FI106376B - Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi - Google Patents
Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi Download PDFInfo
- Publication number
- FI106376B FI106376B FI971104A FI971104A FI106376B FI 106376 B FI106376 B FI 106376B FI 971104 A FI971104 A FI 971104A FI 971104 A FI971104 A FI 971104A FI 106376 B FI106376 B FI 106376B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- formula
- coupling
- solvent
- carried out
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/307,972 US5585504A (en) | 1994-09-16 | 1994-09-16 | Process of making cox-2 inhibitors having a lactone bridge |
US30797294 | 1994-09-16 | ||
PCT/US1995/011539 WO1996008482A1 (en) | 1994-09-16 | 1995-09-12 | Process for making phenyl heterocycles useful as cox-2 inhibitors |
US9511539 | 1995-09-12 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI971104A FI971104A (fi) | 1997-03-14 |
FI971104A0 FI971104A0 (fi) | 1997-03-14 |
FI106376B true FI106376B (fi) | 2001-01-31 |
Family
ID=23191976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI971104A FI106376B (fi) | 1994-09-16 | 1997-03-14 | Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi |
Country Status (12)
Country | Link |
---|---|
US (1) | US5585504A (cs) |
CN (1) | CN1065533C (cs) |
AU (1) | AU3510595A (cs) |
BR (1) | BR9508927A (cs) |
CZ (1) | CZ288797B6 (cs) |
FI (1) | FI106376B (cs) |
RO (1) | RO118585B1 (cs) |
RU (1) | RU2160257C2 (cs) |
SK (1) | SK282789B6 (cs) |
TW (1) | TW325468B (cs) |
UA (1) | UA49809C2 (cs) |
WO (1) | WO1996008482A1 (cs) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2747123B1 (fr) * | 1996-04-04 | 1998-06-26 | Union Pharma Scient Appl | Nouveaux derives diarylmethylidene tetrahydrofurane, leurs procedes de preparation, et leurs utilisations en therapeutique |
US5807873A (en) * | 1996-04-04 | 1998-09-15 | Laboratories Upsa | Diarylmethylidenefuran derivatives and their uses in therapeutics |
US6180651B1 (en) * | 1996-04-04 | 2001-01-30 | Bristol-Myers Squibb | Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics |
US5883267A (en) * | 1996-05-31 | 1999-03-16 | Merck & Co., Inc. | Process for making phenyl heterocycles useful as cox-2 inhibitors |
HRP970289A2 (en) * | 1996-05-31 | 1998-04-30 | Merck & Co Inc | Process for preparing phenyl heterocycles useful as cox-2 inhibitors |
US5985930A (en) | 1996-11-21 | 1999-11-16 | Pasinetti; Giulio M. | Treatment of neurodegenerative conditions with nimesulide |
US6200760B1 (en) | 1997-02-24 | 2001-03-13 | Cornell Research Foundation, Inc. | Method of screening agents as candidates for drugs or sources of drugs |
US6071954A (en) * | 1997-03-14 | 2000-06-06 | Merk Frosst Canada, Inc. | (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors |
JP2001514668A (ja) * | 1997-03-14 | 2001-09-11 | メルク フロスト カナダ アンド カンパニー | Cox−2阻害薬としての酸素連結部を有する(メチルスルホニル)フェニル−2−(5h)−フラノン類 |
US6294558B1 (en) * | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
US6727238B2 (en) * | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
CA2363590A1 (en) * | 1999-03-10 | 2000-09-14 | G.D. Searle & Co. | Method and composition for administering a cyclooxygenase-2 inhibitor |
ES2193921T3 (es) | 1999-12-03 | 2003-11-16 | Pfizer Prod Inc | Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos. |
