FI106029B - Yhdistelmä -DNA-teknisten proteiinien parannettu aktivointi - Google Patents
Yhdistelmä -DNA-teknisten proteiinien parannettu aktivointi Download PDFInfo
- Publication number
- FI106029B FI106029B FI920742A FI920742A FI106029B FI 106029 B FI106029 B FI 106029B FI 920742 A FI920742 A FI 920742A FI 920742 A FI920742 A FI 920742A FI 106029 B FI106029 B FI 106029B
- Authority
- FI
- Finland
- Prior art keywords
- pro
- seq
- arg
- met
- lys
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Adhesive Tapes (AREA)
- Dental Preparations (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4105480A DE4105480A1 (de) | 1991-02-21 | 1991-02-21 | Verbesserte aktivierung von rekombinanten proteinen |
DE4105480 | 1991-02-21 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI920742A0 FI920742A0 (fi) | 1992-02-20 |
FI920742A FI920742A (fi) | 1992-08-22 |
FI106029B true FI106029B (fi) | 2000-11-15 |
Family
ID=6425597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI920742A FI106029B (fi) | 1991-02-21 | 1992-02-20 | Yhdistelmä -DNA-teknisten proteiinien parannettu aktivointi |
Country Status (20)
Country | Link |
---|---|
US (1) | US5578710A (no) |
EP (1) | EP0500108B1 (no) |
JP (1) | JP2528232B2 (no) |
KR (1) | KR950014493B1 (no) |
AT (1) | ATE144284T1 (no) |
AU (1) | AU641081B2 (no) |
CA (1) | CA2061569C (no) |
CZ (1) | CZ282744B6 (no) |
DE (2) | DE4105480A1 (no) |
DK (1) | DK0500108T3 (no) |
ES (1) | ES2093122T3 (no) |
FI (1) | FI106029B (no) |
GR (1) | GR3021395T3 (no) |
HU (1) | HU214881B (no) |
IE (1) | IE920276A1 (no) |
IL (1) | IL101024A (no) |
MX (1) | MX9200709A (no) |
NO (1) | NO300329B1 (no) |
NZ (1) | NZ241570A (no) |
ZA (1) | ZA921230B (no) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5718893A (en) * | 1984-04-15 | 1998-02-17 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
SE9301057L (sv) * | 1993-03-30 | 1994-10-01 | Pharmacia Ab | Beredning med kontrollerad frisättning |
US5536495A (en) * | 1994-04-15 | 1996-07-16 | Foster; Preston F. | Use of G-CSF to reduce acute rejection |
US20030053982A1 (en) | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
AU9096001A (en) | 2000-09-08 | 2002-03-22 | Amgen Inc | G-csf analog compositions and methods |
ES2309167T3 (es) | 2001-02-19 | 2008-12-16 | Merck Patent Gmbh | Metodo para identificar epitotes de celulas t y metodo para preparar moleculas con inmunogenicidad reducida. |
DE60236522D1 (de) | 2001-07-11 | 2010-07-08 | Maxygen Inc | G-csf konjugate |
AU2003210052A1 (en) | 2002-03-20 | 2003-09-29 | Biopolymed Inc. | Preparation of g-csf stoichiometrically conjugated with biocompatible polymers at cystein residue |
US7666627B2 (en) * | 2002-08-08 | 2010-02-23 | Targetex Kft. | Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof |
US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
US7695723B2 (en) | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
US7220407B2 (en) | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
AU2005306894B2 (en) | 2004-11-05 | 2011-11-24 | Northwestern University | Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders |
RU2007149238A (ru) | 2005-06-01 | 2009-07-20 | Максиджен Холдингз Лтд. (Ky) | Пегилированные полипептиды гксф и способы их получения |
CL2007002166A1 (es) * | 2006-07-24 | 2008-01-25 | Tetralogic Pharm Corp | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. |
WO2009023566A2 (en) | 2007-08-09 | 2009-02-19 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
US8758761B2 (en) | 2007-09-30 | 2014-06-24 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
WO2011109556A2 (en) | 2010-03-04 | 2011-09-09 | Pfenex Inc. | Method for producing soluble recombinant interferon protein without denaturing |
NZ601759A (en) | 2010-03-17 | 2013-07-26 | Biogenerix Gmbh | Method for obtaining biologically active recombinant human g-csf |
