FI108132B - Menetelmä kiteisen loracarbef-monohydraatin valmistamiseksi - Google Patents
Menetelmä kiteisen loracarbef-monohydraatin valmistamiseksi Download PDFInfo
- Publication number
- FI108132B FI108132B FI942633A FI942633A FI108132B FI 108132 B FI108132 B FI 108132B FI 942633 A FI942633 A FI 942633A FI 942633 A FI942633 A FI 942633A FI 108132 B FI108132 B FI 108132B
- Authority
- FI
- Finland
- Prior art keywords
- monohydrate
- dihydrate
- crystalline
- preparation
- relative humidity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7155093 | 1993-06-04 | ||
| US08/071,550 US5374719A (en) | 1993-06-04 | 1993-06-04 | Process for converting loracarbef dihydrate to loracarbef monohydrate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI942633A0 FI942633A0 (fi) | 1994-06-03 |
| FI942633L FI942633L (fi) | 1994-12-05 |
| FI108132B true FI108132B (fi) | 2001-11-30 |
Family
ID=22102051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI942633A FI108132B (fi) | 1993-06-04 | 1994-06-03 | Menetelmä kiteisen loracarbef-monohydraatin valmistamiseksi |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5374719A (enExample) |
| EP (1) | EP0627430B1 (enExample) |
| JP (1) | JP3442479B2 (enExample) |
| KR (1) | KR100311699B1 (enExample) |
| CN (1) | CN1042424C (enExample) |
| AT (1) | ATE146472T1 (enExample) |
| AU (1) | AU678000B2 (enExample) |
| BR (1) | BR9402149A (enExample) |
| CA (1) | CA2125001C (enExample) |
| CO (1) | CO4230100A1 (enExample) |
| CZ (1) | CZ283468B6 (enExample) |
| DE (1) | DE69401163T2 (enExample) |
| DK (1) | DK0627430T3 (enExample) |
| ES (1) | ES2097002T3 (enExample) |
| FI (1) | FI108132B (enExample) |
| GR (1) | GR3022111T3 (enExample) |
| HU (1) | HU217066B (enExample) |
| IL (1) | IL109871A (enExample) |
| MY (1) | MY110724A (enExample) |
| NO (1) | NO306302B1 (enExample) |
| NZ (1) | NZ260653A (enExample) |
| PE (1) | PE13195A1 (enExample) |
| PH (1) | PH30304A (enExample) |
| PL (1) | PL174539B1 (enExample) |
| RU (1) | RU2124013C1 (enExample) |
| TW (1) | TW252980B (enExample) |
| UA (1) | UA27812C2 (enExample) |
| YU (1) | YU33394A (enExample) |
| ZA (1) | ZA943827B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550231A (en) * | 1993-06-15 | 1996-08-27 | Eli Lilly And Company | Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof |
| US5580977A (en) * | 1995-03-01 | 1996-12-03 | Eli Lilly And Company | Process for preparing loracarbef monohydrate |
| KR100783863B1 (ko) * | 2002-04-29 | 2007-12-10 | 액테리온 파마슈티칼 리미티드 | 7-아릴-3,9-디아자바이사이클로(3.3.1)논-6-엔 유도체 및고혈압, 심혈관 질환 또는 신장 질환의 치료에서 레닌저해물질로써 이들의 용도 |
| US20070225285A1 (en) * | 2005-11-04 | 2007-09-27 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3502663A (en) * | 1969-04-21 | 1970-03-24 | Lilly Co Eli | Crystalline cephalosporin,method for its manufacture |
| US3531481A (en) * | 1969-04-21 | 1970-09-29 | Lilly Co Eli | Method for manufacture of crystalline cephalosporin |
| JPS5672698A (en) * | 1979-11-14 | 1981-06-16 | Kyowa Hakko Kogyo Co Ltd | Preparation of optically active cephalosporin analogue |
| ZA887409B (en) * | 1987-10-06 | 1990-06-27 | Lilly Co Eli | Crystalline beta-lactam hydrate |
| US4977257A (en) * | 1988-11-14 | 1990-12-11 | Eli Lilly And Company | DMF solvates of a β-lactam antibiotic |
| CA2002596A1 (en) * | 1988-11-14 | 1990-05-14 | Thomas M. Eckrich | Hydrates of b-lactam antibiotic |
-
1993
- 1993-06-04 US US08/071,550 patent/US5374719A/en not_active Expired - Lifetime
-
1994
- 1994-06-01 PL PL94303676A patent/PL174539B1/pl not_active IP Right Cessation
- 1994-06-01 PE PE1994243644A patent/PE13195A1/es not_active Application Discontinuation
- 1994-06-01 AT AT94303945T patent/ATE146472T1/de not_active IP Right Cessation
- 1994-06-01 BR BR9402149A patent/BR9402149A/pt not_active Application Discontinuation
- 1994-06-01 ES ES94303945T patent/ES2097002T3/es not_active Expired - Lifetime
- 1994-06-01 TW TW083105006A patent/TW252980B/zh active
- 1994-06-01 NZ NZ260653A patent/NZ260653A/en unknown
- 1994-06-01 ZA ZA943827A patent/ZA943827B/xx unknown
- 1994-06-01 DE DE69401163T patent/DE69401163T2/de not_active Expired - Fee Related
- 1994-06-01 DK DK94303945.3T patent/DK0627430T3/da active
- 1994-06-01 CZ CZ941342A patent/CZ283468B6/cs not_active IP Right Cessation
- 1994-06-01 EP EP94303945A patent/EP0627430B1/en not_active Expired - Lifetime
- 1994-06-02 KR KR1019940012340A patent/KR100311699B1/ko not_active Expired - Fee Related
- 1994-06-02 CO CO94023737A patent/CO4230100A1/es unknown
- 1994-06-02 MY MYPI94001408A patent/MY110724A/en unknown
- 1994-06-02 CA CA002125001A patent/CA2125001C/en not_active Expired - Fee Related
- 1994-06-02 PH PH48386A patent/PH30304A/en unknown
- 1994-06-02 IL IL10987194A patent/IL109871A/en not_active IP Right Cessation
- 1994-06-02 AU AU64516/94A patent/AU678000B2/en not_active Ceased
- 1994-06-02 NO NO942048A patent/NO306302B1/no not_active IP Right Cessation
- 1994-06-02 UA UA94005241A patent/UA27812C2/uk unknown
- 1994-06-03 CN CN94106984A patent/CN1042424C/zh not_active Expired - Fee Related
- 1994-06-03 RU RU94019424A patent/RU2124013C1/ru not_active IP Right Cessation
- 1994-06-03 YU YU33394A patent/YU33394A/sh unknown
- 1994-06-03 FI FI942633A patent/FI108132B/fi not_active IP Right Cessation
- 1994-06-03 HU HU9401675A patent/HU217066B/hu not_active IP Right Cessation
- 1994-06-03 JP JP12228394A patent/JP3442479B2/ja not_active Expired - Fee Related
-
1996
- 1996-12-19 GR GR960403422T patent/GR3022111T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |