FI108644B - Menetelmä insuliinipitoisten liuosten valmistamiseksi - Google Patents

Menetelmä insuliinipitoisten liuosten valmistamiseksi Download PDF

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Publication number
FI108644B
FI108644B FI925719A FI925719A FI108644B FI 108644 B FI108644 B FI 108644B FI 925719 A FI925719 A FI 925719A FI 925719 A FI925719 A FI 925719A FI 108644 B FI108644 B FI 108644B
Authority
FI
Finland
Prior art keywords
insulin
acetylated
group
process according
buffer
Prior art date
Application number
FI925719A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI925719A (fi
FI925719A0 (fi
Inventor
Bernhard Unger
Rainer Dickhardt
Claudia Graefe
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19914141794 external-priority patent/DE4141794C2/de
Priority claimed from DE19924220293 external-priority patent/DE4220293C2/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of FI925719A0 publication Critical patent/FI925719A0/fi
Publication of FI925719A publication Critical patent/FI925719A/fi
Application granted granted Critical
Publication of FI108644B publication Critical patent/FI108644B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Inorganic Insulating Materials (AREA)
  • Soil Working Implements (AREA)
FI925719A 1991-12-18 1992-12-16 Menetelmä insuliinipitoisten liuosten valmistamiseksi FI108644B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19914141794 DE4141794C2 (de) 1991-12-18 1991-12-18 Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
DE4141794 1991-12-18
DE19924220293 DE4220293C2 (de) 1992-06-20 1992-06-20 Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
DE4220293 1992-06-20

Publications (3)

Publication Number Publication Date
FI925719A0 FI925719A0 (fi) 1992-12-16
FI925719A FI925719A (fi) 1993-06-19
FI108644B true FI108644B (fi) 2002-02-28

Family

ID=25910232

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925719A FI108644B (fi) 1991-12-18 1992-12-16 Menetelmä insuliinipitoisten liuosten valmistamiseksi

Country Status (12)

Country Link
US (1) US5621073A (no)
EP (1) EP0547544B1 (no)
JP (1) JP2736214B2 (no)
AT (1) ATE150032T1 (no)
CA (1) CA2085719C (no)
DE (1) DE59208181D1 (no)
DK (1) DK0547544T3 (no)
ES (1) ES2099193T3 (no)
FI (1) FI108644B (no)
GR (1) GR3023431T3 (no)
NO (1) NO304743B1 (no)
SG (1) SG44748A1 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
DE19838097A1 (de) 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
US6746853B1 (en) 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
CL2007002615A1 (es) * 2006-09-08 2008-04-18 Wyeth Corp Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto.
US20120214199A1 (en) * 2011-02-23 2012-08-23 Elona Biotechnologies Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom
KR20110004366A (ko) 2008-03-18 2011-01-13 노보 노르디스크 에이/에스 프로테아제 안정화되고, 아실화된 인슐린 유사체
PL219335B1 (pl) * 2008-07-04 2015-04-30 Inst Biotechnologii I Antybiotyków Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna
ES2594303T3 (es) 2012-04-11 2016-12-19 Novo Nordisk A/S Formulaciones de insulina
EP2931301B2 (en) 2012-12-17 2021-09-15 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
WO2015138548A1 (en) 2014-03-14 2015-09-17 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
US10155799B2 (en) 2014-07-21 2018-12-18 Merck Sharp & Dohme Corp. Chromatography process for purification of insulin and insulin analogs
CN115154591B (zh) 2016-12-16 2023-04-14 诺和诺德股份有限公司 含胰岛素的药物组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629568C3 (de) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
WO1989001485A1 (en) * 1987-08-14 1989-02-23 Gebro Broschek Kg Purification of raw peptides by preparative medium-pressure liquid chromatography
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE4028120C2 (de) * 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten

Also Published As

Publication number Publication date
EP0547544A2 (de) 1993-06-23
DK0547544T3 (da) 1997-09-08
DE59208181D1 (de) 1997-04-17
CA2085719A1 (en) 1993-06-19
NO924899L (no) 1993-06-21
CA2085719C (en) 2005-03-01
ES2099193T3 (es) 1997-05-16
FI925719A (fi) 1993-06-19
US5621073A (en) 1997-04-15
NO924899D0 (no) 1992-12-17
EP0547544A3 (en) 1994-07-13
JPH05308989A (ja) 1993-11-22
GR3023431T3 (en) 1997-08-29
SG44748A1 (en) 1997-12-19
FI925719A0 (fi) 1992-12-16
JP2736214B2 (ja) 1998-04-02
EP0547544B1 (de) 1997-03-12
NO304743B1 (no) 1999-02-08
ATE150032T1 (de) 1997-03-15

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Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH

Free format text: SANOFI-AVENTIS DEUTSCHLAND GMBH

MA Patent expired