WO2011123570A2 (en) | 2010-04-01 | 2011-10-06 | Pfenex Inc. | Methods for g-csf production in a pseudomonas host cell |
JP6388581B2 (ja) * | 2012-08-02 | 2018-09-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 単量体および多量体分子を生産するための方法およびその使用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4532207A (en) * | 1982-03-19 | 1985-07-30 | G. D. Searle & Co. | Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase |
DK55685A (da) * | 1985-02-07 | 1986-08-08 | Nordisk Gentofte | Enzym eller enzymkompleks med proteolytisk aktivitet |
US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
US5082775A (en) * | 1984-05-11 | 1992-01-21 | Berlex Laboratories, Inc. | Efficient process for isolating insoluble heterologous protein using non-ionic detergents |
US4948729A (en) * | 1985-03-25 | 1990-08-14 | Cetus Corporation | Production of soluble recombinant proteins |
US4783415A (en) * | 1985-03-28 | 1988-11-08 | Meiji Seika Kabushiki Kaisha | Gene coding for signal peptides and utilization thereof |
US5087564A (en) * | 1985-06-20 | 1992-02-11 | Monsanto Company | Release of recombinant peptides from polypeptides using V8 endopeptidase |
DE3636903A1 (de) * | 1985-12-21 | 1987-07-02 | Hoechst Ag | Fusionsproteine mit eukaryotischem ballastanteil |
JPH0618781B2 (ja) * | 1986-10-18 | 1994-03-16 | 中外製薬株式会社 | 感染症治療剤 |
EP0621340A1 (en) * | 1987-03-20 | 1994-10-26 | Creative Biomolecules, Inc. | Product and process for the production and purification of recombinant polypeptides |
US5013653A (en) * | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
EP0371041A1 (en) * | 1987-06-24 | 1990-06-06 | Novo Nordisk A/S | A process for preparing a protein or polypeptide, a dna sequence coding for the polypeptide, a microorganism containing the dna sequence as well as the polypeptide and its use as a pharmaceutical preparation |
DE3835350A1 (de) * | 1988-10-17 | 1990-04-19 | Boehringer Mannheim Gmbh | Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern |
ZA901719B (en) * | 1989-03-19 | 1991-01-30 | Akzo Nv | Hog cholera virus vaccine and diagnostics |
US5191063A (en) * | 1989-05-02 | 1993-03-02 | University Of Medicine And Dentistry Of New Jersey | Production of biologically active polypeptides by treatment with an exogenous peptide sequence |
US5115102A (en) * | 1989-07-21 | 1992-05-19 | Monsanto Company | Variant proteins and polypeptides possessing enhanced affinity for immobilized-metal affinity matrices |
DE69126434D1 (de) * | 1990-08-20 | 1997-07-10 | Novo Nordisk As | Prozess für die Herstellung von biologisch aktivem IGF-1 durch Verwendung von amino-terminal verlängertem IGF-1 |
-
1991
- 1991-02-21 DE DE4105480A patent/DE4105480A1/de not_active Withdrawn
-
1992
- 1992-01-28 IE IE027692A patent/IE920276A1/en not_active IP Right Cessation
- 1992-02-10 NZ NZ241570A patent/NZ241570A/en not_active IP Right Cessation
- 1992-02-14 AU AU10948/92A patent/AU641081B2/en not_active Ceased
- 1992-02-20 FI FI920742A patent/FI106029B/fi not_active IP Right Cessation
- 1992-02-20 AT AT92102864T patent/ATE144284T1/de not_active IP Right Cessation
- 1992-02-20 ES ES92102864T patent/ES2093122T3/es not_active Expired - Lifetime
- 1992-02-20 ZA ZA921230A patent/ZA921230B/xx unknown
- 1992-02-20 CA CA002061569A patent/CA2061569C/en not_active Expired - Fee Related
- 1992-02-20 MX MX9200709A patent/MX9200709A/es not_active IP Right Cessation
- 1992-02-20 DK DK92102864.3T patent/DK0500108T3/da active
- 1992-02-20 NO NO920671A patent/NO300329B1/no unknown
- 1992-02-20 EP EP92102864A patent/EP0500108B1/de not_active Revoked
- 1992-02-20 JP JP4033257A patent/JP2528232B2/ja not_active Expired - Lifetime
- 1992-02-20 HU HU9200548A patent/HU214881B/hu not_active IP Right Cessation
- 1992-02-20 DE DE59207351T patent/DE59207351D1/de not_active Revoked
