FI107880B - Menetelmä IgE-välitteisten yliherkkyysreaktioiden hoitamiseksi tarkoitetun rokotteen, joka sisältää osan IgE:n vakioalueesta, valmistamiseksi - Google Patents
Menetelmä IgE-välitteisten yliherkkyysreaktioiden hoitamiseksi tarkoitetun rokotteen, joka sisältää osan IgE:n vakioalueesta, valmistamiseksi Download PDFInfo
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- FI107880B FI107880B FI941193A FI941193A FI107880B FI 107880 B FI107880 B FI 107880B FI 941193 A FI941193 A FI 941193A FI 941193 A FI941193 A FI 941193A FI 107880 B FI107880 B FI 107880B
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- vaccine
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Classifications
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- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/80—Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/801—Drug, bio-affecting and body treating compositions involving antibody or fragment thereof produced by recombinant dna technology
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/805—Drug, bio-affecting and body treating compositions involving IgE or IgD
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/862—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgE or IgD
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9102808A SE9102808L (sv) | 1991-09-26 | 1991-09-26 | Vaccin, foer humant bruk, vars avsedda effekt aer att lindra symptomen eller foerhindra uppkomsten av ige-medierade allergiska reaktioner |
SE9102808 | 1991-09-26 | ||
PCT/SE1992/000673 WO1993005810A1 (en) | 1991-09-26 | 1992-09-25 | VACCINE COMPRISING PART OF CONSTANT REGION OF IgE FOR TREATMENT OF IgE-MEDIATED ALLERGIC REACTIONS |
SE9200673 | 1992-09-25 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI941193A FI941193A (fi) | 1994-03-14 |
FI941193A0 FI941193A0 (fi) | 1994-03-14 |
FI107880B true FI107880B (fi) | 2001-10-31 |
Family
ID=20383848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI941193A FI107880B (fi) | 1991-09-26 | 1994-03-14 | Menetelmä IgE-välitteisten yliherkkyysreaktioiden hoitamiseksi tarkoitetun rokotteen, joka sisältää osan IgE:n vakioalueesta, valmistamiseksi |
Country Status (16)
Country | Link |
---|---|
US (1) | US5653980A (hu) |
EP (1) | EP0666760B2 (hu) |
JP (2) | JP3583421B2 (hu) |
KR (1) | KR100263359B1 (hu) |
AT (1) | ATE189960T1 (hu) |
AU (1) | AU677573B2 (hu) |
CA (1) | CA2117193C (hu) |
DE (1) | DE69230733T3 (hu) |
DK (1) | DK0666760T4 (hu) |
ES (1) | ES2144424T5 (hu) |
FI (1) | FI107880B (hu) |
GR (1) | GR3033272T3 (hu) |
HU (1) | HU218899B (hu) |
RU (1) | RU2120805C1 (hu) |
SE (1) | SE9102808L (hu) |
WO (1) | WO1993005810A1 (hu) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK96493D0 (da) * | 1993-08-26 | 1993-08-26 | Mouritsen Og Elsner Aps | Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden |
AU707083B2 (en) * | 1993-08-26 | 1999-07-01 | Bavarian Nordic Inc. | Inducing antibody response against self-proteins with the aid of foreign T-cell epitopes |
JP3825798B2 (ja) * | 1994-01-18 | 2006-09-27 | ジェネンテク,インコーポレイテッド | IgEアンタゴニストを用いる寄生虫感染症の治療法 |
