PT100425A - Processo aperfeicoado para a preparacao de {1s-(1r*,2s*,3r*)}-n-(4-(morfolinil)-l-fenil-alanil-3-(2-amino-4-tiazolil)-n-{(1-ciclo-hexil-metil)2,3-di-hidroxi-5-metil-hexil}-l-alaninamida - Google Patents

Processo aperfeicoado para a preparacao de {1s-(1r*,2s*,3r*)}-n-(4-(morfolinil)-l-fenil-alanil-3-(2-amino-4-tiazolil)-n-{(1-ciclo-hexil-metil)2,3-di-hidroxi-5-metil-hexil}-l-alaninamida

Info

Publication number
PT100425A
PT100425A PT100425A PT10042592A PT100425A PT 100425 A PT100425 A PT 100425A PT 100425 A PT100425 A PT 100425A PT 10042592 A PT10042592 A PT 10042592A PT 100425 A PT100425 A PT 100425A
Authority
PT
Portugal
Prior art keywords
hexyl
methyl
morfolinyl
alaninamide
alanyl
Prior art date
Application number
PT100425A
Other languages
English (en)
Other versions
PT100425B (pt
Inventor
Daniel Thomas Belmont
Mark John Hoekman
Valerie Hendrickson
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PT100425A publication Critical patent/PT100425A/pt
Publication of PT100425B publication Critical patent/PT100425B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PT100425A 1991-04-23 1992-04-23 Processo aperfeicoado para a preparacao de {1s-(1r*,2s*,3r*)}-n-(4-(morfolinil)-l-fenil-alanil-3-(2-amino-4-tiazolil)-n-{(1-ciclo-hexil-metil)2,3-di-hidroxi-5-metil-hexil}-l-alaninamida PT100425B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/690,012 US5089616A (en) 1991-04-23 1991-04-23 Process for the preparation of [1S-(1R*,2S*,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide

Publications (2)

Publication Number Publication Date
PT100425A true PT100425A (pt) 1993-08-31
PT100425B PT100425B (pt) 1999-10-29

Family

ID=24770744

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100425A PT100425B (pt) 1991-04-23 1992-04-23 Processo aperfeicoado para a preparacao de {1s-(1r*,2s*,3r*)}-n-(4-(morfolinil)-l-fenil-alanil-3-(2-amino-4-tiazolil)-n-{(1-ciclo-hexil-metil)2,3-di-hidroxi-5-metil-hexil}-l-alaninamida

Country Status (12)

Country Link
US (1) US5089616A (pt)
EP (1) EP0581899A4 (pt)
JP (1) JP3247696B2 (pt)
KR (2) KR100317147B1 (pt)
AU (1) AU653851B2 (pt)
CA (1) CA2106673A1 (pt)
FI (1) FI106030B (pt)
IE (1) IE921288A1 (pt)
MX (1) MX9201831A (pt)
NO (1) NO309479B1 (pt)
PT (1) PT100425B (pt)
WO (1) WO1992018486A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5275950A (en) * 1990-05-11 1994-01-04 Abbott Laboratories Process for the preparation of a renin inhibiting compound
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
US5223615A (en) * 1990-06-28 1993-06-29 Shionogi & Co., Ltd. Dipeptide derivatives
US6376506B1 (en) 1997-01-23 2002-04-23 Syntex (U.S.A.) Llc Sulfamide-metalloprotease inhibitors
ZA98376B (en) * 1997-01-23 1998-07-23 Hoffmann La Roche Sulfamide-metalloprotease inhibitors
US6130220A (en) * 1997-10-16 2000-10-10 Syntex (Usa) Inc. Sulfamide-metalloprotease inhibitors
WO2010143409A1 (ja) * 2009-06-08 2010-12-16 株式会社カネカ 光学活性チアゾリルアラニン誘導体およびその塩の製造方法
US20220232831A1 (en) * 2019-06-11 2022-07-28 Fortephest Ltd. Novel non-coding heterocyclic amino acids (nchaa) and their use as herbicides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1113029B (it) * 1979-03-01 1986-01-20 Simes Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro
US4238923A (en) * 1979-06-22 1980-12-16 Combustion Engineering, Inc. Method of low temperature heat utilization for atmospheric pressure coal gasification
US5238923A (en) * 1989-05-26 1993-08-24 Warner-Lambert Company Amino-substituted heterocycles as renin inhibitors
JPH071427B2 (ja) * 1989-05-26 1995-01-11 株式会社日立製作所 トレンドグラフ表示方式

Also Published As

Publication number Publication date
JP3247696B2 (ja) 2002-01-21
PT100425B (pt) 1999-10-29
US5089616A (en) 1992-02-18
EP0581899A4 (en) 1996-10-02
FI934594A (fi) 1993-10-18
AU2183592A (en) 1992-11-17
NO309479B1 (no) 2001-02-05
KR100317147B1 (ko) 2001-12-22
WO1992018486A1 (en) 1992-10-29
IE921288A1 (en) 1992-11-04
NO933809L (no) 1993-10-22
KR100221767B1 (ko) 1999-09-15
JPH06507406A (ja) 1994-08-25
FI934594A0 (fi) 1993-10-18
EP0581899A1 (en) 1994-02-09
FI106030B (fi) 2000-11-15
CA2106673A1 (en) 1992-10-29
AU653851B2 (en) 1994-10-13
MX9201831A (es) 1992-10-01

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19930331

FG3A Patent granted, date of granting

Effective date: 19990730

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20050131