FI106924B - Kosmetiskt sammansättning som innehåller salicylsyra och förfarande för framställning av detsamma - Google Patents
Kosmetiskt sammansättning som innehåller salicylsyra och förfarande för framställning av detsamma Download PDFInfo
- Publication number
- FI106924B FI106924B FI940993A FI940993A FI106924B FI 106924 B FI106924 B FI 106924B FI 940993 A FI940993 A FI 940993A FI 940993 A FI940993 A FI 940993A FI 106924 B FI106924 B FI 106924B
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- Prior art keywords
- weight
- salicylic acid
- water
- membrane
- composition
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- 230000003993 interaction Effects 0.000 description 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- FOJSRNLMPSFTQV-UHFFFAOYSA-N pentan-1-ol 1-phenylethanone Chemical compound CCCCCO.CC(=O)C1=CC=CC=C1 FOJSRNLMPSFTQV-UHFFFAOYSA-N 0.000 description 1
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- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
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- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
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- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Claims (6)
1. Kosmetisk sammansättning, kännetecknad av, att den innefattar: 5 a) en effektiv mängd av en membranbildande lipidfas som är känd för att bilda antingen ensam eller i kombination, liposomer som innefattar liposomala bilager; b) en effektiv mängd salicylsyra som kommer att lokaliseras innanför den lipidiska, hydrofobiska omgivningen av de liposomala bilagren; 10 c) en effektiv mängd av en membranimpermeabel vattenlöslig organisk bas; och d) resten till 100 vikt% utgörs av vatten.
2. Kosmetisk sammansättning enligt patentkrav 1, kännetecknad av, att den innefattar: a) cirka 0,1-10 vikt% av en membranbildande lipidfas; 20 b) cirka 0,05-20 vikt% salicylsyra; < ( c) cirka 0,05-25 vikt% arginin eller liknande vattenlöslig organisk bas; • · · • · < d) cirka 40-99,8 vikt% vatten; • at ·«· 25 • · · · : T: e) 0 - cirka 20 vikt% andra lämpliga kosmetiska beständsdelar och • · · :,, / varvid alla viktandelar baserar sig pä sammansättningens totalvikt. laa • a
3. Kosmetisk sammansättning enligt patentkrav 1, kännetecknad av, att a · · den innefattar: a a a a a a c t 106924 a) cirka 1-4 vikt% av en membranbildande lipidfas; b) cirka 5-12 vikt% salicylsyra; 5 c) cirka 2-15 vikt% arginin eller liknande vattenlöslig organisk bas; d) cirka 60-90 vikt% vatien; e) 5-15 vikt% andra lämpliga kosmetiska beständsdelar och 10 varvid alla viktandelar baserar sig pä sammansättningens totalvikt.
4. Förfarande för framställning av en kosmetisk sammansättning som innehäller: 15 (i) membranbildande lipider dispergerade i form av liposomer som innefattar liposomala bilager; (ii) salicylsyra fördelaktigt lokaliserad innanför de liposomala bilagermembraner; 20 (iii) en organisk bas impermeabel för membraner fördelaktigt lokaliserad i vattenav-delningen utanför liposomen; ♦ ♦♦ • ♦ · • · (iv) vatten; och • * · « « « « · • · • * f v 25 (v) andra lämpliga kosmetiska ämnesdelar, • ·« · • · « « · · • · I kännetecknat därav, att förfarande innefattar följande steg: • · · < I * < a) dispersion genom bladning av membranbildande lipider och eventuell löslig 30 komponent avsedd att kapsyleras innanför den invändiga vattenavdelningen av •: · : liposomen, i vattenfasen av sammansättningen; * * « · 106924 b) tillsättning av salicylsyra till rädispersionen utan neutralisering; c) tillsättning av eventuella andra lipidlösliga komponenter; 5 d) behandling av den hydrerade rädispersionen under förhällanden av höga skär-ningskrafter som är lämpliga för framställning av liposomema; d) tillsättning av eventuella andra komponenter som är avsedda att bli lokaliserade i vattenavdelningen utanför liposomen; och 10 f) neutralisering av vattenomgivningen utanför liposomen genom tillsättning av vattenlöslig membranimpermeabel bas.
5. Förfarande enligt patentkrav 4, kännetecknat därav, att man först 15 framställer en förprodukt och sedan därefter den slutglitiga produkten.
