IL103301A - Pyrimidine nucleoside derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same - Google Patents

Pyrimidine nucleoside derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Info

Publication number
IL103301A
IL103301A IL103301A IL10330192A IL103301A IL 103301 A IL103301 A IL 103301A IL 103301 A IL103301 A IL 103301A IL 10330192 A IL10330192 A IL 10330192A IL 103301 A IL103301 A IL 103301A
Authority
IL
Israel
Prior art keywords
groups
substituents
group
carbon atoms
substituted
Prior art date
Application number
IL103301A
Other languages
English (en)
Other versions
IL103301A0 (en
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of IL103301A0 publication Critical patent/IL103301A0/xx
Publication of IL103301A publication Critical patent/IL103301A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL103301A 1991-09-30 1992-09-30 Pyrimidine nucleoside derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same IL103301A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25201591 1991-09-30

Publications (2)

Publication Number Publication Date
IL103301A0 IL103301A0 (en) 1993-02-21
IL103301A true IL103301A (en) 1997-07-13

Family

ID=17231394

Family Applications (1)

Application Number Title Priority Date Filing Date
IL103301A IL103301A (en) 1991-09-30 1992-09-30 Pyrimidine nucleoside derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same

Country Status (24)

Country Link
US (1) US5691319A (xx)
EP (1) EP0536936B1 (xx)
JP (1) JP2569251B2 (xx)
KR (1) KR100255491B1 (xx)
CN (1) CN1033227C (xx)
AT (1) ATE141281T1 (xx)
AU (1) AU654212B2 (xx)
BR (1) BR1100621A (xx)
CA (1) CA2079413C (xx)
CZ (1) CZ289477B6 (xx)
DE (1) DE69212759T2 (xx)
DK (1) DK0536936T3 (xx)
ES (1) ES2093211T3 (xx)
FI (1) FI105556B (xx)
GR (1) GR3020893T3 (xx)
HK (1) HK204296A (xx)
HU (2) HU221812B1 (xx)
IL (1) IL103301A (xx)
MX (1) MXPA92005623A (xx)
NO (1) NO179675C (xx)
NZ (1) NZ244574A (xx)
RU (1) RU2085557C1 (xx)
TW (1) TW205042B (xx)
ZA (1) ZA927474B (xx)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
GB9515279D0 (en) * 1995-07-25 1995-09-20 Norsk Hydro As Improved therapeutic agents
CN1050846C (zh) * 1995-08-03 2000-03-29 中国医学科学院医药生物技术研究所 一种抗肿瘤抗生素云南霉素及其制备方法
PL186888B1 (pl) * 1997-01-24 2004-03-31 Conpharma As Pochodne gemcytabiny
US6235782B1 (en) 1998-11-12 2001-05-22 Rifat Pamukcu Method for treating a patient with neoplasia by treatment with a platinum coordination complex
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
AU4430200A (en) * 1999-05-11 2000-11-21 Sankyo Company Limited Liposome preparation of fat-soluble antitumor drug
JP3748536B2 (ja) * 2001-02-09 2006-02-22 三共株式会社 ピリミジンヌクレオシド誘導体の結晶
US6908906B2 (en) 2001-02-09 2005-06-21 Sankyo Company, Limited Crystalline forms of pyrimidine nucleoside derivative
US20050014716A1 (en) * 2003-05-21 2005-01-20 Wang Jin Wei Pancreatic cancer treatment
GB0328180D0 (en) * 2003-12-04 2004-01-07 Cyclacel Ltd Combination
MY142304A (en) 2005-01-31 2010-11-15 Taiho Pharmaceutical Co Ltd Novel pyrimidine nucleoside compound or salt thereof
GB0523041D0 (en) * 2005-11-11 2005-12-21 Cyclacel Ltd Combination
GB0526419D0 (en) 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
EP2045256A4 (en) * 2006-07-21 2009-09-02 Taiho Pharmaceutical Co Ltd 2'CYANOPYRIMIDINE NUCLEOSIDE COMPOUND
GB0625283D0 (en) 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US8124593B2 (en) 2007-11-05 2012-02-28 Cyclacel Limited Methods of treatment using sapacitabine
GB2459779A (en) * 2008-05-08 2009-11-11 Cyclacel Ltd Process for the preparation of 2'-cyano-2'-deoxy-N4-palmitoyl-1-beta-D-arabinofuranosylcytosine
GB0808359D0 (en) * 2008-05-08 2008-06-18 Cyclacel Ltd Process
GB0808357D0 (en) * 2008-05-08 2008-06-18 Cyclacel Ltd Process
US8530445B2 (en) 2008-06-09 2013-09-10 Cyclacel Limited Combinations of sapacitabine or CNDAC with DNA methyltransferase inhibitors such as decitabine and procaine
ES2426025T3 (es) * 2009-05-15 2013-10-18 Delta-Fly Pharma, Inc. Nuevo cristal estable de monoclorhidrato 1-(2'-ciano-2'-desoxi-beta-D-arabinofuranosil)citosina
HUE046177T2 (hu) 2011-04-14 2020-02-28 Cyclacel Ltd Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére
CN102432654A (zh) * 2011-09-26 2012-05-02 宋云龙 吉西他滨酰胺衍生物及其制备方法和用途
AP2014007796A0 (en) 2011-12-22 2014-07-31 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2013241341B2 (en) * 2012-03-28 2016-09-08 Fujifilm Corporation Salt of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine
WO2013171473A1 (en) 2012-05-15 2013-11-21 Cyclacel Limited Dosage regimen for sapacitabine and seliciclib
EP3236972B1 (en) * 2014-12-26 2021-07-28 Emory University Anti-viral n4-hydroxycytidine derivatives
CN108431017B (zh) 2015-12-03 2021-12-21 拜欧赛特有限公司 用于癌症疗法的缀合物的盐
CN108289905A (zh) 2015-12-03 2018-07-17 拜欧赛特有限公司 用于癌症疗法的阿糖胞苷缀合物
WO2019081951A1 (en) 2017-10-27 2019-05-02 Cyclacel Limited DOSAGE REGIME
CA3082191C (en) 2017-12-07 2021-09-21 Emory University N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN108610384B (zh) * 2018-05-31 2022-02-22 沈阳药科大学 基于肠道mct1载体蛋白设计的前药及其制备方法
WO2021079129A1 (en) 2019-10-24 2021-04-29 Cyclacel Limited Dosing regimen

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
EP0151189B1 (en) * 1983-07-20 1990-01-31 Teijin Limited Antineoplastic agent
US4818750A (en) * 1985-09-17 1989-04-04 Burroughs Wellcome Co. Treatment of human viral infections
ZA886890B (en) * 1987-10-09 1989-05-30 Hoffmann La Roche Novel dideoxycytidine derivatives
FR2640267B2 (fr) * 1988-01-19 1992-02-14 Univ Paris Curie Procede de synthese de l'azido-3(prime)-desoxy-3(prime)-thymidine et analogues
US4900828A (en) * 1988-05-12 1990-02-13 Hoffmann-Laroche Inc. Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
FR2632442B1 (fr) * 1988-06-06 1990-09-14 Framatome Sa Dispositif de mesure de parametres dans le coeur d'un reacteur nucleaire en service
JPH02104586A (ja) * 1988-06-21 1990-04-17 Moses Nam Fong Lee ピリミジン誘導体及びその使用
FR2635778A1 (fr) * 1988-08-26 1990-03-02 Ire Celltarg Sa Nouveaux derives de la 3(prime) azido-3(prime) deoxythymidine (azt) actifs contre le virus hiv du sida
JPH0678338B2 (ja) * 1988-09-09 1994-10-05 帝人株式会社 ２′，３′−ジデオキシシチジン−２′−エン誘導体、その製造方法及びそれを有効成分とする抗レトロウイルス剤
JP2559917B2 (ja) * 1990-06-15 1996-12-04 三共株式会社 ピリミジンヌクレオシド誘導体

Also Published As

Publication number Publication date
HU211851A9 (en) 1995-12-28
MXPA92005623A (es) 2002-06-19
FI924381A0 (fi) 1992-09-29
ES2093211T3 (es) 1996-12-16
KR100255491B1 (ko) 2000-05-01
GR3020893T3 (en) 1996-11-30
IL103301A0 (en) 1993-02-21
HK204296A (en) 1996-11-15
DK0536936T3 (da) 1997-01-13
EP0536936A1 (en) 1993-04-14
FI924381A (fi) 1993-03-31
JPH05194497A (ja) 1993-08-03
CA2079413C (en) 2003-09-09
AU2602692A (en) 1993-04-01
NO179675B (no) 1996-08-19
CN1033227C (zh) 1996-11-06
HU9203115D0 (en) 1992-12-28
NO179675C (no) 1996-11-27
HUT62310A (en) 1993-04-28
DE69212759D1 (de) 1996-09-19
HU221812B1 (hu) 2003-01-28
CA2079413A1 (en) 1993-03-31
NO923794L (no) 1993-03-31
RU2085557C1 (ru) 1997-07-27
JP2569251B2 (ja) 1997-01-08
EP0536936B1 (en) 1996-08-14
CZ298592A3 (en) 1993-12-15
NO923794D0 (no) 1992-09-30
ZA927474B (en) 1993-07-14
US5691319A (en) 1997-11-25
CN1072686A (zh) 1993-06-02
ATE141281T1 (de) 1996-08-15
DE69212759T2 (de) 1997-04-03
CZ289477B6 (cs) 2002-01-16
FI105556B (fi) 2000-09-15
TW205042B (xx) 1993-05-01
NZ244574A (en) 1994-01-26
BR1100621A (pt) 1999-12-07
KR930006045A (ko) 1993-04-20
AU654212B2 (en) 1994-10-27

Similar Documents

Publication Publication Date Title
IL103301A (en) Pyrimidine nucleoside derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
TW218018B (xx)
IL97049A0 (en) Aryl-and heteroarylethenylene derivatives,their preparation and pharmaceutical compositions containing them
PT99358A (pt) Processo para a preparacao de composicoes farmaceuticas contendo aminoglicosidos e de reduzida nefrotoxicidade induzida por xantinas
DE10199003I2 (xx)
EP0527687A3 (fr) Nouveaux dérivés d'aryléthylamines, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent
AU5208390A (en) 8-substituted xanthines and their use as pharmaceuticals
HUT62602A (en) Process for producing pharmaceutically active hydrazine derivatives
IL102772A0 (en) 3,5-di-tert.-butyl-4-hydroxyphenyl derivatives,processes for the preparation thereof and pharmaceutical compositions containing them
ES8801618A1 (es) Un procedimiento para preparar derivados de arilciclobutilalquilamina
NO930881D0 (no) Anti-tumor forbindelser
EP1108427A3 (en) Compositions for and uses thereof for altering gene expression with phenylacetate and derivatives thereof
ES474215A1 (es) Procedimiento para la preparacion de derivados imidazolile- tiloxialcoxilicos y sus analogos con agrupacion tio
CA2100655A1 (en) Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
IL103019A0 (en) Dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
ES8705891A1 (es) Un procedimiento para preparar antibioticos de cefalosporina.
CA2090584A1 (fr) Steroides comportant en position 17 un radical methylene lactone, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
GB1435916A (en) Pharmaceutical weight-reducing compositions
ES8308331A1 (es) Un procedimiento de preparacion de cefalosporinas sustituidas en la posicion 3 con un grupo heterociclo-tiometilo.
GB1310642A (en) Alpha-sulfo-and alpha-sulfoalkylacylcephalosporins
FI853866L (fi) 2-pyridin-tiol-derivat, foerfarande foer framstaellning av dessa samt farmaceutiska foereningar innehaollande dessa.
DE69131774D1 (de) Antibakterielle penem-ester derivate
ES8100275A1 (es) Un procedimiento para la preparacion de derivados de 5-fluoruracilo
ES8105319A1 (es) Procedimiento de preparacion de derivados pirazolo (1,5-c) quinazolinos y de sus sales de adicion acidas
IL106564A (en) Tetrahydronaphthalene derivatives their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
RH Patent void
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired