FI106555B - Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi - Google Patents

Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi Download PDF

Info

Publication number
FI106555B
FI106555B FI931740A FI931740A FI106555B FI 106555 B FI106555 B FI 106555B FI 931740 A FI931740 A FI 931740A FI 931740 A FI931740 A FI 931740A FI 106555 B FI106555 B FI 106555B
Authority
FI
Finland
Prior art keywords
nucleophilic
water
acid
glycosaminoglycans
nucleophilic reagent
Prior art date
Application number
FI931740A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI931740A (fi
FI931740A0 (fi
Inventor
Fabrizio Ungarelli
Silvano Piani
Egidio Marchi
Gianfranco Tamagnone
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of FI931740A0 publication Critical patent/FI931740A0/fi
Publication of FI931740A publication Critical patent/FI931740A/fi
Application granted granted Critical
Publication of FI106555B publication Critical patent/FI106555B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI931740A 1992-04-17 1993-04-16 Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi FI106555B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITBO920140A IT1260136B (it) 1992-04-17 1992-04-17 Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
ITBO920140 1992-04-17

Publications (3)

Publication Number Publication Date
FI931740A0 FI931740A0 (fi) 1993-04-16
FI931740A FI931740A (fi) 1993-10-18
FI106555B true FI106555B (fi) 2001-02-28

Family

ID=11338174

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931740A FI106555B (fi) 1992-04-17 1993-04-16 Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi

Country Status (18)

Country Link
US (1) US5430132A (da)
EP (1) EP0565862B1 (da)
JP (1) JP2702377B2 (da)
KR (1) KR0171623B1 (da)
AT (1) ATE154615T1 (da)
AU (1) AU658499B2 (da)
CA (1) CA2093148C (da)
DE (1) DE69311618T2 (da)
DK (1) DK0565862T3 (da)
ES (1) ES2103991T3 (da)
FI (1) FI106555B (da)
GR (1) GR3024582T3 (da)
IL (1) IL105111A (da)
IT (1) IT1260136B (da)
NO (1) NO306305B1 (da)
NZ (1) NZ247197A (da)
TW (1) TW229213B (da)
ZA (1) ZA931799B (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
US6127347A (en) * 1994-01-12 2000-10-03 Univ Michigan Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
NO984143L (no) 1998-09-09 2000-03-10 Norsk Hydro As Ny prosess for å fremstille overflatemodifiserende stoffer
HUP0201712A3 (en) * 1999-06-30 2003-03-28 Weitz Jeffrey I Ancaster Clot associated coagulation factors inhibiting heparin compositions
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
JP2004507562A (ja) * 2000-09-08 2004-03-11 ハミルトン　シビック　ホスピタルズ　リサーチ　ディベロップメント　インコーポレイテッド 抗血栓性組成物
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN103209997B (zh) * 2010-09-14 2016-03-16 国立大学法人宫崎大学 高纯度肝素及其制备方法
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
JP7401882B2 (ja) * 2016-03-09 2023-12-20 株式会社糖鎖工学研究所 硫酸基を有する糖の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4987223A (en) * 1981-12-23 1991-01-22 Choay S.A. Derivatives of the uronic acid
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
DE3821271A1 (de) * 1988-06-23 1989-12-28 Solco Basel Ag Derivatisiertes heparin, verfahren zu dessen herstellung und arzneimittel, welches dieses enthaelt
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5200523A (en) * 1990-10-10 1993-04-06 Monsanto Company Synthesis of nojirimycin derivatives

Also Published As

Publication number Publication date
ZA931799B (en) 1993-12-27
IL105111A (en) 1997-03-18
EP0565862A3 (en) 1993-11-10
FI931740A (fi) 1993-10-18
KR0171623B1 (ko) 1999-02-01
JPH0616704A (ja) 1994-01-25
EP0565862A2 (en) 1993-10-20
DK0565862T3 (da) 1997-12-15
NO306305B1 (no) 1999-10-18
CA2093148C (en) 1999-01-26
KR930021651A (ko) 1993-11-22
ATE154615T1 (de) 1997-07-15
EP0565862B1 (en) 1997-06-18
AU3689693A (en) 1993-10-21
CA2093148A1 (en) 1993-10-18
ITBO920140A0 (it) 1992-04-17
TW229213B (da) 1994-09-01
DE69311618D1 (de) 1997-07-24
DE69311618T2 (de) 1997-12-11
ES2103991T3 (es) 1997-10-01
NO931181D0 (no) 1993-03-30
NO931181L (no) 1993-10-18
ITBO920140A1 (it) 1993-10-17
FI931740A0 (fi) 1993-04-16
IT1260136B (it) 1996-03-28
GR3024582T3 (en) 1997-12-31
US5430132A (en) 1995-07-04
JP2702377B2 (ja) 1998-01-21
AU658499B2 (en) 1995-04-13
NZ247197A (en) 1995-02-24

Similar Documents

Publication Publication Date Title
FI106556B (fi) Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi
FI106555B (fi) Menetelmä puolisynteettisten glykosaminoglykaanien valmistamiseksi
FI101541B (fi) Menetelmä trisakkaridiyksikön sisältävien terapeuttisesti käyttökelpoi sten hiilihydraattijohdannaisten valmistamiseksi
KR20000075663A (ko) 높은 항혈전용해 활성을 갖는 글리코스아미노글리칸
Baumann et al. Concepts for preparation of novel regioselective modified cellulose derivatives sulfated, aminated, carboxylated and acetylated for hemocompatible ultrathin coatings on biomaterials
AU664939B2 (en) Process for the synthesis of semi-synthetic glycosaminoglycans with heparin or heparan structure modified in position 2 of the alpha-L-iduronic-2-O-sulfate acid
Baumann et al. Regioselectively modified cellulose and chitosan derivatives for mono-and multilayer surface coatings of hemocompatible biomaterials
EP0618235B1 (en) Process for the synthesis of semisynthetic glycosaminoglycans containing alpha-L-galacturonic acid substituted with nucleophilic radicals in position 3
CN112842929A (zh) 一种巯基化透明质酸及其制备方法和应用

Legal Events

Date Code Title Description
MA Patent expired