- 1992-02-20 IL IL10102492A patent/IL101024A/en not_active IP Right Cessation
- 1992-02-20 CZ CS92499A patent/CZ282744B6/cs not_active IP Right Cessation
- 1992-02-21 KR KR1019920002697A patent/KR950014493B1/ko not_active IP Right Cessation
-
1993
- 1993-10-21 US US08/139,054 patent/US5578710A/en not_active Expired - Lifetime
-
1996
- 1996-10-17 GR GR960402469T patent/GR3021395T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
KR950014493B1 (ko) | 1995-12-02 |
ZA921230B (en) | 1992-11-25 |
CZ282744B6 (cs) | 1997-09-17 |
EP0500108A3 (en) | 1993-04-07 |
CS49992A3 (en) | 1992-09-16 |
IE920276A1 (en) | 1992-08-26 |
AU1094892A (en) | 1992-08-27 |
IL101024A (en) | 1996-06-18 |
MX9200709A (es) | 1992-09-01 |
DK0500108T3 (da) | 1997-03-24 |
NO300329B1 (no) | 1997-05-12 |
JP2528232B2 (ja) | 1996-08-28 |
FI920742A (fi) | 1992-08-22 |
US5578710A (en) | 1996-11-26 |
CA2061569C (en) | 2000-10-24 |
HU214881B (hu) | 1998-07-28 |
DE59207351D1 (de) | 1996-11-21 |
JPH05244977A (ja) | 1993-09-24 |
FI920742A0 (fi) | 1992-02-20 |
HUT68021A (en) | 1995-04-04 |
NZ241570A (en) | 1994-09-27 |
ES2093122T3 (es) | 1996-12-16 |
KR920016464A (ko) | 1992-09-24 |
AU641081B2 (en) | 1993-09-09 |
EP0500108A2 (de) | 1992-08-26 |
NO920671L (no) | 1992-08-24 |
CA2061569A1 (en) | 1992-08-22 |
DE4105480A1 (de) | 1992-08-27 |
NO920671D0 (no) | 1992-02-20 |
ATE144284T1 (de) | 1996-11-15 |
GR3021395T3 (en) | 1997-01-31 |
EP0500108B1 (de) | 1996-10-16 |
IL101024A0 (en) | 1992-11-15 |
HU9200548D0 (en) | 1992-04-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI106029B (fi) | Yhdistelmä -DNA-teknisten proteiinien parannettu aktivointi | |
KR20070091131A (ko) | 카복시-말단 아미드화 펩티드를 제조하는 방법 | |
Zhang et al. | Biological synthesis of monodisperse derivatives of poly (. alpha., L-glutamic acid): model rodlike polymers | |
Xu et al. | High‐Level Expression of a Soluble Functional Antimicrobial Peptide, Human β‐Defensin 2, in Escherichia coli | |
CN114853881B (zh) | 一种重组人源融合胶原蛋白及其高效羟基化方法与应用 | |
CN111647089A (zh) | 一种重组类人弹性蛋白及其组合物 | |
CN112980865A (zh) | 一种重组类人胶原蛋白工程菌的构建方法 | |
CN107267537B (zh) | 一种杂合抗菌肽mlh的制备方法 | |
CA2206848A1 (en) | Production of peptides using recombinant fusion protein constructs | |
JP5347255B2 (ja) | 組換え蛋白質の可溶性蛋白質としての製造方法 | |
CA2467142C (en) | Improved method for the recombinant production of polypeptides | |
CN101608179B (zh) | 融合肝素酶及其编码基因 | |
EP1981978B1 (en) | Affinity polypeptide for purification of recombinant proteins | |
RU2316590C1 (ru) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pE-His8-TrxL-Ar2, КОДИРУЮЩАЯ ГИБРИДНЫЙ БЕЛОК, СОДЕРЖАЩИЙ АНТИМИКРОБНЫЙ ПЕПТИД АРЕНИЦИН МОРСКОГО КОЛЬЧАТОГО ЧЕРВЯ Arenicola marina, И ШТАММ Escherichia coli BL21(DE3)/pE-His8-TrxL-Ar2 - ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА, СОДЕРЖАЩЕГО АРЕНИЦИН | |
CN111073925B (zh) | 一种基于无序蛋白偶联酶的高效多肽-多肽偶联系统和方法 | |
RU2441072C1 (ru) | ГИБРИДНЫЙ БЕЛОК, ШТАММ БАКТЕРИЙ ESCHERICHIA COLI - ПРОДУЦЕНТ ГИБРИДНОГО БЕЛКА И СПОСОБ ПОЛУЧЕНИЯ БЕЗМЕТИОНИНОВОГО ИНТЕРФЕРОНА АЛЬФА-2b ЧЕЛОВЕКА ИЗ ЭТОГО ГИБРИДНОГО БЕЛКА | |
CN101775404A (zh) | 一种原核表达体系高表达碱性蛋白的方法 | |
KR20080012437A (ko) | 세포막투과 전달 펩타이드 및 이를 포함하는 생물제제 | |
CN112661833A (zh) | 重组人干扰素hIFN-κ基因工程菌株及其构建方法和用途 | |
TW206236B (no) | ||
JP4019145B2 (ja) | 封入体フリーの組換えタンパク質を得る方法 | |
CN114990097A (zh) | L-天冬氨酸-α-脱羧酶突变体及其应用 | |
CN114249839A (zh) | 一种ⅲ型胶原蛋白的融合蛋白、表达系统、药物组合物及应用 | |
RU2181771C1 (ru) | Рекомбинантная плазмидная днк perpins1, кодирующая аминокислотную последовательность рекомбинантного проинсулина человека, и штамм escherichia coli bl21(de3)/perpins1-продуцент рекомбинантного человеческого проинсулина | |
CN112480224A (zh) | 一类融合表达穿膜肽的海洋来源抗氧化蛋白及其制备方法与应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC | Name/ company changed in application |
Owner name: ROCHE DIAGNOSTICS GMBH |
|
MA | Patent expired |