FI105556B - Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta - Google Patents

Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta Download PDF

Info

Publication number
FI105556B
FI105556B FI924381A FI924381A FI105556B FI 105556 B FI105556 B FI 105556B FI 924381 A FI924381 A FI 924381A FI 924381 A FI924381 A FI 924381A FI 105556 B FI105556 B FI 105556B
Authority
FI
Finland
Prior art keywords
groups
carbon atoms
reaction
group
formula
Prior art date
Application number
FI924381A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924381A0 (fi
FI924381A (fi
Inventor
Tomoyuki Shibata
Masakatsu Kaneko
Tomowo Kobayashi
Hitoshi Hotoda
Akira Matsuda
Takuma Sasaki
Yoshihiro Mitsuhashi
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI924381A0 publication Critical patent/FI924381A0/fi
Publication of FI924381A publication Critical patent/FI924381A/fi
Application granted granted Critical
Publication of FI105556B publication Critical patent/FI105556B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI924381A 1991-09-30 1992-09-29 Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta FI105556B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25201591 1991-09-30
JP25201591 1991-09-30

Publications (3)

Publication Number Publication Date
FI924381A0 FI924381A0 (fi) 1992-09-29
FI924381A FI924381A (fi) 1993-03-31
FI105556B true FI105556B (fi) 2000-09-15

Family

ID=17231394

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924381A FI105556B (fi) 1991-09-30 1992-09-29 Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta

Country Status (24)

Country Link
US (1) US5691319A (es)
EP (1) EP0536936B1 (es)
JP (1) JP2569251B2 (es)
KR (1) KR100255491B1 (es)
CN (1) CN1033227C (es)
AT (1) ATE141281T1 (es)
AU (1) AU654212B2 (es)
BR (1) BR1100621A (es)
CA (1) CA2079413C (es)
CZ (1) CZ289477B6 (es)
DE (1) DE69212759T2 (es)
DK (1) DK0536936T3 (es)
ES (1) ES2093211T3 (es)
FI (1) FI105556B (es)
GR (1) GR3020893T3 (es)
HK (1) HK204296A (es)
HU (2) HU221812B1 (es)
IL (1) IL103301A (es)
MX (1) MXPA92005623A (es)
NO (1) NO179675C (es)
NZ (1) NZ244574A (es)
RU (1) RU2085557C1 (es)
TW (1) TW205042B (es)
ZA (1) ZA927474B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
GB9515279D0 (en) 1995-07-25 1995-09-20 Norsk Hydro As Improved therapeutic agents
CN1050846C (zh) * 1995-08-03 2000-03-29 中国医学科学院医药生物技术研究所 一种抗肿瘤抗生素云南霉素及其制备方法
KR100483256B1 (ko) * 1997-01-24 2005-04-15 콘파마 아에스 젬시타빈 유도체
US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
AU4430200A (en) * 1999-05-11 2000-11-21 Sankyo Company Limited Liposome preparation of fat-soluble antitumor drug
US6908906B2 (en) 2001-02-09 2005-06-21 Sankyo Company, Limited Crystalline forms of pyrimidine nucleoside derivative
JP3748536B2 (ja) * 2001-02-09 2006-02-22 三共株式会社 ピリミジンヌクレオシド誘導体の結晶
US20050014716A1 (en) * 2003-05-21 2005-01-20 Wang Jin Wei Pancreatic cancer treatment
GB0328180D0 (en) * 2003-12-04 2004-01-07 Cyclacel Ltd Combination
MY142304A (en) * 2005-01-31 2010-11-15 Taiho Pharmaceutical Co Ltd Novel pyrimidine nucleoside compound or salt thereof
GB0523041D0 (en) * 2005-11-11 2005-12-21 Cyclacel Ltd Combination
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
WO2008010571A1 (fr) 2006-07-21 2008-01-24 Taiho Pharmaceutical Co., Ltd. Composé nucléosidique de 2'cyanopyrimidine
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US8124593B2 (en) 2007-11-05 2012-02-28 Cyclacel Limited Methods of treatment using sapacitabine
GB2459779A (en) * 2008-05-08 2009-11-11 Cyclacel Ltd Process for the preparation of 2'-cyano-2'-deoxy-N4-palmitoyl-1-beta-D-arabinofuranosylcytosine
GB0808357D0 (en) * 2008-05-08 2008-06-18 Cyclacel Ltd Process
GB0808359D0 (en) * 2008-05-08 2008-06-18 Cyclacel Ltd Process
CA2725295C (en) 2008-06-09 2016-11-08 Cyclacel Limited Combination of sapacitabine (cndac) and dna methyltransferase inhibitors such as decitabine and procaine
DK2431376T4 (da) * 2009-05-15 2024-02-26 Delta Fly Pharma Inc Ny stabilt krystal af 1-(2'-cyano-2'-deoxy-ß-D-arabinofuranosyl)cytosinmonohydrochlorid
EP2696878B1 (en) 2011-04-14 2019-07-10 Cyclacel Limited Dosage regimen for sapacitabine and decitabine in combination for treating acute myeloid leukemia
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
CN104114568B (zh) 2011-12-22 2017-09-01 艾丽奥斯生物制药有限公司 取代的核苷、核苷酸及其类似物
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
CN104203969B (zh) * 2012-03-28 2016-08-31 富士胶片株式会社 1-(2-脱氧-2-氟-4-硫代-β-D-阿拉伯呋喃糖基)胞嘧啶的盐
JP6286421B2 (ja) 2012-05-15 2018-02-28 サイクラセル リミテッド サパシタビン及びセリシクリブの投与レジメン
HRP20211456T1 (hr) 2014-12-26 2021-12-24 Emory University Protuvirusni derivati n4-hidroksicitidina
US11104698B2 (en) 2015-12-03 2021-08-31 Biosight Ltd. Salts of conjugates for cancer therapy
EP3383407B1 (en) 2015-12-03 2023-12-06 BioSight Ltd. Cytarabine conjugates for cancer therapy
WO2019081951A1 (en) 2017-10-27 2019-05-02 Cyclacel Limited DOSAGE REGIME
KR102248165B1 (ko) 2017-12-07 2021-05-06 에모리 유니버시티 N4-하이드록시사이티딘 및 유도체 및 이와 관련된 항-바이러스 용도
CN108610384B (zh) * 2018-05-31 2022-02-22 沈阳药科大学 基于肠道mct1载体蛋白设计的前药及其制备方法
WO2021079129A1 (en) 2019-10-24 2021-04-29 Cyclacel Limited Dosing regimen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
DE3481191D1 (de) * 1983-07-20 1990-03-08 Teijin Ltd Antineoplastisches mittel.
US4818750A (en) * 1985-09-17 1989-04-04 Burroughs Wellcome Co. Treatment of human viral infections
ZA886890B (en) * 1987-10-09 1989-05-30 Hoffmann La Roche Novel dideoxycytidine derivatives
FR2640267B2 (fr) * 1988-01-19 1992-02-14 Univ Paris Curie Procede de synthese de l'azido-3(prime)-desoxy-3(prime)-thymidine et analogues
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
FR2632442B1 (fr) * 1988-06-06 1990-09-14 Framatome Sa Dispositif de mesure de parametres dans le coeur d'un reacteur nucleaire en service
EP0348170A3 (en) * 1988-06-21 1990-12-05 Moses Nam Fong Lee Antiviral pyrimidine derivatives
FR2635778A1 (fr) * 1988-08-26 1990-03-02 Ire Celltarg Sa Nouveaux derives de la 3(prime) azido-3(prime) deoxythymidine (azt) actifs contre le virus hiv du sida
JPH0678338B2 (ja) * 1988-09-09 1994-10-05 帝人株式会社 ２′，３′−ジデオキシシチジン−２′−エン誘導体、その製造方法及びそれを有効成分とする抗レトロウイルス剤
JP2559917B2 (ja) * 1990-06-15 1996-12-04 三共株式会社 ピリミジンヌクレオシド誘導体

Also Published As

Publication number Publication date
CN1072686A (zh) 1993-06-02
MXPA92005623A (es) 2002-06-19
FI924381A0 (fi) 1992-09-29
DE69212759D1 (de) 1996-09-19
AU2602692A (en) 1993-04-01
ATE141281T1 (de) 1996-08-15
IL103301A0 (en) 1993-02-21
BR1100621A (pt) 1999-12-07
IL103301A (en) 1997-07-13
DE69212759T2 (de) 1997-04-03
CA2079413C (en) 2003-09-09
HU211851A9 (en) 1995-12-28
EP0536936A1 (en) 1993-04-14
CZ289477B6 (cs) 2002-01-16
FI924381A (fi) 1993-03-31
DK0536936T3 (da) 1997-01-13
HU9203115D0 (en) 1992-12-28
KR100255491B1 (ko) 2000-05-01
CN1033227C (zh) 1996-11-06
HK204296A (en) 1996-11-15
NO179675B (no) 1996-08-19
EP0536936B1 (en) 1996-08-14
JPH05194497A (ja) 1993-08-03
NO179675C (no) 1996-11-27
JP2569251B2 (ja) 1997-01-08
NO923794D0 (no) 1992-09-30
NO923794L (no) 1993-03-31
AU654212B2 (en) 1994-10-27
ES2093211T3 (es) 1996-12-16
CZ298592A3 (en) 1993-12-15
CA2079413A1 (en) 1993-03-31
ZA927474B (en) 1993-07-14
KR930006045A (ko) 1993-04-20
US5691319A (en) 1997-11-25
RU2085557C1 (ru) 1997-07-27
GR3020893T3 (en) 1996-11-30
HU221812B1 (hu) 2003-01-28
NZ244574A (en) 1994-01-26
HUT62310A (en) 1993-04-28
TW205042B (es) 1993-05-01

Similar Documents

Publication Publication Date Title
FI105556B (fi) Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta
KR860001283B1 (ko) 디플루오로 항 바이러스제의 제조방법
US5668113A (en) Method of using 1,5-anhydrohexitol nucleoside analogues to treat viral infections
KR100347218B1 (ko) N-옥시카보닐치환된5'-데옥시-5-플루오로사이티딘
ES2226891T3 (es) Nuevos analogos biciclonucleosidos.
FI93217C (fi) Menetelmä terapeuttisesti aktiivisten nukleosidijohdannaisten estereiden ja amidien valmistamiseksi
Martin et al. Synthesis and antiviral activity of monofluoro and difluoro analogs of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1)
ES2240645T3 (es) Nuevos derivados de pirazina o sus sales, composiciones farmaceuticas que contienen estos derivados o sus sales e intermedios utilizados en su preparacion.
FI118967B (fi) 3'-substituoidut nukleosidijohdannaiset
US4762823A (en) Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
ES2210153T3 (es) Analogos de nucleosidos de pirimidina de accion antiviral.
UA63915C2 (uk) МОНОЦИКЛІЧНИЙ L-НУКЛЕОЗИД, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, СПОСІБ ЛІКУВАННЯ ТА СПОСІБ ІНВЕРСІЙНОГО МОДУЛЮВАННЯ АКТИВНОСТІ Th1 ТА Th2
Manta et al. Fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-2-keto-β-D-glucopyranosyl derivatives of N4-benzoyl cytosine
EP0214708B1 (en) Griseolic acid derivatives, their preparation and their use
FI92491B (fi) Menetelmä farmakologisesti aktiivisten nukleosidijohdannaisten valmistamiseksi
Nishizono et al. Synthesis of thietane nucleosides by glycosidation of thietanose derivatives with nucleobases
CA2064916A1 (en) Substituted 2', 3'-dideoxy-5-trifluoromethyluridines, processes for their preparation and their use in medicaments
JP2839921B2 (ja) リピドａモノサッカライド類縁体
Filippov et al. A study towards total synthesis of antibiotic Agrocin 84
US5733890A (en) Adenylate analogs as potent anti-herpes virus agents
EP0437016A2 (en) Lipid A analogues having immunoactivating and anti-tumour activity
EP0686150A1 (de) Verfahren zur Herstellung von C-Nukleosiden und C-Nukleosid-Analoga, neue C-Nukleoside und C-Nukleosid-Analoga, sowie ihre Verwendung
JP2002284793A (ja) 新規ビシクロヌクレオシド類縁体を含有する核酸試薬

Legal Events

Date Code Title Description
MA Patent expired