DE60004001T2 (de) | 1999-12-03 | 2004-04-15 | Pfizer Products Inc., Groton | Acetylenderivate zur Verwendung als schmerzstillendes oder entzündungshemmendes Mittel |
TR200302047T4 (tr) | 1999-12-03 | 2004-01-21 | Pfizer Products Inc. | Anti-iltihabik / analjezik maddeler olarak heteroaril fenil pirazol bileşikleri. |
IL149581A0 (en) | 1999-12-03 | 2002-11-10 | Pfizer Prod Inc | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents |
CO5261556A1 (es) | 1999-12-08 | 2003-03-31 | Pharmacia Corp | Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico |
DE10012825B4 (de) * | 2000-03-16 | 2004-04-15 | Bayer Corp. | Verfahren zur Herstellung von spirocyclischen Tetronsäurederivaten |
CN1102586C (zh) * | 2000-04-07 | 2003-03-05 | 中国科学院上海有机化学研究所 | β位含有芳基取代基的γ-丁烯酸内酯及其固相合成法 |
US20020128267A1 (en) * | 2000-07-13 | 2002-09-12 | Rebanta Bandyopadhyay | Method of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disorders |
AU2001285334A1 (en) * | 2000-08-29 | 2002-03-13 | Peter Van Patten | Combination for the treatment of migraine comprising a cyclooxygenase-2 inhibitor and acetylsalicylic acid |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
ATE298749T1 (de) | 2001-07-05 | 2005-07-15 | Pfizer Prod Inc | Heterocyclo-alkylsulfonyl pyrazole als entzündungshemmende/analgetische mittel |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
GT200200183A (es) | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
WO2003037336A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer |
ES2213485B1 (es) | 2003-02-13 | 2005-12-16 | Almirall Prodesfarma, S.A. | Derivados de la 2-fenilpiran-4-ona. |
PT1534305E (pt) * | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
SI2266584T1 (sl) * | 2003-05-07 | 2012-12-31 | Osteologix A/S, Symbion | Sestavek s stroncijem in vitaminom D za profilakso in/ali zdravljenje patologij hrustanca in/ali kosti |
AU2003263582A1 (en) * | 2003-08-14 | 2005-03-07 | Shasun Chemicals And Drugs Limited | Process for the manufacture of rofecoxib |
WO2005044227A1 (en) * | 2003-11-05 | 2005-05-19 | Glenmark Pharmaceuticals Limited | Topical pharmaceutical compositions |
US20050100594A1 (en) * | 2003-11-12 | 2005-05-12 | Nilendu Sen | Pharmaceutical formulation containing muscle relaxant and COX-II inhibitor |
WO2020106522A1 (en) | 2018-11-21 | 2020-05-28 | Tremeau Pharmaceuticals, Inc. | Purified forms of rofecoxib, methods of manufacture and use |
US10945992B1 (en) | 2019-11-13 | 2021-03-16 | Tremeau Pharmaceuticals, Inc. | Dosage forms of rofecoxib and related methods |
US11161833B1 (en) | 2021-04-09 | 2021-11-02 | Tremeau Pharmaceuticals, Inc. | Deuterated etoricoxib, methods of manufacture, and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE9422447U1 (de) * | 1993-01-15 | 2002-10-17 | G D Searle Llc Chicago | 3,4-Diarylthiophene und Analoga davon, sowie deren Verwendung als entzündungshemmende Mittel |
US5462939A (en) * | 1993-05-07 | 1995-10-31 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1β-converting enzyme inhibitors |
CN1143365A (zh) * | 1994-01-10 | 1997-02-19 | 麦克弗罗斯特(加拿大)有限公司 | 作为cox-2抑制剂的苯基杂环类化合物 |
-
1994
- 1994-09-16 US US08/307,972 patent/US5585504A/en not_active Expired - Fee Related
-
1995
- 1995-09-08 TW TW084109387A patent/TW325468B/zh active
- 1995-09-12 CN CN95195075A patent/CN1065533C/zh not_active Expired - Fee Related