FR2715304B1 (fr) * | 1994-01-26 | 1996-04-26 | Merieux Serums Vaccins Pasteur | Vaccin anti-allergique. |
RU2193413C2 (ru) | 1996-03-01 | 2002-11-27 | Новартис Аг | Пептидные иммуногены для вакцинации и лечения аллергии |
SK285639B6 (sk) * | 1997-04-15 | 2007-05-03 | Pharmexa A/S | Modifikovaná ľudská TNFalfa molekula, DNA kódujúce takéto TNFalfa molekuly, spôsob výroby modifikovanej ľudskej TNFalfa molekuly, vakcíny obsahujúce modifikované TNFalfa molekuly a DNA a ich použitie |
US7393529B2 (en) | 1998-04-09 | 2008-07-01 | Idexx Laboratories, Inc. | Methods and compositions for inhibiting binding of IgE to a high affinity receptor |
US6504013B1 (en) | 2000-02-01 | 2003-01-07 | Idexx Laboratories, Inc. | Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody |
US6734287B1 (en) | 1998-04-09 | 2004-05-11 | Idexx Laboratories, Inc. | Specific binding proteins for treating canine allergy |
US6913749B2 (en) * | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
EP1621209A3 (en) * | 1998-11-02 | 2006-04-19 | Resistentia Pharmaceuticals AB | Vaccines based on domains of chimeric immunoglobulin E peptides |
US6511814B1 (en) | 1999-03-26 | 2003-01-28 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6602719B1 (en) | 1999-03-26 | 2003-08-05 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
EP2361635A3 (en) | 2000-08-30 | 2011-09-14 | Pfizer Products Inc. | Anti IgE vaccines |
JP2003047482A (ja) * | 2001-05-22 | 2003-02-18 | Pfizer Prod Inc | 非アナフィラキシー誘発性IgEワクチン |
EP1497654A4 (en) * | 2001-08-13 | 2006-06-07 | Chen Swey Shen Alex | IMMUNOGLOBULIN E VACCINES AND METHODS OF USE |
US7425620B2 (en) | 2002-08-14 | 2008-09-16 | Scott Koenig | FcγRIIB-specific antibodies and methods of use thereof |
ES2316780T3 (es) * | 2002-09-05 | 2009-04-16 | Resistentia Pharmaceuticals Ab | Vacunas contra alergia. |
US20050026881A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease |
US20090263381A1 (en) * | 2003-07-31 | 2009-10-22 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease |
ES2599319T3 (es) | 2006-06-26 | 2017-02-01 | Macrogenics, Inc. | Anticuerpos específicos de Fc RIIB y métodos de uso de éstos |
US20080118524A1 (en) * | 2006-10-20 | 2008-05-22 | Stefan Persson | Anti-IgE Vaccines |
SG186611A1 (en) | 2008-12-09 | 2013-01-30 | Pfizer Vaccines Llc | Ige ch3 peptide vaccine |
AU2010217100B2 (en) * | 2009-02-25 | 2014-03-27 | Academia Sinica | Anti-CepsilonmX antibodies capable of binding to human mIgE on B lymphocytes |
CA2800774A1 (en) | 2010-06-07 | 2011-12-15 | Pfizer Vaccines Llc | Ige ch3 peptide vaccine |
US9187553B2 (en) * | 2012-01-25 | 2015-11-17 | Swey-Shen Chen | Displaying native human IgE neutralizing FcepsilonRIa-contacting IgE B-cell epitopes by constraining super beta(b)-strands and cystine knots on thermostable protein scaffold |
CN104603150A (zh) | 2012-04-20 | 2015-05-06 | 中央研究院 | 与CH4和CεmX结构域之间的连接处结合的抗mIgE抗体 |
JP5918851B2 (ja) * | 2012-06-18 | 2016-05-18 | 日本全薬工業株式会社 | IgEペプチドワクチン |
US20150004161A1 (en) * | 2013-07-01 | 2015-01-01 | University Of Maryland | Fc Coupled Compositions and Methods of Their Use |
EP3703753A4 (en) | 2017-10-31 | 2021-08-18 | Oneness Biotech Co., Ltd. | TREATMENT OF IGE-MEDIATED ALLERGIC DISEASES |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8616166D0 (en) * | 1986-07-02 | 1986-08-06 | Research Corp Ltd | Polypeptide competitor |
GB8727045D0 (en) * | 1987-11-19 | 1987-12-23 | Research Corp Ltd | Immunoglobulin e competitor |
DE122006000007I1 (de) * | 1987-12-31 | 2006-04-27 | Tanox Biosystems Inc | Antigene epitope, die sich ausschlisslich auf ige-tragenden B-Lymphocyten befinden. |
GB8910263D0 (en) * | 1989-05-04 | 1989-06-21 | Ciba Geigy Ag | Monoclonal antibodies specific for an immunoglobulin isotype |
GB8913737D0 (en) * | 1989-06-15 | 1989-08-02 | Univ Birmingham | A novel anti-allergy treatment |
-
1991
- 1991-09-26 SE SE9102808A patent/SE9102808L/xx not_active Application Discontinuation
-
1992
- 1992-09-25 US US08/196,227 patent/US5653980A/en not_active Expired - Lifetime
- 1992-09-25 JP JP50558293A patent/JP3583421B2/ja not_active Expired - Fee Related
- 1992-09-25 EP EP92920757A patent/EP0666760B2/en not_active Expired - Lifetime
- 1992-09-25 CA CA002117193A patent/CA2117193C/en not_active Expired - Fee Related
- 1992-09-25 HU HU9400845A patent/HU218899B/hu not_active IP Right Cessation
- 1992-09-25 AU AU26765/92A patent/AU677573B2/en not_active Ceased
- 1992-09-25 KR KR1019940700753A patent/KR100263359B1/ko not_active IP Right Cessation
- 1992-09-25 AT AT92920757T patent/ATE189960T1/de not_active IP Right Cessation
- 1992-09-25 DK DK92920757T patent/DK0666760T4/da active
- 1992-09-25 WO PCT/SE1992/000673 patent/WO1993005810A1/en active IP Right Grant
- 1992-09-25 ES ES92920757T patent/ES2144424T5/es not_active Expired - Lifetime
- 1992-09-25 DE DE69230733T patent/DE69230733T3/de not_active Expired - Fee Related
- 1992-09-25 RU RU94020409A patent/RU2120805C1/ru not_active IP Right Cessation
-
1994
- 1994-03-14 FI FI941193A patent/FI107880B/fi active
-
2000
- 2000-04-19 GR GR20000400955T patent/GR3033272T3/el unknown
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2004
- 2004-03-23 JP JP2004084530A patent/JP2004231663A/ja active Pending
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GR3033272T3 (en) | 2000-09-29 |
AU677573B2 (en) | 1997-05-01 |
EP0666760B2 (en) | 2007-10-10 |
DK0666760T4 (da) | 2008-01-21 |
HUT69782A (en) | 1995-09-28 |
JP2004231663A (ja) | 2004-08-19 |
HU9400845D0 (en) | 1994-06-28 |
WO1993005810A1 (en) | 1993-04-01 |
CA2117193C (en) | 2008-06-17 |
JPH06510768A (ja) | 1994-12-01 |
JP3583421B2 (ja) | 2004-11-04 |
ES2144424T5 (es) | 2008-03-01 |
KR100263359B1 (ko) | 2000-08-01 |
DK0666760T3 (da) | 2000-07-31 |
ATE189960T1 (de) | 2000-03-15 |
FI941193A (fi) | 1994-03-14 |
EP0666760A1 (en) | 1995-08-16 |
FI941193A0 (fi) | 1994-03-14 |
US5653980A (en) | 1997-08-05 |
SE9102808D0 (sv) | 1991-09-26 |
ES2144424T3 (es) | 2000-06-16 |
RU2120805C1 (ru) | 1998-10-27 |
DE69230733D1 (de) | 2000-04-06 |
DE69230733T2 (de) | 2000-08-03 |
EP0666760B1 (en) | 2000-03-01 |
DE69230733T3 (de) | 2008-05-21 |
HU218899B (hu) | 2000-12-28 |
CA2117193A1 (en) | 1993-04-01 |
SE9102808L (sv) | 1993-03-27 |
AU2676592A (en) | 1993-04-27 |
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