FI106030B - Parannettu menetelmä [1S-(1R*,2S*,3R*)]-N-(4-morfolinyylisulfonyyli)-L-fenyylialanyyli-3-(2-amino-4-tiatsolyyli)-N-[(1-sykloheksyylimetyyli) -2,3-dihydroksi-5-metyyliheksyyli]-L-alaniiniamidin valmistamiseksi - Google Patents

Parannettu menetelmä [1S-(1R*,2S*,3R*)]-N-(4-morfolinyylisulfonyyli)-L-fenyylialanyyli-3-(2-amino-4-tiatsolyyli)-N-[(1-sykloheksyylimetyyli) -2,3-dihydroksi-5-metyyliheksyyli]-L-alaniiniamidin valmistamiseksi Download PDF

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Publication number
FI106030B
FI106030B FI934594A FI934594A FI106030B FI 106030 B FI106030 B FI 106030B FI 934594 A FI934594 A FI 934594A FI 934594 A FI934594 A FI 934594A FI 106030 B FI106030 B FI 106030B
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FI
Finland
Prior art keywords
compound
formula
solvent
acid
co2h
Prior art date
Application number
FI934594A
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English (en)
Finnish (fi)
Swedish (sv)
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FI934594A0 (fi
FI934594A (fi
Inventor
Daniel Thomas Belmont
Valerie Hendrickson
Mark John Hoekman
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI934594A0 publication Critical patent/FI934594A0/fi
Publication of FI934594A publication Critical patent/FI934594A/fi
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Publication of FI106030B publication Critical patent/FI106030B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
FI934594A 1991-04-23 1993-10-18 Parannettu menetelmä [1S-(1R*,2S*,3R*)]-N-(4-morfolinyylisulfonyyli)-L-fenyylialanyyli-3-(2-amino-4-tiatsolyyli)-N-[(1-sykloheksyylimetyyli) -2,3-dihydroksi-5-metyyliheksyyli]-L-alaniiniamidin valmistamiseksi FI106030B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69001291 1991-04-23
US07/690,012 US5089616A (en) 1991-04-23 1991-04-23 Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide
PCT/US1992/003146 WO1992018486A1 (en) 1991-04-23 1992-04-15 Improved process for the preparation of [1s-(1r*, 2s*, 3r*)]-n-(4-(morpholinylsulfonyl)-l-phenylalanyl-3-(2-amino-4-thiazolyl)-n-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-l-alaninamide
US9203146 1992-04-15

Publications (3)

Publication Number Publication Date
FI934594A0 FI934594A0 (fi) 1993-10-18
FI934594A FI934594A (fi) 1993-10-18
FI106030B true FI106030B (fi) 2000-11-15

Family

ID=24770744

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934594A FI106030B (fi) 1991-04-23 1993-10-18 Parannettu menetelmä [1S-(1R*,2S*,3R*)]-N-(4-morfolinyylisulfonyyli)-L-fenyylialanyyli-3-(2-amino-4-tiatsolyyli)-N-[(1-sykloheksyylimetyyli) -2,3-dihydroksi-5-metyyliheksyyli]-L-alaniiniamidin valmistamiseksi

Country Status (12)

Country Link
US (1) US5089616A (ja)
EP (1) EP0581899A4 (ja)
JP (1) JP3247696B2 (ja)
KR (2) KR100221767B1 (ja)
AU (1) AU653851B2 (ja)
CA (1) CA2106673A1 (ja)
FI (1) FI106030B (ja)
IE (1) IE921288A1 (ja)
MX (1) MX9201831A (ja)
NO (1) NO309479B1 (ja)
PT (1) PT100425B (ja)
WO (1) WO1992018486A1 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
US5275950A (en) * 1990-05-11 1994-01-04 Abbott Laboratories Process for the preparation of a renin inhibiting compound
US5223615A (en) * 1990-06-28 1993-06-29 Shionogi & Co., Ltd. Dipeptide derivatives
ZA98376B (en) * 1997-01-23 1998-07-23 Hoffmann La Roche Sulfamide-metalloprotease inhibitors
US6376506B1 (en) 1997-01-23 2002-04-23 Syntex (U.S.A.) Llc Sulfamide-metalloprotease inhibitors
US6130220A (en) * 1997-10-16 2000-10-10 Syntex (Usa) Inc. Sulfamide-metalloprotease inhibitors
WO2010143409A1 (ja) * 2009-06-08 2010-12-16 株式会社カネカ 光学活性チアゾリルアラニン誘導体およびその塩の製造方法
US20220232831A1 (en) * 2019-06-11 2022-07-28 Fortephest Ltd. Novel non-coding heterocyclic amino acids (nchaa) and their use as herbicides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1113029B (it) * 1979-03-01 1986-01-20 Simes Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro
US4238923A (en) * 1979-06-22 1980-12-16 Combustion Engineering, Inc. Method of low temperature heat utilization for atmospheric pressure coal gasification
US5238923A (en) * 1989-05-26 1993-08-24 Warner-Lambert Company Amino-substituted heterocycles as renin inhibitors
JPH071427B2 (ja) * 1989-05-26 1995-01-11 株式会社日立製作所 トレンドグラフ表示方式

Also Published As

Publication number Publication date
IE921288A1 (en) 1992-11-04
EP0581899A1 (en) 1994-02-09
MX9201831A (es) 1992-10-01
AU653851B2 (en) 1994-10-13
PT100425B (pt) 1999-10-29
EP0581899A4 (en) 1996-10-02
KR100221767B1 (ko) 1999-09-15
FI934594A0 (fi) 1993-10-18
NO933809L (no) 1993-10-22
US5089616A (en) 1992-02-18
CA2106673A1 (en) 1992-10-29
AU2183592A (en) 1992-11-17
PT100425A (pt) 1993-08-31
NO309479B1 (no) 2001-02-05
FI934594A (fi) 1993-10-18
KR100317147B1 (ko) 2001-12-22
WO1992018486A1 (en) 1992-10-29
JPH06507406A (ja) 1994-08-25
JP3247696B2 (ja) 2002-01-21

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