals, Inc. Human pancreatic secretory trypsin inhibitors produced by recombinant dna methods and processes for the production of same
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
US5851983A (en) * 1987-12-28 1998-12-22 Teijin Limited Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
DE58907373D1 (de) * 1988-03-07 1994-05-11 Ciba Geigy Modifizierte Proteine.
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
US5646015A (en) * 1988-08-31 1997-07-08 Astra Ab Excretion of heterologous proteins from E. coli
US5223407A (en) * 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
US6869925B1 (en) * 1992-09-09 2005-03-22 Amgen Inc. Inhibition of retrovirus infection
US6017880A (en) * 1994-03-09 2000-01-25 Amgen Inc. Inhibition of retrovirus infection
PL316444A1 (en) * 1994-03-23 1997-01-20 Tokyo Tanabe Co Novel agent against viral diseases of respiratory tracts
US5633227A (en) * 1994-09-12 1997-05-27 Miles, Inc. Secretory leukocyte protease inhibitor as an inhibitor of tryptase
SE9702401D0 (sv) 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
DE3247922A1 (de) * 1982-12-24 1984-06-28 Boehringer Ingelheim International GmbH, 6507 Ingelheim Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten
DE122080T1 (de) * 1983-03-25 1985-05-23 Celltech Ltd., Slough, Berkshire Verfahren zur herstellung eines proteins.
JPS60186290A (ja) * 1983-08-10 1985-09-21 チモ−ジエネテイツクス インコ−ポレ−テツド アルフア−1−アンチトリプシンを細菌に表現させる方法
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin

Also Published As

Publication number Publication date
JP2683500B2 (ja) 1997-11-26
FI108943B (fi) 2002-04-30
WO1986003519A1 (en) 1986-06-19
MX9203519A (es) 1992-08-01
GR852940B (de) 1986-04-07
JPH06315384A (ja) 1994-11-15
DK372086D0 (da) 1986-08-05
NO863182L (no) 1986-08-06
EP0205475B2 (de) 2002-09-04
NO863182D0 (no) 1986-08-06
DE3587875T2 (de) 1994-10-13
PT81624B (pt) 1987-10-20
ATE108205T1 (de) 1994-07-15
CA1296273C (en) 1992-02-25
EP0205475B1 (de) 1994-07-06
EP0205475A1 (de) 1986-12-30
PT81624A (en) 1986-01-01
IL95223A0 (en) 1991-06-10
NO301122B1 (no) 1997-09-15
IE64175B1 (en) 1995-07-12
NZ214456A (en) 1988-02-12
DD253642A5 (de) 1988-01-27
DE3587875D1 (de) 1994-08-11
EP0205475A4 (de) 1990-06-27
HU204563B (en) 1992-01-28
FI863188A0 (fi) 1986-08-05
AU5202986A (en) 1986-07-01
IL77227A (en) 1992-08-18
IE853083L (en) 1986-06-06
IL95223A (en) 1992-08-18
DE3587875T3 (de) 2003-01-02
HUT41442A (en) 1987-04-28
AU590238B2 (en) 1989-11-02
FI863188A (fi) 1986-08-05

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