FI105097B - Menetelmä terapeuttisesti käyttökelpoisen 4-amino-2-(4,4-dimetyyli-imidatsolidin-2-on-1-yyli)pyrimidiini-5-karboksyylihappo-[N-metyyli-N-(3-trifluorimetyylifenyyli)amidin] hydrokloridisuolan valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen 4-amino-2-(4,4-dimetyyli-imidatsolidin-2-on-1-yyli)pyrimidiini-5-karboksyylihappo-[N-metyyli-N-(3-trifluorimetyylifenyyli)amidin] hydrokloridisuolan valmistamiseksi Download PDF

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Publication number
FI105097B
FI105097B FI930718A FI930718A FI105097B FI 105097 B FI105097 B FI 105097B FI 930718 A FI930718 A FI 930718A FI 930718 A FI930718 A FI 930718A FI 105097 B FI105097 B FI 105097B
Authority
FI
Finland
Prior art keywords
compound
acid
methyl
water
hydrochloride
Prior art date
Application number
FI930718A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI930718A (fi
FI930718A0 (fi
Inventor
Ernold Granzer
Michael Leineweber
Klaus-Dieter Kampe
Manfred Huettinger
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI930718A0 publication Critical patent/FI930718A0/fi
Publication of FI930718A publication Critical patent/FI930718A/fi
Application granted granted Critical
Publication of FI105097B publication Critical patent/FI105097B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI930718A 1992-02-22 1993-02-18 Menetelmä terapeuttisesti käyttökelpoisen 4-amino-2-(4,4-dimetyyli-imidatsolidin-2-on-1-yyli)pyrimidiini-5-karboksyylihappo-[N-metyyli-N-(3-trifluorimetyylifenyyli)amidin] hydrokloridisuolan valmistamiseksi FI105097B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4205483 1992-02-22
DE4205483 1992-02-22

Publications (3)

Publication Number Publication Date
FI930718A0 FI930718A0 (fi) 1993-02-18
FI930718A FI930718A (fi) 1993-08-23
FI105097B true FI105097B (fi) 2000-06-15

Family

ID=6452363

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930718A FI105097B (fi) 1992-02-22 1993-02-18 Menetelmä terapeuttisesti käyttökelpoisen 4-amino-2-(4,4-dimetyyli-imidatsolidin-2-on-1-yyli)pyrimidiini-5-karboksyylihappo-[N-metyyli-N-(3-trifluorimetyylifenyyli)amidin] hydrokloridisuolan valmistamiseksi

Country Status (16)

Country Link
US (1) US5795899A (hu)
EP (1) EP0557877B1 (hu)
JP (1) JP3258744B2 (hu)
AT (1) ATE158581T1 (hu)
AU (2) AU658265B2 (hu)
CA (1) CA2089956A1 (hu)
DE (1) DE59307402D1 (hu)
DK (1) DK0557877T3 (hu)
ES (1) ES2109382T3 (hu)
FI (1) FI105097B (hu)
GR (1) GR3025235T3 (hu)
HU (1) HU210621B (hu)
IL (1) IL104792A (hu)
NO (1) NO300892B1 (hu)
NZ (2) NZ264767A (hu)
ZA (1) ZA931183B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE147384T1 (de) * 1992-02-22 1997-01-15 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DE19625088A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19625089A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
US7087597B1 (en) 1999-10-12 2006-08-08 Takeda Pharmaceutical Company Limited Pyrimidine 5-carboxamide compounds, process for producing the same and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2853220A1 (de) * 1978-12-09 1980-07-03 Hoechst Ag Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
DE3522940A1 (de) * 1985-06-27 1987-01-08 Hoechst Ag 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln
ATE147384T1 (de) * 1992-02-22 1997-01-15 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Also Published As

Publication number Publication date
US5795899A (en) 1998-08-18
EP0557877B1 (de) 1997-09-24
NO930595D0 (no) 1993-02-19
IL104792A (en) 1997-09-30
HU210621B (en) 1995-06-28
DE59307402D1 (de) 1997-10-30
EP0557877A1 (de) 1993-09-01
JP3258744B2 (ja) 2002-02-18
GR3025235T3 (en) 1998-02-27
HU9300459D0 (en) 1993-05-28
NO300892B1 (no) 1997-08-11
AU1136595A (en) 1995-04-13
ZA931183B (en) 1993-09-16
AU3376093A (en) 1993-08-26
AU658265B2 (en) 1995-04-06
NO930595L (no) 1993-08-23
JPH06184137A (ja) 1994-07-05
NZ245937A (en) 1994-12-22
DK0557877T3 (da) 1998-04-27
ATE158581T1 (de) 1997-10-15
IL104792A0 (en) 1993-06-10
AU669463B2 (en) 1996-06-06
NZ264767A (en) 1995-10-26
HUT63410A (en) 1993-08-30
CA2089956A1 (en) 1993-08-23
FI930718A (fi) 1993-08-23
FI930718A0 (fi) 1993-02-18
ES2109382T3 (es) 1998-01-16

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