6. Förfarande enligt patentkrav 4, kännetecknat därav, att slutprodukten produceras utan framställning av en förprodukt. 20 « 4 ··· • · 1 2 3 • · • ♦ · * · « • · · « · « • · • · • · 1 · « · • · · • · · 2 • ♦ I 3 « ' i • « «
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3652993A | 1993-03-24 | 1993-03-24 | |
| US3652993 | 1993-03-24 |
Publications (3)
| Publication Number | Publication Date |
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| FI940993A0 FI940993A0 (sv) | 1994-03-02 |
| FI940993L FI940993L (sv) | 1994-09-25 |
| FI106924B true FI106924B (sv) | 2001-05-15 |
Family
ID=21889094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI940993A FI106924B (sv) | 1993-03-24 | 1994-03-02 | Kosmetiskt sammansättning som innehåller salicylsyra och förfarande för framställning av detsamma |
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| US (1) | US5585109A (sv) |
| EP (1) | EP0616799B1 (sv) |
| JP (1) | JP3238264B2 (sv) |
| AT (1) | ATE192327T1 (sv) |
| AU (1) | AU673023B2 (sv) |
| DE (1) | DE69328545T2 (sv) |
| DK (1) | DK0616799T3 (sv) |
| ES (1) | ES2147744T3 (sv) |
| FI (1) | FI106924B (sv) |
| MY (1) | MY112093A (sv) |
| NO (1) | NO302332B1 (sv) |
| NZ (1) | NZ250660A (sv) |
| SG (1) | SG65599A1 (sv) |
| TW (1) | TW299233B (sv) |
| ZA (1) | ZA939802B (sv) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5578323A (en) | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
| US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
| DE4420727A1 (de) * | 1994-06-15 | 1995-12-21 | Rovi Gmbh | Hautfreundliche wäßrige Liposomendispersionen, enthaltend alpha-Hydroxycarbonsäuren und/oder alpha-Hydroxyketosäuren in ihrer Salzform |
| FR2726468B1 (fr) * | 1994-11-03 | 1996-12-13 | Oreal | Utilisation de derive de l'acide salicylique comme stabilisant d'une emulsion huile-dans-eau |
| US20020048596A1 (en) * | 1994-12-30 | 2002-04-25 | Gregor Cevc | Preparation for the transport of an active substance across barriers |
| US6001347A (en) | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
| GB9511938D0 (en) * | 1995-06-13 | 1995-08-09 | Unilever Plc | Cosmetic composition |
| US6071535A (en) * | 1996-01-31 | 2000-06-06 | Collaborative Laboratories, Inc. | Lipid vesicles formed with alkylammonium fatty acid salts |
| US6183774B1 (en) | 1996-01-31 | 2001-02-06 | Collaborative Laboratories, Inc. | Stabilizing vitamin A derivatives by encapsulation in lipid vesicles formed with alkylammonium fatty acid salts |
| US5874105A (en) * | 1996-01-31 | 1999-02-23 | Collaborative Laboratories, Inc. | Lipid vesicles formed with alkylammonium fatty acid salts |
| IL126318A (en) | 1996-03-29 | 2004-09-27 | Emisphere Tech Inc | Compounds and compositions for delivering active agents and some novel carrier compounds |
| WO1997047288A1 (en) | 1996-06-14 | 1997-12-18 | Emisphere Technologies, Inc. | Microencapsulated fragrances and method for preparation |
| US6890901B2 (en) | 1996-09-27 | 2005-05-10 | Jagotec Ag | Hyaluronic drug delivery system |
| US5935572A (en) * | 1997-01-10 | 1999-08-10 | Collaborative Laboratories, Inc. | Composition containing protease separate from glycosidase for removing nits in treating lice infestation |
| US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| JP3515321B2 (ja) * | 1997-05-07 | 2004-04-05 | ポーラ化成工業株式会社 | 不均一改善化粧料 |
| KR100483391B1 (ko) * | 1998-01-16 | 2005-04-15 | 칼라 액세스, 인크. | 안정화된 미백 조성물 및 이의 제조 방법 |
| FR2782919B1 (fr) * | 1998-09-04 | 2001-05-25 | Roc Sa | Composition contre le vieillissement et son utilisation |
| SI1031346T1 (en) | 1999-01-27 | 2002-08-31 | Idea Ag | Noninvasive vaccination through the skin |
| PT1031347E (pt) | 1999-01-27 | 2002-09-30 | Idea Ag | Transporte/imunizacao transnasal com veiculos muitissimo adaptaveis |
| GB9902527D0 (en) * | 1999-02-04 | 1999-03-24 | Phares Pharm Res Nv | Compositions |
| FR2789329B1 (fr) | 1999-02-05 | 2001-03-02 | Oreal | Composition cosmetique et/ou dermatologique constituee par une emulsion du type huile-dans-l'eau formee de vesicules lipidiques dispersees dans une phase aqueuse contenant au moins un actif acide hydrophile |
| AU5409699A (en) * | 1999-07-05 | 2001-01-22 | Idea Ag | A method for the improvement of transport across adaptable semi-permeable barriers |
| WO2001017507A1 (en) * | 1999-09-03 | 2001-03-15 | Arch Personal Care Products, L.P. | Preserved liposomes |
| WO2002098404A1 (en) * | 2001-06-01 | 2002-12-12 | Tendskin Company | Topical compositions for veterinary uses |
| US6866896B2 (en) * | 2002-02-05 | 2005-03-15 | Elisha Holding Llc | Method for treating metallic surfaces and products formed thereby |
| US6783766B2 (en) | 2002-03-06 | 2004-08-31 | Dow Global Technologies Inc. | Process for preparing a cosmetic formulation |
| US20030045473A1 (en) * | 2002-07-19 | 2003-03-06 | Sarama Robert Joseph | Compositions, kits, and methods for cardiovascular health |
| US7473432B2 (en) * | 2002-10-11 | 2009-01-06 | Idea Ag | NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery |
| EP1811961A2 (en) * | 2004-11-12 | 2007-08-01 | Idea Ag | Extended surface aggregates in the treatment of skin conditions |
| KR101352187B1 (ko) * | 2005-03-10 | 2014-02-17 | 제이알 켐, 엘엘씨 | 안정한 유기 퍼옥사이드 조성물 |
| US20090306023A1 (en) * | 2005-06-29 | 2009-12-10 | Ramirez Jose E | Stable organic peroxide compositions |
| US7556820B2 (en) * | 2005-06-29 | 2009-07-07 | Jr Chem, Llc | Stable organic peroxide compositions |
| JP4134250B1 (ja) | 2007-07-03 | 2008-08-20 | 崎 隆 川 | セルロース系物質よる単糖類並びにエタノールの製造方法 |
| FR2946251B1 (fr) * | 2009-06-08 | 2011-05-20 | Oreal | Composition cosmetique comprenant un derive d'acide salicylique et de la carnosine. |
| US20110200545A1 (en) * | 2010-02-14 | 2011-08-18 | Nyangenya Maniga | Deodorant composition and methods for use thereof |
| FR3027797B1 (fr) * | 2014-10-30 | 2020-07-10 | L'oreal | Utilisation de derives d'acide salicylique lipophiles |
| KR101702482B1 (ko) * | 2015-04-30 | 2017-02-03 | 주식회사 엔에스텍 | 나노리포좀이 형성되어 피부면역력, 살균력 및 흡수력이 향상된 화장료 조성물 및 그 제조방법 |
| EP3448529B1 (en) * | 2016-04-26 | 2023-10-18 | Peace Out Inc. | Medicated hydrocolloid dressing for acne treatment |
| US10912739B2 (en) | 2017-10-16 | 2021-02-09 | Peace Out Inc. | Hydrocolloid-based skin treatment |
| WO2020227319A1 (en) * | 2019-05-06 | 2020-11-12 | Spinart, LLC | Formulations and methods for preparing stable cosmetic compositions |
| CN112043616B (zh) * | 2020-10-21 | 2022-09-20 | 烟台新时代健康产业日化有限公司 | 一种基于缓释技术的祛痘复合物及祛痘精华液 |
| US11684586B1 (en) | 2022-02-28 | 2023-06-27 | Peace Out, Llc | Anhydrous hydrocolloid matrix comprising homogeneously distributed encapsulated therapeutic agents |
| CN115645362B (zh) * | 2022-10-24 | 2024-04-26 | 中国海洋大学 | 一种水杨酸天然低共熔溶剂及低共熔凝胶和应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH538863A (it) * | 1969-03-14 | 1973-07-15 | Finanz Kompensations Anst | Eccipiente per cosmetici, contenente aminoacidi basici e polimeri carbossivinilici |
| GB1523965A (en) * | 1976-03-19 | 1978-09-06 | Ici Ltd | Pharmaceutical compositions containing steroids |
| US4217344A (en) * | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4708861A (en) * | 1984-02-15 | 1987-11-24 | The Liposome Company, Inc. | Liposome-gel compositions |
| US4755387A (en) * | 1985-03-21 | 1988-07-05 | The Procter & Gamble Company | Therapeutic particles |
| US4895727A (en) * | 1985-05-03 | 1990-01-23 | Chemex Pharmaceuticals, Inc. | Pharmaceutical vehicles for exhancing penetration and retention in the skin |
| US4822604A (en) * | 1985-05-20 | 1989-04-18 | S. C. Johnson & Son, Inc. | Local treatment of dandruff, seborrheic dermatitis, and psoriasis |
| US5230899A (en) * | 1985-08-07 | 1993-07-27 | Smithkline Beecham Corporation | Methods and compositions for making liposomes |
| IL79114A (en) * | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
| US4816247A (en) * | 1985-09-11 | 1989-03-28 | American Cyanamid Company | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs |
| US5145675A (en) * | 1986-03-31 | 1992-09-08 | Advanced Polymer Systems, Inc. | Two step method for preparation of controlled release formulations |
| CA1320130C (en) * | 1986-06-12 | 1993-07-13 | Alan L. Weiner | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| GB8630273D0 (en) * | 1986-12-18 | 1987-01-28 | Til Medical Ltd | Pharmaceutical delivery systems |
| US5154930A (en) * | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
| US4999348A (en) * | 1987-12-11 | 1991-03-12 | Estee Lauder Inc. | Liquid crystal containing cosmetic and pharmaceutical compositions and methods for utilizing such compositions |
| FR2630346B1 (fr) * | 1988-04-22 | 1991-03-22 | Dubois Jacques | Produits nouveaux comportant une emulsion d'eau et d'hydrocarbures paraffiniques huileux additionnes d'extraits de lecithine et procedes de fabrication |
| FR2631339B1 (fr) * | 1988-05-10 | 1990-11-16 | Cird | Nouveaux eicosanoides sulfures et leur application en pharmacie et en cosmetique |
| US5133965A (en) * | 1988-06-08 | 1992-07-28 | Fountain Pharmaceuticals, Inc. | Dressing material having adsorbed thereon a solvent dilution microcarrier precursor solution |
| DE3826946C1 (sv) * | 1988-08-09 | 1990-03-15 | A. Nattermann & Cie Gmbh, 5000 Koeln, De | |
| US4981681A (en) * | 1988-08-26 | 1991-01-01 | Vittorio Tosti | Lotion mixture and method of treating psoriasis |
| US5049392A (en) * | 1989-01-18 | 1991-09-17 | The Liposome Company, Inc. | Osmotically dependent vesicles |
| US5000941A (en) * | 1989-05-16 | 1991-03-19 | Milton P. Chernack | Dentifrice containing microencapsulated oxygen |
| US5085856A (en) * | 1990-07-25 | 1992-02-04 | Elizabeth Arden Co., Division Of Conopco, Inc. | Cosmetic water-in-oil emulsion lipstick comprising a phospholipid and glycerol fatty acid esters emulsifying system |
-
1993
- 1993-12-10 SG SG1996008636A patent/SG65599A1/en unknown
- 1993-12-10 EP EP93309953A patent/EP0616799B1/en not_active Expired - Lifetime
- 1993-12-10 DE DE69328545T patent/DE69328545T2/de not_active Expired - Lifetime
- 1993-12-10 ES ES93309953T patent/ES2147744T3/es not_active Expired - Lifetime
- 1993-12-10 DK DK93309953T patent/DK0616799T3/da active
- 1993-12-10 AT AT93309953T patent/ATE192327T1/de active
- 1993-12-28 JP JP33714793A patent/JP3238264B2/ja not_active Expired - Lifetime
- 1993-12-30 ZA ZA939802A patent/ZA939802B/xx unknown
-
1994
- 1994-01-07 MY MYPI94000046A patent/MY112093A/en unknown
- 1994-01-11 NZ NZ250660A patent/NZ250660A/en unknown
- 1994-01-12 AU AU53141/94A patent/AU673023B2/en not_active Expired
- 1994-01-25 NO NO940249A patent/NO302332B1/no unknown
- 1994-01-28 TW TW083100711A patent/TW299233B/zh not_active IP Right Cessation
- 1994-03-02 FI FI940993A patent/FI106924B/sv not_active IP Right Cessation
-
1995
- 1995-08-24 US US08/518,956 patent/US5585109A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NZ250660A (en) | 1995-12-21 |
| DE69328545T2 (de) | 2001-07-05 |
| NO940249D0 (no) | 1994-01-25 |
| DE69328545D1 (de) | 2000-06-08 |
| EP0616799A1 (en) | 1994-09-28 |
| MY112093A (en) | 2001-04-30 |
| NO302332B1 (no) | 1998-02-23 |
| FI940993L (sv) | 1994-09-25 |
| TW299233B (sv) | 1997-03-01 |
| ZA939802B (en) | 1994-08-18 |
| ES2147744T3 (es) | 2000-10-01 |
| ATE192327T1 (de) | 2000-05-15 |
| US5585109A (en) | 1996-12-17 |
| NO940249L (no) | 1994-09-26 |
| HK1010696A1 (en) | 1999-06-25 |
| AU673023B2 (en) | 1996-10-24 |
| AU5314194A (en) | 1994-09-29 |
| EP0616799B1 (en) | 2000-05-03 |
| JPH06279230A (ja) | 1994-10-04 |
| SG65599A1 (en) | 1999-06-22 |
| JP3238264B2 (ja) | 2001-12-10 |
| DK0616799T3 (da) | 2000-09-18 |
| FI940993A0 (sv) | 1994-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |