GR3025235T3 - Soluble salts of 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5-carboxylic acid N-methyl-N-(3-trifluoromethyl-phenyl)-amide, process for their preparation, their use as medicine and initial products - Google Patents

Soluble salts of 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5-carboxylic acid N-methyl-N-(3-trifluoromethyl-phenyl)-amide, process for their preparation, their use as medicine and initial products

Info

Publication number
GR3025235T3
GR3025235T3 GR970402871T GR970402871T GR3025235T3 GR 3025235 T3 GR3025235 T3 GR 3025235T3 GR 970402871 T GR970402871 T GR 970402871T GR 970402871 T GR970402871 T GR 970402871T GR 3025235 T3 GR3025235 T3 GR 3025235T3
Authority
GR
Greece
Prior art keywords
trifluoromethyl
amide
dimethyl
phenyl
amino
Prior art date
Application number
GR970402871T
Other languages
English (en)
Inventor
Klaus-Dieter Dr Kampe
Ernold Dr Dr Granzer
Michael Dr Leineweber
Manfred Prof Dr Huettinger
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of GR3025235T3 publication Critical patent/GR3025235T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GR970402871T 1992-02-22 1997-10-31 Soluble salts of 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5-carboxylic acid N-methyl-N-(3-trifluoromethyl-phenyl)-amide, process for their preparation, their use as medicine and initial products GR3025235T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4205483 1992-02-22

Publications (1)

Publication Number Publication Date
GR3025235T3 true GR3025235T3 (en) 1998-02-27

Family

ID=6452363

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970402871T GR3025235T3 (en) 1992-02-22 1997-10-31 Soluble salts of 4-amino-2-(4,4-dimethyl-imidazolidin-2-on-1-yl)-pyrimidin-5-carboxylic acid N-methyl-N-(3-trifluoromethyl-phenyl)-amide, process for their preparation, their use as medicine and initial products

Country Status (16)

Country Link
US (1) US5795899A (el)
EP (1) EP0557877B1 (el)
JP (1) JP3258744B2 (el)
AT (1) ATE158581T1 (el)
AU (2) AU658265B2 (el)
CA (1) CA2089956A1 (el)
DE (1) DE59307402D1 (el)
DK (1) DK0557877T3 (el)
ES (1) ES2109382T3 (el)
FI (1) FI105097B (el)
GR (1) GR3025235T3 (el)
HU (1) HU210621B (el)
IL (1) IL104792A (el)
NO (1) NO300892B1 (el)
NZ (2) NZ264767A (el)
ZA (1) ZA931183B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE147384T1 (de) * 1992-02-22 1997-01-15 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
DE19625089A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19625088A1 (de) * 1996-06-24 1998-01-02 Hoechst Ag 4-Amino-2-ureido-pyrimidin-5-carbonsäureamide, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE60025243T2 (de) * 1999-10-12 2006-06-22 Takeda Pharmaceutical Co. Ltd. Pyrimidin-5-carboximidverbindungen, verfahren zur herstellung derselben und deren verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2853220A1 (de) * 1978-12-09 1980-07-03 Hoechst Ag Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
DE3522940A1 (de) * 1985-06-27 1987-01-08 Hoechst Ag 4-amino-2-(imidazolidin-2-on-1-yl)-pyrimidin-5-carbonsaeure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln
ATE147384T1 (de) * 1992-02-22 1997-01-15 Hoechst Ag 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung

Also Published As

Publication number Publication date
DE59307402D1 (de) 1997-10-30
IL104792A (en) 1997-09-30
JP3258744B2 (ja) 2002-02-18
CA2089956A1 (en) 1993-08-23
FI930718A (fi) 1993-08-23
FI105097B (fi) 2000-06-15
NZ264767A (en) 1995-10-26
ATE158581T1 (de) 1997-10-15
AU658265B2 (en) 1995-04-06
HU9300459D0 (en) 1993-05-28
ES2109382T3 (es) 1998-01-16
AU669463B2 (en) 1996-06-06
AU1136595A (en) 1995-04-13
ZA931183B (en) 1993-09-16
DK0557877T3 (da) 1998-04-27
HU210621B (en) 1995-06-28
NZ245937A (en) 1994-12-22
EP0557877B1 (de) 1997-09-24
NO930595L (no) 1993-08-23
FI930718A0 (fi) 1993-02-18
NO300892B1 (no) 1997-08-11
EP0557877A1 (de) 1993-09-01
JPH06184137A (ja) 1994-07-05
HUT63410A (en) 1993-08-30
NO930595D0 (no) 1993-02-19
AU3376093A (en) 1993-08-26
IL104792A0 (en) 1993-06-10
US5795899A (en) 1998-08-18

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