- 1995-09-12 RU RU97106093/04A patent/RU2160257C2/ru not_active IP Right Cessation
- 1995-09-12 CZ CZ1997792A patent/CZ288797B6/cs not_active IP Right Cessation
- 1995-09-12 UA UA97041788A patent/UA49809C2/uk unknown
- 1995-09-12 AU AU35105/95A patent/AU3510595A/en not_active Abandoned
- 1995-09-12 RO RO97-00484A patent/RO118585B1/ro unknown
- 1995-09-12 WO PCT/US1995/011539 patent/WO1996008482A1/en active Search and Examination
- 1995-09-12 SK SK316-97A patent/SK282789B6/sk unknown
- 1995-09-12 BR BR9508927A patent/BR9508927A/pt not_active Application Discontinuation
-
1997
- 1997-03-14 FI FI971104A patent/FI106376B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI971104A (fi) | 1997-03-14 |
CZ288797B6 (cs) | 2001-09-12 |
UA49809C2 (uk) | 2002-10-15 |
CN1159191A (zh) | 1997-09-10 |
RO118585B1 (ro) | 2003-07-30 |
CZ79297A3 (en) | 1997-07-16 |
SK282789B6 (sk) | 2002-12-03 |
TW325468B (en) | 1998-01-21 |
AU3510595A (en) | 1996-03-29 |
BR9508927A (pt) | 1997-12-30 |
RU2160257C2 (ru) | 2000-12-10 |
FI971104A0 (fi) | 1997-03-14 |
US5585504A (en) | 1996-12-17 |
WO1996008482A1 (en) | 1996-03-21 |
CN1065533C (zh) | 2001-05-09 |
SK31697A3 (en) | 1997-10-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI106376B (fi) | Menetelmä COX-inhibiittoreina käyttökelpoisten fenyyliheterosyklien valmistamiseksi | |
FI114913B (fi) | Menetelmä terapeuttisesti käyttökelpoisten furanonijohdannaisten valmistamiseksi ja menetelmässä käyttökelpoinen lähtöaine | |
US5849943A (en) | Stilbene derivatives useful as cyclooxygenase-2 inhibitors | |
EP0828724B1 (en) | Diaryl-5-oxygenated-2-(5h)-furanones as cox-2 inhibitors | |
MXPA01012903A (es) | Compuestos de 5-aril-1h-1, 2, 4-triazola como inhibidores de ciclooxigenasa-2 y composiciones farmaceuticas que los contienen. | |
JP2002503647A (ja) | ビアリル−酢酸誘導体および該化合物のcox−2阻害薬としての使用 | |
CA2301742C (en) | 2,3,5-trisubstituted pyridines as inhibitors of cyclooxygenase-2 | |
EP1601644A1 (en) | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors | |
HU204029B (en) | Process for producing sulfonamide derivatives and pharmaceutical compositions comprising same | |
CN101910144B (zh) | 对羟基苯丙烯酸衍生物及其应用 | |
US6080876A (en) | Process for making phenyl heterocycles useful as COX-2 inhibitors | |
JP2707936B2 (ja) | β−オキソ−β−ベンゼンプロパンチオアミド誘導体 | |
US6071954A (en) | (methylsulfonyl)phenyl-2-(5H)-furanones with oxygen link as COX-2 inhibitors | |
ES2278980T3 (es) | Derivados de 4'-metanosulfonil-bifenilo como un inhibidor muy selectivo de ciclooxigenasa-2. | |
AU741790B2 (en) | Diaryl-5-alkyl-5-methyl-2(5H)-furanones as selective cyclooxygenase-2 inhibitors | |
JPH0830063B2 (ja) | 新規なイミダゾ−ル誘導体およびその塩 | |
KR100576339B1 (ko) | 피리다진-4-온 유도체, 그 제조방법 및 약제학적 조성물 | |
US6495713B2 (en) | Synthesis of ketosulfone esters | |
KR100576338B1 (ko) | 피리다진-4-온 유도체, 그 제조방법 및 약제학적 조성물 | |
AU2004240700B2 (en) | Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors | |
KR100576337B1 (ko) | 피리다진-4-온 유도체, 그 제조방법 및 약제학적 조성물 | |
KR100576343B1 (ko) | 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물 | |
WO2011012660A1 (en) | Antitumor 1,2-diphenylpyrrole compounds and their preparation process | |
MXPA98006213A (en) | Diphenylesthylenes as profarmacos for inhibitors of cyclooxygenes | |
KR20050052619A (ko) | 피리다진-4-온 유도체, 그 제조방법 및 약제학적 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |