ES2144424T3 - Vacuna que comprende parte de la region constante de ige para el tratamiento de reacciones alergicas inducidas por ige. - Google Patents
Vacuna que comprende parte de la region constante de ige para el tratamiento de reacciones alergicas inducidas por ige.Info
- Publication number
- ES2144424T3 ES2144424T3 ES92920757T ES92920757T ES2144424T3 ES 2144424 T3 ES2144424 T3 ES 2144424T3 ES 92920757 T ES92920757 T ES 92920757T ES 92920757 T ES92920757 T ES 92920757T ES 2144424 T3 ES2144424 T3 ES 2144424T3
- Authority
- ES
- Spain
- Prior art keywords
- ige
- vaccine
- mediated
- treatment
- allergic reactions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960005486 vaccine Drugs 0.000 title abstract 6
- 206010020751 Hypersensitivity Diseases 0.000 title abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 230000007815 allergy Effects 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/80—Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/801—Drug, bio-affecting and body treating compositions involving antibody or fragment thereof produced by recombinant dna technology
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/805—Drug, bio-affecting and body treating compositions involving IgE or IgD
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/862—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgE or IgD
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
LA INVENCION SE REFIERE A UNA VACUNA, PREFERENTEMENTE PARA SERES HUMANOS, CONTRA LAS REACCIONES ALERGICAS MEDIADAS POR LA IGE. LA VACUNA CONTIENE UNA PROTEINA QUE TIENE TODA LA SECUENCIA DE AMINOACIDOS DE LOS DOMINIOS CONSTANTES CH2-CH3 DE LA CADENA EPSILON DE LA MOLECULA IGE O UNA UNIDAD ESTRUCTURALMENTE ESTABLE DE DICHA SECUENCIA DE AMINOACIDOS, EN DONDE LA PROTEINA SE PUEDE ENCONTRAR OPCIONALMENTE ACOPLADA A UNA O MAS PROTEINAS DE SOPORTE HETEROLOGAS Y OPCIONALMENTE CONTIENEN UN AUXILIAR. LA VACUNA SE INYECTA, CON O SIN AUXILIAR, PARA AUMENTAR LA CONCENTRACION DE ANTICUERPOS ENDOGENOS CONTRA LA IGE EN EL PLASMA DE SUJETOS ALERGICOS. EN LA PRACTICA, LA VACUNA SE PUEDE UTILIZAR CONTRA TODOS LOS TIPOS DE ALERGIAS MEDIADAS POR LA IGE PUESTO QUE LOS ANTICUERPOS NO DEPENDEN DE LA ESPECIFICIDAD DEL ANTIGENO DE LA MOLECULA IGE PERO REDUCIRA LA RESERVA TOTAL DE IGE DEL SUJETO. POR TANTO LA VACUNA ES UTIL PARA EL TRATAMIENTO DE SUJETOS QUE PADECEN DIFERENTES TIPOS DE ALERGIAS MEDIADAS POR LA IGE.LAS CONCENTRACIONES AUMENTADAS DE ANTICUERPOS CONTRA LA IGE REDUCEN LA RESERVA LIBRE DE IGE ESPECIFICA AL ANTIGENO, CON LO QUE REDUCE EN GRAN MEDIDA EL RIESGO DE UNA LIBERACION MEDIADA POR EL ALERGENO DE SUSTANCIAS FISIOLOGICAMENTE MUY ACTIVAS ALMACENADAS O PRODUCIDAS JUNTO CON LA LIBERACION DE GRANULOS DE LAS CELULAS MASTETICAS Y LEUCOCITOS BASOFILICOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9102808 | 1991-09-26 | ||
SE9102808A SE9102808L (sv) | 1991-09-26 | 1991-09-26 | Vaccin, foer humant bruk, vars avsedda effekt aer att lindra symptomen eller foerhindra uppkomsten av ige-medierade allergiska reaktioner |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2144424T3 true ES2144424T3 (es) | 2000-06-16 |
ES2144424T5 ES2144424T5 (es) | 2008-03-01 |
Family
ID=20383848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92920757T Expired - Lifetime ES2144424T5 (es) | 1991-09-26 | 1992-09-25 | Vacuna que comprende parte de la region constante de ige para el tratamiento de reacciones alergicas inducidas por ige. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5653980A (es) |
EP (1) | EP0666760B2 (es) |
JP (2) | JP3583421B2 (es) |
KR (1) | KR100263359B1 (es) |
AT (1) | ATE189960T1 (es) |
AU (1) | AU677573B2 (es) |
CA (1) | CA2117193C (es) |
DE (1) | DE69230733T3 (es) |
DK (1) | DK0666760T4 (es) |
ES (1) | ES2144424T5 (es) |
FI (1) | FI107880B (es) |
GR (1) | GR3033272T3 (es) |
HU (1) | HU218899B (es) |
RU (1) | RU2120805C1 (es) |
SE (1) | SE9102808L (es) |
WO (1) | WO1993005810A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK96493D0 (da) * | 1993-08-26 | 1993-08-26 | Mouritsen Og Elsner Aps | Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden |
AU707083B2 (en) * | 1993-08-26 | 1999-07-01 | Bavarian Nordic Inc. | Inducing antibody response against self-proteins with the aid of foreign T-cell epitopes |
JP3825798B2 (ja) * | 1994-01-18 | 2006-09-27 | ジェネンテク,インコーポレイテッド | IgEアンタゴニストを用いる寄生虫感染症の治療法 |
FR2715304B1 (fr) * | 1994-01-26 | 1996-04-26 | Merieux Serums Vaccins Pasteur | Vaccin anti-allergique. |
HUP9901109A3 (en) * | 1996-03-01 | 1999-11-29 | Novartis Ag | Peptide immunogens for vaccination against and treatment of allergy |
PL194221B1 (pl) * | 1997-04-15 | 2007-05-31 | Pharmexa As | Zmodyfikowana cząsteczka ludzkiego TNFalfa, dimery, oligomery lub multimery zmodyfikowanej cząsteczki ludzkiego TNFalfa, wyizolowana cząsteczka DNA, wektor, wektor ekspresyjny, komórka gospodarza, sposób wytwarzania zmodyfikowanej cząsteczki ludzkiego TNFalfa, szczepionki przeciwko TNFalfa oraz zastosowanie przynajmniej jednej zmodyfikowanej cząsteczki ludzkiego TNFalfa |
US7393529B2 (en) | 1998-04-09 | 2008-07-01 | Idexx Laboratories, Inc. | Methods and compositions for inhibiting binding of IgE to a high affinity receptor |
US6504013B1 (en) | 2000-02-01 | 2003-01-07 | Idexx Laboratories, Inc. | Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody |
US6734287B1 (en) | 1998-04-09 | 2004-05-11 | Idexx Laboratories, Inc. | Specific binding proteins for treating canine allergy |
EP1621209A3 (en) * | 1998-11-02 | 2006-04-19 | Resistentia Pharmaceuticals AB | Vaccines based on domains of chimeric immunoglobulin E peptides |
US6913749B2 (en) | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
US6602719B1 (en) | 1999-03-26 | 2003-08-05 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6511814B1 (en) | 1999-03-26 | 2003-01-28 | Idexx Laboratories, Inc. | Method and device for detecting analytes in fluids |
US6887472B2 (en) | 2000-08-30 | 2005-05-03 | Pfizer Inc. | Anti-IgE vaccines |
JP2003047482A (ja) * | 2001-05-22 | 2003-02-18 | Pfizer Prod Inc | 非アナフィラキシー誘発性IgEワクチン |
EP1497654A4 (en) * | 2001-08-13 | 2006-06-07 | Chen Swey Shen Alex | IMMUNOGLOBULIN E VACCINES AND METHODS OF USE |
CA2495251C (en) | 2002-08-14 | 2018-03-06 | Macrogenics, Inc. | Fc.gamma.riib-specific antibodies and methods of use thereof |
EP1545607B1 (en) * | 2002-09-05 | 2008-11-19 | Resistentia Pharmaceuticals AB | Allergy vaccines |
US20050026881A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease |
US20090263381A1 (en) * | 2003-07-31 | 2009-10-22 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease |
HUE030269T2 (en) | 2006-06-26 | 2017-04-28 | Macrogenics Inc | FC RIIB-specific antibodies and methods for their use |
US20080118524A1 (en) * | 2006-10-20 | 2008-05-22 | Stefan Persson | Anti-IgE Vaccines |
EP2865389A1 (en) | 2008-12-09 | 2015-04-29 | Pfizer Vaccines LLC | IgE CH3 peptide vaccine |
SG174161A1 (en) * | 2009-02-25 | 2011-11-28 | Tsewen Chang | ANTI-CemX ANTIBODIES CAPABLE OF BINDING TO HUMAN mIgE ON B LYMPHOCYTES |
EP2942061A3 (en) * | 2010-06-07 | 2016-01-13 | Pfizer Vaccines LLC | Ige ch3 peptide vaccine |
US9187553B2 (en) * | 2012-01-25 | 2015-11-17 | Swey-Shen Chen | Displaying native human IgE neutralizing FcepsilonRIa-contacting IgE B-cell epitopes by constraining super beta(b)-strands and cystine knots on thermostable protein scaffold |
US9587034B2 (en) | 2012-04-20 | 2017-03-07 | Academia Sinica | Anti-mIgE antibodies that bind to the junction between CH4 and CεmX domains |
JP5918851B2 (ja) * | 2012-06-18 | 2016-05-18 | 日本全薬工業株式会社 | IgEペプチドワクチン |
US20150004161A1 (en) * | 2013-07-01 | 2015-01-01 | University Of Maryland | Fc Coupled Compositions and Methods of Their Use |
CN111741768A (zh) | 2017-10-31 | 2020-10-02 | 合一生技股份有限公司 | 治疗IgE介导的过敏性疾病 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8616166D0 (en) * | 1986-07-02 | 1986-08-06 | Research Corp Ltd | Polypeptide competitor |
GB8727045D0 (en) * | 1987-11-19 | 1987-12-23 | Research Corp Ltd | Immunoglobulin e competitor |
AU618317B2 (en) * | 1987-12-31 | 1991-12-19 | Tanox Biosystems, Inc. | Unique antigenic epitopes on ige-bearing b lymphocytes |
GB8910263D0 (en) * | 1989-05-04 | 1989-06-21 | Ciba Geigy Ag | Monoclonal antibodies specific for an immunoglobulin isotype |
GB8913737D0 (en) * | 1989-06-15 | 1989-08-02 | Univ Birmingham | A novel anti-allergy treatment |
-
1991
- 1991-09-26 SE SE9102808A patent/SE9102808L/xx not_active Application Discontinuation
-
1992
- 1992-09-25 CA CA002117193A patent/CA2117193C/en not_active Expired - Fee Related
- 1992-09-25 RU RU94020409A patent/RU2120805C1/ru not_active IP Right Cessation
- 1992-09-25 DK DK92920757T patent/DK0666760T4/da active
- 1992-09-25 AU AU26765/92A patent/AU677573B2/en not_active Ceased
- 1992-09-25 HU HU9400845A patent/HU218899B/hu not_active IP Right Cessation
- 1992-09-25 AT AT92920757T patent/ATE189960T1/de not_active IP Right Cessation
- 1992-09-25 KR KR1019940700753A patent/KR100263359B1/ko not_active IP Right Cessation
- 1992-09-25 ES ES92920757T patent/ES2144424T5/es not_active Expired - Lifetime
- 1992-09-25 WO PCT/SE1992/000673 patent/WO1993005810A1/en active IP Right Grant
- 1992-09-25 US US08/196,227 patent/US5653980A/en not_active Expired - Lifetime
- 1992-09-25 JP JP50558293A patent/JP3583421B2/ja not_active Expired - Fee Related
- 1992-09-25 EP EP92920757A patent/EP0666760B2/en not_active Expired - Lifetime
- 1992-09-25 DE DE69230733T patent/DE69230733T3/de not_active Expired - Fee Related
-
1994
- 1994-03-14 FI FI941193A patent/FI107880B/fi active
-
2000
- 2000-04-19 GR GR20000400955T patent/GR3033272T3/el unknown
-
2004
- 2004-03-23 JP JP2004084530A patent/JP2004231663A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP3583421B2 (ja) | 2004-11-04 |
EP0666760A1 (en) | 1995-08-16 |
HU9400845D0 (en) | 1994-06-28 |
EP0666760B1 (en) | 2000-03-01 |
DE69230733T3 (de) | 2008-05-21 |
CA2117193C (en) | 2008-06-17 |
FI941193A (fi) | 1994-03-14 |
JPH06510768A (ja) | 1994-12-01 |
AU677573B2 (en) | 1997-05-01 |
DE69230733D1 (de) | 2000-04-06 |
HU218899B (hu) | 2000-12-28 |
AU2676592A (en) | 1993-04-27 |
ES2144424T5 (es) | 2008-03-01 |
SE9102808L (sv) | 1993-03-27 |
KR100263359B1 (ko) | 2000-08-01 |
JP2004231663A (ja) | 2004-08-19 |
US5653980A (en) | 1997-08-05 |
FI107880B (fi) | 2001-10-31 |
SE9102808D0 (sv) | 1991-09-26 |
CA2117193A1 (en) | 1993-04-01 |
RU2120805C1 (ru) | 1998-10-27 |
FI941193A0 (fi) | 1994-03-14 |
GR3033272T3 (en) | 2000-09-29 |
DK0666760T4 (da) | 2008-01-21 |
WO1993005810A1 (en) | 1993-04-01 |
DE69230733T2 (de) | 2000-08-03 |
HUT69782A (en) | 1995-09-28 |
DK0666760T3 (da) | 2000-07-31 |
EP0666760B2 (en) | 2007-10-10 |
ATE189960T1 (de) | 2000-03-15 |
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